On the nature of antibody combining sites: Unusual structural features that may confer on these sites an enhanced capacity for binding ligands

The protein data bank: A computer-based archival file for macromolecular structures

1977 • 8,627 citations

Some Factors in the Interpretation of Protein Denaturation

1959 • 4,817 citations

Structure of the human class I histocompatibility antigen, HLA-A2

1987 • 3,453 citations

The Anatomy and Taxonomy of Protein Structure

1981 • 3,376 citations

Analytical molecular surface calculation

1983 • 2,454 citations

Conformational parameters for amino acids in helical, β-sheet, and random coil regions calculated from proteins

1974 • 2,173 citations

Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution.

1981 • 1,432 citations

Canonical structures for the hypervariable regions of immunoglobulins

1987 • 1,357 citations

Amino Acid Preferences for Specific Locations at the Ends of α Helices

1988 • 1,356 citations

AN ANALYSIS OF THE SEQUENCES OF THE VARIABLE REGIONS OF BENCE JONES PROTEINS AND MYELOMA LIGHT CHAINS AND THEIR IMPLICATIONS FOR ANTIBODY COMPLEMENTARITY

1970 • 1,308 citations

Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-.ANG. resolution

1981 • 1,286 citations

Environment and exposure to solvent of protein atoms. Lysozyme and insulin

1973 • 1,259 citations

Serine Proteases: Structure and Mechanism of Catalysis

1977 • 1,238 citations

Three-Dimensional Structure of an Antigen-Antibody Complex at 2.8 Å Resolution

1986 • 1,173 citations

Hydrophobicity of Amino Acid Residues in Globular Proteins

1985 • 1,168 citations

Analysis and prediction of the different types of β-turn in proteins

1988 • 962 citations

The Antigenic Structure of Proteins: A Reappraisal

1984 • 957 citations

Interior and surface of monomeric proteins

1987 • 924 citations

Three-Dimensional Structure of Immunoglobulins

1979 • 692 citations

Aromatic rings act as hydrogen bond acceptors

1988 • 685 citations

Three-dimensional structure of an antibody-antigen complex.

1987 • 615 citations

Phosphocholine binding immunoglobulin Fab McPC603

1986 • 576 citations

Three-dimensional structure of a complex of antibody with influenza virus neuraminidase

1987 • 556 citations

The Three-Dimensional Structure of a Phosphorylcholine-Binding Mouse Immunoglobulin Fab and the Nature of the Antigen Binding Site

1974 • 465 citations

Structure of an antibody-antigen complex: crystal structure of the HyHEL-10 Fab-lysozyme complex.

1989 • 456 citations

Crystallographic refinement and atomic models of the intact immunoglobulin molecule Kol and its antigen-binding fragment at 3.0 Å and 1.9 Å resolution

1980 • 455 citations

Dynamics of ligand binding to heme proteins

1979 • 440 citations

Domain association in immunoglobulin molecules

1985 • 389 citations

Three-Dimensional Structure of the Fab′ Fragment of a Human Immunoglobulin at 2.8-Å Resolution

1973 • 381 citations

Structural Basis of Antibody Function

1983 • 371 citations

On the attribution of binding energy in antigen-antibody complexes McPC 603, D1.3, and HyHEL-5

1989 • 367 citations

Proteins : structures and molecular principles

1983 • 357 citations

Structure of a λ-type Bence-Jones protein at 3.5-Å resolution

1973 • 356 citations

Preliminary refinement and structural analysis of the Fab fragment from human immunoglobulin new at 2.0 A resolution.

1978 • 293 citations

Myoglobin and the Structure of Proteins

1963 • 285 citations

Structure and Function of Cytochromes C

1977 • 279 citations

Molecular structure of a dimer composed of the variable portions of the Bence-Jones protein REI refined at 2.0-Å resolution

1975 • 266 citations

The Three Dimensional Structure of a Combining Region-Ligand Complex of Immunoglobulin NEW at 3.5-Å Resolution

1974 • 227 citations

ATTEMPTS TO LOCATE COMPLEMENTARITY‐DETERMINING RESIDUES IN THE VARIABLE POSITIONS OF LIGHT AND HEAVY CHAINS *

1971 • 212 citations

Unusual distributions of amino acids in complementarity-determining (hypervariable) segments of heavy and light chains of immunoglobulins and their possible roles in specificity of antibody-combining sites.

1977 • 196 citations

Antibody-antigen complexes.

1988 • 189 citations

The galactan‐binding immunoglobulin Fab J539: An x‐ray diffraction study at 2.6‐Å resolution

1986 • 175 citations

The independent distribution of amino acid near neighbor pairs into polypeptides

1977 • 167 citations

Structure at 4.5 Å; Resolution of a Phosphorylcholine-binding Fab

1973 • 113 citations

Structural basis for the specificity of antibody–antigen reactions and structural mechanisms for the diversification of antigen-binding specificities

1977 • 94 citations

Structural invariants of antigen binding: comparison of immunoglobulin VL-VH and VL-VL domain dimers.

1985 • 79 citations

Three-dimensional structure of Fab R19.9, a monoclonal murine antibody specific for the p-azobenzenearsonate group.

1989 • 72 citations

Influence of solvent accessibility and intermolecular contacts on atomic mobilities in hemerythrins.

1985 • 67 citations

On the specificity of antibody/antigen interactions: Phosphocholine binding to McPC603 and the correlation of three-dimensional structure and sequence data

1985 • 67 citations

Structure and Polymorphism of Murine and Human Class II Major Histocompatibility Antigens

1985 • 62 citations

Structural Analysis of the Functional Sites of Class I HLA Antigens

1985 • 49 citations

Crystal structure of galactan-binding mouse immunoglobulin J539 Fab at 4.5-A resolution.

1979 • 42 citations

Immunoglobulin Structures at High Resolution

1975 • 40 citations

A model of the Fc of immunoglobulin E

1986 • 38 citations