Examination of B lymphoid cell lines for membrane immunoglobulin-stimulated tyrosine phosphorylation and src-family tyrosine kinase mRNA expression

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

1985 • 2,145 citations

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

1991 • 2,028 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

1989 • 978 citations

Surface IgM-kappa specificity on a Burkitt lymphoma cell in vivo and in derived culture lines.

1968 • 833 citations

The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes.

1988 • 716 citations

Establishment and Characterization of BALB/c Lymphoma Lines with B Cell Properties

1979 • 677 citations

Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor.

1990 • 647 citations

CYTOLOGY OF BURKITT'S TUMOUR (AFRICAN LYMPHOMA)

1964 • 627 citations

Interaction of the IL-2 Receptor with thesrc-Family Kinase p56^lck: Identification of Novel Intermolecular Association

1991 • 576 citations

A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA

1985 • 550 citations

Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction.

1990 • 526 citations

Cellular Mechanisms of Immunologic Tolerance

1983 • 521 citations

Direct activation of the serine/threonine kinase activity of raf-1 through tyrosine phosphorylation by the PDGF β-receptor

1989 • 513 citations

T Cell Antigen Receptor-Mediated Activation of Phospholipase C Requires Tyrosine Phosphorylation

1990 • 476 citations

Association of B Cell Antigen Receptor with Protein Tyrosine Kinase Lyn

1991 • 471 citations

Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases.

1991 • 433 citations

Activated B cells express receptors for, and proliferate in response to, pure interleukin 2.

1984 • 361 citations

Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1.

1991 • 351 citations

Stimulation of protein tyrosine phosphorylation by the B-lymphocyte antigen receptor

1990 • 346 citations

Neuronal pp60 ^{c- src} Contains a Six-Amino Acid Insertion Relative to Its Non-Neuronal Counterpart

1987 • 313 citations

Molecular Mechanisms of Transmembrane Signaling in B Lymphocytes

1987 • 279 citations

Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells.

1987 • 278 citations

Specific Expression of a Tyrosine Kinase Gene, blk , in B Lymphoid Cells

1990 • 234 citations

Protein tyrosine phosphorylation is induced in murine B lymphocytes in response to stimulation with anti-immunoglobulin.

1990 • 225 citations

yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family.

1986 • 219 citations

Tyrosine phosphorylation of phospholipase C induced by membrane immunoglobulin in B lymphocytes.

1991 • 205 citations

B lymphocyte activation is accompanied by phosphorylation of a 72-kDa protein-tyrosine kinase

1991 • 204 citations

Expression of a novel form of the fyn proto-oncogene in hematopoietic cells.

1989 • 174 citations

The role of tyrosine phosphorylation in signal transduction through surface Ig in human B cells. Inhibition of tyrosine phosphorylation prevents intracellular calcium release.

1991 • 163 citations

The CH Series of Murine B Cell Lymphomas: Neoplastic Analogues of Ly‐1⁺ Normal B Cells

1986 • 161 citations

The role of class II molecules in human B cell activation. Association with phosphatidyl inositol turnover, protein tyrosine phosphorylation, and proliferation.

1990 • 156 citations

Activation of a tyrosine protein kinase is an early event in the stimulation of T lymphocytes by interleukin-2.

1988 • 152 citations

Selective expression of a protein-tyrosine kinase, p56lyn, in hematopoietic cells and association with production of human T-cell lymphotropic virus type I.

1989 • 152 citations

Mechanism of Interleukin-2 Signaling: Mediation of Different Outcomes by a Single Receptor and Transduction Pathway

1989 • 148 citations

Characterization of cDNA clones for the human c-yes gene.

1987 • 147 citations

Molecular Aspects of B-Lymphocyte Activation

1987 • 136 citations

PROLIFERATION AND DIFFERENTIATION OF LYMPHOID CELLS: STUDIES WITH HUMAN LYMPHOID CELL LINES AND IMMUNOGLOBULIN SYNTHESIS

1971 • 108 citations

Flow Cytometry Analysis of Murine B Cell Lymphoma Differentiation

1979 • 108 citations

Specialized protein tyrosine kinase proto-oncogenes in hematopoietic cells

1989 • 99 citations

fgr proto-oncogene mRNA induced in B lymphocytes by Epstein–Barr virus infection

1986 • 97 citations

Isolation of a cDNA copy of an RNA species expressed in murine pre-B cells.

1986 • 78 citations

Tissue-specific expression and developmental regulation of the human fgr proto-oncogene.

1989 • 75 citations

Growth regulation of the B lymphoma cell line WEHI-231 by anti-immunoglobulin, lipopolysaccharide, and other bacterial products.

1986 • 74 citations

Activation of phospholipase C in human B cells is dependent on tyrosine phosphorylation.

1991 • 68 citations

Overexpression of src family gene for tyrosine-kinase p59fyn in CD4-CD8- T cells of mice with a lymphoproliferative disorder.

1989 • 68 citations

Surface immunoglobulin crosslinking activates a tyrosine kinase pathway in B cells that is independent of protein kinase C.

1991 • 65 citations

Tyrosine phosphorylations in vivo associated with v-fms transformation.

1988 • 59 citations

Independent control of immunoglobulin heavy and light chain expression in a murine pre-B-cell line

1981 • 58 citations

Lymphoma models for B cell activation and tolerance IV. Growth inhibition by anti‐Ig of CH31 and CH33 B lymphoma cells

1986 • 51 citations

Establishment and characterization of BALB/c lymphoma lines with B cell properties

1980 • 40 citations

Identification of cDNA clones that code for protein-tyrosine kinases by screening expression libraries with antibodies against phosphotyrosine.

1988 • 25 citations

Molecular analysis of immunoglobulin expression in variants of murine B lymphoma, 70Z/3

1987 • 21 citations

Molecular cloning and sequencing of the murine c-fgr gene.

1990 • 9 citations