Control of human breast cancer by estrogen, growth factors, and oncogenes

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Angiogenic Factors

1987 • 3,702 citations

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

1986 • 2,878 citations

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

1984 • 2,564 citations

Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.

1986 • 2,499 citations

Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A

1986 • 2,341 citations

Growth Factors and Cancer

1991 • 2,044 citations

The biology of platelet-derived growth factor

1986 • 2,036 citations

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

1986 • 1,866 citations

Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene

1985 • 1,804 citations

The Molecular Genetics of Cancer

1987 • 1,729 citations

Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells

1985 • 1,687 citations

The c-erb-A gene encodes a thyroid hormone receptor

1986 • 1,505 citations

Early Signals in the Mitogenic Response

1986 • 1,498 citations

Textbook of Endocrinology

1952 • 1,475 citations

Growth factors from murine sarcoma virus-transformed cells.

1978 • 1,457 citations

Monoclonal antibodies localize oestrogen receptor in the nuclei of target cells

1984 • 1,416 citations

Autocrine Secretion and Malignant Transformation of Cells

1980 • 1,370 citations

Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer

1985 • 1,360 citations

The c-erb-A protein is a high-affinity receptor for thyroid hormone

1986 • 1,340 citations

Sequence and Expression of Human Estrogen Receptor Complementary DNA

1986 • 1,321 citations

Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture.

1986 • 1,282 citations

Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors

1986 • 1,244 citations

The Biochemistry of Glycoproteins and Proteoglycans

1980 • 1,231 citations

Transforming Growth Factor-β: Biological Function and Chemical Structure

1986 • 1,198 citations

Angiogenesis Induced by Degradation Products of Hyaluronic Acid

1985 • 1,128 citations

Type beta transforming growth factor: a bifunctional regulator of cellular growth.

1985 • 1,107 citations

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

1986 • 1,100 citations

Amplification of a Novel v- erb B-Related Gene in a Human Mammary Carcinoma

1985 • 1,064 citations

Multiple, Distinct Forms of Bovine and Human Protein Kinase C Suggest Diversity in Cellular Signaling Pathways

1986 • 1,044 citations

Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185

1986 • 1,020 citations

Evidence that transforming growth factor-β is a hormonally regulated negative growth factor in human breast cancer cells

1987 • 998 citations

Isolation of the bovine and human genes for müllerian inhibiting substance and expression of the human gene in animal cells

1986 • 997 citations

Functional domains of the human glucocorticoid receptor

1986 • 933 citations

Dual control of cell growth by somatomedins and platelet-derived growth factor.

1979 • 926 citations

Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes

1984 • 906 citations

Synthesis of messenger RNAs for transforming growth factors alpha and beta and the epidermal growth factor receptor by human tumors.

1987 • 895 citations

Human transforming growth factor-α: Precursor structure and expression in E. coli

1984 • 888 citations

Growth factors: Mechanism of action and relation to oncogenes

1984 • 885 citations

Nuclear localization of unoccupied oestrogen receptors

1984 • 882 citations

EPIDERMAL-GROWTH-FACTOR RECEPTOR STATUS AS PREDICTOR OF EARLY RECURRENCE OF AND DEATH FROM BREAST CANCER

1987 • 881 citations

The Complete Primary Structure of Protein Kinase C—the Major Phorbol Ester Receptor

1986 • 878 citations

Transforming Growth Factor-α: a More Potent Angiogenic Mediator than Epidermal Growth Factor

1986 • 856 citations

Expression of Cellular Oncogenes in Human Malignancies

1984 • 840 citations

Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats

1985 • 829 citations

The effects of estrogens and antiestrogens on hormone-responsive human breast cancer in long-term tissue culture.

1976 • 820 citations

Cellular tumorigenicity in nude mice: Correlation with cell growth in semi-solid medium

1974 • 814 citations

Estrogen control of progesterone receptor in human breast cancer. Correlation with nuclear processing of estrogen receptor.

1978 • 797 citations

cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines

1986 • 786 citations

Growth Inhibitor from BSC-1 Cells Closely Related to Platelet Type β Transforming Growth Factor

1984 • 779 citations

Mechanism of Action of the Female Sex Hormones

1972 • 763 citations

Translocations Among Antibody Genes in Human Cancer

1983 • 736 citations

Cloning of the human estrogen receptor cDNA.

