Cytolytic pathways in haematopoietic stem-cell transplantation

Apoptosis by Death Factor

1997 • 5,038 citations

Bone marrow transplant

1989 • 3,423 citations

Graft-versus-leukemia reactions after bone marrow transplantation

1990 • 2,781 citations

Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. European Group for Blood and Marrow Transplantation Working Party Chronic Leukemia [see comments]

1995 • 2,026 citations

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

CD95's deadly mission in the immune system

2000 • 1,714 citations

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

1994 • 1,558 citations

Antileukemic Effect of Graft-versus-Host Disease in Human Recipients of Allogeneic-Marrow Grafts

1979 • 1,538 citations

Hematopoietic cell transplantation in older patients with hematologic malignancies: replacing high-dose cytotoxic therapy with graft-versus-tumor effects

2001 • 1,420 citations

HSV-TK Gene Transfer into Donor Lymphocytes for Control of Allogeneic Graft-Versus-Leukemia

1997 • 1,180 citations

Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

1994 • 1,073 citations

The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen.

1992 • 839 citations

A fresh look at tumor immunosurveillance and immunotherapy

2001 • 723 citations

Fas ligand in human serum

1996 • 682 citations

Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia

2000 • 679 citations

Hematopoietic Cell Transplantation

2015 • 664 citations

Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations

2000 • 650 citations

Tumor necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft-vs.-host disease.

1987 • 609 citations

Hematopoietic Cell Transplantation

2000 • 514 citations

CD8+ T cells clear influenza virus by perforin or Fas-dependent processes.

1997 • 493 citations

Decreased tumor surveillance in perforin-deficient mice.

1996 • 487 citations

Essential roles of the Fas ligand in the development of hepatitis

1997 • 483 citations

The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis

2001 • 454 citations

Transplantation of Anergic Histoincompatible Bone Marrow Allografts

1999 • 448 citations

Allogeneic cell therapy with donor peripheral blood cells and recombinant human interleukin-2 to treat leukemia relapse after allogeneic bone marrow transplantation

1996 • 439 citations

Haematopoietic cell transplantation as immunotherapy

2001 • 415 citations

How do cytotoxic lymphocytes kill their targets?

1998 • 398 citations

Mannose 6-Phosphate/Insulin-like Growth Factor II Receptor Is a Death Receptor for Granzyme B during Cytotoxic T Cell–Induced Apoptosis

2000 • 393 citations

Pathophysiologic mechanisms of acute graft-vs.-host disease

1999 • 348 citations

Human minor histocompatibility antigens: new concepts for marrow transplantation and adoptive immunotherapy

1997 • 346 citations

CD8-depleted donor lymphocyte infusion as treatment for relapsed chronic myelogenous leukemia after allogeneic bone marrow transplantation

1995 • 341 citations

Toxicity and Efficacy of Defined Doses of CD4+ Donor Lymphocytes for Treatment of Relapse After Allogeneic Bone Marrow Transplant

1998 • 328 citations

TNF-Related Apoptosis-Inducing Ligand (TRAIL) Induces Apoptosis in Fas Ligand-Resistant Melanoma Cells and Mediates CD4 T Cell Killing of Target Cells

1998 • 316 citations

Cytotoxic T cells deficient in both functional fas ligand and perforin show residual cytolytic activity yet lose their capacity to induce lethal acute graft-versus-host disease.

1996 • 310 citations

The role of cell-mediated cytotoxicity in acute GVHD after MHC-matched allogeneic bone marrow transplantation in mice.

1996 • 303 citations

LPS antagonism reduces graft-versus-host disease and preserves graft-versus-leukemia activity after experimental bone marrow transplantation

2001 • 288 citations

The Ligands and Receptors of the Lymphotoxin System

1995 • 262 citations

Involvement of TNF-Related Apoptosis-Inducing Ligand in Human CD4+ T Cell-Mediated Cytotoxicity

1999 • 230 citations

Differential Effects of Anti-Fas Ligand and Anti-Tumor Necrosis Factor α Antibodies on Acute Graft-Versus-Host Disease Pathologies

1998 • 228 citations

A Role for Perforin in Downregulating T-Cell Responses during Chronic Viral Infection

1999 • 227 citations

A null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity.

1994 • 224 citations

Maximal Proliferation of Cytotoxic T Lymphocytes Requires Reverse Signaling through Fas Ligand

1998 • 217 citations

Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation.

1997 • 212 citations

Polarized type 2 alloreactive CD4+ and CD8+ donor T cells fail to induce experimental acute graft-versus-host disease.

