Allogeneic cell therapy with donor peripheral blood cells and recombinant human interleukin-2 to treat leukemia relapse after allogeneic bone marrow transplantation

Graft-versus-leukemia reactions after bone marrow transplantation

1990 • 2,781 citations

A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes

1990 • 1,630 citations

Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients

1990 • 1,544 citations

Antileukemic Effect of Chronic Graft-versus-Host Disease

1981 • 1,112 citations

Infusions of Donor Leukocytes to Treat Epstein-Barr Virus-Associated Lymphoproliferative Disorders after Allogeneic Bone Marrow Transplantation

1994 • 1,078 citations

Diagnosis of chronic myeloid and acute lymphocytic leukemias by detection of leukemia-specific mRNA sequences amplified in vitro.

1988 • 741 citations

Influence of acute and chronic graft-versus-host disease on relapse and survival after bone marrow transplantation from HLA-identical siblings as treatment of acute and chronic leukemia [published erratum appears in Blood 1989 Aug 15;74(3):1180]

1989 • 623 citations

Induction of Graft-versus-Host Disease as Immunotherapy for Relapsed Chronic Myeloid Leukemia

1994 • 510 citations

ELIMINATION OF GRAFT-VERSUS-HOST DISEASE BY IN-VITRO DEPLETION OF ALLOREACTIVE LYMPHOCYTES WITH A MONOCLONAL RAT ANTI-HUMAN LYMPHOCYTE ANTIBODY (CAMPATH-1)

1984 • 436 citations

Methotrexate and cyclosporine versus cyclosporine alone for prophylaxis of graft-versus-host disease in patients given HLA-identical marrow grafts for leukemia: long-term follow-up of a controlled trial

1989 • 434 citations

Graft-versus-Host Disease as Adoptive Immunotherapy in Patients with Advanced Hematologic Neoplasms

1989 • 361 citations

Relapse of chronic myeloid leukemia after allogeneic bone marrow transplant: the case for giving donor leukocyte transfusions before the onset of hematologic relapse

1994 • 358 citations

Salvage immunotherapy using donor leukocyte infusions as treatment for relapsed chronic myelogenous leukemia after allogeneic bone marrow transplantation: efficacy and toxicity of a defined T-cell dose

1993 • 356 citations

Increased risk of leukemia relapse with high-dose cyclosporine A after allogeneic marrow transplantation for acute leukemia

1991 • 234 citations

Marrow transplantation for acute lymphoblastic leukemia: factors affecting relapse and survival

1989 • 232 citations

Clinical and immunologic effects of prolonged infusion of low-dose recombinant interleukin-2 after autologous and T-cell-depleted allogeneic bone marrow transplantation

1992 • 205 citations

Transplantation of allogeneic bone marrow without graft-versus-host disease using total lymphoid irradiation.

1978 • 177 citations

Donor leukocyte infusions for chronic myeloid leukemia relapsed after allogeneic bone marrow transplantation.

1993 • 173 citations

T-cell-depleted allogeneic bone marrow transplantation for acute leukaemia using Campath-1 antibodies and post-transplant administration of donor's peripheral blood lymphocytes for prevention of relapse

1995 • 167 citations

Graft-versus-leukemia reactions after bone marrow transplantation

1990 • 166 citations

Effect of low-dose interleukin-2 on disease relapse after T-cell- depleted allogeneic bone marrow transplantation

1994 • 152 citations

REMISSION OF RELAPSED LEUKÆMIA DURING A GRAFT-VERSUS-HOST REACTION A "GRAFT-VERSUS-LEUKÆMIA REACTION" IN MAN?

1978 • 150 citations

Delayed infusion of normal donor cells after MHC-matched bone marrow transplantation provides an antileukemia reaction without graft-versus-host disease.

1993 • 147 citations

Cytogenetic and histologic correlations in malignant lymphoma

1987 • 145 citations

Hematologic relapse of chronic myelogenous leukemia following allogeneic bone marrow transplantation: apparent graft-versus-leukemia effect following abrupt discontinuation of immunosuppression.

1992 • 133 citations

Antileukemic effect of graft-versus-host disease contributes to improved survival after allogeneic marrow transplantation.

1981 • 126 citations

The graft-versus-leukemia (GVL) phenomenon: is GVL separable from GVHD?

1990 • 117 citations

Impact of pretransplant conditioning and donor T cells on chimerism, graft-versus-host disease, graft-versus-leukemia reactivity, and tolerance after bone marrow transplantation

1991 • 110 citations

Durable complete remission of acute nonlymphocytic leukemia associated with discontinuation of immunosuppression following relapse after allogeneic bone marrow transplantation. A case report of a probable graft-versus-leukemia effect.

