Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B-CLL progenitor generation.

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

Xenogeneic Monoclonal Antibodies to Mouse Lymphoid Differentiation Antigens*

1979 • 1,989 citations

Sequences at the somatic recombination sites of immunoglobulin light-chain genes

1979 • 859 citations

Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions.

1982 • 755 citations

Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation.

1990 • 672 citations

Polymerase Chain Reaction with Single-Sided Specificity: Analysis of T Cell Receptor δ Chain

1989 • 640 citations

Development of the Primary Antibody Repertoire

1987 • 629 citations

The LY‐1B Cell Lineage

1986 • 603 citations

Progenitors for Ly-1 B cells are distinct from progenitors for other B cells.

1985 • 599 citations

Junctional sequences of T cell receptor γδ genes: Implications for γδ T cell lineages and for a novel intermediate of V-(D)-J joining

1989 • 572 citations

Early Restriction of the Human Antibody Repertoire

1987 • 546 citations

Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells

1984 • 540 citations

Multiple Recurrent Genomic Defects in Follicular Lymphoma

1987 • 535 citations

B220: a B cell-specific member of the T200 glycoprotein family

1981 • 525 citations

Nonhomologous recombination in mammalian cells: role for short sequence homologies in the joining reaction.

1986 • 465 citations

Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments.

1982 • 411 citations

Activation Of Cellular Oncogenes in Hemopoietic Cells by Chromosome Translocation

1986 • 354 citations

The adult T-cell receptor 5-chain is diverse and distinct from that of fetal thymocytes

1988 • 320 citations

Expansion and functional activity of Ly‐1⁺ B cells upon transfer of peritoneal cells into allotype‐congenic, newborn mice

1987 • 318 citations

λ5, a new light-chain-related locus selectively expressed in pre-B lymphocytes

1986 • 302 citations

Normal, Autoimmune, and Malignant CD5+ B Cells: The LY-1 B Lineage?

1988 • 302 citations

Stable Expression and Somatic Hypermutation of Antibody V Regions in B-Cell Developmental Pathways

1989 • 271 citations

Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells

1984 • 261 citations

Beyond Clonal Selection and Network

1989 • 215 citations

Distinct antigen receptor repertoires of two classes of murine epithelium-associated T cells

1989 • 215 citations

A novel pathway of DNA end-to-end joining

1990 • 213 citations

Characterization of a human colon/lung carcinoma oncogene

1983 • 208 citations

VHDJH formation and DJH replacement during pre-B differentiation: non-random usage of gene segments.

1986 • 186 citations

Formation of disulphide-linked µ2ω2 tetramers in pre-B cells by the 18K ω-immunoglobulin light chain

1987 • 179 citations

Autoantibody-associated kappa light chain variable region gene expressed in chronic lymphocytic leukemia with little or no somatic mutation. Implications for etiology and immunotherapy.

1988 • 177 citations

Preferential linkage of bcl-2 to immunoglobulin light chain gene in chronic lymphocytic leukemia.

1990 • 172 citations

Joining of nonhomologous DNA double strand breaksin vitro

1988 • 166 citations

Flow cytometric analysis of cell proliferation dynamics in the B cell compartment of the mouse

1989 • 157 citations

Nonhomologous Recombination in Mammalian Cells: Role for Short Sequence Homologies in the Joining Reaction

1986 • 154 citations

Organization of the murine Ig-related lambda 5 gene transcribed selectively in pre-B lymphocytes.

1987 • 150 citations

Members of novel VH gene families are found in VDJ regions of polyclonally activated B-lymphocytes.

1985 • 147 citations

Restricted Ig variable region gene expression among Ly-1+ B cell lymphomas.

1988 • 141 citations

Functional characterization of monoclonal auto‐antiidiotype antibodies isolated from the early B cell repertoire of BALB/c mice

1986 • 139 citations

Germline antibody V regions as determinants of clonal persistence and malignant growth in the B cell compartment.

1988 • 139 citations

Only d_fl16, d_sp2, and d_q52 gene families exist in mouse immunoglobulin heavy chain diversity gene loci, of which d_fl16 and d_sp2 originate from the same primordial d_h gene

1989 • 137 citations

Permanent alteration of the murine Ly‐1 B repertoire due to selective depletion of Ly‐1 B cells in neonatal animals

1989 • 116 citations

In vivo suppression of perinatal multispecific B cells results in a distortion of the adult B cell repertoire

1986 • 115 citations

[5] Terminal transferase: Use in the tailing of DNA and for in Vitro mutagenesis

1983 • 114 citations

A monoclonal antibody against Igh6-4 determinant

1986 • 88 citations

Repetitive usage of immunoglobulin VH and D gene segments in CD5+ Ly-1 B clones of (NZB x NZW)F1 mice.

1988 • 77 citations

Clonal proliferation unlinked to terminal deoxynucleotidyl transferase synthesis in thymocytes of young mice.

1983 • 74 citations

Establishment and Functional Implications of B‐cell Connectivity

1989 • 60 citations

自己免疫疾患に関与するLy-1B細胞の分化

1986 • 57 citations

Positive selection of γδ T cells

1990 • 45 citations

Molecular Genetics of Human B-cell Neoplasia

1986 • 37 citations

Structural characterization of antiidiotypic antibodies. Evidence that Ab2s are derived from the germline differently than Ab1s.

1989 • 20 citations