The Ligands and Receptors of the Lymphotoxin System

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

Amino Acid Sequences Common to Rapidly Degraded Proteins: The PEST Hypothesis

1986 • 2,566 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death

1994 • 1,920 citations

Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin

1984 • 1,738 citations

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

1993 • 1,719 citations

Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes

1989 • 1,715 citations

Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in Vitro

1985 • 1,596 citations

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

1994 • 1,558 citations

Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

1994 • 1,549 citations

Growth factor signaling by receptor tyrosine kinases

1992 • 1,450 citations

A novel domain within the 55 kd TNF receptor signals cell death

1993 • 1,302 citations

Mice lacking the tumour necrosis factor receptor 1 are resistant to IMF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes

1993 • 1,267 citations

The CD40 Antigen and its Ligand

1994 • 1,259 citations

Protection from Fas-Mediated Apoptosis by a Soluble Form of the Fas Molecule

1994 • 1,120 citations

A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: Ramifications for the complex physiology of TNF

1988 • 1,105 citations

Crystal structure of the soluble human 55 kd TNF receptor-human TNFβ complex: Implications for TNF receptor activation

1993 • 1,073 citations

TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced “Acidic” sphingomyelin breakdown

1992 • 1,058 citations

Molecular and biological characterization of a murine ligand for CD40

1992 • 1,029 citations

A Receptor for Tumor Necrosis Factor Defines an Unusual Family of Cellular and Viral Proteins

1990 • 977 citations

Molecular cloning and expression of a receptor for human tumor necrosis factor

1990 • 973 citations

Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families

1988 • 967 citations

The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling

1994 • 934 citations

Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor

1990 • 918 citations

Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis.

1988 • 889 citations

A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen

1993 • 857 citations

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells

1994 • 844 citations

Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo.

1992 • 842 citations

The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome

1993 • 840 citations

CD40 Ligand Gene Defects Responsible for X-Linked Hyper-IgM Syndrome

1993 • 836 citations

Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors.

1992 • 832 citations

Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor

1989 • 821 citations

The two different receptors for tumor necrosis factor mediate distinct cellular responses.

1991 • 815 citations

Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity.

1993 • 801 citations

Induction of Apoptosis by the Low-Affinity NGF Receptor

1993 • 774 citations

Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM

1993 • 739 citations

Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions.

1991 • 735 citations

CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM

1993 • 719 citations

An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis.

1990 • 692 citations

Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease

1992 • 654 citations

Constitutive and induced expression of APO-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells.

1993 • 643 citations

Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity

1984 • 638 citations

Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation.

1991 • 621 citations

Ligand passing: the 75-kDa tumor necrosis factor (TNF) receptor recruits TNF for signaling by the 55-kDa TNF receptor.

1993 • 573 citations

Two tumor necrosis factor-binding proteins purified from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors.

1990 • 557 citations

Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production.

1991 • 553 citations

CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF

1993 • 541 citations

A structural superfamily of growth factors containing a cystine knot motif

1993 • 529 citations

A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas.

1989 • 527 citations

Fas transduces activation signals in normal human T lymphocytes.

1993 • 521 citations

Purification and characterization of the Fas-ligand that induces apoptosis.

1994 • 521 citations

The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity.

1992 • 518 citations

Structure of tumour necrosis factor

1989 • 512 citations

The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding.

1989 • 511 citations

New protein fold revealed by a 2.3-Å resolution crystal structure of nerve growth factor

1991 • 500 citations

Recombinant human tumor necrosis factor increases mRNA levels and surface expression of HLA-A,B antigens in vascular endothelial cells and dermal fibroblasts in vitro.

1986 • 496 citations

Immunoregulatory activity of recombinant human tumor necrosis factor (TNF)-alpha: induction of TNF receptors on human T cells and TNF-alpha-mediated enhancement of T cell responses.

1987 • 490 citations

Lymphotoxin ?, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface

1993 • 468 citations

Cell Death Mechanisms and the Immune System

1991 • 459 citations

Human tumor necrosis factor produced by human B-cell lines: synergistic cytotoxic interaction with human interferon.

1983 • 458 citations

Shedding of tumor necrosis factor receptors by activated human neutrophils.

1990 • 443 citations

Effect of bcl-2 on Fas antigen-mediated cell death.