1985 • 720 citations

The transforming growth factor-β system, a complex pattern of cross-reactive ligands and receptors

1987 • 710 citations

BIOCHEMICAL INTERACTIONS OF TUMOR CELLS WITH THE BASEMENT MEMBRANE

1986 • 693 citations

Human Endothelial Cell Growth Factor: Cloning, Nucleotide Sequence, and Chromosome Localization

1986 • 679 citations

A fixed site of DNA replication in eucaryotic cells

1980 • 669 citations

Cellular Localization of Somatomedin (Insulin-Like Growth Factor) Messenger RNA in the Human Fetus

1987 • 663 citations

Overexpression of the EGF receptor-related proto-oncogene erbB-2 in human mammary tumor cell lines by different molecular mechanisms.

1987 • 619 citations

EPIDERMAL-GROWTH-FACTOR RECEPTORS IN HUMAN BLADDER CANCER: COMPARISON OF INVASIVE AND SUPERFICIAL TUMOURS

1985 • 611 citations

Mechanisms of Tumor Progression

2010 • 608 citations

Human basic fibroblast growth factor: nucleotide sequence and genomic organization.

1986 • 604 citations

Functional role for c-myc in mitogenic response to platelet-derived growth factor

1984 • 578 citations

Estrogenic Regulation of Growth and Polypeptide Growth Factor Secretion in Human Breast Carcinoma

1987 • 576 citations

Evidence that the phosphorylation of tyrosine is essential for cellular transformation by Rous sarcoma virus

1980 • 560 citations

Type beta transforming growth factor is an inhibitor of myogenic differentiation.

1986 • 559 citations

Induction of c-sis mRNA and activity similar to platelet-derived growth factor by transforming growth factor beta: a proposed model for indirect mitogenesis involving autocrine activity.

1986 • 541 citations

Tumor cell autocrine motility factor.

1986 • 539 citations

Localisation of the oestradiol-binding and putative DNA-binding domains of the human oestrogen receptor.

1986 • 533 citations

Protein kinase C activation by diacylglycerol second messengers

1986 • 498 citations

EPIDERMAL-GROWTH-FACTOR RECEPTORS AND OESTROGEN RECEPTORS IN HUMAN BREAST CANCER

1985 • 496 citations

A secreted glycoprotein induced by estrogen in human breast cancer cell lines

1980 • 481 citations

Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains

1986 • 471 citations

Inhibition of protein kinase C by tamoxifen.

1985 • 464 citations

Human-tumor-derived cell lines contain common and different transforming genes

1981 • 455 citations

Growth Inhibition of Human Tumor Cells in Athymic Mice by Anti-Epidermal Growth Factor Receptor Monoclonal Antibodies

1984 • 443 citations

Identification of transforming gene in two human sarcoma cell lines as a new member of the ras gene family located on chromosome 1

1983 • 441 citations

Inhibition of Endothelial Regeneration by Type-Beta Transforming Growth Factor from Platelets

1986 • 439 citations

Immunochemical studies of estrogen receptors

1984 • 439 citations

Serum-free growth of human mammary epithelial cells: rapid clonal growth in defined medium and extended serial passage with pituitary extract.

1984 • 435 citations

Biochemical pharmacology of antiestrogen action.

1984 • 417 citations

Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo[a]pyrene.

1985 • 416 citations

Estrogen Receptor in a Human Cell Line (MCF-7) from Breast Carcinoma

1973 • 415 citations

Genetic alteration of the c-myc protooncogene (MYC) in human primary breast carcinomas.

1986 • 413 citations

Regulation of myogenic differentiation by type beta transforming growth factor.

1986 • 408 citations

Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production

1986 • 406 citations

Sequence of cDNA encoding human insulin-like growth factor I precursor

1983 • 401 citations

AMPLIFICATION OF c-erbB-2 ONCOGENE IN HUMAN ADENOCARCINOMAS IN VIVO

1986 • 400 citations

Effect of estrogens and antiestrogens on growth of human breast cancer cells in athymic nude mice.

1985 • 396 citations

Textbook of endocrinology

1982 • 388 citations

Cellular transformation by coordinated action of three peptide growth factors from human platelets

1984 • 383 citations

Alpha and beta human transforming growth factors stimulate prostaglandin production and bone resorption in cultured mouse calvaria.

1985 • 382 citations

Allosteric regulation of the epidermal growth factor receptor kinase.

