Dependence of Activated Gα12-induced G1 to S Phase Cell Cycle Progression on Both Ras/Mitogen-activated Protein Kinase and Ras/Rac1/Jun N-terminal Kinase Cascades in NIH3T3 Fibroblasts

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Principles of CDK regulation

1995 • 3,267 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

G1 phase progression: Cycling on cue

1994 • 2,706 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Cyclin D1 is a nuclear protein required for cell cycle progression in G1.

1993 • 1,605 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

Transcription Factor ATF2 Regulation by the JNK Signal Transduction Pathway

1995 • 1,453 citations

GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours

1989 • 1,405 citations

Heterotrimeric C proteins: Organizers of transmembrane signals

1995 • 1,388 citations

Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase

1994 • 1,370 citations

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

1992 • 1,358 citations

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1993 • 1,313 citations

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G ₁

1995 • 1,142 citations

Expression of transcription factor E2F1 induces quiescent cells to enter S phase

1993 • 960 citations

Cellular Targets for Activation by the E2F1 Transcription Factor Include DNA Synthesis- and G₁/S-Regulatory Genes

1995 • 910 citations

An essential role for Rac in Ras transformation

1995 • 895 citations

Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins

1989 • 846 citations

Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits

1994 • 814 citations

Transforming p21 Mutants and c-Ets-2 Activate the Cyclin D1 Promoter through Distinguishable Regions

1995 • 803 citations

Activation of Rac1, RhoA, and Mitogen-Activated Protein Kinases Is Required for Ras Transformation

1995 • 683 citations

Lysophosphatidic Acid, a Multifunctional Phospholipid Messenger

1995 • 592 citations

The jun and fos protein families are both required for cell cycle progression in fibroblasts.

1991 • 442 citations

Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras.

1994 • 418 citations

Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts.

1993 • 377 citations

An E2F-binding site mediates cell-cycle regulated repression of mouse B-myb transcription.

1993 • 342 citations

A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter.

1993 • 315 citations

Tyrosine kinases in activation of the MAP kinase cascade by G-protein-coupled receptors

1996 • 275 citations

Structure and cell cycle-regulated transcription of the human cyclin A gene.

1994 • 272 citations

The heterotrimeric G q protein-coupled angiotensin II receptor activates p21 ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytes.

1996 • 265 citations

G alpha 12 and G alpha 13 subunits define a fourth class of G protein alpha subunits.

1991 • 250 citations

Signal transduction from cell surface to nucleus in development and disease

1992 • 246 citations

Signaling from G Protein-coupled Receptors to c-Jun Kinase Involves βγ Subunits of Heterotrimeric G Proteins Acting on a Ras and Rac1-dependent Pathway

1996 • 246 citations

Effect of a dominant inhibitory Ha-ras mutation on mitogenic signal transduction in NIH 3T3 cells.

1990 • 242 citations

Involvement of Ras and Raf in the Gi-coupled acetylcholine muscarinic m2 receptor activation of mitogen-activated protein (MAP) kinase kinase and MAP kinase.

1993 • 241 citations

Gi-mediated activation of the p21ras-mitogen-activated protein kinase pathway by alpha 2-adrenergic receptors expressed in fibroblasts.

1993 • 234 citations

Mutant α subunits of Gi2 inhibit cyclic AMP accumulation

1991 • 224 citations

Activation of Jun Kinase/Stress-activated Protein Kinase by GTPase-deficient Mutants of Gα12 and Gα13

1995 • 178 citations

Mutations of Gs α Designed to Alter the Reactivity of the Protein with Bacterial Toxins

1989 • 177 citations

A mutant alpha subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cells.

1993 • 176 citations

Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse.

1989 • 175 citations

The effects of bombesin on polyphosphoinositide and calcium metabolism in Swiss 3T3 cells.

1987 • 175 citations

Recombinant Gq alpha. Mutational activation and coupling to receptors and phospholipase C.

1992 • 156 citations

Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product.

1993 • 145 citations

A mutant alpha subunit of Gi2 induces neoplastic transformation of Rat-1 cells.

1991 • 138 citations

Mutant alpha subunits of G12 and G13 proteins induce neoplastic transformation of Rat-1 fibroblasts.

1994 • 113 citations

Protein kinase C-dependent and -independent activation of Na+/H+ exchanger by G alpha 12 class of G proteins.

1994 • 109 citations

The transforming activity of activated Gα12

1993 • 100 citations

G12 Requirement for Thrombin-stimulated Gene Expression and DNA Synthesis in 1321N1 Astrocytoma Cells

1995 • 96 citations

Epitope-tag vectors for eukaryotic protein production

1995 • 73 citations

A requirement for Ras protein function in thrombin-stimulated mitogenesis in astrocytoma cells.

1993 • 71 citations

G12 and G13 α-Subunits Are Immunochemically Detectable in Most Membranes of Various Mammalian Cells and Tissues

1994 • 64 citations

MAP kinase activation is essential for oncogenic transformation of NIH3T3 cells by Mos.

1995 • 61 citations

Independent effects of platelet-derived growth factor isoforms on mitogen-activated protein kinase activation and mitogenesis in human dermal fibroblasts

1994 • 48 citations

Endothelin, its diverse biological activities and mechanisms of action

1989 • 40 citations

What are the functions of the pertussis toxin-insensitive G proteins G 12 , G 13 and G z ?

1994 • 19 citations