1993 • 442 citations

The Structure of Tumor Necrosis Factor-α at 2.6 Å Resolution

1989 • 441 citations

Human Fas ligand: gene structure, chromosomal location and species specificity

1994 • 435 citations

Unraveling Function in the TNF Ligand and Receptor Families

1994 • 431 citations

The active form of tumor necrosis factor is a trimer.

1987 • 430 citations

A nonsecretable cell surface mutant of tumor necrosis factor (TNF) kills by cell-to-cell contact

1990 • 409 citations

Antibodies to a soluble form of a tumor necrosis factor (TNF) receptor have TNF-like activity.

1990 • 396 citations

Tumor necrosis factor alpha (TNF-alpha)-induced cell adhesion to human endothelial cells is under dominant control of one TNF receptor type, TNF-R55.

1993 • 395 citations

Virus proteins that counteract host immune defenses

1992 • 392 citations

cDNA sequences of two inducible T-cell genes.

1989 • 392 citations

Generation and characterization of hamster monoclonal antibodies that neutralize murine tumor necrosis factors.

1989 • 385 citations

T cell activation by clustered tyrosine kinases

1993 • 379 citations

Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha.

1991 • 376 citations

Characterization of the MRC OX40 antigen of activated CD4 positive T lymphocytes--a molecule related to nerve growth factor receptor.

1990 • 375 citations

Tumor necrosis factor's cytotoxic activity is signaled by the p55 TNF receptor

1993 • 341 citations

Increased levels of soluble tumor necrosis factor receptors in the sera and synovial fluid of patients with rheumatic diseases

1992 • 341 citations

Soluble forms of tumor necrosis factor receptors (TNF-Rs). The cDNA for the type I TNF-R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and a soluble form of the receptor.

1990 • 335 citations

Molecular cloning of a ligand for the inducible T cell gene 4‐1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor

1993 • 328 citations

A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice

1994 • 327 citations

A tumor necrosis factor (TNF) receptor-IgG heavy chain chimeric protein as a bivalent antagonist of TNF activity.

1991 • 326 citations

The Binding and Lysis of Target Cells by Cytotoxic Lymphocytes: Molecular and Cellular Aspects

1994 • 312 citations

Stimulation of human T-cell proliferation by specific activation of the 75-kDa tumor necrosis factor receptor.

1993 • 297 citations

A second tumor necrosis factor receptor gene product can shed a naturally occurring tumor necrosis factor inhibitor.

1990 • 292 citations

A Central Role of Perforin in Cytolysis?

1991 • 288 citations

Lymphotoxin and tumor necrosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalitogenicity

1990 • 285 citations

Human lymphotoxin. Production by a lymphoblastoid cell line, purification, and initial characterization.

1984 • 284 citations

Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34.

1994 • 284 citations

Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor

1993 • 280 citations

Protection against endotoxic shock by a tumor necrosis factor receptor immunoadhesin.

1991 • 279 citations

The p70 tumor necrosis factor receptor mediates cytotoxicity

1992 • 277 citations

Myxoma virus expresses a secreted protein with homology to the tumor necrosis factor receptor gene family that contributes to viral virulence

1991 • 273 citations

Lymphocyte Cytotoxicity in vitro: Activation and Release of a Cytotoxic Factor

1968 • 266 citations

Characterization of binding and biological effects of monoclonal antibodies against a human tumor necrosis factor receptor.

1990 • 263 citations

CD40 ligand and its role in X-linked hyper-IgM syndrome

1993 • 257 citations

Region E3 of adenovirus: A cassette of genes involved in host immunosurveillance and virus-cell interactions

1991 • 249 citations

Isolation and characterization of a tumor necrosis factor binding protein from urine

1989 • 249 citations

The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family.

1991 • 245 citations

Molecular mechanisms of tumor necrosis factor‐induced cytotoxicity

1994 • 238 citations

CD40 ligand expression is defective in a subset of patients with common variable immunodeficiency.

1994 • 236 citations

A metalloprotease inhibitor blocks shedding of the 80-kD TNF receptor and TNF processing in T lymphocytes.

1995 • 234 citations

Antigen processing and recognition

1992 • 234 citations

Increased serum levels of soluble receptors for tumor necrosis factor in cancer patients.

1991 • 234 citations

Characterization in vitro of a human tumor necrosis factor-binding protein. A soluble form of a tumor necrosis factor receptor.

