Host T Cells Resist Graft-Versus-Host Disease Mediated by Donor Leukocyte Infusions

Evaluation of survival data and two new rank order statistics arising in its consideration.

1966 • 7,595 citations

CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

1998 • 2,658 citations

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

2000 • 2,090 citations

Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. European Group for Blood and Marrow Transplantation Working Party Chronic Leukemia [see comments]

1995 • 2,026 citations

Nonmyeloablative Stem Cell Transplantation and Cell Therapy as an Alternative to Conventional Bone Marrow Transplantation With Lethal Cytoreduction for the Treatment of Malignant and Nonmalignant Hematologic Diseases

1998 • 1,984 citations

Changes in thymic function with age and during the treatment of HIV infection

1998 • 1,887 citations

Induction of Tumor Immunity by Removing CD25+CD4+ T Cells: A Common Basis Between Tumor Immunity and Autoimmunity

1999 • 1,475 citations

MOUSE CD1-SPECIFIC NK1 T CELLS: Development, Specificity, and Function

1997 • 1,326 citations

Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation.

1997 • 1,290 citations

Suppressor Effector Function of CD4+CD25+ Immunoregulatory T Cells Is Antigen Nonspecific

2000 • 1,282 citations

Thymus and Autoimmunity: Production of CD25+CD4+ Naturally Anergic and Suppressive T Cells as a Key Function of the Thymus in Maintaining Immunologic Self-Tolerance

1999 • 1,223 citations

Prevention of Graft Versus Host Disease by Inactivation of Host Antigen-Presenting Cells

1999 • 1,218 citations

Age, Thymopoiesis, and CD4+ T-Lymphocyte Regeneration after Intensive Chemotherapy

1995 • 1,066 citations

Phenotypically distinct subsets of CD4⁺ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice

1993 • 1,064 citations

Transplant-lite: induction of graft-versus-malignancy using fludarabine-based nonablative chemotherapy and allogeneic blood progenitor-cell transplantation as treatment for lymphoid malignancies.

1998 • 967 citations

CD4+CD25+ T Cells Inhibit Both the Induction and Effector Function of Autoreactive T Cells and Represent a Unique Lineage of Immunoregulatory Cells

1998 • 893 citations

Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors

1997 • 886 citations

4-1BB Costimulatory Signals Preferentially Induce CD8+ T Cell Proliferation and Lead to the Amplification In Vivo of Cytotoxic T Cell Responses

1997 • 777 citations

Adoptive immunotherapy evaluating escalating doses of donor leukocytes for relapse of chronic myeloid leukemia after bone marrow transplantation: separation of graft-versus-leukemia responses from graft-versus-host disease

1995 • 772 citations

Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity.

1994 • 630 citations

Cytokine dysregulation and acute graft-versus-host disease

1992 • 617 citations

Induction of Graft-versus-Host Disease as Immunotherapy for Relapsed Chronic Myeloid Leukemia

1994 • 510 citations

Graft-versus-Host Disease as Adoptive Immunotherapy in Patients with Advanced Hematologic Neoplasms

1989 • 361 citations

Role of 4-1BB in immune responses

1998 • 312 citations

Bone Marrow NK1.1− and NK1.1+ T Cells Reciprocally Regulate Acute Graft versus Host Disease

1999 • 312 citations

Cytotoxic T cells deficient in both functional fas ligand and perforin show residual cytolytic activity yet lose their capacity to induce lethal acute graft-versus-host disease.

1996 • 310 citations

The role of cell-mediated cytotoxicity in acute GVHD after MHC-matched allogeneic bone marrow transplantation in mice.

1996 • 303 citations

RISK FACTORS FOR ACUTE GRAFT-VERSUS-HOST DISEASE IN HISTOCOMPATIBLE DONOR BONE MARROW TRANSPLANTATION

1991 • 271 citations

4-1BB Ligand, a Member of the TNF Family, Is Important for the Generation of Antiviral CD8 T Cell Responses

1999 • 259 citations

Differential roles of IL-1 and TNF-α on graft-versus-host disease and graft versus leukemia

1999 • 249 citations

Differential effects of the absence of interferon-gamma and IL-4 in acute graft-versus-host disease after allogeneic bone marrow transplantation in mice.

