Stimulation of κ Light-Chain Gene Rearrangement by the Immunoglobulin μ Heavy Chain in a Pre-B-Cell Line

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

1985 • 2,145 citations

Surface IgM-kappa specificity on a Burkitt lymphoma cell in vivo and in derived culture lines.

1968 • 833 citations

Development of the Primary Antibody Repertoire

1987 • 629 citations

A critical role of λ5 protein in B cell development

1992 • 583 citations

Organization and reorganization of immunoglobulin genes in A-MuLV-transformed cells: Rearrangement of heavy but not light chain genes

1981 • 497 citations

V(D)J Recombination: Molecular Biology and Regulation

1992 • 464 citations

Activation of immunoglobulin kappa gene rearrangement correlates with induction of germline kappa gene transcription

1989 • 432 citations

Targeted disruption of µ chain membrane exon causes loss of heavy-chain allelic exclusion

1992 • 376 citations

The proteins encoded by the VpreB and lambda 5 pre-B cell-specific genes can associate with each other and with mu heavy chain.

1990 • 352 citations

Molecular and cellular origins of B lymphocyte diversity

1991 • 346 citations

Stimulation of protein tyrosine phosphorylation by the B-lymphocyte antigen receptor

1990 • 346 citations

Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals

1987 • 346 citations

Introduction of a μ immunoglobulin gene into the mouse germ line: Specific expression in lymphoid cells and synthesis of functional antibody

1984 • 304 citations

Allelic Exclusion in Transgenic Mice That Express the Membrane form of Immunoglobulin μ

1987 • 293 citations

Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription.

1991 • 289 citations

Continuing kappa-gene rearrangement in a cell line transformed by Abelson murine leukemia virus

1982 • 278 citations

Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells

1984 • 261 citations

Transmission and expression of a specific pair of rearranged immunoglobulin μ and κ genes in a transgenic mouse line

1985 • 244 citations

The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface.

1990 • 221 citations

Evidence that murine pre-B cells synthesise μ heavy chains but no light chains

1979 • 208 citations

B cell development regulated by gene rearrangement: Arrest of maturation by membrane-bound Dμ protein and selection of DH element reading frames

1991 • 203 citations

Developmental stage specificity of the lymphoid V(D)J recombination activity.

1987 • 199 citations

Activation of V kappa gene rearrangement in pre-B cells follows the expression of membrane-bound immunoglobulin heavy chains.

1987 • 187 citations

Immunoglobulin Gene Rearrangement in Immature B Cells

1980 • 172 citations

A transgenic immunoglobulin Mu gene prevents rearrangement of endogenous genes

1985 • 169 citations

MECHANISM AND DEVELOPMENTAL PROGRAM OF IMMUNOGLOBULIN GENE REARRANGEMENT IN MAMMALS

1989 • 144 citations

Feedback inhibition of immunoglobulin gene rearrangement by membrane mu, but not by secreted mu heavy chains.

1988 • 138 citations

Transgenic Mice with Immunoglobulin Genes

1987 • 137 citations

Isolation of scid pre-B cells that rearrange kappa light chain genes: formation of normal signal and abnormal coding joins.

1989 • 128 citations

Organization and expression of immunoglobulin genes in fetal liver hybridomas.

1981 • 116 citations

Normal pre-B cells express a receptor complex of mu heavy chains and surrogate light-chain proteins.

1991 • 109 citations

Flow Cytometry Analysis of Murine B Cell Lymphoma Differentiation

1979 • 108 citations

Light-chain gene expression before heavy-chain gene rearrangement in pre-B cells transformed by Epstein-Barr virus.

1989 • 97 citations

Crosslinking of the cell surface immunoglobulin (μ-surrogate light chains complex) on pre-B cells induces activation of V gene rearrangements at the immunoglobulin κ locus

1992 • 83 citations

The omega/lambda 5 surrogate immunoglobulin light chain is expressed on the surface of transitional B lymphocytes in murine bone marrow.

1991 • 79 citations

The immunoglobulin light chain related protein λ5 is expressed on the surface of mouse pre-B cell lines and can function as a signal transducing molecule

1991 • 77 citations

Two types of mu chain complexes are expressed during differentiation from pre-B to mature B cells.

1990 • 76 citations

Molecular requirements for the mu-induced light chain gene rearrangement in pre-B cells.

1991 • 65 citations

Initiation and processing of two kappa immunoglobulin germ line transcripts in mouse B cells.

1990 • 59 citations

Function and Control of Recombination‐Activating Gene Activity^a

1992 • 58 citations

Independent control of immunoglobulin heavy and light chain expression in a murine pre-B-cell line

1981 • 58 citations

The Omega and Iota Surrogate Immunoglobulin Light Chains

1988 • 56 citations

Wild-type V(D)J recombination in scid pre-B cells.

1990 • 53 citations

CD45 isoform switching precedes the activation-driven death of human thymocytes by apoptosis

1991 • 42 citations

Roles of protein and carbohydrate in glycoprotein processing and secretion. Studies using mutants expressing altered IgM mu chains.

1981 • 42 citations

A novel germ-line J_Ktranscript starting immediately upstream of J_K1

1989 • 34 citations

Tyrosine phosphorylation and the mechanism of signal transduction by the B‐lymphocyte antigen receptor

1992 • 31 citations

A rapid test for V(D)J recombinase activity

1990 • 26 citations

A human b-cell lymphoma synthesizing and expressing surface mu-chain in the absence of detectable light chain

1981 • 22 citations

Allelic inclusion in a pre-B-cell line that generates immunoglobulin heavy chain genes in vitro.

1987 • 21 citations

Analysis of surface mu-chain expression in human lymphoblastoid cell lines that do not produce light chains.

1984 • 16 citations

Surface μ heavy chain expressed on pre-B lymphomas transduces Ca2+ signals but fails to cause growth arrest of pre-B lymphomas

1992 • 8 citations

Regulation of B-cell development by pre-B-cell receptors

1991 • 8 citations