Respiratory Chain-Generated Oxidative Stress Following Treatment of Leukemic Blasts with DNA-Damaging Agents

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

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1983 • 5,487 citations

The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

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A model for p53-induced apoptosis

1997 • 2,502 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy

1998 • 1,381 citations

Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria

1985 • 1,201 citations

Activation of the OxyR Transcription Factor by Reversible Disulfide Bond Formation

1998 • 1,162 citations

Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species

1997 • 801 citations

Acid Sphingomyelinase–Deficient Human Lymphoblasts and Mice Are Defective in Radiation-Induced Apoptosis

1996 • 795 citations

Superoxide in Apoptosis

1998 • 773 citations

Reactive Oxygen Species Released from Mitochondria during Brief Hypoxia Induce Preconditioning in Cardiomyocytes

1998 • 715 citations

The Central Executioner of Apoptosis: Multiple Connections between Protease Activation and Mitochondria in Fas/APO-1/CD95- and Ceramide-induced Apoptosis

1997 • 625 citations

Reactive oxygen intermediates as mediators of programmed cell death in plants and animals

1999 • 594 citations

Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.

1993 • 581 citations

Oxidants in mitochondria: from physiology to diseases

1995 • 543 citations

Gene expression and the thiol redox state

1999 • 511 citations

Bcl-xL Prevents Cell Death following Growth Factor Withdrawal by Facilitating Mitochondrial ATP/ADP Exchange

1999 • 496 citations

Implication of Mitochondrial Hydrogen Peroxide Generation in Ceramide-induced Apoptosis

1997 • 485 citations

p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2

1999 • 479 citations

Direct Inhibition of Mitochondrial Respiratory Chain Complex III by Cell-permeable Ceramide

1997 • 442 citations

Mitochondrial complex I deficiency leads to increased production of superoxide radicals and induction of superoxide dismutase.

1996 • 381 citations

Thioredoxin Peroxidase Is a Novel Inhibitor of Apoptosis with a Mechanism Distinct from That of Bcl-2

1997 • 372 citations

Sites of inhibition of mitochondrial electron transport in macrophage-injured neoplastic cells.

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Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial glutathione status in loss of mitochondrial function and activation of transcription factor nuclear factor-kappa B: studies with isolated mitochondria and rat hepatocytes.

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Bridge over Troubled Waters

1999 • 294 citations

Mitochondrial Phospholipid Hydroperoxide Glutathione Peroxidase Suppresses Apoptosis Mediated by a Mitochondrial Death Pathway

1999 • 285 citations

N-acetylcysteine (D- and L-stereoisomers) prevents apoptotic death of neuronal cells

1995 • 273 citations

Mitochondrial implication in apoptosis. Towards an endosymbiont hypothesis of apoptosis evolution

1997 • 251 citations

Thioredoxin, a gene found overexpressed in human cancer, inhibits apoptosis in vitro and in vivo.

1997 • 244 citations

Isoforms of mammalian peroxiredoxin that reduce peroxides in presence of thioredoxin

1999 • 237 citations

Redox regulation of apoptosis: Impact of thiol oxidation status on mitochondrial function

1997 • 214 citations

Redox regulation of manganese superoxide dismutase

1996 • 180 citations

The Thiol-specific Antioxidant Enzyme Prevents Mitochondrial Permeability Transition

1998 • 174 citations

1-beta-D-Arabinofuranosylcytosine stimulates ceramide and diglyceride formation in HL-60 cells.

1994 • 166 citations

Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment.

2000 • 151 citations

Selenium and the thioredoxin and glutaredoxin systems.

1997 • 150 citations

The involvement of poly(ADP‐ribose) polymerase in the oxidative stress responses in plants

1998 • 140 citations

Antioxidant Function of the Mitochondrial Protein SP-22 in the Cardiovascular System

1999 • 132 citations

Adult T cell leukemia (ATL)-derived factor/human thioredoxin prevents apoptosis of lymphoid cells induced by L-cystine and glutathione depletion: possible involvement of thiol-mediated redox regulation in apoptosis caused by pro-oxidant state.

1997 • 126 citations

Resistance to radiation-induced apoptosis in Burkitt's lymphoma cells is associated with defective ceramide signaling.

1997 • 126 citations

The proliferation in suspension of the progenitors of the blast cells in acute myeloblastic leukemia

1985 • 122 citations

Detection of changes in mitochondrial function during apoptosis by simultaneous staining with multiple fluorescent dyes and correlated multiparameter flow cytometry

1999 • 118 citations

Intracellular redox changes during apoptosis.

1996 • 110 citations

Relationships between the mitochondrial permeability transition and oxidative stress during ara-C toxicity.

1997 • 105 citations

Induction and nuclear translocation of thioredoxin by oxidative damage in the mouse kidney: independence of tubular necrosis and sulfhydryl depletion.

1997 • 103 citations

Simultaneous detection of mitochondrial respiratory chain activity and reactive oxygen in digitonin-permeabilized cells using flow cytometry

2000 • 95 citations

Role of superoxide in apoptosis induced by growth factor withdrawal

1998 • 90 citations

Simultaneous detection of mitochondrial respiratory chain activity and reactive oxygen in digitonin‐permeabilized cells using flow cytometry

2000 • 85 citations

Thioredoxin Expression and Localization in Human Cell Lines: Detection of Full-Length and Truncated Species

1997 • 84 citations

Redox Control of Neuronal Damage during Brain Ischemia after Middle Cerebral Artery Occlusion in the Rat: Immunohistochemical and Hybridization Studies of Thioredoxin

1998 • 79 citations

Thioredoxin Is Transcriptionally Induced upon Activation of Heat Shock Factor 2

1997 • 65 citations

Induction of mitochondrial manganese superoxide dismutase confers resistance to apoptosis in acute myeloblastic leukaemia cells exposed to etoposide

2000 • 64 citations

Generation of reactive oxygen intermediates after treatment of blasts of acute myeloblastic leukemia with cytosine arabinoside: role of bcl-2.

1996 • 59 citations

Mechanism of cytosine arabinoside toxicity to the blast cells of acute myeloblastic leukemia: involvement of free radicals.

1995 • 53 citations

Decreased antioxidant defence and increased oxidant stress during dexamethasone-induced apoptosis: bcl-2 prevents the loss of antioxidant enzyme activity.

1996 • 52 citations

An Oxidative Stress-Mediated Death Pathway in Irradiated Human Leukemia Cells Mapped Using Multilaser Flow Cytometry

1998 • 48 citations

Oxidative stress adaptation improves postischemic ventricular recovery

1995 • 42 citations

Mitochondrial respiratory chain deficiency leads to overexpression of antioxidant enzymes

1997 • 24 citations