Human minor histocompatibility antigens: new concepts for marrow transplantation and adoptive immunotherapy

The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

1987 • 2,403 citations

Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system

1974 • 2,058 citations

Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. European Group for Blood and Marrow Transplantation Working Party Chronic Leukemia [see comments]

1995 • 2,026 citations

The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides

1986 • 1,723 citations

Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients

1990 • 1,544 citations

Methotrexate and Cyclosporine Compared with Cyclosporine Alone for Prophylaxis of Acute Graft versus Host Disease after Marrow Transplantation for Leukemia

1986 • 1,453 citations

Use of gene-modified virus-specific T lymphocytes to control Epstein-Barr-virus-related lymphoproliferation

1995 • 1,207 citations

Identification of a Peptide Recognized by Five Melanoma-Specific Human Cytotoxic T Cell Lines

1994 • 841 citations

Altered Peptide Ligand–Induced Partial T Cell Activation: Molecular Mechanisms and Role in T Cell Biology

1996 • 698 citations

Prominent role of secondary anchor residues in peptide binding to HLA-A2.1 molecules

1993 • 630 citations

Tumor necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft-vs.-host disease.

1987 • 609 citations

Mismatches of Minor Histocompatibility Antigens between HLA-Identical Donors and Recipients and the Development of Graft-Versus-Host Disease after Bone Marrow Transplantation

1996 • 603 citations

Lethal graft-versus-host disease after bone marrow transplantation across minor histocompatibility barriers in mice. Prevention by removing mature T cells from marrow.

1978 • 524 citations

The major histocompatibility complex determines susceptibility to cytotoxic T cells directed against minor histocompatibility antigens.

1975 • 479 citations

Methods for the study of histocompatibility genes

1948 • 469 citations

In vitro cell-mediated immune responses to the male specific(H-Y) antigen in mice.

1975 • 454 citations

Cellular peptide composition governed by major histocompatibility complex class I molecules

1990 • 438 citations

Identification of a Graft Versus Host Disease-Associated Human Minor Histocompatibility Antigen

1995 • 429 citations

Human H-Y: a Male-Specific Histocompatibility Antigen Derived from the SMCY Protein

1995 • 358 citations

Y-antigen killing by T cells of women is restricted by HLA

1977 • 326 citations

Maternally transmitted histocompatibility antigen of mice: A hydrophobic peptide of a mitochondrially encoded protein

1990 • 324 citations

Tissue distribution of human minor histocompatibility antigens. Ubiquitous versus restricted tissue distribution indicates heterogeneity among human cytotoxic T lymphocyte-defined non-MHC antigens.

1992 • 320 citations

The HLA-A*0201-Restricted H-Y Antigen Contains a Posttranslationally Modified Cysteine That Significantly Affects T Cell Recognition

1997 • 294 citations

Human CD4+ T cells specifically recognize a shared melanoma-associated antigen encoded by the tyrosinase gene.

1994 • 287 citations

A Randomized Study of the Prevention of Acute Graft-versus-Host Disease

1982 • 262 citations

Primary stimulation by dendritic cells induces antiviral proliferative and cytotoxic T cell responses in vitro.

1989 • 260 citations

Principles for Adoptive T Cell Therapy of Human Viral Diseases

1995 • 256 citations

Proteasome subunits encoded by the major histocompatibility complex are not essential for antigen presentation

1992 • 250 citations

T cell suppression in transplantation tolerance through linked recognition.

1996 • 246 citations

Determinant selection of major histocompatibility complex class I-restricted antigenic peptides is explained by class I-peptide affinity and is strongly influenced by nondominant anchor residues.

1994 • 216 citations

Characterization of Naturally Occurring Minor Histocompatibility Peptides Including H-4 and H-Y

1990 • 215 citations

Allogeneic cell therapy for relapsed leukemia after bone marrow transplantation with donor peripheral blood lymphocytes.

1995 • 215 citations

Identification of a mouse male-specific transplantation antigen, H-Y

1995 • 192 citations

Human minor histocompatibility antigens

1996 • 190 citations

An H–YDb epitope is encoded by a novel mouse Y chromosome gene

1996 • 181 citations

A minor transplantation antigen detected by MHC-restricted cytotoxic T lymphocytes during graft-versus-host disease

1983 • 179 citations

Allele-specific differences in the interaction of MHC class I molecules with transporters associated with antigen processing.

