A Role for Oxidative Stress in Apoptosis: Oxidation and Externalization of Phosphatidylserine Is Required for Macrophage Clearance of Cells Undergoing Fas-Mediated Apoptosis

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.

1992 • 3,279 citations

Programmed Cell Death in Animal Development

1997 • 2,690 citations

Corpse clearance defines the meaning of cell death

2000 • 1,528 citations

A receptor for phosphatidylserine-specific clearance of apoptotic cells

2000 • 1,480 citations

A Stable Nonfluorescent Derivative of Resorufin for the Fluorometric Determination of Trace Hydrogen Peroxide: Applications in Detecting the Activity of Phagocyte NADPH Oxidase and Other Oxidases

1997 • 1,338 citations

Triggering and modulation of apoptosis by oxidative stress

2000 • 1,315 citations

Phagocytosis and clearance of apoptotic cells is mediated by MER

2001 • 1,153 citations

Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-β1 secretion and the resolution of inflammation

2002 • 1,090 citations

Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-β1 secretion and the resolution of inflammation

2002 • 897 citations

The role of phosphatidylserine in recognition of apoptotic cells by phagocytes

1998 • 724 citations

Mechanisms of phosphatidylserine exposure, a phagocyte recognition signal, on apoptotic T lymphocytes.

1995 • 675 citations

Loss of Phospholipid Asymmetry and Surface Exposure of Phosphatidylserine Is Required for Phagocytosis of Apoptotic Cells by Macrophages and Fibroblasts

2001 • 633 citations

Systemic Exposure to Irradiated Apoptotic Cells Induces Autoantibody Production

1998 • 573 citations

Appearance of Phosphatidylserine on Apoptotic Cells Requires Calcium-mediated Nonspecific Flip-Flop and Is Enhanced by Loss of the Aminophospholipid Translocase

1997 • 483 citations

Monoclonal antibodies against oxidized low-density lipoprotein bind to apoptotic cells and inhibit their phagocytosis by elicited macrophages: Evidence that oxidation-specific epitopes mediate macrophage recognition

1999 • 461 citations

Lipid translocation across the plasma membrane of mammalian cells

1999 • 437 citations

Protease Involvement in Fodrin Cleavage and Phosphatidylserine Exposure in Apoptosis

1996 • 409 citations

CD36 is required for phagocytosis of apoptotic cells by human macrophages that use either a phosphatidylserine receptor or the vitronectin receptor (alpha v beta 3).

1998 • 397 citations

Phosphatidylserine Externalization during CD95-induced Apoptosis of Cells and Cytoplasts Requires ICE/CED-3 Protease Activity

1996 • 386 citations

Recognizing death: the phagocytosis of apoptotic cells

1998 • 381 citations

Rapid and Specific Efflux of Reduced Glutathione during Apoptosis Induced by Anti-Fas/APO-1 Antibody

1996 • 354 citations

Involvement of Caspases in Neutrophil Apoptosis: Regulation by Reactive Oxygen Species

1998 • 341 citations

CD36 Is Required for Phagocytosis of Apoptotic Cells by Human Macrophages That Use Either a Phosphatidylserine Receptor or the Vitronectin Receptor (αvβ3)

1998 • 321 citations

Receptors for oxidized low density lipoprotein

1999 • 209 citations

Plasma Membrane Alterations and Cytoskeletal Changes in Apoptosis

1997 • 206 citations

Recognition and destruction of neoplastic cells by activated macrophages: discrimination of altered self

1988 • 186 citations

Caspase-Independent Cell Death Induced by Anti-CD2 or Staurosporine in Activated Human Peripheral T Lymphocytes

1998 • 173 citations

Oxidative signaling pathway for externalization of plasma membrane phosphatidylserine during apoptosis

2000 • 167 citations

Oxidative stress interferes with cancer chemotherapy: inhibition of lymphoma cell apoptosis and phagocytosis

2000 • 158 citations

Phosphatidylserine Exposure during Apoptosis Is a Cell-Type-Specific Event and Does Not Correlate with Plasma Membrane Phospholipid Scramblase Expression

1999 • 151 citations

Multiple systems for recognition of apoptotic lymphocytes by macrophages.

1997 • 133 citations

Bcl-2 inhibits selective oxidation and externalization of phosphatidylserine during paraquat-induced apoptosis

1997 • 98 citations

Phosphatidylserine Receptors: Role of CD36 in Binding of Anionic Phospholipid Vesicles to Monocytic Cells

1999 • 95 citations

Random versus Selective Membrane Phospholipid Oxidation in Apoptosis: Role of Phosphatidylserine

1998 • 67 citations

Delineation of the Signaling Pathways Involved in Glucocorticoid-Induced and Spontaneous Apoptosis of Rat Thymocytes

2000 • 58 citations

Independent Mechanisms for Macrophage Binding and Macrophage Phagocytosis of Damaged Erythrocytes

1997 • 44 citations

Nitric Oxide Dissociates Lipid Oxidation from Apoptosis and Phosphatidylserine Externalization during Oxidative Stress

1999 • 40 citations

Sensitive and Specific Fluorescent Probing of Oxidative Stress in Different Classes of Membrane Phospholipids in Live Cells Using Metabolically Integrated cis-Parinaric Acid

2003 • 30 citations

Involvement of Caspases in Neutrophil Apoptosis: Regulation by Reactive Oxygen Species

1998 • 28 citations