1990 • 227 citations

Analysis of the Complete Genome of Smallpox Variola Major Virus Strain Bangladesh-1975

1994 • 226 citations

Phenotypic, functional, and molecular genetic comparisons of the abnormal lymphoid cells of C3H-lpr/lpr and C3H-gld/gld mice.

1986 • 224 citations

Localization of tumor necrosis factor receptors in the synovial tissue and cartilage‐pannus junction in patients with rheumatoid arthritis. Implications for local actions of tumor necrosis factor α

1992 • 216 citations

Identification of a 60-kD tumor necrosis factor (TNF) receptor as the major signal transducing component in TNF responses.

1990 • 215 citations

T2 open reading frame from the shope fibroma virus encodes a soluble form of the TNF receptor

1991 • 215 citations

Human tumor necrosis factor alpha (TNF alpha) mutants with exclusive specificity for the 55-kDa or 75-kDa TNF receptors.

1993 • 211 citations

Cytoplasmic phospholipase A2 activity and gene expression are stimulated by tumor necrosis factor: dexamethasone blocks the induced synthesis.

1993 • 208 citations

Expression of the types A and B tumor necrosis factor (TNF) receptors is independently regulated, and both receptors mediate activation of the transcription factor NF-kappa B. TNF alpha is not needed for induction of a biological effect via TNF receptors.

1990 • 207 citations

Lymphotoxin

1988 • 205 citations

CD40 molecules induce down-modulation and endocytosis of T cell surface T cell-B cell activating molecule/CD40-L. Potential role in regulating helper effector function.

1994 • 205 citations

Renaturation and tumor necrosis factor-alpha stimulation of a 97-kDa ceramide-activated protein kinase.

1994 • 205 citations

Cell cycle-specific effects of tumor necrosis factor.

1984 • 204 citations

CYTOTOXICITY MEDIATED BY SOLUBLE ANTIGEN AND LYMPHOCYTES IN DELAYED HYPERSENSITIVITY

1968 • 200 citations

Fas antigen and p55 TNF receptor signal apoptosis through distinct pathways.

1994 • 198 citations

Human 55-kDa receptor for tumor necrosis factor coupled to signal transduction cascades.

1992 • 197 citations

Mapping the Lectin-Like Activity of Tumor Necrosis Factor

1994 • 192 citations

Protection from tumor necrosis factor-mediated cytolysis by overexpression of plasminogen activator inhibitor type-2.

1991 • 189 citations

Tumor necrosis factor induces rapid production of 1'2'diacylglycerol by a phosphatidylcholine-specific phospholipase C.

1991 • 188 citations

The structure of human lymphotoxin (tumor necrosis factor-beta) at 1.9-A resolution.

1992 • 187 citations

Expression of surface lymphotoxin and tumor necrosis factor on activated T, B, and natural killer cells.

1992 • 183 citations

Human TNF mutants with selective activity on the p55 receptor

1993 • 182 citations

Correlation between serum levels of soluble tumor necrosis factor receptor and disease activity in systemic lupus erythematosus

1993 • 177 citations

TNF induces internalization of the p60 receptor and shedding of the p80 receptor.

1994 • 175 citations

Tumor necrosis factor (TNF) receptor expression in T lymphocytes. Differential regulation of the type I TNF receptor during activation of resting and effector T cells.

1991 • 174 citations

Extensive genetic polymorphism in the human tumor necrosis factor region and relation to extended HLA haplotypes.

1991 • 171 citations

The 26-kD transmembrane form of tumor necrosis factor alpha on activated CD4+ T cell clones provides a costimulatory signal for human B cell activation.

1993 • 168 citations

Preparations of lymphotoxin induce resistance to their own cytotoxic effect.

1984 • 168 citations

A 3-D model for the CD40 ligand predicts that it is a compact trimer similar to the tumor necrosis factors

1993 • 168 citations

Potential virulence determinants in terminal regions of variola smallpox virus genome

1993 • 167 citations

Expression of BCL-2 protein enhances the survival of mouse fibrosarcoid cells in tumor necrosis factor-mediated cytotoxicity.

1993 • 163 citations

B cells regulate expression of CD40 ligand on activated T cells by lowering the mRNA level and through the release of soluble CD40

1994 • 157 citations

Recombinant 55-kDa tumor necrosis factor (TNF) receptor. Stoichiometry of binding to TNF alpha and TNF beta and inhibition of TNF activity.

