GIT1 Mediates Src-dependent Activation of Phospholipase Cγ by Angiotensin II and Epidermal Growth Factor

Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.

1996 • 2,456 citations

Regulation of Phosphoinositide-Specific Phospholipase C

2001 • 1,604 citations

Angiotensin II induces hypertrophy, not hyperplasia, of cultured rat aortic smooth muscle cells.

1988 • 1,077 citations

Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

1989 • 978 citations

Regulation of inositol phospholipid-specific phospholipase C isozymes.

1992 • 740 citations

Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor

1995 • 737 citations

Angiotensin II-stimulated protein synthesis in cultured vascular smooth muscle cells.

1989 • 558 citations

Paxillin LD4 Motif Binds PAK and PIX through a Novel 95-kD Ankyrin Repeat, ARF–GAP Protein: A Role in Cytoskeletal Remodeling

1999 • 466 citations

Vasoconstriction: A New Activity for Platelet-Derived Growth Factor

1986 • 430 citations

Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling

2002 • 417 citations

Angiotensin II Induces c-fos mRNA in Aortic Smooth Muscle

1989 • 401 citations

REGULATION OF EUKARYOTIC PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C AND PHOSPHOLIPASE D

1997 • 390 citations

Signal transduction pathways of angiotensin II--induced c-fos gene expression in cardiac myocytes in vitro. Roles of phospholipid-derived second messengers.

1993 • 389 citations

Ligand-Independent Activation of Vascular Endothelial Growth Factor Receptor 2 by Fluid Shear Stress Regulates Activation of Endothelial Nitric Oxide Synthase

2003 • 385 citations

Coupling of PAK-Interacting Exchange Factor PIX to GIT1 Promotes Focal Complex Disassembly

2000 • 353 citations

High throughput protein characterization by automated reverse‐phase chromatography/electrospray tandem mass spectrometry

1998 • 315 citations

Angiotensin II Signal Transduction in Vascular Smooth Muscle

1997 • 306 citations

β ₂ -Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein

1998 • 290 citations

Convergence of Angiotensin II and Platelet-derived Growth Factor Receptor Signaling Cascades in Vascular Smooth Muscle Cells

1995 • 288 citations

C-TAK1 Regulates Ras Signaling by Phosphorylating the MAPK Scaffold, KSR1

2001 • 277 citations

The heterotrimeric G q protein-coupled angiotensin II receptor activates p21 ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytes.

1996 • 265 citations

Spa2p Interacts with Cell Polarity Proteins and Signaling Components Involved in Yeast Cell Morphogenesis

1998 • 242 citations

β-Arrestin-mediated ADP-ribosylation Factor 6 Activation and β2-Adrenergic Receptor Endocytosis

2001 • 224 citations

A Tyrosine-phosphorylated Protein That Binds to an Important Regulatory Region on the Cool Family of p21-activated Kinase-binding Proteins

1999 • 221 citations

Dependence on the Motif YIPP for the Physical Association of Jak2 Kinase with the Intracellular Carboxyl Tail of the Angiotensin II AT1 Receptor

1997 • 218 citations

Angiotensin II stimulates tyrosine phosphorylation of phospholipase C-gamma 1 in vascular smooth muscle cells.

1994 • 204 citations

Epidermal growth factor, a vascular smooth muscle mitogen, induces rat aortic contraction.

1985 • 203 citations

Angiotensin II stimulates sis-inducing factor-like DNA binding activity. Evidence that the AT1A receptor activates transcription factor-Stat91 and/or a related protein.