1986 • 381 citations

c-myc oncogene protein synthesis is independent of the cell cycle in human and avian cells

1985 • 371 citations

Epithelial Wound Healing Enhanced by Transforming Growth Factor-α and Vaccinia Growth Factor

1987 • 368 citations

Autocrine saturation of pro-urokinase receptors on human A431 cells

1986 • 361 citations

Factors involved in the modulation of cell proliferation in vivo and in vitro: The role of fibroblast and epidermal growth factors in the proliferative response of mammalian cells

1978 • 360 citations

The ovalbumin gene is associated with the nuclear matrix of chicken oviduct cells

1982 • 356 citations

Tumorigenesis by mouse mammary tumor virus: Proviral activation of a cellular gene in the common integration region int-2

1984 • 356 citations

Expression of insulin-like growth factor-II transcripts in Wilms' tumour

1985 • 352 citations

Expression in rat fibroblasts of a human transforming growth factor-α cDNA results in transformation

1986 • 346 citations

Human breast carcinoma cells in continuous culture: a review.

1978 • 345 citations

TGF-β inhibition of endothelial cell proliferation: Alteration of EGF binding and EGF-induced growth-regulatory (competence) gene expression

1987 • 344 citations

Normal embryo fibroblasts release transforming growth factors in a latent form

1984 • 336 citations

Amplification of the neu (c-erbB-2) oncogene in human mammmary tumors is relatively frequent and is often accompanied by amplification of the linked c-erbA oncogene.

1987 • 335 citations

Phosphoinositides in mitogenesis: Neomycin inhibits thrombin-stimulated phosphoinositide turnover and initiation of cell proliferation

1985 • 332 citations

MDA-468, a human breast cancer cell line with a high number of epidermal growth factor (EGF) receptors, has an amplified EGF receptor gene and is growth inhibited by EGF

1985 • 332 citations

Role of epidermal growth factor in carcinogenesis.

1986 • 330 citations

Characterization of estrogen responsive transforming activity in human breast cancer cell lines.

1986 • 330 citations

Molecular Biology of the Human T-Lymphotropic Retroviruses

1986 • 324 citations

Epidermal Growth Factor Is a Major Growth-Promoting Agent in Human Milk

1980 • 315 citations

STEROIDAL PURE ANTIOESTROGENS

1987 • 313 citations

Secretion of an insulin-like growth factor-I-related protein by human breast cancer cells.

1986 • 310 citations

A 90,000-dalton binding protein common to both steroid receptors and the Rous sarcoma virus transforming protein, pp60v-src.

1985 • 304 citations

Sequence of the pS2 mRNA induced by estrogen in the human breast cancer cell line MCF-7

1984 • 304 citations

The specific binding of estrogens and androgens to the nuclear matrix of sex hormone responsive tissues.

1980 • 304 citations

c-myc gene is transcribed at high rate in G0-arrested fibroblasts and is post-transcriptionally regulated in response to growth factors

1985 • 300 citations

Two Syngeneic Cell Lines from Human Breast Tissue: The Aneuploid Mammary Epithelial (Hs578T) and the Diploid Myoepithelial (Hs578Bst) Cell Lines 2

1977 • 299 citations

N-myc amplification causes down-modulation of MHC class I antigen expression in neuroblastoma

1986 • 297 citations

Induction of Epidermal Growth Factor-Related Polypeptides by 17β-Estradiol in MCF-7 Human Breast Cancer Cells

1986 • 296 citations

Enhanced levels of insulin-like growth factor messenger RNA in human colon carcinomas and liposarcomas.

1986 • 293 citations

Cell proliferation kinetics of MCF-7 human mammary carcinoma cells in culture and effects of tamoxifen on exponentially growing and plateau-phase cells.

1983 • 288 citations

Participation of c- myc Protein in DNA Synthesis of Human Cells

1986 • 282 citations

Epidermal growth factor binding by breast tumor biopsies and relationship to estrogen receptor and progestin receptor levels.

1984 • 279 citations

Transforming protein of simian sarcoma virus stimulates autocrine growth of SSV-transformed cells through PDGF cell-surface receptors

1984 • 277 citations

Effects of tamoxifen on human breast cancer cell cycle kinetics: accumulation of cells in early G1 phase.

1983 • 275 citations

Bioactivities, estrogen receptor interactions, and plasminogen activator-inducing activities of tamoxifen and hydroxy-tamoxifen isomers in MCF-7 human breast cancer cells.