1991 • 154 citations

Purification and characterization of an inhibitor (soluble tumor necrosis factor receptor) for tumor necrosis factor and lymphotoxin obtained from the serum ultrafiltrates of human cancer patients.

1990 • 154 citations

Cytoplasmic truncation of the p55 tumour necrosis factor (TNF) receptor abolishes signalling, but not induced shedding of the receptor.

1992 • 152 citations

Lymphotoxin Is an Important T Cell-Derived Growth Factor for Human B Cells

1987 • 151 citations

Membrane tumour necrosis factor-α is involved in the polyclonal B-cell activation induced by HIV-infected human T cells

1993 • 147 citations

Dissociation of TNF-alpha cytotoxic and proinflammatory activities by p55 receptor- and p75 receptor-selective TNF-alpha mutants.

1994 • 147 citations

Tumor necrosis factor-induced activation and increased tyrosine phosphorylation of mitogen-activated protein (MAP) kinase in human fibroblasts.

1993 • 146 citations

Characterization of surface lymphotoxin forms. Use of specific monoclonal antibodies and soluble receptors.

1995 • 146 citations

Identification of a truncated form of the nerve growth factor receptor.

1988 • 145 citations

Tumor necrosis factor alpha is an autocrine growth factor for normal human B cells.

1994 • 145 citations

Formation of Ion-Permeable Channels by Tumor Necrosis Factor-α

1992 • 143 citations

Complementary DNA cloning of a receptor for tumor necrosis factor and demonstration of a shed form of the receptor.

1990 • 139 citations

Ki‐1 (CD30) antigen is released by Ki‐1‐positive tumor cells in vitro and in vivo. I. Partial characterization of soluble Ki‐1 antigen and detection of the antigen in cell culture supernatants and in serum by an enzyme‐linked immunosorbent assay

1989 • 138 citations

Tumour necrosis factor is a compact trimer

1987 • 136 citations

Tumor necrosis factor (TNF-α) and lymphotoxin (TNF-β)

1992 • 136 citations

Tumor necrosis factors-alpha and -beta bind to the same two types of tumor necrosis factor receptors and maximally activate the transcription factor NF-kappa B at low receptor occupancy and within minutes after receptor binding.

1990 • 132 citations

Tumor necrosis factor α in autoimmunity: pretty girl or old witch?

1992 • 128 citations

Adenovirus E1A renders infected cells sensitive to cytolysis by tumor necrosis factor.

1989 • 125 citations

The human OX40 homolog: cDNA structure, expression and chromosomal assignment of the ACT35 antigen

1994 • 124 citations

Functional characterization of the human tumor necrosis factor receptor p75 in a transfected rat/mouse T cell hybridoma.

1992 • 123 citations

Tumor necrosis factor receptor signaling. A dominant negative mutation suppresses the activation of the 55-kDa tumor necrosis factor receptor.

1992 • 117 citations

T-BAM/CD40-L on helper T lymphocytes augments lymphokine-induced B cell Ig isotype switch recombination and rescues B cells from programmed cell death.

1994 • 117 citations

Synergistic enhancement by tumor necrosis factor of in vitro cytotoxicity from chemotherapeutic drugs targeted at DNA topoisomerase II.

1987 • 116 citations

The involvement of human tumor necrosis factors-alpha and -beta in the mixed lymphocyte reaction.

1988 • 111 citations

Inhibition of tumor necrosis factor (TNF)-mediated NF-kappa B activation by selective blockade of the human 55-kDa TNF receptor.

1992 • 109 citations

Effect of bcl-2 proto-oncogene expression on cellular sensitivity to tumor necrosis factor-mediated cytotoxicity.

1993 • 109 citations

Cell-mediated cytotoxicity

1993 • 108 citations

A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family

1993 • 106 citations

The adenovirus E3-14.7K protein is a general inhibitor of tumor necrosis factor-mediated cytolysis.

1990 • 106 citations

Emerging families of cytokines and receptors

1993 • 105 citations

Tumor necrosis factor induces a selective shedding of its p75 receptor from human neutrophils.

1994 • 105 citations

Involvement of the 55- and 75-kDa tumor necrosis factor receptors in the generation of lymphokine-activated killer cell activity and proliferation of natural killer cells.

1991 • 105 citations

Role of TNF-alpha in CD8+ cytotoxic T lymphocyte-mediated lysis.

