Src Regulates Distinct Pathways for Cell Volume Control through Vav andPhospholipaseCγ

Cell Migration: Integrating Signals from Front to Back

2003 • 4,755 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Cellular Motility Driven by Assembly and Disassembly of Actin Filaments

2003 • 4,038 citations

Functional Significance of Cell Volume Regulatory Mechanisms

1998 • 1,871 citations

Rho and Rac Take Center Stage

2004 • 1,797 citations

Rho-stimulated contractility drives the formation of stress fibers and focal adhesions.

1996 • 1,614 citations

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

1999 • 1,558 citations

FAK–Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly

2004 • 1,330 citations

Guanine nucleotide exchange factors for Rho GTPases: turning on the switch

2002 • 1,225 citations

The relationship between force and focal complex development

2002 • 876 citations

Mechanism of Actin-Based Motility

2001 • 694 citations

Integrins in Mechanotransduction

2004 • 690 citations

Interplay between Rac and Rho in the control of substrate contact dynamics

1999 • 623 citations

A role for Rac in Tiaml-induced membrane ruffling and invasion

1995 • 562 citations

Integrin signaling to the actin cytoskeleton

2003 • 497 citations

Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism

2000 • 429 citations

Activation of Rac1 by a Crk SH3-binding protein, DOCK180

1998 • 426 citations

Calcium signaling in cell volume regulation

1992 • 349 citations

The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility

1998 • 290 citations

Integrin-mediated Adhesion Regulates Cell Polarity and Membrane Protrusion through the Rho Family of GTPases

2001 • 280 citations

Leading the way: directional sensing through phosphatidylinositol 3-kinase and other signaling pathways

2003 • 272 citations

Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2

1998 • 265 citations

Vav2 Is an Activator of Cdc42, Rac1, and RhoA

2000 • 250 citations

Vav1 Transduces T Cell Receptor Signals to the Activation of Phospholipase C-γ1 via Phosphoinositide 3-Kinase-dependent and -independent Pathways

2002 • 214 citations

Phosphorylation of Tyrosine 291 Enhances the Ability of WASp to Stimulate Actin Polymerization and Filopodium Formation

2002 • 206 citations

GIT1 functions in a motile, multi-molecular signaling complex that regulates protrusive activity and cell migration

2002 • 197 citations

Vav2 Activates Rac1, Cdc42, and RhoA Downstream from Growth Factor Receptors but Not β1 Integrins

2000 • 191 citations

Translocation of Src kinase to the cell periphery is mediated by the actin cytoskeleton under the control of the Rho family of small G proteins.

1996 • 176 citations

Coupling membrane protrusion and cell adhesion

2003 • 176 citations

Contingent Phosphorylation/Dephosphorylation Provides a Mechanism of Molecular Memory in WASP

2003 • 173 citations

Tyrosine Phosphorylation Mediates Both Activation and Downmodulation of the Biological Activity of Vav

2000 • 170 citations

Sustained Activation of N-WASP through Phosphorylation Is Essential for Neurite Extension

2002 • 168 citations

Rac1 Function Is Required for Src-induced Transformation

2003 • 166 citations

Vav1 Regulates Phospholipase Cγ Activation and Calcium Responses in Mast Cells

2001 • 156 citations

Isolation and characterization of murine vav2, a member of the vav family of proto-oncogenes.

1996 • 143 citations

Mechanical Strain Induces pp60 Activation and Translocation to Cytoskeleton in Fetal Rat Lung Cells

1996 • 133 citations

pp60c-src and related tyrosine kinases: a role in the assembly and reorganization of matrix adhesions

2001 • 117 citations

Phosphatidylinositol 3-Kinase Contributes to Cell Volume Regulation through Effects on ATP Release

1998 • 114 citations

Involvement of integrins and Src in tauroursodeoxycholate-induced and swelling-induced choleresis

2003 • 107 citations

αPIX nucleotide exchange factor is activated by interaction with phosphatidylinositol 3-kinase

1999 • 105 citations

Involvement of Integrins in Osmosensing and Signaling toward Autophagic Proteolysis in Rat Liver

2003 • 103 citations

Vav2 is required for cell spreading

2001 • 100 citations

Differential Requirement for LAT and SLP-76 in GPVI versus T Cell Receptor Signaling

2002 • 90 citations

Enhanced Activity of a Large Conductance, Calcium-sensitive K+ Channel in the Presence of Src Tyrosine Kinase

2000 • 83 citations

GIT1 Mediates Src-dependent Activation of Phospholipase Cγ by Angiotensin II and Epidermal Growth Factor

2003 • 82 citations

RACK1 Regulates G₁/S Progression by Suppressing Src Kinase Activity

2004 • 76 citations

Trio amino-terminal guanine nucleotide exchange factor domain expression promotes actin cytoskeleton reorganization, cell migration and anchorage-independent cell growth

1999 • 66 citations

DIP (mDia interacting protein) is a key molecule regulating Rho and Rac in a Src-dependent manner

2004 • 66 citations

Src and the control of cell division

1996 • 65 citations

Vav3 is regulated during the cell cycle and effects cell division

2002 • 38 citations

Antitumour effects of PLC-γ1-(SH2)2-TAT fusion proteins on EGFR/c-erbB-2-positive breast cancer cells

2004 • 38 citations

Hypotonicity induces membrane protrusions and actin remodeling via activation of small GTPases Rac and Cdc42 in Rat-1 fibroblasts

2003 • 37 citations

Activator Protein 1 Activation following Hypoosmotic Stress in HepG2 Cells Is Actin Cytoskeleton Dependent

2001 • 36 citations

Liver cell volume regulation: Size matters

2001 • 36 citations

Purinergic-independent Calcium Signaling Mediates Recovery from Hepatocellular Swelling

2001 • 34 citations

Characterization of a swelling-activated anion conductance in homozygous typing cell hepatoma cells

1997 • 32 citations

Calcium Mobilization Evoked by Hepatocellular Swelling Is Linked to Activation of Phospholipase Cγ

2002 • 31 citations

Structural reaction pattern of hepatocytes following exposure to hypotonicity

1993 • 27 citations

Deleted Work

1955 • 0 citations