1984 • 274 citations

Epidermal Growth Factor Receptor Gene Expression in Estrogen Receptor-Positive and Negative Human Breast Cancer Cell Lines

1987 • 274 citations

Cloning and sequencing of the intronless gene for angiogenin, a human angiogenesis factor

1985 • 273 citations

Autocrine Growth Stimulation of the MCF 7 Breast Cancer Cells by the Estrogen-Regulated 52 K Protein*

1986 • 273 citations

Estrogen-Induced Factors of Breast Cancer Cells Partially Replace Estrogen to Promote Tumor Growth

1986 • 273 citations

Effect of estradiol on human breast cancer cells in culture.

1983 • 272 citations

Synthesis and secretion of platelet-derived growth factor by human breast cancer cell lines.

1987 • 266 citations

Different transforming growth factor-α species are derived from a glycosylated and palmitoylated transmembrane precursor

1987 • 264 citations

Purification and characterization of heparin-binding endothelial cell growth factors.

1986 • 263 citations

Evidence for a functional role of endogenously produced somatomedinlike peptides in the regulation of DNA synthesis in cultured human fibroblasts and porcine smooth muscle cells.

1985 • 257 citations

Somatomedin-C receptors and growth effects in human breast cells maintained in long-term tissue culture.

1984 • 256 citations

Cultured fibroblast monolayers secrete a protein that alters the cellular binding of somatomedin-C/insulinlike growth factor I.

1986 • 231 citations

Analysis of pp60c-src protein kinase activity in human tumor cell lines and tissues.

1986 • 230 citations

Immunotoxins

1986 • 230 citations

Presence of epidermal growth factor receptor as an indicator of poor prognosis in patients with breast cancer.

1985 • 230 citations

Ha-ras oncogene expression directed by a milk protein gene promoter: tissue specificity, hormonal regulation, and tumor induction in transgenic mice.

1987 • 228 citations

Differential effects of transforming growth factor-beta on proliferation of normal and malignant rat liver epithelial cells in culture.

1986 • 224 citations

Epidermal growth factor stimulation of human breast cancer cells in culture.

1980 • 223 citations

Monoclonal antibodies of predefined specificity detect activated ras gene expression in human mammary and colon carcinomas.

1984 • 223 citations

Presence of transforming growth factors in human breast cancer cells.

1984 • 222 citations

New human transforming genes detected by a tumorigenicity assay.

1984 • 217 citations

Loss of a c-H-ras-1 allele and aggressive human primary breast carcinomas.

1986 • 214 citations

Expression of epidermal growth factor receptor in human cultured cells and tissues: relationship to cell lineage and stage of differentiation.

1986 • 214 citations

Basement Membrane and the Invasive Activity of Metastatic Tumor Cells

1986 • 209 citations

A position 12-activated H-ras oncogene in all HS578T mammary carcinosarcoma cells but not normal mammary cells of the same patient.

1984 • 207 citations

ras gene Amplification and malignant transformation.

1985 • 204 citations

Characterization of epidermal growth factor receptor and action on human breast cancer cells in culture.

1984 • 201 citations

Activation of growth factor secretion in tumorigenic states of breast cancer induced by 17 beta-estradiol or v-Ha-ras oncogene.

1987 • 199 citations

Direct inhibitory effects of somatostatin (analogues) on the growth of human breast cancer cells.

1987 • 191 citations

Epidermal growth factor receptors in human breast cancer

1984 • 190 citations

A retrovirus vector expressing the putative mammary oncogene int-1 causes partial transformation of a mammary epithelial cell line

1986 • 189 citations

Transfection of v- ras ^H DNA into MCF-7 Human Breast Cancer Cells Bypasses Dependence on Estrogen for Tumorigenicity

1985 • 185 citations

Induction of cell division in medium lacking serum growth factor by SV40

1971 • 185 citations

Cell Culture Methods for Molecular and Cell Biology

1985 • 184 citations

Carbohydrate Recognition Systems for Receptor-Mediated Pinocytosis

1980 • 184 citations

Estrogen responsive proliferation of clonal human breast carcinoma cells in athymic mice

1980 • 178 citations

Cancer cells. 3: Growth factors and transformation

1985 • 176 citations

Estrogens Stimulate Cell Proliferation and Induce Secretory Proteins in a Human Breast Cancer Cell Line (T₄₇D)*

1982 • 175 citations

Gonadotropin-Releasing Hormone Binding Sites in Human Breast Carcinoma

1985 • 170 citations

Expression of pp60c-src protein kinase in adult and fetal human tissue: high activities in some sarcomas and mammary carcinomas.