1993 • 102 citations

Effect of tumor necrosis factor on GTP binding and GTPase activity in HL-60 and L929 cells.

1988 • 101 citations

Nerve growth factor revisited

1993 • 100 citations

Plasma tumor necrosis factor soluble receptors in chronic renal failure

1992 • 99 citations

Tumor necrosis factor (TNF-α) and lymphotoxin (TNF-β)

1992 • 97 citations

Lymphotoxin is expressed as a heteromeric complex with a distinct 33-kDa glycoprotein on the surface of an activated human T cell hybridoma.

1992 • 97 citations

The CD27 membrane receptor, a lymphocyte‐specific member of the nerve growth factor receptor family, gives rise to a soluble form by protein processing that does not involve receptor endocytosis

1992 • 92 citations

Role of Perforin in Lymphocyte-Mediated Cytolysis

1992 • 89 citations

Soluble receptors for tumour necrosis factor: a putative marker of disease progression in HIV infection.

1993 • 85 citations

Studies on the differing effects of tumor necrosis factor and lymphotoxin on the growth of several human tumor lines.

1989 • 78 citations

Mechanism of release of soluble forms of tumor necrosis factor/lymphotoxin receptors by phorbol myristate acetate-stimulated human THP-1 cells in vitro.

1993 • 77 citations

Independent regulation of 55‐kDa and 75‐kDa tumor necrosis factor receptors during activation of human peripheral blood B lymphocytes

1991 • 77 citations

Tumorigenic poxviruses: Genomic organization and dna sequence of the telomeric region of the shope fibroma virus genome

1987 • 75 citations

Lymphotoxin is an autocrine growth factor for Epstein-Barr virus-infected B cell lines.

1993 • 74 citations

Evidence for multiple lytic pathways used by cytotoxic T lymphocytes.

1989 • 74 citations

Characterization of a recombinant extracellular domain of the type 1 tumor necrosis factor receptor: evidence for tumor necrosis factor .alpha. induced receptor aggregation

1992 • 72 citations

Site-directed mutational analysis of human tumor necrosis factor-alpha receptor binding site and structure-functional relationship.

1992 • 69 citations

Lymphotoxin and an associated 33-kDa glycoprotein are expressed on the surface of an activated human T cell hybridoma.

1991 • 68 citations

Efficient purification of recombinant human tumor necrosis factor beta from Escherichia coli yields biologically active protein with a trimeric structure that binds to both tumor necrosis factor receptors

1991 • 68 citations

Biochemical properties of the 75-kDa tumor necrosis factor receptor. Characterization of ligand binding, internalization, and receptor phosphorylation.

1992 • 67 citations

Molecular autoimmunity

1992 • 64 citations

Soluble receptors for tumour necrosis factor

1993 • 63 citations

Specific induction of 80-kDa tumor necrosis factor receptor shedding in T lymphocytes involves the cytoplasmic domain and phosphorylation.

1993 • 61 citations

Rapid phosphorylation of a 27 kDa protein induced by tumor necrosis factor

1988 • 58 citations

Resistance to killing by tumor necrosis factor in an adipocyte cell line caused by a defect in arachidonic acid biosynthesis.

1991 • 57 citations

Tumor necrosis factor receptors in lymphoid tissues and lymphomas. Source and site of action of tumor necrosis factor alpha.

1991 • 56 citations

Evidence for tumor necrosis factor-alpha involvement in the optimal induction of class I allospecific cytotoxic T cells.

1990 • 55 citations

Differential regulation of lymphotoxin (LT), lymphotoxin-beta (LT-beta), and TNF-alpha in murine T cell clones activated through the TCR.

1994 • 53 citations

Glucocorticoids inhibit TNFα-induced cytosolic phospholipase A2 activity

1992 • 52 citations

Construction and Evaluation of a hncDNA Library of Human 12p Transcribed Sequences Derived from a Somatic Cell Hybrid

1993 • 50 citations

Human tumor necrosis factor mutants with preferential binding to and activity on either the R55 or R75 receptor

1994 • 49 citations

The type B receptor for tumor necrosis factor-alpha mediates DNA fragmentation in HL-60 and U937 cells and differentiation in HL-60 cells

1992 • 49 citations

TNF Receptor Distribution in Human Tissues

1993 • 48 citations

TNF receptor signal transduction. Ligand-dependent stimulation of a serine protein kinase activity associated with (CD120a) TNFR60.

