Assembly of the Truncated Immunoglobulin Heavy Chain Dμ into Antigen Receptor–Like Complexes in Pre-B Cells but Not in B Cells

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene

1991 • 1,783 citations

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.

1991 • 1,622 citations

An hsp70-like protein in the ER: Identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein

1986 • 1,457 citations

Posttranslational association of immunoglobulin heavy chain binding protein with nascent heavy chains in nonsecreting and secreting hybridomas.

1986 • 896 citations

Immunoglobulin heavy chain binding protein

1983 • 849 citations

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

1995 • 726 citations

Tyrosine kinases Lyn and Syk regulate B cell receptor-coupled Ca2+ mobilization through distinct pathways.

1994 • 664 citations

Two mRNAs with different 3′ ends encode membrane-bound and secreted forms of immunoglobulin μ chain

1980 • 659 citations

Syk tyrosine kinase required for mouse viability and B-cell development

1995 • 632 citations

A critical role of λ5 protein in B cell development

1992 • 583 citations

The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver.

1993 • 573 citations

Direct activation of the serine/threonine kinase activity of raf-1 through tyrosine phosphorylation by the PDGF β-receptor

1989 • 513 citations

Antigen Receptors on B Lymphocytes

1992 • 509 citations

Somatic hyperconversion diversifies the single VH gene of the chicken with a high incidence in the D region

1989 • 467 citations

Molecular cloning of a porcine gene syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis

1991 • 449 citations

Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice.

1994 • 426 citations

Lack of N regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequences.

1990 • 414 citations

Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B-CLL progenitor generation.

1990 • 396 citations

Targeted disruption of µ chain membrane exon causes loss of heavy-chain allelic exclusion

1992 • 376 citations

The proteins encoded by the VpreB and lambda 5 pre-B cell-specific genes can associate with each other and with mu heavy chain.

1990 • 352 citations

Stimulation of protein tyrosine phosphorylation by the B-lymphocyte antigen receptor

1990 • 346 citations

Introduction of a μ immunoglobulin gene into the mouse germ line: Specific expression in lymphoid cells and synthesis of functional antibody

1984 • 304 citations

λ5, a new light-chain-related locus selectively expressed in pre-B lymphocytes

1986 • 302 citations

Association of the 72-kDa protein-tyrosine kinase PTK72 with the B cell antigen receptor.

1992 • 298 citations

Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells

1984 • 261 citations

The expression of Vpre-B/λ5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice

1994 • 238 citations

Tyrosine phosphorylation of components of the B-cell antigen receptors following receptor crosslinking.

1991 • 235 citations

On the nature of antibody combining sites: Unusual structural features that may confer on these sites an enhanced capacity for binding ligands

1990 • 233 citations

Analysis of the B-cell progenitor compartment at the level of single cells

1994 • 232 citations

The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface.

1990 • 221 citations

Identity of the immunoglobulin heavy-chain-binding protein with the 78,000-dalton glucose-regulated protein and the role of posttranslational modifications in its binding function.

1988 • 211 citations

B lymphocyte activation is accompanied by phosphorylation of a 72-kDa protein-tyrosine kinase

1991 • 204 citations

B cell development regulated by gene rearrangement: Arrest of maturation by membrane-bound Dμ protein and selection of DH element reading frames

1991 • 203 citations

Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation.

1994 • 189 citations

Interaction of BiP with newly synthesized immunoglobulin light chain molecules: cycles of sequential binding and release.

1992 • 187 citations

Activation of V kappa gene rearrangement in pre-B cells follows the expression of membrane-bound immunoglobulin heavy chains.

1987 • 187 citations

Formation of disulphide-linked µ2ω2 tetramers in pre-B cells by the 18K ω-immunoglobulin light chain

1987 • 179 citations

Regulated progression of a cultured pre-B-cell line to the B-cell stage

1985 • 174 citations

Immunoglobulin heavy chain and binding protein complexes are dissociated in vivo by light chain addition.

1990 • 174 citations

Expression of surrogate light chain receptors is restricted to a late stage in pre-B cell differentiation

1993 • 170 citations

The CH Series of Murine B Cell Lymphomas: Neoplastic Analogues of Ly‐1⁺ Normal B Cells

1986 • 161 citations

Only d_fl16, d_sp2, and d_q52 gene families exist in mouse immunoglobulin heavy chain diversity gene loci, of which d_fl16 and d_sp2 originate from the same primordial d_h gene

1989 • 137 citations

The Role of Igβ in Precursor B Cell Transition and Allelic Exclusion

1995 • 133 citations

B-cell antigen receptor motifs have redundant signalling capabilities and bind the tyrosine kinases PTK72, Lyn and Fyn

1993 • 112 citations

Flow Cytometry Analysis of Murine B Cell Lymphoma Differentiation

1979 • 108 citations

Analysis of Junctional Diversity During B Lymphocyte Development

1990 • 107 citations

Enumeration and characterization of DJH structures in mouse fetal liver.