1983 • 166 citations

Oral-Contraceptive Use and the Risk of Breast Cancer

1986 • 165 citations

Expression of H-ras correlates with metastatic potential: evidence for direct regulation of the metastatic phenotype in 10T1/2 and NIH 3T3 cells.

1987 • 163 citations

Construction of a Novel Oncogene Based on Synthetic Sequences Encoding Epidermal Growth Factor

1987 • 162 citations

Multihormonal Regulation of Insulin-Like Growth Factor-I-Related Protein in MCF-7 Human Breast Cancer Cells

1988 • 161 citations

Two Different cis -Active Elements Transfer the Transcriptional Effects of Both EGF and Phorbol Esters

1986 • 161 citations

Tumorigenic and metastatic properties of "normal" and ras-transfected NIH/3T3 cells.

1985 • 159 citations

Cell Proliferation of Estrogen-Sensitive Cells: The Case for Negative Control*

1987 • 157 citations

Amplification of the c-myc oncogene in one of five human breast carcinoma cell lines.

1984 • 152 citations

Frequent expression of growth factors for mesenchymal cells in human mammary carcinoma cell lines.

1987 • 151 citations

Epidermal growth factor stimulates the phosphorylation of the calcium-dependent 35,000-dalton substrate in intact A-431 cells.

1985 • 149 citations

Distribution of an estrogen-induced protein with a molecular weight of 24,000 in normal and malignant human tissues and cells.

1983 • 148 citations

Phosphorylation, glycosylation, and proteolytic activity of the 52-kD estrogen-induced protein secreted by MCF7 cells.

1987 • 147 citations

A unique family of endothelial cell polypeptide mitogens: the antigenic and receptor cross-reactivity of bovine endothelial cell growth factor, brain-derived acidic fibroblast growth factor, and eye-derived growth factor-II.

1985 • 146 citations

Epidermal growth factor stimulates the synthesis of its own receptor in a human breast cancer cell line.

1986 • 145 citations

Expression of the 21,000 molecular weight ras protein in a spectrum of benign and malignant human mammary tissues.

1986 • 140 citations

Receptor binding and growth-promoting activity of insulin-like growth factors in human breast cancer cells (T-47D) in culture.

1984 • 139 citations

Activation of related transforming genes in mouse and human mammary carcinomas.

1981 • 139 citations

Effects of serum and insulin on the sensitivity of the human breast cancer cell line MCF-7 to estrogen and antiestrogens.

1981 • 138 citations

Induction of plasminogen activator by estrogen in a human breast cancer cell line (MCF-7)

1979 • 137 citations

Dispersion of the ras family of transforming genes to four different chromosomes in man

1983 • 137 citations

Stimulation by insulin-like growth factors is required for cellular transformation by type beta transforming growth factor.

1985 • 137 citations

Effects of epidermal growth factor receptor concentration on tumorigenicity of A431 cells in nude mice.

1986 • 135 citations

Calmodulin-stimulated phosphorylation of 17 beta-estradiol receptor on tyrosine.

1984 • 134 citations

Estrogen receptor. Unoccupied sites in nuclei of a breast tumor cell line.

1977 • 131 citations

Selection and Characterization of a Breast Cancer Cell Line Resistant to the Antiestrogen LY 117018

1985 • 130 citations

Modulation of insulinlike growth factor I binding to human fibroblast monolayer cultures by insulinlike growth factor carrier proteins released to the incubation media.

1986 • 130 citations

Influence of cell proliferation and cell cycle phase on expression of estrogen receptor in MCF-7 breast cancer cells.

1984 • 129 citations

Variables controlling somatomedin production by cultured human fibroblasts

1983 • 129 citations

Isolation of a Somatomedin-Binding Protein from Preterm Amniotic Fluid. Development of a Radioimmunoassay*

1984 • 127 citations

Protein kinases in signal transduction

1984 • 123 citations

High-molecular-weight transforming growth factor activity in the urine of patients with disseminated cancer.

1983 • 122 citations

Biologically active precursor for transforming growth factor type alpha, released by retrovirally transformed cells.

1986 • 121 citations

Production of PDGF‐like growth factor by breast cancer cell lines

1985 • 120 citations

Expression of p21 ras oncoproteins in human cancers.