1994 • 48 citations

Crystallization of trimeric recombinant human tumor necrosis factor (cachectin).

1988 • 48 citations

Biochemical characterization of the extracellular domain of the 75-kilodalton tumor necrosis factor receptor

1993 • 46 citations

Production of lymphotoxin (LTα) and a soluble dimeric form of its receptor using the baculovirus expression system

1994 • 45 citations

Aspartic acid 50 and tyrosine 108 are essential for receptor binding and cytotoxic activity of tumour necrosis factor beta (lymphotoxin)

1991 • 45 citations

Characterization of the receptor for tumor necrosis factor (TNF) and lymphotoxin (LT) on human T lymphocytes. TNF and LT differ in their receptor binding properties and the induction of MHC class I proteins on a human CD4+ T cell hybridoma.

1990 • 44 citations

Modulation of two forms of tumor necrosis factor receptors and their cellular response by soluble receptors and their monoclonal antibodies.

1992 • 44 citations

Glucocorticoid Independence of Acute Thymic Involution Induced by Lymphotoxin and Estrogen

1994 • 43 citations

Characterization of individual tumor necrosis factor α- and β-producing cells after polyclonal T cell activation

1989 • 42 citations

Expression of perforin and membrane-bound lymphotoxin (tumor necrosis factor-beta) in virus-specific CD4+ human cytotoxic T-cell clones

1993 • 39 citations

Chromosomal location of the human tumor necrosis factor receptor genes

1991 • 39 citations

Cellular immunity and the immunotherapy of cancer

1990 • 38 citations

Structural and functional domains in human tumour necrosis factors

1991 • 37 citations

Production of transmembrane and secreted forms of tumor necrosis factor (TNF)-alpha by HIV-1-specific CD4+ cytolytic T lymphocyte clones. Evidence for a TNF-alpha-independent cytolytic mechanism.

1992 • 35 citations

Enhancement of tumor necrosis factor cytotoxicity by lithium chloride is associated with increased inositol phosphate accumulation.

1993 • 34 citations

Okadaic acid induces down-modulation and shedding of tumor necrosis factor receptors. Comparison with another tumor promoter, phorbol ester.

1993 • 33 citations

Tumor necrosis factor cytotoxicity is associated with phospholipase D activation

1993 • 32 citations

Expression of a TNF inhibitor in transgenic mice.

1993 • 32 citations

Protein kinases negatively affect nuclear factor-kappa B activation by tumor necrosis factor-alpha at two different stages in promyelocytic HL60 cells.

1992 • 31 citations

Induction of sensitivity to the cytotoxic action of tumor necrosis factor alpha by adenovirus E1A is independent of transformation and transcriptional activation

1990 • 30 citations

Involvement of an Asn/Val cleavage site in the production of a soluble form of a human tumor necrosis factor (TNF) receptor. Site-directed mutagenesis of a putative cleavage site in the p55 TNF receptor chain.

1992 • 27 citations

MHC-Linked Diabetogenic Gene of the NOD Mouse: Molecular Mapping of the 3′ Boundary of the Diabetogenic Region

1993 • 27 citations

Sensitization of tumor cells to tumor necrosis factor action by the protein kinase inhibitor staurosporine.

1993 • 27 citations

Genomic organization and chromosomal localization of the human CD27 gene.

1992 • 25 citations

Disruption in the AU motif of the mouse TNF-α3′ UTR correlates with reduced TNF production by macrophagesin vitro

1993 • 25 citations

Polymorphism of the mouse TNF-i locus: sequence studies of the 3'-untranslated region and first intron

1993 • 25 citations

Overexpression of metallothionein confers resistance to the cytotoxic effect of TNF with cadmium in MCF-7 breast carcinoma cells.

1992 • 25 citations

The murine lymphotoxin gene promoter. Characterization and negative regulation.

1990 • 23 citations

The alymphoplasia (aly) mutation co-segregates with the intercellular adhesion molecule-2 (lcam-2) on mouse chromosome 11

1994 • 22 citations

Expression of Membrane‐associated Lymphotoxin/Tumor Necrosis Factor‐β on Human Lymphokine‐activated Killer Cells

1991 • 22 citations

Crystal structure of TNF.