1995 • 204 citations

Differential use of Fas ligand and perforin cytotoxic pathways by donor T cells in graft-versus-host disease and graft-versus-leukemia effect

2001 • 187 citations

Spontaneous Development of Plasmacytoid Tumors in Mice with Defective Fas–Fas Ligand Interactions

1998 • 181 citations

Phase I-II trial of a monoclonal anti-tumor necrosis factor alpha antibody for the treatment of refractory severe acute graft-versus-host disease

1992 • 176 citations

IL-11 separates graft-versus-leukemia effects from graft-versus-host disease after bone marrow transplantation

1999 • 175 citations

A Role for Fas in Negative Selection of Thymocytes In Vivo

1998 • 167 citations

A major role for the Fas pathway in acute graft-versus-host disease.

1996 • 158 citations

Cells of Th2 cytokine phenotype prevent LPS-induced lethality during murine graft-versus-host reaction. Regulation of cytokines and CD8+ lymphoid engraftment.

1994 • 147 citations

Delayed infusion of normal donor cells after MHC-matched bone marrow transplantation provides an antileukemia reaction without graft-versus-host disease.

1993 • 147 citations

Graft-Versus-Leukemia Effect and Graft-Versus-Host Disease Can Be Differentiated by Cytotoxic Mechanisms in a Murine Model of Allogeneic Bone Marrow Transplantation

1999 • 144 citations

Graft-versus-host-disease-associated lymphoid hypoplasia and B cell dysfunction is dependent upon donor T cell-mediated Fas-ligand function, but not perforin function

1997 • 141 citations

Phase I-II trial of a monoclonal anti-tumor necrosis factor alpha antibody for the treatment of refractory severe acute graft-versus-host disease

1992 • 139 citations

The role of granzyme B in murine models of acute graft-versus-host disease and graft rejection

1996 • 138 citations

Opposing Roles of CD28:B7 and CTLA-4:B7 Pathways in Regulating In Vivo Alloresponses in Murine Recipients of MHC Disparate T Cells

1999 • 127 citations

TRAIL (Apo2 Ligand) and TWEAK (Apo3 Ligand) Mediate CD4+ T Cell Killing of Antigen-Presenting Macrophages

2000 • 125 citations

Fas ligand- mediated killing by intestinal intraepithelial lymphocytes. Participation in intestinal graft-versus-host disease.

1998 • 125 citations

Granulocyte Colony-Stimulating Factor–Mobilized Allogeneic Stem Cell Transplantation Maintains Graft-Versus-Leukemia Effects Through a Perforin-Dependent Pathway While Preventing Graft-Versus-Host Disease

1999 • 119 citations

Role of perforin in controlling B-cell hyperactivity and humoral autoimmunity

2000 • 115 citations

Differential expression of Fas and Fas ligand in acute and chronic graft-versus-host disease: up-regulation of Fas and Fas ligand requires CD8+ T cell activation and IFN-gamma production.

1998 • 106 citations

Anti-Third Party CD8+ CTLs as Potent Veto Cells

2000 • 100 citations

A Phase I-II Clinical Trial to Evaluate Removal of CD4 Cells and Partial Depletion of CD8 Cells From Donor Marrow for HLA-Mismatched Unrelated Recipients

1999 • 98 citations

Perforin Protects Against Autoimmunity in Lupus-Prone Mice

1998 • 95 citations

CD4+ AND CD8+ T CELLS EACH CAN UTILIZE A PERFORIN-DEPENDENT PATHWAY TO MEDIATE LETHAL GRAFT-VERSUS-HOST DISEASE IN MAJOR HISTOCOMPATIBILITY COMPLEX-DISPARATE RECIPIENTS1

1997 • 90 citations

Involvement of Donor T-Cell Cytotoxic Effector Mechanisms in Preventing Allogeneic Marrow Graft Rejection

1998 • 90 citations

Differential Expression of Fas and Fas Ligand in Acute and Chronic Graft-Versus-Host Disease: Up-Regulation of Fas and Fas Ligand Requires CD8+ T Cell Activation and IFN-γ Production

1998 • 87 citations

Adoptive immunotherapy using donor leukocytes following bone marrow transplantation for chronic myeloid leukemia: is T cell dose important in determining biological response?

