Back to search

Lipid Antioxidant, Etoposide, Inhibits Phosphatidylserine Externalization and Macrophage Clearance of Apoptotic Cells by Preventing Phosphatidylserine Oxidation

Data up to Jan 2025

Published2004
Citations76
References61

Total Citations Per Year

Abstract

References (61)

A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES

1957 • 63,238 citations

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.

1992 • 3,279 citations

Reduction Potentials of One-Electron Couples Involving Free Radicals in Aqueous Solution

1989 • 1,989 citations

A blast from the past: clearance of apoptotic cells regulates immune responses

2002 • 1,558 citations

Corpse clearance defines the meaning of cell death

2000 • 1,528 citations

A receptor for phosphatidylserine-specific clearance of apoptotic cells

2000 • 1,480 citations

A rapid and sensitive sub-micro phosphorus determination

1961 • 951 citations

Etoposide: four decades of development of a topoisomerase II inhibitor

1998 • 907 citations

Antioxidants in relation to lipid peroxidation

1987 • 684 citations

Dual regulation of caspase activity by hydrogen peroxide: implications for apoptosis

1997 • 663 citations

C-reactive protein binds to both oxidized LDL and apoptotic cells through recognition of a common ligand: Phosphorylcholine of oxidized phospholipids

2002 • 518 citations

Fluorescence assay for phospholipid membrane asymmetry

1991 • 484 citations

Appearance of Phosphatidylserine on Apoptotic Cells Requires Calcium-mediated Nonspecific Flip-Flop and Is Enhanced by Loss of the Aminophospholipid Translocase

1997 • 483 citations

Monoclonal antibodies against oxidized low-density lipoprotein bind to apoptotic cells and inhibit their phagocytosis by elicited macrophages: Evidence that oxidation-specific epitopes mediate macrophage recognition

1999 • 461 citations

Phagocyte receptors for apoptotic cells: recognition, uptake, and consequences

2001 • 427 citations

Secondary leukemias induced by topoisomerase-targeted drugs

1998 • 414 citations

Phagocyte receptors for apoptotic cells: recognition, uptake, and consequences

2001 • 394 citations

Determination of lipid phosphorus in the nanomolar range

1970 • 389 citations

Aminophospholipid Asymmetry: A Matter of Life and Death

2003 • 384 citations

Recognition and phagocytosis of cells undergoing apoptosis

1997 • 330 citations

Mitochondria, oxygen free radicals, and apoptosis

2001 • 300 citations

A Role for Oxidative Stress in Apoptosis: Oxidation and Externalization of Phosphatidylserine Is Required for Macrophage Clearance of Cells Undergoing Fas-Mediated Apoptosis

2002 • 260 citations

Role of peroxide and superoxide anion during tumour cell apoptosis

1997 • 221 citations

Risk of Secondary Leukemia After a Solid Tumor in Childhood According to the Dose of Epipodophyllotoxins and Anthracyclines: A Case-Control Study by the Société Française d’Oncologie Pédiatrique

2003 • 207 citations

The role of regulated CFTR trafficking in epithelial secretion

2003 • 198 citations

Continuous Analysis of the Mechanism of Activated Transbilayer Lipid Movement in Platelets

1995 • 179 citations

Oxidative signaling pathway for externalization of plasma membrane phosphatidylserine during apoptosis

2000 • 167 citations

Oxidative stress interferes with cancer chemotherapy: inhibition of lymphoma cell apoptosis and phagocytosis

2000 • 158 citations

Phosphatidylserine Exposure during Apoptosis Is a Cell-Type-Specific Event and Does Not Correlate with Plasma Membrane Phospholipid Scramblase Expression

1999 • 151 citations

NADPH Oxidase-dependent Oxidation and Externalization of Phosphatidylserine during Apoptosis in Me2SO-differentiated HL-60 Cells

2002 • 139 citations

Regulation of phosphatidylserine exposure and phagocytosis of apoptotic T lymphocytes

1999 • 138 citations

Bleomycin pharmacology: mechanism of action and resistance, and clinical pharmacokinetics.

