Graft-Versus-Leukemia Effect and Graft-Versus-Host Disease Can Be Differentiated by Cytotoxic Mechanisms in a Murine Model of Allogeneic Bone Marrow Transplantation

Graft-versus-leukemia reactions after bone marrow transplantation

1990 • 2,781 citations

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

1994 • 1,558 citations

Antileukemic Effect of Graft-versus-Host Disease in Human Recipients of Allogeneic-Marrow Grafts

1979 • 1,538 citations

The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor

1995 • 1,311 citations

Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

1994 • 1,073 citations

Bone Marrow Transplantation for Chronic Myelogenous Leukemia in Chronic Phase

1988 • 887 citations

T-cell depletion of HLA-identical transplants in leukemia

1991 • 771 citations

Cytokine dysregulation and acute graft-versus-host disease

1992 • 617 citations

Tumor necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft-vs.-host disease.

1987 • 609 citations

Cytokine dysregulation and acute graft-versus-host disease

1992 • 565 citations

Decreased tumor surveillance in perforin-deficient mice.

1996 • 487 citations

Treatment of Murine Leukaemia with X Rays and Homologous Bone Marrow

1956 • 449 citations

The kinetics of immune reconstitution after human marrow transplantation

1987 • 428 citations

Lymphocyte-mediated cytotoxicity: Two pathways and multiple effector molecules

1994 • 414 citations

α-FETOPROTEIN IN INDIAN CHILDHOOD CIRRHOSIS

1974 • 409 citations

A nonsecretable cell surface mutant of tumor necrosis factor (TNF) kills by cell-to-cell contact

1990 • 409 citations

Impact of T-cell depletion on outcome of allogeneic bone-marrow transplantation for standardrisk leukaemias.

1987 • 358 citations

IMPACT OF T-CELL DEPLETION ON OUTCOME OF ALLOGENEIC BONE-MARROW TRANSPLANTATION FOR STANDARD-RISK LEUKAEMIAS

1987 • 314 citations

Cytotoxic T cells deficient in both functional fas ligand and perforin show residual cytolytic activity yet lose their capacity to induce lethal acute graft-versus-host disease.

1996 • 310 citations

Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes

1994 • 307 citations

The role of cell-mediated cytotoxicity in acute GVHD after MHC-matched allogeneic bone marrow transplantation in mice.

1996 • 303 citations

Fas and its ligand in a general mechanism of T-cell-mediated cytotoxicity.

1994 • 294 citations

HOW DOES BONE-MARROW TRANSPLANTATION CURE LEUKAEMIA?

1984 • 277 citations

Treatment of Donor Bone Marrow with Monoclonal Anti-T-Cell Antibody and Complement for the Prevention of Graft-Versus-Host Disease

1986 • 275 citations

Karnofsky Memorial Lecture. Marrow transplantation for malignant diseases.

1983 • 275 citations

Fas expression and function in normal and malignant breast cell lines.

1996 • 236 citations

Graft-versus-Host-Reactions: A Review

1976 • 227 citations

Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation.

1997 • 212 citations

T CELL DEPLETION WITH CAMPATH-1 IN ALLOGENEIC BONE MARROW TRANSPLANTATION

1988 • 189 citations

Perforin, Fas ligand, and tumor necrosis factor are the major cytotoxic molecules used by lymphokine-activated killer cells.

1996 • 187 citations

Marrow Transplantation for Malignant Disease

1987 • 171 citations

Fas/Apo-1 (CD95) receptor lacking the intracytoplasmic signaling domain protects tumor cells from Fas-mediated apoptosis.

1996 • 169 citations

A major role for the Fas pathway in acute graft-versus-host disease.

1996 • 158 citations

Leukemia relapse after allogeneic bone marrow transplantation: a review

1994 • 156 citations

Resistance to Fas-mediated apoptosis in human hepatoma cells.