1986 • 119 citations

Evidence for the involvement of the submandibular gland epidermal growth factor in mouse mammary tumorigenesis.

1985 • 118 citations

Mammary fibroblast influence on normal mouse mammary epithelial cell responses to estrogen in vitro.

1986 • 117 citations

Loss of epidermal growth factor requirement and malignant transformation

1979 • 117 citations

EPIDERMAL-GROWTH-FACTOR RECEPTORS AND ESTROGEN-RECEPTORS IN HUMAN-BREAST CANCER

1985 • 114 citations

Epidermal growth factor receptor gene-amplified MDA-468 breast cancer cell line and its nonamplified variants.

1987 • 114 citations

Immunological detection and quantitation of alpha transforming growth factors in human breast carcinoma cells

1986 • 114 citations

Post-transcriptional control of the onset of DNA synthesis by an insulin-like growth factor.

1984 • 113 citations

17 beta-estradiol regulates and v-Ha-ras transfection constitutively enhances MCF7 breast cancer cell interactions with basement membrane.

1986 • 113 citations

Transforming growth factor-beta modulates the high-affinity receptors for epidermal growth factor and transforming growth factor-alpha.

1985 • 111 citations

Augmentation of the response of normal mammary epithelial cells to estradiol by mammary stroma.

1983 • 110 citations

Proliferation kinetics of a human breast cancer line in vitro following treatment with 17beta-estradiol and 1-beta-D-arabinofuranosylcytosine.

1978 • 110 citations

Estradiol receptor: phosphorylation on tyrosine in uterus and interaction with anti-phosphotyrosine antibody.

1986 • 109 citations

Loss of growth responsiveness to epidermal growth factor and enhanced production of alpha‐transforming growth factors in ras‐transformed mouse mammary epithelial cells

1987 • 108 citations

Physiological Effects of Transforming Growth Factor in the Newborn Mouse

1985 • 107 citations

Serum regulation of the estrogen responsiveness of the human breast cancer cell line MCF-7.

1983 • 103 citations

Human malignant tumours of the breast, as compared to their respective normal tissue, have elevated expression of the Harvey ras oncogene.

1984 • 103 citations

Transformation of human mammary epithelial cells by oncogenic retroviruses.

1988 • 103 citations

Expression and characterization of transforming growth factor alpha precursor protein in transfected mammalian cells.

1987 • 100 citations

Transforming growth factors in solid human malignant neoplasms.

1983 • 98 citations

High Frequency of Rare Alleles of the Human c-Ha-ras-1 Proto-oncogene in Breast Cancer Patients2

1986 • 96 citations

Amplified expression of p21 ras protein in hormone-dependent mammary carcinomas of humans and rodents

1985 • 94 citations

In Vitro Growth Promotion of Human Mammary Carcinoma Cells by Steroid Hormones, Tamoxifen, and Prolactin23

1984 • 92 citations

Effects of steroid hormones and peptide growth factors on protooncogene c-fos expression in human breast cancer cells.

1988 • 90 citations

Indirect mechanism of oestradiol stimulation of cell proliferation of human breast cancer cell lines

1986 • 89 citations

Evidence for an increased somatomedin-C/insulin-like growth factor I content in primary human lung tumors

1987 • 89 citations

Demonstration of a Specific Serum Carrier Protein of Nonsuppressible Insulin-like Activity in Vivo*

1977 • 88 citations

Alpha-transforming growth factor secreted by untransformed bovine anterior pituitary cells in culture. II. Identification using a sequence-specific monoclonal antibody.

1986 • 86 citations

Partial purification of transforming growth factors from human milk.

1986 • 84 citations

Cloning of estrogen-regulated messenger RNA sequences from human breast cancer cells.

1986 • 84 citations

Estrogen- and tamoxifen-induced rearrangement of cytoskeletal and adhesion structures in breast cancer MCF-7 cells.

1986 • 83 citations

Internalization of transforming growth factor‐β and its receptor in BALB/c 3T3 fibroblasts

1986 • 82 citations

Effects of estrogen and antiestrogen on DNA polymerase in human breast cancer.

1980 • 79 citations

Enhanced spontaneous metastasis of mouse carcinoma cells transfected with an activated c‐Ha‐ras‐1 gene

1986 • 79 citations

Purification of a mammary-derived growth factor from human milk and human mammary tumors.

1985 • 79 citations

Immunotoxins: redirecting nature's poisons

1985 • 78 citations

Transformation and stimulation of DNA synthesis in NIH-3T3 cells are a titratable function of normal p21N-ras expression.