1995 • 86 citations

Selective removal of alloreactive cells from haematopoietic stem cell grafts: graft engineering for GVHD prophylaxis

1999 • 81 citations

Host T Cells Resist Graft-Versus-Host Disease Mediated by Donor Leukocyte Infusions

2000 • 80 citations

Perforin and Lymphocyte‐mediated Cytolysis

1995 • 78 citations

Fas-DeficientlprMice Are More Susceptible to Graft-Versus-Host Disease

2000 • 72 citations

A Role for Perforin in Activation-Induced T Cell Death In Vivo: Increased Expansion of Allogeneic Perforin-Deficient T Cells in SCID mice

1999 • 72 citations

Principles of graft-vs.-leukemia reactivity.

1995 • 70 citations

Involvement of Fas-Mediated Apoptosis in the Hematopoietic Progenitor Cells of Graft-Versus-Host Reaction-Associated Myelosuppression

1998 • 69 citations

Increased soluble Fas-ligand in sera of bone marrow transplant recipients with acute graft-versus-host disease

1998 • 65 citations

THE ROLE OF PURIFIED CD8+ T CELLS IN GRAFT-VERSUS-LEUKEMIA ACTIVITY AND ENGRAFTMENT AFTER ALLOGENEIC BONE MARROW TRANSPLANTATION

1995 • 63 citations

Therapeutic effect of an anti-Fas ligand mAb on lethal graft-versus-host disease

1999 • 62 citations

A Metalloproteinase Inhibitor Prevents Lethal Acute Graft-Versus-Host Disease in Mice

1997 • 61 citations

Differential use of FasL- and perforin-mediated cytolytic mechanisms by T-cell subsets involved in graft-versus-myeloid leukemia responses

2000 • 58 citations

Major histocompatibility complex–mismatched allogeneic bone marrow transplantation using perforin and/or Fas ligand double-defective CD4+ donor T cells: involvement of cytotoxic function by donor lymphocytes prior to graft-versus-host disease pathogenesis

2001 • 56 citations

Perforin- and Fas-mediated cytotoxic pathways are not required for allogeneic resistance to bone marrow grafts in mice.

1995 • 52 citations

Intestinal crypt cell apoptosis in murine acute graft versus host disease is mediated by tumour necrosis factor α and not by the FasL-Fas interaction: effect of pentoxifylline on the development of mucosal atrophy

1999 • 48 citations

Levels of soluble FasL and FasL gene expression during the development of graft-versus-host disease in DLT-treated patients

1999 • 47 citations

Soluble Fas Levels in Sera of Bone Marrow Transplantation Recipients Are Increased During Acute Graft-Versus-Host Disease But Not During Infections

1998 • 46 citations

Accumulation and Activation-Induced Release of Preformed Fas (CD95) Ligand During the Pathogenesis of Experimental Graft-Versus-Host Disease

2001 • 41 citations

Graft-vs.-lymphoma effect in an allogeneic hematopoietic stem cell transplantation model

1999 • 39 citations

Enhanced Antibody and Cytokine Responses to Influenza Viral Antigens in Perforin-Deficient Mice

1998 • 37 citations

Acute and chronic graft-versus-host disease

1993 • 31 citations

ROLE AND REGULATION OF PIG CD59 AND MEMBRANE COFACTOR PROTEIN/CD46 EXPRESSED ON PIG AORTIC ENDOTHELIAL CELLS1

2000 • 28 citations

Allogeneic bone marrow cells that facilitate complete chimerism and eliminate tumor cells express both CD8 and T-cell antigen receptor–αβ

2001 • 26 citations

Fas ligand-deficient gld mice are more susceptible to graft-versus-host-disease.

2000 • 24 citations

Effect of Graft-versus-Host Disease (GVHD) on Host Hematopoietic Progenitor Cells Is Mediated by Fas–Fas Ligand Interactions but This Does Not Explain the Effect of GVHD on Donor Cells

1999 • 24 citations

SELECTIVE CD4+ T-CELL DEPLETION DOES NOT PREVENT GRAFT-VERSUS-HOST DISEASE1

1998 • 24 citations

Cytotoxically impaired transplant recipients can efficiently resist major histocompatibility complex--matched bone marrow allografts

2000 • 22 citations

Difference in the expression of Fas/Fas-ligand and the lymphocyte subset reconstitution according to the occurrence of acute GVHD

1997 • 20 citations

T-cell subsets mediate graft-versus-myeloid leukemia responses via different cytotoxic mechanisms

2000 • 19 citations

Differential use of FasL- and perforin-mediated cytolytic mechanisms by T-cell subsets involved in graft-versus-myeloid leukemia responses

2000 • 14 citations