Phosphorylation of Tyrosine 291 Enhances the Ability of WASp to Stimulate Actin Polymerization and Filopodium Formation

Scar1 and the related Wiskott–Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex

1998 • 933 citations

Autoinhibition and activation mechanisms of the Wiskott–Aldrich syndrome protein

2000 • 739 citations

N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases.

1996 • 667 citations

Mechanism of N-Wasp Activation by Cdc42 and Phosphatidylinositol 4,5-Bisphosphate

2000 • 615 citations

Integration of Multiple Signals Through Cooperative Regulation of the N-WASP-Arp2/3 Complex

2000 • 512 citations

Activation by Cdc42 and Pip2 of Wiskott-Aldrich Syndrome Protein (Wasp) Stimulates Actin Nucleation by Arp2/3 Complex

2000 • 498 citations

Wiskott-Aldrich Syndrome Protein-Deficient Mice Reveal a Role for WASP in T but Not B Cell Activation

1998 • 494 citations

Wiskott-Aldrich syndrome protein regulates podosomes in primary human macrophages

1999 • 422 citations

Rho, Rac and Cdc42 regulate actin organization and cell adhesion in macrophages

1997 • 415 citations

Actin-based motility of vaccinia virus mimics receptor tyrosine kinase signalling

1999 • 407 citations

Nck and Phosphatidylinositol 4,5-Bisphosphate Synergistically Activate Actin Polymerization through the N-WASP-Arp2/3 Pathway

2001 • 400 citations

Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott–Aldrich syndrome

1996 • 397 citations

Endocytic protein intersectin-l regulates actin assembly via Cdc42 and N-WASP

2001 • 357 citations

Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation in host cells

2001 • 354 citations

Configuration of human dendritic cell cytoskeleton by Rho GTPases, the WAS protein, and differentiation

2001 • 332 citations

Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex

2000 • 323 citations

Structure of Cdc42 in complex with the GTPase-binding domain of the ‘Wiskott–Aldrich syndrome’ protein

1999 • 319 citations

A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization

2000 • 318 citations

Proteolytic cleavage of the urokinase receptor substitutes for the agonist-induced chemotactic effect.

1996 • 306 citations

A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration

1998 • 283 citations

WIP regulates N-WASP-mediated actin polymerization and filopodium formation

2001 • 280 citations

Influence of the C Terminus of Wiskott-Aldrich Syndrome Protein (WASp) and the Arp2/3 Complex on Actin Polymerization

1999 • 277 citations

The Wiskott–Aldrich syndrome protein directs actin-based motility by stimulating actin nucleation with the Arp2/3 complex

1999 • 263 citations

Selective regulation of integrin–cytoskeleton interactions by the tyrosine kinase Src

1999 • 257 citations

Chemotaxis of macrophages is abolished in the Wiskott‐Aldrich syndrome

1998 • 241 citations

Essential role of neural Wiskott-Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts.

2002 • 226 citations

Defective Actin Reorganization and Polymerization of Wiskott-Aldrich T Cells in Response to CD3-Mediated Stimulation

1997 • 206 citations

Physical and functional association of Src-related protein tyrosine kinases with Fc gamma RII in monocytic THP-1 cells.

1994 • 198 citations

Wiskott-Aldrich syndrome protein is necessary for efficient IgG-mediated phagocytosis

2000 • 197 citations

Requirement for Rho GTPases and PI 3-kinases during apoptotic cell phagocytosis by macrophages

2001 • 160 citations

Inducible recruitment of Cdc42 or WASP to a cell-surface receptor triggers actin polymerization and filopodium formation

1999 • 156 citations

Wiskott–Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases

1996 • 154 citations

WASP Recruitment to the T Cell:APC Contact Site Occurs Independently of Cdc42 Activation

2001 • 153 citations

Impaired integrin-mediated signal transduction, altered cytoskeletal structure and reduced motility in Hck/Fgr deficient macrophages

1999 • 149 citations

Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn.

1994 • 148 citations

A Novel Neural Wiskott-Aldrich Syndrome Protein (N-Wasp) Binding Protein, Wish, Induces Arp2/3 Complex Activation Independent of Cdc42

2001 • 147 citations

The Intersectin 2 Adaptor Links Wiskott Aldrich Syndrome Protein (WASp)-mediated Actin Polymerization to T Cell Antigen Receptor Endocytosis

2001 • 133 citations

Activation of the Arp2/3 Complex by the Listeria ActA Protein

2001 • 129 citations

Cutting Edge: The Wiskott-Aldrich Syndrome Protein Is Required for Efficient Phagocytosis of Apoptotic Cells

2001 • 125 citations

Intrinsic dendritic cell abnormalities in Wiskott-Aldrich syndrome

1998 • 123 citations

ActA and human zyxin harbour Arp2/3-independent actin-polymerization activity

2001 • 119 citations

The Fc gamma RI receptor signals through the activation of hck and MAP kinase.

1995 • 114 citations

Tyrosine phosphorylation of the Wiskott‐Aldrich Syndrome protein by Lyn and Btk is regulated by CDC42

1998 • 111 citations

Transmembrane signaling by antigen receptors of B and T lymphocytes

1995 • 109 citations

Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways.

1996 • 109 citations

Involvement of Wiskott-Aldrich Syndrome Protein in B-Cell Cytoplasmic Tyrosine Kinase Pathway

1999 • 108 citations

Differential Involvement of Src Family Kinases in Fcγ Receptor-Mediated Phagocytosis

2000 • 100 citations

Activation of Arp2/3 Complex by Wiskott-Aldrich Syndrome Protein Is Linked to Enhanced Binding of ATP to Arp2

2001 • 72 citations

Purification and characterization of a soluble catalytic fragment of the human transmembrane leukocyte antigen related (LAR) protein tyrosine phosphatase from an E. coli expression system

1991 • 67 citations

Regulation and Function of WASp in Platelets by the Collagen Receptor, Glycoprotein VI

1999 • 63 citations

Urokinase receptor-dependent and -independent p56/59hck activation state is a molecular switch between myelomonocytic cell motility and adherence

1999 • 61 citations

Hck Enhances the Adherence of Lipopolysaccharide-stimulated Macrophages via Cbl and Phosphatidylinositol 3-Kinase

2000 • 42 citations

Interaction between Wiskott-Aldrich Syndrome protein (WASP) and the Fyn protein-tyrosine kinase.

1999 • 16 citations