1996 • 174 citations

Variable capacity of L3T4+ T cells to cause lethal graft-versus-host disease across minor histocompatibility barriers in mice.

1987 • 170 citations

Host-Specific Interleukin-2–Secreting Donor T-Cell Precursors as Predictors of Acute Graft-versus-Host Disease in Bone Marrow Transplantation between HLA-Identical Siblings

1992 • 167 citations

Studies on Tolerance of the Y Chromosome Antigen in Mice

1960 • 161 citations

Recognition of minor histocompatibility antigens on lymphocytic and myeloid leukemic cells by cytotoxic T-cell clones

1994 • 156 citations

Leukemia relapse after allogeneic bone marrow transplantation: a review

1994 • 156 citations

Strong and Weak Histocompatibility Gene Differences in Mice and Their Role in the Rejection of Homografts of Tumors and Skin

1956 • 143 citations

Maternally Transmitted Antigen of Mice: A Model Transplantation Antigen

1991 • 141 citations

Growth inhibition of clonogenic leukemic precursor cells by minor histocompatibility antigen-specific cytotoxic T lymphocytes.

1991 • 141 citations

Polymorphism of Adhesion Molecule CD31 and Its Role in Acute Graft-Versus-Host Disease

1996 • 139 citations

Frequency of anti-recipient alloreactive helper T-cell precursors in donor blood and graft-versus-host disease after HLA-identical sibling bone-marrow transplantation

1993 • 134 citations

INTERLEUKIN-1 IS A CRITICAL EFFECTOR MOLECULE DURING CYTOKINE DYSREGULATION IN GRAFT VERSUS HOST DISEASE TO MINOR HISTOCOMPATIBILITY ANTIGENS1

1993 • 134 citations

Generation of CD4+ cytotoxic T-lymphocyte clones from a patient with severe graft-versus-host disease after allogeneic bone marrow transplantation: implications for graft-versus-leukemia reactivity

1995 • 131 citations

A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens

1994 • 129 citations

Separation of the genetic loci for the H–Y antigen and for testis determination on human Y chromosome

1987 • 125 citations

Distinct Ir genes for helper and killer cells in the cytotoxic response to H-Y antigen.

1979 • 122 citations

Features of T cells causing H-2-restricted lethal graft-vs.-host disease across minor histocompatibility barriers.

1982 • 121 citations

T cell-recognized antigenic peptides derived from the cellular genome are not protein degradation products but can be generated directly by transcription and translation of short subgenic regions. A hypothesis

1989 • 121 citations

Immunogenetics of human minor histocompatibility antigens: their polymorphism and immunodominance

1992 • 117 citations

Naturally processed peptides longer than nine amino acid residues bind to the class I MHC molecule HLA-A2.1 with high affinity and in different conformations.

1994 • 112 citations

Rejection of bone-marrow graft by recipient-derived cytotoxic T lymphocytes against minor histocompatibility antigens

1990 • 110 citations

Recognition of a B cell leukemia-associated minor histocompatibility antigen by CTL.

1997 • 107 citations

The Depletion of T Cell Subsets in Vitro and in Vivo

1986 • 105 citations

Clonal analysis of murine graft-vs-host disease. I. Phenotypic and functional analysis of T lymphocyte clones.

1986 • 105 citations

L3T4-positive T cells participate in the induction of graft-vs-host disease in response to minor histocompatibility antigens.

1987 • 92 citations

Histocompatibility genes of mice. VI. Allografts in mice congenic at various non-H-2 histocompatibility loci.

1966 • 90 citations

Interferon-α And Donor Buffy Coat Transfusions For Treatment Of Relapsed Chronic Myeloid Leukemia After Allogeneic Bone Marrow Transplantation

1993 • 88 citations

HISTOCOMPATIBILITY GENES OF MICE

1966 • 78 citations

The effects of natural altered peptide ligands on the whole blood cytotoxic T lymphocyte response to human immunodeficiency virus

1995 • 74 citations

The Non‐H‐2 Histocompatibility Loci and Their Antigens

1973 • 71 citations

Cytokine involvement in predicting clinical graft-versus-host disease in allogeneic bone marrow transplant recipients.

1994 • 66 citations

Immunodominance in the graft-vs-host disease T cell response to minor histocompatibility antigens.

