Mechanism-Based Chemopreventive Strategies Against Etoposide-Induced Acute Myeloid Leukemia: Free Radical/Antioxidant Approach

Acute Myeloid Leukemia in Children Treated with Epipodophyllotoxins for Acute Lymphoblastic Leukemia

1991 • 723 citations

Determination of lipid phosphorus in the nanomolar range

1970 • 389 citations

Mechanism of Action of Antitumor Drug Etoposide: A Review

1988 • 291 citations

Secondary acute myeloid leukemia in children with acute lymphoblastic leukemia treated with etoposide.

1993 • 269 citations

Properties and usefulness of the original K-562 human myelogenous leukemia cell line

1979 • 253 citations

High performance liquid chromatographic separation and direct ultraviolet detection of phospholipids

1977 • 234 citations

When good enzymes go bad: Conversion of topoisomerase II to a cellular toxin by antineoplastic drugs

1993 • 203 citations

Characterization of an Amsacrine-resistant Line of Human Leukemia Cells

1989 • 179 citations

Epipodophyllotoxin-related leukemia. Identification of a new subset of secondary leukemia

1991 • 178 citations

Site-specific DNA cleavage within the MLL breakpoint cluster region induced by topoisomerase II inhibitors [see comments]

1996 • 171 citations

Structure of the Green Heme in Myeloperoxidase

1995 • 155 citations

The clinical pharmacology of etoposide

1991 • 136 citations

Chromosome band 11q23 translocation breakpoints are DNA topoisomerase II cleavage sites.

1995 • 107 citations

Recycling and antioxidant activity of tocopherol homologs of differing hydrocarbon chain lengths in liver microsomes

1990 • 83 citations

L-asparaginase may potentiate the leukemogenic effect of the epipodophyllotoxins.

1995 • 82 citations

Non-random peroxidation of different classes of membrane phospholipids in live cells detected by metabolically integrated cis-parinaric acid

1996 • 74 citations

Peroxidase-catalyzed metabolism of etoposide (VP-16-213) and covalent binding of reactive intermediates to cellular macromolecules.

1987 • 74 citations

Population pharmacokinetics of total and unbound etoposide

1997 • 69 citations

Ascorbate Is the Primary Reductant of the Phenoxyl Radical of Etoposide in the Presence of Thiols both in Cell Homogenates and in Model Systems

1994 • 66 citations

Characterization of free radicals produced during oxidation of etoposide (VP-16) and its catechol and quinone derivatives. An ESR study

1989 • 63 citations

High Frequency of Etoposide (VP-16)-Related Secondary Leukemia in Children with Non-Hodgkinʼs Lymphoma

1993 • 62 citations

High-dose chemotherapy in germ cell tumours: a large single centre experience

1998 • 57 citations

Synergistic increase in chromosomal breakage within the euchromatin induced by an interaction of the benzene metabolites phenol and hydroquinone in mice

1995 • 56 citations

Detection of glutathione thiyl free radical catalyzed by prostaglandin H synthase present in keratinocytes

1989 • 52 citations

Report of the Cancer Therapy Evaluation Program Monitoring Plan for Secondary Acute Myeloid Leukemia Following Treatment With Epipodophyllotoxins

1993 • 51 citations

Detection and Characterization of the Electron Paramagnetic Resonance-Silent Glutathionyl-5,5-dimethyl-1-pyrrolineN-Oxide Adduct Derived from Redox Cycling of Phenoxyl Radicals in Model Systems and HL-60 Cells

1996 • 48 citations

Free radical metabolism of VP-16 and inhibition of anthracycline-induced lipid peroxidation

1983 • 47 citations

Etoposide causes illegitimate V(D)J recombination in human lymphoid leukemic cells

1996 • 43 citations

Acute promyelocytic leukemia witht(15;17) abnormality after chemotherapy containing etoposide for langerhans cell histiocytosis

1993 • 41 citations

Phenoxyl Radicals of Etoposide (VP-16) Can Directly Oxidize Intracellular Thiols: Protective Versus Damaging Effects of Phenolic Antioxidants

1995 • 41 citations

Reactions of glutathione with the catechol, the ortho-quinone and the semi-quinone free radical of etoposide Consequences for DNA inactivation

1992 • 40 citations

The Post-translational Processing of Myeloperoxidase Is Regulated by the Availability of Heme

1994 • 38 citations

Histamine-induced differentiation of HL-60 cells

1992 • 37 citations

[33] Thiyl free radical metabolites of thiol drugs, glutathione, and proteins

1990 • 34 citations

Peroxidase-Catalyzed Pro- versus Antioxidant Effects of 4-Hydroxytamoxifen: Enzyme Specificity and Biochemical Sequelae

1998 • 28 citations

New Thiol Active Fluorophores for Intracellular Thiols and Glutathione Measurement

1996 • 21 citations

Tyrosinase-Induced Free Radical Formation From VP-16,213: Relationship To Cytotoxicity

1990 • 17 citations

Detection of Myeloperoxidase Gene Expression in Minimally Differentiated Acute Myelogenous Leukemia (AML-M0) Using In Situ Hybridization

1995 • 15 citations

Copper-dependent oxidative and topoisomerase II-mediated DNA cleavage by a netropsin/4'-(9-acridinylamino)methanesulfon-m-anisidide combilexin.

1997 • 10 citations

Reduction of phenoxyl radicals of the antitumour agent etoposide (VP-16) by glutathione and protein sulfhydryls in human leukaemia cells: Implications for cytotoxicity

1996 • 7 citations

Combination Chemotherapy with Teniposide (VM26) and Carboplatin in Small Cell Lung Cancer

1993 • 5 citations