1992 • 136 citations

Phospholipid signaling in apoptosis: peroxidation and externalization of phosphatidylserine

2000 • 119 citations

Antioxidants and the Response of Skin to Oxidative Stress: Vitamin E as a Key Indicator

2002 • 115 citations

Mitochondrial redox signaling during apoptosis.

1999 • 107 citations

Correlated flow cytometric analysis of terminal events in apoptosis reveals the absence of some changes in some model systems

1997 • 94 citations

Pro-oxidant and antioxidant mechanisms of etoposide in HL-60 cells: role of myeloperoxidase.

2001 • 93 citations

Redox Cycling of Phenol Induces Oxidative Stress in Human Epidermal Keratinocytes

2000 • 93 citations

Caspase-Independent Phosphatidylserine Exposure During Apoptosis of Primary T Lymphocytes

2002 • 90 citations

Mechanism-Based Chemopreventive Strategies Against Etoposide-Induced Acute Myeloid Leukemia: Free Radical/Antioxidant Approach

1999 • 83 citations

Peroxidase-catalyzed metabolism of etoposide (VP-16-213) and covalent binding of reactive intermediates to cellular macromolecules.

1987 • 74 citations

Fas‐triggered phosphatidylserine exposure is modulated by intracellular ATP

2002 • 66 citations

Characterization of free radicals produced during oxidation of etoposide (VP-16) and its catechol and quinone derivatives. An ESR study

1989 • 63 citations

-Lipoic acid and -lipoamide prevent oxidant-induced lysosomal rupture and apoptosis

2001 • 60 citations

Oxidative stress inhibits the phagocytosis of apoptotic cells that have externalized phosphatidylserine

2002 • 60 citations

Apoptosis and macrophage clearance of neutrophils: regulation by reactive oxygen species

2003 • 59 citations

Cytokine production by macrophages in association with phagocytosis of etoposide-treated P388 cells in vitro and in vivo

2001 • 57 citations

Chronic oral etoposide

1991 • 50 citations

Respiratory Chain-Generated Oxidative Stress Following Treatment of Leukemic Blasts with DNA-Damaging Agents

2001 • 48 citations

ANG II stimulates PKC-dependent ERK activation, DNA synthesis, and cell division in intestinal epithelial cells

2003 • 47 citations

Selective Peroxidation and Externalization of Phosphatidylserine in Normal Human Epidermal Keratinocytes During Oxidative Stress Induced by Cumene Hydroperoxide

2002 • 43 citations

Reactions of glutathione with the catechol, the ortho-quinone and the semi-quinone free radical of etoposide Consequences for DNA inactivation

1992 • 40 citations

Metabolism of dexrazoxane (ICRF-187) used as a rescue agent in cancer patients treated with high-dose etoposide

2003 • 33 citations

Myeloperoxidase-dependent caspase-3 activation and apoptosis in HL-60 cells: protection by the antioxidants ascorbate and (dihydro)lipoic acid

2002 • 32 citations

High-dose etoposide with granulocyte colony-stimulating factor for mobilization of peripheral blood progenitor cells: efficacy and toxicity at three dose levels

1998 • 26 citations

Phosphatidylserine exposure in Fas type I cells is mitochondria‐dependent

2003 • 25 citations

Extended-Schedule Oral Etoposide in Selected Neoplasms and Overview of Administration and Scheduling Issues

1999 • 18 citations

Tyrosinase-Induced Free Radical Formation From VP-16,213: Relationship To Cytotoxicity

1990 • 17 citations

Differential Regulation of Hydrogen Peroxide and Fas-Dependent Apoptosis Pathways by Dehydroascorbate, the Oxidized Form of Vitamin C

2002 • 16 citations

[14] Peroxidation of phosphatidylserine in mechanisms of apoptotic signaling

2002 • 11 citations

Etoposide-induced apoptosis in lymphoblastoid leukaemic MOLT-4 cells: evidence that chromatin condensation, loss of phosphatidylserine asymmetry and apoptotic body formation can occur independently.

2002 • 6 citations

Cited By (0)

Loading...
Lipid Antioxidant, Etoposide, Inhibits Phosphatidylserine Externalization and Macrophage… (2004) – Journal of Biological Chemistry | Metascience Observatory Explorer