1994 • 182 citations

Mitogen-activated Protein (MAP) Kinase Is Regulated by the MAP Kinase Phosphatase (MKP-1) in Vascular Smooth Muscle Cells

1995 • 177 citations

Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity

2000 • 175 citations

Electroporation of pp60c− Antibodies Inhibits the Angiotensin II Activation of Phospholipase C-γ1 in Rat Aortic Smooth Muscle Cells

1995 • 175 citations

Involvement of PYK2 in Angiotensin II Signaling of Vascular Smooth Muscle Cells

1999 • 168 citations

Angiotensin II Activates pp60 ^c- ^src in Vascular Smooth Muscle Cells

1995 • 167 citations

The LD4 motif of paxillin regulates cell spreading and motility through an interaction with paxillin kinase linker (PKL)

2001 • 164 citations

Activation of Extracellular Signal–Regulated Kinases (ERK1/2) by Angiotensin II Is Dependent on c-Src in Vascular Smooth Muscle Cells

1998 • 162 citations

Angiotensin II Induces Transactivation of Two Different Populations of the Platelet-derived Growth Factor β Receptor

2000 • 162 citations

Agonist-stimulated cytoskeletal reorganization and signal transduction at focal adhesions in vascular smooth muscle cells require c-Src

1999 • 161 citations

Increased Expression of Axl Tyrosine Kinase After Vascular Injury and Regulation by G Protein–Coupled Receptor Agonists in Rats

1998 • 160 citations

GIT Proteins, A Novel Family of Phosphatidylinositol 3,4,5-Trisphosphate-stimulated GTPase-activating Proteins for ARF6

2000 • 153 citations

Src and Multiple MAP Kinase Activation in Cardiac Hypertrophy and Congestive Heart Failure Under Chronic Pressure-overload: Comparison with Acute Mechanical Stretch

2001 • 144 citations

Thrombin Stimulates Phosphorylation of Insulin-like Growth Factor-1 Receptor, Insulin Receptor Substrate-1, and Phospholipase C-γ1 in Rat Aortic Smooth Muscle Cells

1995 • 143 citations

Angiotensin II Controls p21 Activity via pp60

1996 • 138 citations

The GIT Family of ADP-ribosylation Factor GTPase-activating Proteins

2000 • 134 citations

A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-γ1

2003 • 127 citations

p95-APP1 links membrane transport to Rac-mediated reorganization of actin

2000 • 125 citations

Phospholipase C and termination of G-protein-mediated signalling in vivo

2000 • 122 citations

Temporal Dispersion of Activation of Phospholipase C-β1 and -γ Isoforms by Angiotensin II in Vascular Smooth Muscle Cells

1998 • 121 citations

Angiotensin II-induced protein tyrosine phosphorylation in neonatal rat cardiac fibroblasts.

1994 • 117 citations

Angiotensin II stimulates phospholipases C and A2 in cultured rat mesangial cells

1987 • 114 citations

Spa2p Functions as a Scaffold-like Protein to Recruit the Mpk1p MAP Kinase Module to Sites of Polarized Growth

2002 • 100 citations

In Vitro Tyrosine Phosphorylation of PLC-γ1 and PLC-γ2 by SRC-Family Protein Tyrosine Kinases

1993 • 89 citations

Angiotensin II-induced Tyrosine Phosphorylation of Signal Transducers and Activators of Transcription 1 Is Regulated by Janus-activated Kinase 2 and Fyn Kinases and Mitogen-activated Protein Kinase Phosphatase 1

1998 • 85 citations

Molecular and Functional Identification of m ₁ Muscarinic Acetylcholine Receptors in Rat Ventricular Myocytes

1996 • 72 citations

MAP Kinase Cascades: Scaffolding Signal Specificity

2002 • 52 citations

The Third Cytoplasmic Loop of the Angiotensin II Type 1 Receptor Exerts Differential Effects on Extracellular Signal–Regulated Kinase (ERK1/ERK2) and Apoptosis via Ras- and Rap1-Dependent Pathways

2000 • 43 citations

Angiotensin II Stimulates Tyrosine Phosphorylation of Phospholipase C-γ–Associated Proteins

1997 • 32 citations

Activation of Phospholipase Cγin Schizosaccharomyces pombe by Coexpression of Receptor or Nonreceptor Tyrosine Kinases

1995 • 24 citations

Src Kinase Mediates the Regulation of Phospholipase C-γ Activity by Glycosphingolipids

2003 • 19 citations

Analysis of the subcellular distribution of avian p95-APP2, an ARF-GAP orthologous to mammalian paxillin kinase linker

2002 • 13 citations

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