G protein βγ subunit-dependent Rac-guanine nucleotide exchange activity of Ras-GRF1/CDC25 ^Mm

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Protein modules and signalling networks

1995 • 2,447 citations

Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme

1989 • 1,244 citations

p115 RhoGEF, a GTPase Activating Protein for Gα ₁₂ and Gα ₁₃

1998 • 834 citations

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

1997 • 769 citations

Direct Stimulation of the Guanine Nucleotide Exchange Activity of p115 RhoGEF by Gα ₁₃

1998 • 765 citations

RasGRP, a Ras Guanyl Nucleotide- Releasing Protein with Calcium- and Diacylglycerol-Binding Motifs

1998 • 662 citations

STRUCTURE AND FUNCTION OF SIGNAL-TRANSDUCING GTP-BINDING PROTEINS

1991 • 630 citations

Rho Family GTPases and Neuronal Growth Cone Remodelling: Relationship between Increased Complexity Induced by Cdc42Hs, Rac1, and Acetylcholine and Collapse Induced by RhoA and Lysophosphatidic Acid

1997 • 601 citations

Role of c-Src Tyrosine Kinase in G Protein-coupled Receptorand Gβγ Subunit-mediated Activation of Mitogen-activated Protein Kinases

1996 • 524 citations

Binding of G protein beta gamma-subunits to pleckstrin homology domains.

1994 • 479 citations

A role for the Ras signalling pathway in synaptic transmission and long-term memory

1997 • 474 citations

Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines

1996 • 454 citations

Coupling of Ras and Rac Guanosine Triphosphatases Through the Ras Exchanger Sos

1998 • 452 citations

Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF

1995 • 424 citations

How receptor tyrosine kinases activate ras

1993 • 393 citations

Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21

1992 • 361 citations

Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product.

1994 • 314 citations

Lck Regulates Vav Activation of Members of the Rho Family of GTPases

1997 • 305 citations

Dbl family proteins

1997 • 260 citations

Signaling from G Protein-coupled Receptors to c-Jun Kinase Involves βγ Subunits of Heterotrimeric G Proteins Acting on a Ras and Rac1-dependent Pathway

1996 • 246 citations

Cloning by functional complementation of a mouse cDNA encoding a homologue of CDC25, a Saccharomyces cerevisiae RAS activator.

1992 • 234 citations

Phosphorylation-dependent activation of the Ras-GRF/CDC25Mm exchange factor by muscarinic receptors and G-protein βγ subunits

1996 • 178 citations

The Small GTP-binding Protein Rho Activates c-Jun N-terminal Kinases/Stress-activated Protein Kinases in Human Kidney 293T Cells

1996 • 171 citations

Activation of p38 Mitogen-activated Protein Kinase by Signaling through G Protein-coupled Receptors

1997 • 154 citations

Gα12 Stimulates c-Jun NH2-terminal Kinase through the Small G Proteins Ras and Rac

1996 • 152 citations

Cloning and Characterization of Ras-GRF2, a Novel Guanine Nucleotide Exchange Factor for Ras

1997 • 131 citations

A region of proto-dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC24, and the human breakpoint cluster gene, bcr.

1991 • 129 citations

Activation of Tsk and Btk tyrosine kinases by G protein beta gamma subunits.

1995 • 127 citations

Gα12 and Gα13 Regulate Extracellular Signal-regulated Kinase and c-Jun Kinase Pathways by Different Mechanisms in COS-7 Cells

1996 • 112 citations

Isolation of multiple mouse cDNAs with coding homology to Saccharomyces cerevisiae CDC25: identification of a region related to Bcr, Vav, Dbl and CDC24.

1992 • 106 citations

The N-Terminal Pleckstrin, Coiled-Coil, and IQ Domains of the Exchange Factor Ras-GRF Act Cooperatively To Facilitate Activation by Calcium

1996 • 104 citations

Identification of a mammalian gene structurally and functionally related to the CDC25 gene of Saccharomyces cerevisiae.

1992 • 91 citations

The exchange factor Ras-GRF2 activates Ras-dependent and Rac-dependent mitogen-activated protein kinase pathways

1998 • 91 citations

Lysophosphatidic Acid Induces Threonine Phosphorylation of Tiam1 in Swiss 3T3 Fibroblasts via Activation of Protein Kinase C

1997 • 86 citations

Tyrosine phosphorylation of ACK in response to temperature shift‐down, hyperosmotic shock, and epidermal growth factor stimulation

1996 • 59 citations

Dependence of Activated Gα12-induced G1 to S Phase Cell Cycle Progression on Both Ras/Mitogen-activated Protein Kinase and Ras/Rac1/Jun N-terminal Kinase Cascades in NIH3T3 Fibroblasts

1997 • 57 citations

G protein βγ subunit activates Ras, Raf, and MAP kinase in HEK 293 cells

1995 • 56 citations

Activation of the exchange factor Ras‐GRF by calcium requires an intact Dbl homology domain

1997 • 54 citations

Functional Involvement of mSos in Interleukin-3 and Thrombin Stimulation of the Ras, Mitogen-Activated Protein Kinase Pathway in BaF3 Murine Hematopoietic Cells

1998 • 13 citations