1990 • 65 citations

Immunodominance in the T-Cell response to multiple non-H-2 histocompatibility antigens

1986 • 65 citations

Deletion Mapping by Immunoselection against the H-Y Histocompatibility Antigen Further Resolves the Sxra Region of the Mouse Y Chromosome and Reveals Complexity of the Hya Locus

1994 • 65 citations

Identification of an immunodominant mouse minor histocompatibility antigen (MiHA). T cell response to a single dominant MiHA causes graft-versus-host disease.

1996 • 64 citations

Restricted recognition of β2-microglobulin by cytotoxic T lymphocytes

1986 • 64 citations

Correlation of minor histocompatibility antigen-specific cytotoxic T lymphocytes with graft-versus-host disease status and analyses of tissue distribution of their target antigens

1993 • 61 citations

EFFECTOR MECHANISMS IN GRAFT-VERSUS-HOST DISEASE IN RESPONSE TO MINOR HISTOCOMPATIBILITY ANTIGENS

1990 • 59 citations

Immunodominance in the immune response to ?multiple? histocompatibility antigens

1982 • 58 citations

HLA-RESTRICTED CYTOTOXICITY AGAINST MALE-SPECIFIC (H-Y) ANTIGEN AFTER ACUTE REJECTION OF AN HLA-IDENTICAL SIBLING KIDNEY CLONAL DISTRIBUTION OF THE CYTOTOXIC CELLS

1982 • 57 citations

EFFECTOR MECHANISMS IN GRAFT-VERSUS-HOST DISEASE IN RESPONSE TO MINOR HISTOCOMPATIBILITY ANTIGENS

1990 • 56 citations

Dysregulation of Cytokines During Graft-Versus-Host Disease

1996 • 56 citations

Cell-mediated immunity to non-HLA antigens of the host by donor lymphocytes in patients with chronic graft-vs-host disease.

1980 • 56 citations

Polymorphism of adhesion molecule CD31 is not a significant risk factor for graft-versus-host disease

1996 • 54 citations

T CELL SUBSETS INVOLVED IN LETHAL GRAFT-VERSUS-HOST DISEASE DIRECTED TO IMMUNODOMINANT MINOR HISTOCOMPATIBILITY ANTIGENS

1994 • 52 citations

Persistence of host Langerhans cells following allogeneic bone marrow transplantation: possible relationship with acute graft-versus-host disease

1985 • 51 citations

Nuclear myxovirus-resistance protein Mx is a minor histocompatibility antigen.

1990 • 43 citations

Detection of HLA restricted anti-minor histocompatibility antigen(s) reactive cells from skin GVHD lesions

1984 • 42 citations

Molecular analysis of an HLA-A2 functional variant CLA defined by cytolytic T lymphocytes.

1986 • 42 citations

Minor histocompatibility antigen H-Y is expressed on human hematopoietic progenitor cells.

1988 • 41 citations

Differential recognition of the serologically defined HLA-A2 antigen by allogeneic cytotoxic T Cells

1982 • 41 citations

Existence of mature human CD4⁺ T cells with genuine class I restriction

1992 • 40 citations

ALLOREACTIVE T CELL RESPONSES BETWEEN HLA-IDENTICAL SIBLINGS

1985 • 37 citations

Recognition of influenza virus proteins by cytotoxic T lymphocytes

1987 • 36 citations

The functional basis of minor histocompatibility loci.

1993 • 36 citations

Immunization against tumor and minor histocompatibility antigens by eluted cellular peptides loaded on antigen processing defective cells

1993 • 36 citations

The peptide p2Ca is immunodominant in allorecognition of Ld by beta chain variable region V beta 8+ but not V beta 8- strains.

1994 • 35 citations

Complexity at the mouse minor histocompatibility locusH-4

1990 • 35 citations

Few peptides dominate cytotoxic T lymphocyte responses to single and multiple minor histocompatibility antigens

1993 • 35 citations

The inhibition of different T cell lines specific for the same antigen with TCR antagonist peptides.

1993 • 34 citations

Dominant and cryptic antigens in the MHC class I restricted T cell response across a complex minor histocompatibility barrier: analysis and mapping by elution of cellular peptides

1995 • 34 citations

Dendritic cells as specialized antigen-presenting cells

1989 • 33 citations

Quantitative assessment of posttransplant host-specific interleukin-2- secreting T-helper cell precursors in patients with and without acute graft-versus-host disease after allogeneic HLA-identical sibling bone marrow transplantation

1993 • 32 citations

Graft-versus-host disease associated T helper cell responses specific for minor histocompatibility antigens are mainly restricted by HLA-DR molecules.

