Tyrosinase-Induced Free Radical Formation From VP-16,213: Relationship To Cytotoxicity

The Tyrosine Hydroxylase Activity of Mammalian Tyrosinase

1966 • 360 citations

Mechanism of Action of Antitumor Drug Etoposide: A Review

1988 • 291 citations

Effect of VP-16-213 on the intracellular degradation of DNA in HeLa cells

1976 • 197 citations

Comparison of cytotoxicity and DNA breakage activity of congeners of podophyllotoxin including VP16-213 and VM26: a quantitative structure-activity relationship

1984 • 188 citations

Characterization of acquired epipodophyllotoxin resistance in a Chinese hamster ovary cell line: loss of drug-stimulated DNA cleavage activity.

1986 • 165 citations

L-Dopa: Selective Toxicity for Melanoma Cells in Vitro

1977 • 159 citations

Free radicals in anticancer drug pharmacology

1989 • 106 citations

Dopamine: A Novel Antitumor Agent Active Against B-16 Melanoma In Vivo

1978 • 92 citations

DNA strand breaks produced by etoposide (VP-16,213) in sensitive and resistant human breast tumor cells: implications for the mechanism of action.

1988 • 76 citations

In vitro metabolism of etoposide (VP-16-213) by liver microsomes and irreversible binding of reactive intermediates to microsomal proteins

1987 • 69 citations

Characterization of free radicals produced during oxidation of etoposide (VP-16) and its catechol and quinone derivatives. An ESR study

1989 • 63 citations

Effects of the ortho-quinone and catechol of the antitumor drug VP-16-213 on the biological activity of single-stranded and double-stranded ΦX174 DNA

1988 • 33 citations

Sensitivity of human melanoma cells to L-dopa and DL-buthionine (S,R)-sulfoximine.

1989 • 32 citations

Iron‐dependent hydroxyl radical formation and DNA damage from a novel metabolite of the clinically active antitumor drug VP‐16

1988 • 32 citations

Interactions of the antitumor drug, etoposide, with reduced thiols in vitro and in vivo

1987 • 30 citations

Structure-activity relationships defining the cytotoxicity of catechol analogues against human malignant melanoma.

1988 • 23 citations

Oxygen radicals in biology and medicine

1989 • 13 citations

Podophyllotoxin derivatives VP-16 and VM-26.

1987 • 11 citations

Role of Free Radicals in Etoposide (Vp-16,213) Action

1988 • 2 citations