1986 • 77 citations

Dual effects of the progestin R5020 on proteins released by the T47D human breast cancer cells.

1984 • 75 citations

1,25-dihydroxyvitamin D3 receptor in a cultured human breast cancer cell line (MCF 7 cells)

1980 • 75 citations

Dihydrofolate reductase gene amplification and possible rearrangement in estrogen-responsive methotrexate-resistant human breast cancer cells.

1982 • 75 citations

Effect of estrogens and antiestrogens on growth-regulatory enzymes in human breast cancer cells in tissue culture.

1985 • 75 citations

Insulin-Like Growth Factor (IGF)&slash;Somatomedin Receptor Subtypes: Structure, Function, and Relationships to Insulin Receptors and IGF Carrier Proteins

1986 • 72 citations

Transcriptional control of thymidine kinase gene expression by estrogen and antiestrogens in MCF-7 human breast cancer cells.

1986 • 72 citations

Evidence for a direct growth-stimulating effect of estradiol on human MCF-7 cells in vivo.

1984 • 69 citations

Purification and properties of a mammary-uterine-pituitary tumor cell growth factor from pregnant sheep uterus.

1984 • 68 citations

Immunodetection and modulation of cellular growth with antibodies against native transforming growth factor-beta 1.

1987 • 68 citations

Allele Increasing Susceptibility to Human Breast Cancer May Be Linked to the Glutamate-Pyruvate Transaminase Locus

1980 • 67 citations

Distinct high-performance liquid chromatography pattern of transforming growth factor activity in urine of cancer patients as compared with that of normal individuals.

1984 • 67 citations

Characterization of estrogen and progesterone receptors and the dissociated regulation of growth and progesterone receptor stimulation by estrogen in MDA-MB-134 human breast cancer cells.

1986 • 66 citations

Increased level of amplification of the c-myc oncogene in tumors induced in nude mice by a human breast carcinoma cell line.

1985 • 66 citations

Identification of a High Affinity Nuclear Acceptor Site for Estrogen Receptor of Calf Uterus

1974 • 66 citations

Oral-Contraceptive Use and the Risk of Breast Cancer. The Cancer and Steroid Hormone Study of the Centers for Disease Control and the National Institute of Child Health and Human Development

1987 • 65 citations

Microsomal binding sites for nonsteroidal anti-estrogens in MCF 7 human mammary carcinoma cells. Demonstration of high affinity and narrow specificity for basic ether derivatives of triphenylethylene.

1984 • 64 citations

Lactate dehydrogenase in estrogen-responsive human breast cancer cells.

1978 • 64 citations

Introduction of estrogen-responsiveness into mammalian cell lines

1986 • 64 citations

Ultrastructural localization of a platelet-derived growth factor/v-sis-related protein(s) in cytoplasm and nucleus of simian sarcoma virus-transformed cells.

1987 • 63 citations

Growth factor requirements of oncogene-transformed NIH 3T3 and BALB/c 3T3 cells cultured in defined media.

1986 • 62 citations

New acceptor cell for transfected genomic DNA: oncogene transfer into a mouse mammary epithelial cell line.

1985 • 62 citations

Chromosomal proteins regulate steroid binding to chromatin

1976 • 61 citations

Varying degrees of amplification of the N-ras oncogene in the human breast cancer cell line MCF-7.

1985 • 60 citations

Negative regulators of cell growth

1986 • 58 citations

Subcellular compartmentalization of estrogen receptors in human breast cancer cells

1980 • 56 citations

Alterations in Phosphoinositide Metabolism Associated with 17β-Estradiol and Growth Factor Treatment of MCF-7 Breast Cancer Cells

1988 • 55 citations

Use of two MCF-7 cell variants to evaluate the growth regulatory potential of estrogen-induced products.

1986 • 51 citations

Two new estrogen-supersensitive variants of the MCF-7 human breast cancer cell line

1983 • 47 citations

Evidence for a novel pituitary factor that potentiates the mitogenic effect of estrogen in human breast cancer cells.

1985 • 46 citations

Purification and characterization of a low molecular weight transforming growth factor from the urine of melanoma patients.

1985 • 45 citations

The matrix of human breast tumor cells is mitogenic for fibroblasts.