1992 • 99 citations

The expression of the Ig H chain repertoire in developing bone marrow B lineage cells.

1991 • 95 citations

Differentiation of growth signal requirement of B lymphocyte precursor is directed by expression of immunoglobulin.

1991 • 92 citations

Generation and regeneration of cells of the B-lymphocyte lineage

1993 • 89 citations

Structure and Function of the B Cell Antigen Receptor

1993 • 86 citations

Crosslinking of the cell surface immunoglobulin (μ-surrogate light chains complex) on pre-B cells induces activation of V gene rearrangements at the immunoglobulin κ locus

1992 • 83 citations

The omega/lambda 5 surrogate immunoglobulin light chain is expressed on the surface of transitional B lymphocytes in murine bone marrow.

1991 • 79 citations

The immunoglobulin light chain related protein λ5 is expressed on the surface of mouse pre-B cell lines and can function as a signal transducing molecule

1991 • 77 citations

Two types of mu chain complexes are expressed during differentiation from pre-B to mature B cells.

1990 • 76 citations

Development of B-lineage cells in the bone marrow of scid/scid mice following the introduction of functionally rearranged immunoglobulin transgenes.

1990 • 68 citations

Molecular requirements for the mu-induced light chain gene rearrangement in pre-B cells.

1991 • 65 citations

Reading of D genes in variable frames as a source of antibody diversity

1985 • 60 citations

Lymphocyte membrane IgG and secreted IgG are structurally and allotypically distinct.

1980 • 59 citations

The Omega and Iota Surrogate Immunoglobulin Light Chains

1988 • 56 citations

A mutation of the mu transmembrane that disrupts endoplasmic reticulum retention. Effects on association with accessory proteins and signal transduction.

1994 • 54 citations

Cell surface expression of the short immunoglobulin μ chain (Dμ protein) in murine pre-B cells is differently regulated from that of the intact μ chain

1991 • 52 citations

Role of the mu immunoglobulin heavy chain transmembrane and cytoplasmic domains in B cell antigen receptor expression and signal transduction.

1993 • 48 citations

Signal transmission through the B cell-specific MB-1 molecule at the pre-B cell stage

1991 • 46 citations

Cellular Stages and Molecular Steps of Murine B-cell Development

1989 • 44 citations

Examination of B lymphoid cell lines for membrane immunoglobulin-stimulated tyrosine phosphorylation and src-family tyrosine kinase mRNA expression

1992 • 43 citations

CD45 isoform switching precedes the activation-driven death of human thymocytes by apoptosis

1991 • 42 citations

Cross-linking of B cell receptor-related MB-1 molecule induces protein tyrosine phosphorylation in early B lineage cells.

1993 • 40 citations

Immunoglobulin gamma 2b transgenes inhibit heavy chain gene rearrangement, but cannot promote B cell development.

1993 • 37 citations

B-lineage cells in μ-transgenic scid mice proliferate in response to IL-7 but fail to show evidence of immunoglobulin light chain gene rearrangement

1993 • 36 citations

Analysis of Lymphoid Population in Scid Mice; Detection of a Potential B Lymphocyte Progenitor Population Present at Normal Levels in Scid Mice by Three Color Flow Cytometry With B220 and S7

1989 • 32 citations

Influence of surrogate L chain on D_HJ_H-reading frame 2 suppression in mouse precursor B cells

1994 • 31 citations

Allelic exclusion in transgenic mice expressing a heavy chain disease‐like human μ protein

1991 • 25 citations

Allelic inclusion in a pre-B-cell line that generates immunoglobulin heavy chain genes in vitro.

1987 • 21 citations

Stimulation of κ Light-Chain Gene Rearrangement by the Immunoglobulin μ Heavy Chain in a Pre-B-Cell Line

1993 • 18 citations

Surface μ heavy chain expressed on pre-B lymphomas transduces Ca2+ signals but fails to cause growth arrest of pre-B lymphomas

1992 • 8 citations

Regulation of B-cell development by pre-B-cell receptors

1991 • 8 citations

Stimulation of kappa light-chain gene rearrangement by the immunoglobulin mu heavy chain in a pre-B-cell line.

1993 • 7 citations