1992 • 21 citations

Bacterial Expression, Facile Purification and Properties of Recombinant Human Lymphotoxin (Tumor Necrosis Factor Beta)

1989 • 21 citations

Inhibitors of ADP-ribose polymerase decrease the resistance of HER2/neu-expressing cancer cells to the cytotoxic effects of tumor necrosis factor.

1991 • 21 citations

An autocrine growth factor constitutively produced by a human lymphoblastoid B-cell line is serologically related to lymphotoxin (TNF-β)

1989 • 21 citations

Divergent responses of human astrocytoma and non-neoplastic astrocytes to tumor necrosis factor alpha involve the 55 kDa tumor necrosis factor receptor

1993 • 20 citations

Analysis of the structure-function relationship of tumour necrosis factor. Human/mouse chimeric TNF proteins: General properties and epitope analysis

1990 • 20 citations

Definition of microsatellite size variants forTnfa andHsp70 in autoimmune and nonautoimmune mouse strains

1992 • 20 citations

Studies of membrane-associated and soluble (secreted) lymphotoxin in human lymphokine-activated T-killer cells in vitro.

1992 • 19 citations

Lymphotoxin activates hepatic T cells and simultaneously induces profound thymic atrophy.

1992 • 18 citations

Tumor necrosis factor receptor genes,TNFR1 andTNFR2, on human chromosomes 12 and 1

1991 • 16 citations

CD antigens 1993.

1994 • 15 citations

N-Linked Sugar Chain Structure of Recombinant Human Lymphotoxin Produced by CHO Cells: The Functional Role of Carbohydrate as to Its Lectin-like Character and Clearance Velocity

1993 • 15 citations

Regulation of cachectin biosynthesis occurs at multiple levels.

1990 • 15 citations

The Role of Lymphotoxin in Inflammation

1988 • 15 citations

The gene for the type 1 tumor necrosis factor receptor (TNF-R1) is localized on band 12p13

1991 • 15 citations

Sensitivity to tumour necrosis factor-mediated cytolysis is unrelated to manganous superoxide dismutase messenger RNA levels among transformed mouse fibroblasts.

1991 • 14 citations

Cytotoxicity mediated by tumor necrosis factor in variant subclones of the ME‐180 cervical carcinoma line: Modulation by specific inhibitors of DNA topoisomerase II

1989 • 14 citations

Characterization of recombinant human lymphotoxin (tumor necrosis factor-β) produced by a mammalian cell line

1989 • 12 citations

Heterogeneous proliferative effect of tumor necrosis factor‐α and lymphotoxin on mitogen‐activated B cells from B‐chronic lymphocytic leukemia

1993 • 11 citations

Lymphotoxin gene expression by melanocytes and melanoma cell lines and persistence of unspliced mRNA

1993 • 11 citations

Membrane‐associated Lymphotoxin Expression and Functional Analysis of Lymphokine‐activated Killer Cells Derived from Tumor‐infiltrating Lymphocytes

1993 • 9 citations

Mechanisms of lymphocyte-mediated cytotoxicity. II. biochemical and serologic identification of a precursor lymphotoxin form (pre-LT) produced by MLC-sensitized human T lymphocytes in vitro.

1981 • 9 citations

Human B-cell TNF-beta microheterogeneity.

1992 • 9 citations

In vitro transformation by Epstein‐Barr virus induces a switch in growth factor and anti‐IgM responsiveness in a human leukemic B cell clone

1990 • 7 citations

Cytolytic T cells keep their secrets

1993 • 5 citations

Lymphotoxin produced by human B- and T-cell lines appears in two distinct forms

1991 • 4 citations

The alymphoplasia (aly) mutation co-segregates with the intercellular adhesion molecule-2 (ICAM-2) on mouse chromosome11

1994 • 4 citations

Molecular identification of the human tumor necrosis factor receptor on interleukin-2-stimulated peripheral blood lymphocytes

1990 • 4 citations

Bacterial expression, facile purification and properties of recombinant human Lymphotoxin (Tumor necrosis factor β)

1989 • 4 citations

Galloway Memorial Lecture. Protein engineering of tumor necrosis factor-beta and its applications in cancer, septicaemia and cachexia.

1993 • 3 citations

Dissociation of TNF- cytotoxic and proinflammatory activities by p55 and p75 receptor-selective TNF- mutants

1994 • 3 citations