1998 • 234 citations

Unusual T cell populations in adult murine bone marrow. Prevalence of CD3+CD4-CD8- and alpha beta TCR+NK1.1+ cells.

1990 • 196 citations

Donor CD8 cells prevent allogeneic marrow graft rejection in mice: potential implications for marrow transplantation in humans.

1993 • 195 citations

Blockade of CD40 ligand-CD40 interaction impairs CD4+ T cell-mediated alloreactivity by inhibiting mature donor T cell expansion and function after bone marrow transplantation.

1997 • 193 citations

Donor-derived interferon gamma is required for inhibition of acute graft-versus-host disease by interleukin 12.

1998 • 188 citations

Mouse Leukemia: Therapy with Monoclonal Antibodies Against a Thymus Differentiation Antigen

1980 • 183 citations

Veto Cells

1988 • 150 citations

Graft-versus-host-disease-associated lymphoid hypoplasia and B cell dysfunction is dependent upon donor T cell-mediated Fas-ligand function, but not perforin function

1997 • 141 citations

Delayed infusion of immunocompetent donor cells after bone marrow transplantation breaks graft-host tolerance allows for persistent antileukemic reactivity without severe graft-versus-host disease

1995 • 137 citations

IL-12 stimulates the development of acute graft-versus-host disease in mice that normally would develop chronic, autoimmune graft-versus-host disease.

1994 • 131 citations

Interleukin-12 inhibits murine graft-versus-host disease

1995 • 128 citations

Opposing Roles of CD28:B7 and CTLA-4:B7 Pathways in Regulating In Vivo Alloresponses in Murine Recipients of MHC Disparate T Cells

1999 • 127 citations

Infusion of anti-B7.1 (CD80) and anti-B7.2 (CD86) monoclonal antibodies inhibits murine graft-versus-host disease lethality in part via direct effects on CD4+ and CD8+ T cells.

1996 • 120 citations

Comparative Outcomes of T-Cell–Depleted and Non–T-Cell–Depleted Allogeneic Bone Marrow Transplantation for Chronic Myelogenous Leukemia: Impact of Donor Lymphocyte Infusion

1999 • 118 citations

IL-12 is a central mediator of acute graft-versus-host disease in mice.

1996 • 109 citations

T-Cell Depletion Plus Salvage Immunotherapy With Donor Leukocyte Infusions as a Strategy to Treat Chronic-Phase Chronic Myelogenous Leukemia Patients Undergoing HLA-Identical Sibling Marrow Transplantation

1999 • 95 citations

Neutralizing IL-12 during induction of murine acute graft-versus-host disease polarizes the cytokine profile toward a Th2-type alloimmune response and confers long term protection from disease.

1997 • 92 citations

Adoptive immunotherapy in canine mixed chimeras after nonmyeloablative hematopoietic cell transplantation

2000 • 90 citations

Involvement of Donor T-Cell Cytotoxic Effector Mechanisms in Preventing Allogeneic Marrow Graft Rejection

1998 • 90 citations

CD28/B7 interactions are required for sustaining the graft-versus-leukemia effect of delayed post-bone marrow transplantation splenocyte infusion in murine recipients of myeloid or lymphoid leukemia cells.

1997 • 81 citations

Infusion of donor lymphocytes into stable canine radiation chimeras: implications for mechanism of transplantation tolerance.

1976 • 81 citations

Interleukin-12 Inhibits Graft-Versus-Host Disease Through an Fas-Mediated Mechanism Associated With Alterations in Donor T-Cell Activation and Expansion

1998 • 76 citations

Role of Immunoregulatory Donor T Cells in Suppression of Graft-Versus-Host Disease Following Donor Leukocyte Infusion Therapy

1999 • 75 citations

Clonal deletion of postthymic T cells: veto cells kill precursor cytotoxic T lymphocytes.

