Correlated flow cytometric analysis of terminal events in apoptosis reveals the absence of some changes in some model systems

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.

1992 • 3,279 citations

Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis

1994 • 1,969 citations

Features of apoptotic cells measured by flow cytometry

1992 • 1,912 citations

Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages.

1989 • 1,540 citations

Phagocyte recognition of cells undergoing apoptosis

1993 • 1,000 citations

Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation

1992 • 685 citations

Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes.

1994 • 605 citations

Programmed Cell Death in the Immune System

1991 • 575 citations

Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production.

1993 • 488 citations

Impairment of function in aging neutrophils is associated with apoptosis.

1993 • 467 citations

Calpain activation in apoptosis

1994 • 445 citations

Dexamethasone-induced apoptosis involves cleavage of DNA to large fragments prior to internucleosomal fragmentation.

1993 • 419 citations

bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages.

1994 • 288 citations

A flow cytometric method using Hoechst 33342 and propidium iodide for simultaneous cell cycle analysis and apoptosis determination in unfixed cells

1994 • 249 citations

Rapid quantitation of apoptosis in pure and heterogeneous cell populations using flow cytometry

1994 • 245 citations

Sensitive method for measuring apoptosis and cell surface phenotype in human thymocytes by flow cytometry

1994 • 226 citations

Detection of apoptosis of immature CD4+8+ thymocytes by flow cytometry

1991 • 226 citations

Increased membrane permeability of apoptotic thymocytes: A flow cytometric study

1993 • 200 citations

Protease inhibitors selectively block T cell receptor-triggered programmed cell death in a murine T cell hybridoma and activated peripheral T cells.

1993 • 198 citations

Decreased membrane phospholipid packing and decreased cell size precede DNA cleavage in mature mouse B cell apoptosis.

1994 • 161 citations

Regulation of cell adhesion molecule expression and function associated with neutrophil apoptosis

1995 • 158 citations

Nucleic acid dyes for detection of apoptosis in live cells

1995 • 125 citations

Apoptosis and Its Modulation in Human Promyelocytic HL-60 Cells Treated with DNA Topoisomerase I and II Inhibitors

1993 • 113 citations

Role of proteolysis in apoptosis: involvement of serine proteases in internucleosomal DNA fragmentation in immature thymocytes

1993 • 109 citations

Etoposide-induced cytotoxicity in two human T-cell leukemic lines: delayed loss of membrane permeability rather than DNA fragmentation as an indicator of programmed cell death.

1993 • 62 citations

Cytokines suppress apoptosis independent of increases in reactive oxygen levels.

1996 • 52 citations

Identification of a transitional preapoptotic population of thymocytes.

1993 • 52 citations

Flow cytometric ratio analysis of the Hoechst 33342 emission spectrum: multiparametric characterization of apoptotic lymphocytes

1996 • 43 citations

Early mobilization of Ca2+ is not required for glucocorticoid-induced apoptosis in thymocytes.

1993 • 39 citations

Effect of glucocorticosteroid treatment on intracellular calcium homeostasis in mouse lymphoma cells

1993 • 38 citations

Flow‐cytometric analysis of apoptotic and nonapoptotic T‐cell receptor‐transgenic thymocytes following in vitro presentation of antigen

1994 • 19 citations

Measurement of intracellular pH

1981 • 16 citations

DNA staining changes associated with apoptosis and necrosis in blood lymphocytes of individuals with HIV infection

1995 • 16 citations

Detection and characterization of apoptotic peripheral blood lymphocytes in human immunodeficiency virus infection and cancer chemotherapy by a novel flow immunocytometric method

1994 • 8 citations