Differential Expression of Fas and Fas Ligand in Acute and Chronic Graft-Versus-Host Disease: Up-Regulation of Fas and Fas Ligand Requires CD8+ T Cell Activation and IFN-γ Production

The Fas Death Factor

1995 • 4,070 citations

Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors.

1979 • 1,301 citations

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.

1987 • 1,060 citations

The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen.

1992 • 839 citations

IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T cell-mediated cytolysis in the absence of complement.

1980 • 835 citations

Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity.

1993 • 801 citations

Expression of interleukin-2 receptors as a differentiation marker on intrathymic stem cells

1985 • 613 citations

Membrane Fas Ligand Kills Human Peripheral Blood T Lymphocytes, and Soluble Fas Ligand Blocks the Killing

1997 • 503 citations

FasGene Mutations in the Canale–Smith Syndrome, an Inherited Lymphoproliferative Disorder Associated with Autoimmunity

1996 • 486 citations

Unequal Death in T Helper Cell (Th)1 and Th2 Effectors: Th1, but not Th2, Effectors Undergo Rapid Fas/FasL-mediated Apoptosis

1997 • 460 citations

Expansion or Elimination of B Cells In Vivo: Dual Roles for CD40- and Fas (CD95)-Ligands Modulated by the B Cell Antigen Receptor

1996 • 405 citations

Concanamycin A, a powerful tool for characterization and estimation of contribution of perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity.

1996 • 401 citations

Graft-versus-host reactions: clues to the etiopathology of a spectrum of immunological diseases

1984 • 354 citations

Cytotoxic T cells deficient in both functional fas ligand and perforin show residual cytolytic activity yet lose their capacity to induce lethal acute graft-versus-host disease.

1996 • 310 citations

Participation of target Fas protein in apoptosis pathway induced by CD4+ Th1 and CD8+ cytotoxic T cells.

1994 • 309 citations

The role of cell-mediated cytotoxicity in acute GVHD after MHC-matched allogeneic bone marrow transplantation in mice.

1996 • 303 citations

Interferon-γ-Inducing Factor, a Novel Cytokine, Enhances Fas Ligand-Mediated Cytotoxicity of Murine T Helper 1 Cells

1996 • 277 citations

Cytokine gene expression after in vivo primary immunization with goat antibody to mouse IgD antibody.

1991 • 250 citations

Kinetics of Th1 and Th2 cytokine production during the early course of acute and chronic murine graft-versus-host disease. Regulatory role of donor CD8+ T cells.

1995 • 232 citations

Autoimmune disease. a problem of defective apoptosis

1994 • 224 citations

Mechanism and Biological Significance of CD4‐mediated Cytotoxicity

1995 • 211 citations

Polymorphism of murine Fas ligand that affects the biological activity

1997 • 201 citations

Role of cytotoxic T lymphocytes in the prevention of lupus-like disease occurring in a murine model of graft-vs-host disease.

1987 • 169 citations

T-cell interactions in autoimmunity

1988 • 163 citations

A major role for the Fas pathway in acute graft-versus-host disease.

1996 • 158 citations

IL-12 stimulates the development of acute graft-versus-host disease in mice that normally would develop chronic, autoimmune graft-versus-host disease.

1994 • 131 citations

Th1 CD4+ lymphocytes delete activated macrophages through the Fas/APO-1 antigen pathway.

1995 • 118 citations

IL-4 induces Fas resistance in B cells.

1996 • 115 citations

IL-12 is a central mediator of acute graft-versus-host disease in mice.

1996 • 109 citations

Fas‐mediated Cytotoxicity ‐ A New Immunoregulatory and Pathogenic Function of Thl CD4⁺ T Cells

1995 • 71 citations

B cells in systemic autoimmune disease: recent insights from Fas-deficient mice and men

1996 • 60 citations

Apoptosis abnormalities of splenic lymphocytes in autoimmune lpr and gld mice.

1995 • 59 citations

Kinetics of T cell activation in acute and chronic forms of murine graft-versus-host disease.

1991 • 51 citations

CYTOTOXICITY IN GRAFT-VERSUS-HOST REACTION

1972 • 37 citations

Cytotoxic T Lymphocytes: The Newly Identified Fas (CD95)-Mediated Killing Mechanism and a Novel Aspect of Their Biological Functions

1995 • 34 citations

Functional heterogeneity of L3T4+ T cells in MRL-lpr/lpr mice. L3T4+ T cells suppress major histocompatibility complex-self-restricted L3T4+ T helper cell function in association with autoimmunity.

1988 • 31 citations

Anti-receptor anti-MHC cytotoxic T lymphocytes: their role in the resistance to graft vs host reaction.

1987 • 24 citations

Allosuppression of B cells in vitro by graft‐vs.‐host reaction‐derived T cells is caused by cytotoxic T lymphocytes

1989 • 13 citations