1992 • 74 citations

Mechanism of protection from graft-vs-host disease in murine mixed allogeneic chimeras. I. Development of a null cell population suppressive of cell-mediated lympholysis responses and derived from the syngeneic bone marrow component.

1988 • 74 citations

Cloned natural suppressor cells prevent lethal graft-vs-host disease.

1987 • 72 citations

Prevention of allogeneic marrow graft rejection by donor T cells that do not recognize recipient alloantigens: potential role of a veto mechanism

1996 • 66 citations

Requirements for the induction and adoptive transfer of cyclosporine-induced syngeneic graft-versus-host disease.

1989 • 65 citations

Specific suppressor cells in graft–host tolerance of HLA-identical marrow transplantation

1981 • 65 citations

SUPPRESSOR CELLS IN TRANSPLANTATION TOLERANCE I. SUPPRESSOR CELLS IN THE MECHANISM OF TOLERANCE IN RADIATION CHIMERAS

1981 • 64 citations

Graft-vs.-host and graft-vs.-leukemia reactions after delayed infusions of donor T-subsets

1999 • 64 citations

Infusion of Donor Lymphocytes into Stable Canine Radiation Chimeras: Implications for Mechanism of Transplantation Tolerance

1976 • 62 citations

Veto Function in Vitro and in Vivo

1989 • 41 citations

Graft rejection by cytolytic T cells. Specificity of the effector mechanism in the rejection of allogeneic marrow.

1990 • 41 citations

Booster irradiation to the spleen following total body irradiation. A new immunosuppressive approach for allogeneic bone marrow transplantation.

1988 • 39 citations

Prevention and treatment of graft-versus-host disease by down-regulation of anti-host reactivity with veto cells of host origin

1999 • 35 citations

GRAFT REJECTION BY CYTOLYTIC T CELLS

1990 • 34 citations

Natural suppressor cells in spleens of irradiated, bone marrow-reconstituted mice and normal bone marrow: Lack of SCA-1 expression and enrichment by depletion of MAC1-positive cells

1990 • 33 citations

Mechanism of protection from graft-versus-host disease mortality by IL-2. III. Early reductions in donor T cell subsets and expansion of a CD3+CD4-CD8- cell population.

1992 • 32 citations

DO DONOR CELLS FUNCTION AS VETO CELLS IN THE INDUCTION AND MAINTENANCE OF TOLERANCE ACROSS AN MHC DISPARITY IN MIXED LYMPHOID RADIATION CHIMERAS?

1993 • 29 citations

In vivo inhibition of cytokine responsiveness and graft-versus-host disease mortality by rapamycin leads to a clinical-pathological syndrome discrete from that observed with cyclosporin A

1996 • 28 citations

Analysis of the Requirements for the Induction of CD4+ T Cell Alloantigen Hyporesponsiveness by Ex Vivo Anti-CD40 Ligand Antibody

2000 • 28 citations

SUPPRESSOR CELLS IN TRANSPLANTATION TOLERANCE

1981 • 28 citations

PREVENTION OF SYNGENEIC GRAFT-VERSUS-HOST DISEASE BY RECOVERY OF THYMIC MICROENVIRONMENT AFTER CYCLOSPORINE

1991 • 21 citations

Generation and characterization of IL-2-activated veto cells.

1992 • 15 citations

Cyclosporine A and peripheral tolerance. Inhibition of veto cell-mediated clonal deletion of postthymic precursor cytotoxic T lymphocytes.

1992 • 14 citations

Cellular modulation of acute graft-vs.-host disease.

1997 • 8 citations

Prevention of allogeneic marrow graft rejection by donor T cells that do not recognize recipient alloantigens: potential role of a veto mechanism

1996 • 5 citations

Interleukin-12 Inhibits Graft-Versus-Host Disease Through an Fas-Mediated Mechanism Associated With Alterations in Donor T-Cell Activation and Expansion

1998 • 4 citations

Deleted Work

1955 • 0 citations