1990 • 97 citations

Eradication of murine leukemia with histoincompatible marrow grafts in mice conditioned with total lymphoid irradiation (TLI)

1981 • 97 citations

Interferon-α And Donor Buffy Coat Transfusions For Treatment Of Relapsed Chronic Myeloid Leukemia After Allogeneic Bone Marrow Transplantation

1993 • 88 citations

In vitro separation of host specific graft-versus-host and graft-versus-leukemia cytotoxic T cell activities.

1992 • 86 citations

Characterization of alloimmunization-induced T lymphocytes reactive against AKR leukemia in vitro and correlation with graft-vs-leukemia activity in vivo.

1983 • 83 citations

Donor leucocyte infusions after chemotherapy for patients relapsing with acute leukaemia following allogeneic BMT.

1993 • 83 citations

T cell and NK cell mediated graft-versus-leukaemia reactivity following donor buffy coat transfusion to treat relapse after marrow transplantation for chronic myeloid leukaemia.

1993 • 81 citations

CAMPATH-1 Monoclonal Antibodies in Bone Marrow Transplantation

1994 • 79 citations

Use of Recombinant Human Interleukin-2 in Conjunction with Bone Marrow Transplantation as a Model for Control of Minimal Residual Disease in Malignant Hematological Disorders: I. Treatment of Murine Leukemia in Conjunction with Allogeneic Bone Marrow Transplantation and IL-2-Activated Cell-Mediated Immunotherapy

1992 • 77 citations

Adoptive immunotherapy for recurrent CML after BMT.

1993 • 73 citations

Effective graft-versus-leukemia effects independent of graft-versus-host disease after T cell-depleted allogeneic bone marrow transplantation in a murine model of B cell leukemia/lymphoma. Role of cell therapy and recombinant IL-2.

1994 • 70 citations

Use of recombinant human interleukin-2 in conjunction with syngeneic bone marrow transplantation in mice as a model for control of minimal residual disease in malignant hematologic disorders

1991 • 62 citations

Improved single-step PCR assay for sex identification post-allogeneic sex-mismatched BMT.

1996 • 62 citations

Time pattern of the antileukemic effect of graft-versus-host reaction in mice.

1971 • 56 citations

Immunotherapy of Minimal Residual Disease by Immunocompetent Lymphocytes and Their Activation by Cytokines

1992 • 53 citations

Adoptive immunotherapy in conjunction with bone marrow transplantation--amplification of natural host defence mechanisms against cancer by recombinant IL-2.

1988 • 48 citations

Molecular remission occurring after donor leukocyte infusions for the treatment of relapsed chronic myelogenous leukemia after allogeneic bone marrow transplantation.

1992 • 43 citations

Graft-versus-leukemia reactions in humans. The Advisory Committee of the International Bone Marrow Transplant Registry.

1989 • 40 citations

Reinduction of remission of chronic myeloid leukemia by donor leukocyte transfusion following relapse after bone marrow transplantation: recovery complicated by initial pancytopenia and late dermatomyositis.

1993 • 37 citations

A pilot study of low‐dose cyclosporin for graft‐versus‐host prophylaxis in marrow transplantation

1992 • 36 citations

POSSIBILITY OF GRAFT-VS-LEUKEMIA DETERMINANTS INDEPENDENT OF THE MAJOR HISTOCOMPATIBILITY COMPLEX IN ALLOGENEIC MARROW TRANSPLANTATION

1983 • 35 citations

Enhancement of GVL effect with rhIL-2 following BMT in a murine model for acute myeloid leukemia in SJL/J mice.

1995 • 34 citations

Methotrexate and cyclosporine versus cyclosporine alone for prophylaxis of graft-versus-host disease in patients given HLA-identical marrow grafts for leukemia: long-term follow-up of a controlled trial

1989 • 32 citations

Immunological evaluation of patients with hematological malignancies receiving ambulatory cytokine-mediated immunotherapy with recombinant human interferon-α2a and interleukin-2

1992 • 22 citations

IL-2 activated cell-mediated immunotherapy: control of minimal residual disease in malignant disorders by allogeneic lymphocytes and IL-2.

1990 • 21 citations

Marrow transplantation for acute lymphoblastic leukemia: factors affecting relapse and survival

1989 • 17 citations

Increased risk of leukemia relapse with high-dose cyclosporine A after allogeneic marrow transplantation for acute leukemia

1991 • 14 citations

Effect of low-dose interleukin-2 on disease relapse after T-cell- depleted allogeneic bone marrow transplantation

1994 • 10 citations

Effect of hematopoietic chimerism on the course of rauscher's viral mouse leukemia. Abstr.

1963 • 10 citations