Phosphorylation-dependent activation of the Ras-GRF/CDC25Mm exchange factor by muscarinic receptors and G-protein βγ subunits

Proteins regulating Ras and its relatives

1993 • 1,930 citations

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1993 • 1,236 citations

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1993 • 1,077 citations

Stimulation of p21ras upon T-cell activation

1990 • 882 citations

Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits

1994 • 814 citations

A Dissection and tissue culture manual of the nervous system

1989 • 762 citations

Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway

1995 • 541 citations

cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells.

1994 • 473 citations

Distinct Pathways of Gi- and Gq-mediated Mitogen-activated Protein Kinase Activation

1995 • 451 citations

Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF

1995 • 424 citations

Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras.

1994 • 418 citations

Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts.

1993 • 377 citations

Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21

1992 • 361 citations

Requirements for Phosphorylation of Map Kinase During Meiosis in Xenopus Oocytes

1992 • 316 citations

Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes.

1991 • 288 citations

Involvement of Ras and Raf in the Gi-coupled acetylcholine muscarinic m2 receptor activation of mitogen-activated protein (MAP) kinase kinase and MAP kinase.

1993 • 241 citations

Cloning by functional complementation of a mouse cDNA encoding a homologue of CDC25, a Saccharomyces cerevisiae RAS activator.

1992 • 234 citations

A Cytosolic Protein Catalyzes the Release of GDP from p21 ^ras

1990 • 231 citations

HRas-dependent pathways can activate morphological and genetic markers of cardiac muscle cell hypertrophy.

1993 • 228 citations

Gq- and ras-dependent pathways mediate hypertrophy of neonatal rat ventricular myocytes following alpha 1-adrenergic stimulation.

1994 • 189 citations

Regulation of Epidermal Growth Factor Receptor Signaling by Phosphorylation of the Ras Exchange Factor hSOS1

1996 • 106 citations

Mutants of Rab3A analogous to oncogenic Ras mutants. Sensitivity to Rab3A-GTPase activating protein and Rab3A-guanine nucleotide releasing factor

1993 • 92 citations

Muscarinic receptors transform NIH 3T3 cells through a Ras-dependent signalling pathway inhibited by the Ras-GTPase-activating protein SH3 domain.

1994 • 88 citations

Expression of alternative forms of Ras exchange factors GRF and SOS1 in different human tissues and cell lines.

1996 • 58 citations

Differential response of the Ras exchange factor, Ras-GRF to tyrosine kinase and G protein mediated signals.

1995 • 58 citations

Expression of functional G protein beta gamma dimers of defined subunit composition using a baculovirus expression system.

1992 • 56 citations

Regulated and Constitutive Activity by CDC25^Mm (GRF), a Ras-Specific Exchange Factor

1993 • 47 citations

Mitogenic neurotransmitters

1989 • 43 citations

Selective amplification of endothelin-stimulated inositol 1,4,5-trisphosphate and calcium signaling by v-src transformation of rat-1 fibroblasts.

1992 • 32 citations

Regulated and constitutive activity by CDC25Mm (GRF), a Ras-specific exchange factor.

1993 • 32 citations

M1Muscarinic Receptors Heterologously Expressed in Cardiac Myocytes Mediate Ras-dependent Changes in Gene Expression

1995 • 28 citations