Generation and regeneration of cells of the B-lymphocyte lineage

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.

1991 • 1,622 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

1992 • 944 citations

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

1992 • 850 citations

Expression and function of c-kit in hemopoietic progenitor cells.

1991 • 756 citations

A critical role of λ5 protein in B cell development

1992 • 583 citations

Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes

1993 • 403 citations

Searching for hematopoietic stem cells: evidence that Thy-1.1lo Lin- Sca-1+ cells are the only stem cells in C57BL/Ka-Thy-1.1 bone marrow.

1992 • 368 citations

Bipotential precursors of B cells and macrophages in murine fetal liver

1992 • 367 citations

Exclusion and inclusion of α and β T cell receptor alleles

1992 • 346 citations

Molecular and cellular origins of B lymphocyte diversity

1991 • 346 citations

The generation and fate of thymocytes.

1990 • 309 citations

Support of human hematopoiesis in long-term bone marrow cultures by murine stromal cells selectively expressing the membrane-bound and secreted forms of the human homolog of the steel gene product, stem cell factor.

1992 • 306 citations

The surrogate light chain in B-cell development

1993 • 282 citations

Direct and synergistic effects of interleukin 11 on murine hemopoiesis in culture.

1991 • 234 citations

Phenotypic and functional characterization of c-kit expression during intrathymic T cell development.

1992 • 194 citations

Insulin-like growth factor-I regulates pro-B cell differentiation

1992 • 190 citations

Clonal proliferation of murine lymphohemopoietic progenitors in culture.

1992 • 163 citations

Proliferation kinetics and the lifespan of B cells in central and peripheral lymphoid organs

1991 • 156 citations

Regulation of N-region diversity in antigen receptors through thymocyte differentiation and thymus ontogeny.

1992 • 154 citations

Engagement of the T-cell receptor during positive selection in the thymus down-regulates RAG-1 expression.

1992 • 152 citations

Predominance of VH-D-JH junctions occurring at sites of short sequence homology results in limited junctional diversity in neonatal antibodies.

1992 • 146 citations

Changes in frequencies of clonable pre B cells during life in different lymphoid organs of mice

1993 • 138 citations

T cell receptor (TCR) beta chain homodimers on the surface of immature but not mature alpha, gamma, delta chain deficient T cell lines.

1992 • 137 citations

Mouse kappa light-chain recombination signal sequences mediate recombination more frequently than do those of lambda light chain.

1991 • 121 citations

The human fetal omentum: a site of B cell generation.

1992 • 120 citations

The c‐kit‐encoded tyrosine kinase regulates the proliferation of early pre‐B cells

1991 • 113 citations

The (4;11)(q21;q23) chromosome translocations in acute leukemias involve the VDJ recombinase.

1992 • 109 citations

Enumeration and characterization of DJH structures in mouse fetal liver.

1992 • 99 citations

Development of a bone marrow culture for maintenance and growth of normal human B cell precursors.

1991 • 97 citations

The expression of the Ig H chain repertoire in developing bone marrow B lineage cells.

1991 • 95 citations

Surface IgM mediated regulation of RAG gene expression in E mu-N-myc B cell lines.

1992 • 90 citations

Interleukin-7 induces N-myc and c-myc expression in normal precursor B lymphocytes.

1992 • 86 citations

Interferon‐γ arrests proliferation and causes apoptosis in stromal cell/interleukin‐7‐dependent normal murine pre‐B cell lines and clones in vitro, but does not induce differentiation to surface immunoglobulin‐positive B cells

1993 • 86 citations

Enrichment and characterization of uncommitted B-cell precursors from fetal liver at day 12 of gestation.

1992 • 86 citations

The omega/lambda 5 surrogate immunoglobulin light chain is expressed on the surface of transitional B lymphocytes in murine bone marrow.

1991 • 79 citations

Interleukin-7 induces the proliferation of normal human B-cell precursors

1991 • 79 citations

Predominance of nonproductive rearrangements of VH81X gene segments evidences a dependence of B cell clonal maturation on the structure of nascent H chains.

1991 • 71 citations

In vitro proliferation of primitive hemopoietic stem cells supported by stromal cells: evidence for the presence of a mechanism(s) other than that involving c-kit receptor and its ligand.

1992 • 69 citations

Developmentally controlled selection of antibody genes: Characterization of individual V_H7183 genes and evidence for stage‐specific somatic diversification

1992 • 64 citations

B Lymphopoiesis in the Mouse

1993 • 59 citations

Variable gene usage, physiology and development of Ly-1+ (CD5+) B cells

1992 • 56 citations

Early and late B-cell development in the mouse

1992 • 53 citations

A novel regulatory myosin light chain gene distinguishes pre-B cell subsets and is IL-7 inducible.

1992 • 45 citations

Dynamics and localization of early B-lymphocyte precursor cells (pro-B cells) in the bone marrow of scid mice

1992 • 44 citations

Highly restricted expression of a stromal cell determinant in mouse bone marrow in vivo.

1992 • 42 citations

The λ/λ ratio in surface immunoglobulin molecules on B lymphocytes differentiating from D_HJ_H‐rearranged murine pre‐B cell clones in vitro

1991 • 41 citations

Differential expression of the c-myb proto-oncogene marks the pre-B cell/B cell junction in murine B lymphoid tumors.

1987 • 38 citations

Thymus reconstitution by c-kit-expressing hematopoietic stem cells purified from adult mouse bone marrow.

1992 • 38 citations

Separation of pluripotent stem cells and early B lymphocyte precursors with antibody Fall-3.

1991 • 35 citations

Transcriptional down-regulation of N-myc expression during B-cell development.

1992 • 34 citations

Early B-cell development in chickens, sheep and rabbits

1992 • 32 citations

Dynamics and localization of early B-lymphocyte precursor cells (pro-B cells) in the bone marrow of scid mice

1992 • 32 citations

Biased reading frames of pre-existing DH--JH coding joints and preferential nucleotide insertions at VH--DJH signal joints of excision products of immunoglobulin heavy chain gene rearrangements.

1992 • 26 citations

Altered phenotypic expression of immunoglobulin heavy-chain variable-region (VH) genes in Alicia rabbits probably reflects a small deletion in the VH genes closest to the joining region.

1990 • 25 citations

A survey of protein‐DNA interaction sites within the murine immunoglobulin heavy chain locus reveals a particularly complex pattern around the DQ₅₂ element

1992 • 24 citations

Ig gene rearrangements on individual alleles of Abelson murine leukemia cell lines from (C57BL/6 x BALB/c) F1 fetal livers.

1991 • 20 citations

Identification of IL-7-dependent bone marrow-derived Thy-1-B220- lymphoid cell clones that rearrange and express both Ig and T cell receptor genes.

1992 • 19 citations

Molecular and cellular aspects of early B-cell development

1991 • 18 citations

What determines the k/λ ratio

1992 • 9 citations

A stromal cell-specific monoclonal antibody augments the stromal cell-dependent B lymphopoiesis.

1992 • 5 citations

Receptor Editing in Immature Self-Reactive B-cells

1993 • 1 citations