1984 • 45 citations

Antiestrogen Stimulation of the Production of a 37,000 Molecular Weight Secreted Protein and Estrogen Stimulation of the Production of a 32,000 Molecular Weight Secreted Protein in MCF-7 Human Breast Cancer Cells*

1987 • 45 citations

Phorbol esters inhibit the proliferation of MCF-7 cells

1986 • 45 citations

A New Human Breast Carcinoma Cell Line (PMC42) With Stem Cell Characteristics. III. Hormone Receptor Status and Responsiveness

1984 • 44 citations

Establishment of two rabbit mammary epithelial cell lines with distinct oncogenic potential and differentiated phenotype after microinjection of transforming genes.

1986 • 40 citations

Purification and characterization of a novel transforming growth factor.

1987 • 39 citations

Mesenchyme-mediated effect of testosterone on embryonic mammary epithelium.

1978 • 39 citations

Mitogenic effects of the proto-oncogene and oncogene forms of c-H-ras DNA in human diploid fibroblasts.

1986 • 38 citations

Rapid changes in specific estrogen binding elicited by cGMP or cAMP in cytosol from human endometrial cells.

1983 • 38 citations

Expression of epidermal growth factor and transforming growth factor-beta in human salivary gland adenocarcinoma cell line.

1985 • 38 citations

Cell-mediated co-action of transforming growth factors: incubation of type beta with normal rat kidney cells produces a soluble activity that prolongs the ruffling response to type alpha.

1986 • 37 citations

Comparative Study of Harvey-<i>RAS</i> Oncogene Expression with Conventional Clinicopathologic Parameters of Breast Cancer

1986 • 37 citations

Activation of the ribosomal DNA promoter in cells exposed to insulinlike growth factor I.

1987 • 37 citations

Response to estrogen by the human mammary carcinoma cell line CAMA-1.

1982 • 36 citations

Metabolism of steroid-modifying anticancer agents

1988 • 36 citations

Transfection with plasmid pSV2gptEJ induces chromosome rearrangements in CHEF cells.

1987 • 36 citations

Hormonal regulation of de novo pyrimidine synthesis and utilization in human breast cancer cells in tissue culture.

1983 • 35 citations

Comparison of growth factors functionally related to epidermal growth factor in the urine of normal and human tumor-bearing athymic mice.

1985 • 33 citations

Relationship between the expression of estrogen-regulated genes and estrogen-stimulated proliferation of MCF-7 mammary tumor cells.

1985 • 32 citations

Textbook of Endocrinology

1948 • 31 citations

Isolation and characterization of an estrogen-inhibited variant derived from the MCF-7 breast cancer cell line.

1984 • 29 citations

Do antiestrogens and antiprogestins act as hormone antagonists or receptor-targeted drugs in breast cancer?

1987 • 29 citations

Estrogen inhibition of a Mr 39,000 glycoprotein secreted by human breast cancer cells.

1987 • 28 citations

Cell culture methods for molecular and cell biology. Vol. 1, 2, 3 & 4.

1984 • 25 citations

Identification of an antigen associated with transforming genes of human and mouse mammary carcinomas.

1982 • 24 citations

Estrogen Receptors in the Male

1981 • 23 citations

A Factor From Plasma-Derived Human Serum That Inhibits the Growth of the Mammary Cell Line MCF-7: Characterization and Purification<xref ref-type="fn" rid="FN2">2</xref>

1984 • 22 citations

[Estrogen-induced proteins secreted by MCF7 human breast cancer cells stimulate their proliferation].

1983 • 20 citations

Development of Monoclonal Antibodies to the Human Breast Carcinoma Cell Line PMC42<xref ref-type="fn" rid="FN1">2</xref>

1986 • 17 citations

HIGH MOLECULAR WEIGHT SOMATOMEDIN-C/IGF-I FROM T47D HUMAN MAMMARY CARCINOMA CELLS: IMMUNOREACTIVITY AND BIOACTIVITY

1983 • 11 citations

Combining endocrine and chemotherapy — any true benefits?

1984 • 10 citations

Endocytosis of polypeptides and their receptors

1985 • 9 citations

The possible link between receptor phosphorylation and internalization

1985 • 8 citations

Polyoma Virus Transformation of Rat Kidney Fibroblasts Results in Loss of Requirement For Insulin and Retinoic Acid

1983 • 7 citations

Phorbol ester induced phosphorylation of the estrogen receptor in intact MCF-7 human breast cancer cells

1986 • 2 citations

Deleted Work

1955 • 0 citations