Activation of the exchange factor Ras‐GRF by calcium requires an intact Dbl homology domain

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions

1995 • 1,367 citations

FUNCTION AND REGULATION OF RAS

1993 • 1,161 citations

Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.

1993 • 966 citations

Stimulation of p21ras upon T-cell activation

1990 • 882 citations

A role for Rac in Tiaml-induced membrane ruffling and invasion

1995 • 562 citations

Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3.

1994 • 553 citations

Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway

1995 • 541 citations

The PH domain: a common piece in the structural pathcwork of signalling proteins

1993 • 536 citations

The Dbl family of oncogenes

1996 • 497 citations

Binding of G protein beta gamma-subunits to pleckstrin homology domains.

1994 • 479 citations

PH Domains: Diverse Sequences with a Common Fold Recruit Signaling Molecules to the Cell Surface

1996 • 464 citations

Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF

1995 • 424 citations

Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbloncogene product

1991 • 424 citations

Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21

1992 • 361 citations

Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation.

1996 • 335 citations

Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product.

1994 • 314 citations

Control of the yeast bud-site assembly GTPase Cdc42. Catalysis of guanine nucleotide exchange by Cdc24 and stimulation of GTPase activity by Bem3.

1994 • 283 citations

Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator.

1994 • 281 citations

Tyrosine kinases in activation of the MAP kinase cascade by G-protein-coupled receptors

1996 • 275 citations

Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap.

1994 • 270 citations

The heterotrimeric G q protein-coupled angiotensin II receptor activates p21 ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytes.

1996 • 265 citations

ralGDS family members interact with the effector loop of ras p21.

1994 • 260 citations

Interactions among Proteins Involved in Bud-site Selection and Bud-site Assembly in Saccharomyces cerevisiae

1995 • 209 citations

A novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways.

1994 • 195 citations

Phosphorylation-dependent activation of the Ras-GRF/CDC25Mm exchange factor by muscarinic receptors and G-protein βγ subunits

1996 • 178 citations

Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family.

1995 • 162 citations

Direct Involvement of the Small GTP-binding Protein Rho in lbc Oncogene Function

1995 • 156 citations

The Pleckstrin Homology Domain Mediates Transformation by Oncogenic Dbl through Specific Intracellular Targeting

1996 • 136 citations

Isolation of multiple mouse cDNAs with coding homology to Saccharomyces cerevisiae CDC25: identification of a region related to Bcr, Vav, Dbl and CDC24.

1992 • 106 citations

The N-Terminal Pleckstrin, Coiled-Coil, and IQ Domains of the Exchange Factor Ras-GRF Act Cooperatively To Facilitate Activation by Calcium

1996 • 104 citations

Guanine-nucleotide exchange factors: a family of positive regulators of Ras and related GTPases

1994 • 104 citations

Molecular cloning and characterization of the human dbl proto-oncogene: evidence that its overexpression is sufficient to transform NIH/3T3 cells.

1988 • 93 citations

Nuclear Signaling by Endothelin-1 Requires Src Protein-tyrosine Kinases

1996 • 77 citations

In Vivo Functional Analysis of the Ras Exchange Factor Son of Sevenless

1995 • 76 citations

Functional Roles for the Pleckstrin and Dbl Homology Regions in the Ras Exchange Factor Son-of-sevenless

1995 • 65 citations