1995 • 152 citations

Graft-Versus-Host Disease: Pathophysiological and Clinical Aspects

1984 • 150 citations

Graft-versus-host-disease-associated lymphoid hypoplasia and B cell dysfunction is dependent upon donor T cell-mediated Fas-ligand function, but not perforin function

1997 • 141 citations

Colon carcinoma cells use different mechanisms to escape CD95-mediated apoptosis.

1998 • 140 citations

Allospecific CD8+ Tc1 and Tc2 populations in graft-versus-leukemia effect and graft-versus-host disease.

1996 • 137 citations

Recent advances in graft‐versus‐host disease (GVHD) prevention

1997 • 134 citations

Generation of CD4+ cytotoxic T-lymphocyte clones from a patient with severe graft-versus-host disease after allogeneic bone marrow transplantation: implications for graft-versus-leukemia reactivity

1995 • 131 citations

Relative perforin- and Fas-mediated lysis in T1 and T2 CD8 effector populations.

1995 • 129 citations

Graft‐versus‐Host Disease

1985 • 117 citations

The graft-versus-leukemia (GVL) phenomenon: is GVL separable from GVHD?

1990 • 117 citations

Lymphocyte depletion of donor bone marrow by counterflow centrifugal elutriation: results of a phase I clinical trial

1988 • 104 citations

CD6-Depleted Allogeneic Bone Marrow Transplantation for Acute Leukemia in First Complete Remission

1997 • 96 citations

INCREASING UTILIZATION OF BONE MARROW TRANSPLANTATION

1986 • 92 citations

CD4+ AND CD8+ T CELLS EACH CAN UTILIZE A PERFORIN-DEPENDENT PATHWAY TO MEDIATE LETHAL GRAFT-VERSUS-HOST DISEASE IN MAJOR HISTOCOMPATIBILITY COMPLEX-DISPARATE RECIPIENTS1

1997 • 90 citations

Recognition of clonogenic leukemic cells, remission bone marrow and HLA-identical donor bone marrow by CD8+ or CD4+ minor histocompatibility antigen-specific cytotoxic T lymphocytes.

1995 • 89 citations

In vitro separation of host specific graft-versus-host and graft-versus-leukemia cytotoxic T cell activities.

1992 • 86 citations

Expression and function of CD95 (FAS/APO‐1) in leukaemia‐lymphoma tumour lines

1997 • 73 citations

T-cell-depleted allogeneic bone marrow transplantation in adults with acute nonlymphocytic leukemia in first remission

1992 • 73 citations

TNF receptor p55 controls early acute graft-versus-host disease.

1997 • 72 citations

T-cell-depleted allogeneic bone marrow transplantation in adults with acute nonlymphocytic leukemia in first remission

1992 • 72 citations

The potential role of NK cells in the separation of graft‐versus‐tumor effects from graft‐versus‐host disease after allogeneic bone marrow transplantation

1997 • 66 citations

Distinct T cell populations distinguish chronic myeloid leukaemia cells from lymphocytes in the same individual: a model for separating GVHD from GVL reactions.

1994 • 63 citations

Contribution of Fas ligand to cardiac allograft rejection

1996 • 61 citations

A Metalloproteinase Inhibitor Prevents Lethal Acute Graft-Versus-Host Disease in Mice

1997 • 61 citations

Graft-versus-host effect after allogeneic hematopoietic stem cell transplantation: GVHD and GVL

1996 • 53 citations

Differential CD95 expression and function in T and B lineage acute lymphoblastic leukemia cells

1997 • 49 citations

T CELL DEPLETION WITH ANTI-CD5 IMMUNOTOXIN IN HISTOCOMPATIBLE BONE MARROW TRANSPLANTATION

1990 • 44 citations

Induction of graft-versus-leukemia (GVL) activity in murine leukemia models after IL-2 pretreatment of syngeneic and allogeneic bone marrow grafts.

1994 • 19 citations

A Metalloproteinase Inhibitor Prevents Lethal Acute Graft-Versus-Host Disease in Mice

1997 • 15 citations