1990 • 32 citations

Functional expression of minor histocompatibility antigens on human peripheral blood dendritic cells and epidermal Langerhans cells

1996 • 32 citations

Interindividual conservation of T-cell receptor beta chain variable regions by minor histocompatibility antigen-specific HLA-A*0201- restricted cytotoxic T-cell clones

1995 • 32 citations

Anti-self HLA may be clonally expressed.

1979 • 31 citations

High frequencies of cytotoxic T cell precursors against minor histocompatibility antigens after HLA-identical BMT: absence of correlation with GVHD.

1993 • 31 citations

Studies on the mechanism of tolerance or graft-versus-host disease in allogeneic bone marrow recipients at the level of cytotoxic T-cell precursor frequencies

1992 • 29 citations

A genetic analysis of human minor histocompatibility antigens demonstrates Mendelian segregation independent of HLA

1993 • 28 citations

Localization to chromosome 22 of a gene encoding a human minor histocompatibility antigen.

1996 • 28 citations

Phase II study of busulfan, cyclophosphamide and fractionated total body irradiation as a preparatory regimen for allogeneic bone marrow transplantation in patients with advanced myeloid malignancies.

1995 • 27 citations

Endogenous retroviruses lead to the expression of a histocompatibility antigen detectable by skin graft rejection.

1987 • 27 citations

A molecular deletion map of the Y chromosome long arm defining X and autosomal homologous regions and the localisation of the HYA locus to the proximal region of the Yq euchromatin

1992 • 27 citations

Prevention of graft-versus-host disease by peptides binding to class II major histocompatibility complex molecules

1994 • 26 citations

Immunodominance in the T cell response to multiple non-H-2 histocompatibility antigens. IV. Partial tissue distribution and mapping of immunodominant antigens.

1987 • 25 citations

Pretransplant detection of human minor histocompatibility antigen- specific naive and memory interleukin-2-secreting T cells within class I major histocompatibility complex (MHC)-restricted CD8+ and class II MHC-restricted CD4+ T-cell subsets

1993 • 25 citations

T CELL SUBSETS REQUIRED FOR IN VIVO AND IN VITRO RESPONSES TO SINGLE AND MULTIPLE MINOR HISTOCOMPATIBILITY ANTIGENS

1992 • 25 citations

Graft-versus-host mortality induced by noncytolytic CD4+ T cell clones specific for non-H-2 antigens.

1990 • 24 citations

Immunodominance in the T cell response to multiple non-H-2 histocompatibility antigens. III. Single histocompatibility antigens dominate the male antigen.

1986 • 24 citations

LACK OF GVHD ACROSS CLASSICAL SINGLE MINOR HISTOCOMPATIBILITY (miH) LOCUS BARRIERS IN MICE1,2

1996 • 23 citations

Recognition of distinct epitopes on the HLA-A2 antigen by cytotoxic T lymphocytes

1986 • 22 citations

THE PREFERENTIAL CYTOLYTIC T LYMPHOCYTE RESPONSE TO IMMUNODOMINANT MINOR HISTOCOMPATIBILITY ANTIGEN PEPTIDES1

1996 • 22 citations

ABSENCE OF CORRELATION BETWEEN CYTOLYTIC T LYMPHOCYTES AND LETHAL MURINE GRAFT-VERSUS-HOST DISEASE IN RESPONSE TO MINOR HISTOCOMPATIBILITY ANTIGENS

1984 • 22 citations

PHENOTYPE AND FUNCTION OF T LYMPHOCYTES INFILTRATING THE SKIN DURING GRAFT-VERSUS-HOST DISEASE FOLLOWING ALLOGENEIC BONE MARROW TRANSPLANTATION

1989 • 21 citations

NO EFFECT OF H-Y MINOR HISTOCOMPATIBILITY ANTIGEN IN ZERO-MISMATCHED LIVING-DONOR RENAL TRANSPLANTS

1994 • 21 citations

Presentation of human minor histocompatibility antigens by HLA-B35 and HLA-B38 molecules.

1990 • 21 citations

Selective depletion of marrow-T cytotoxic lymphocytes (CD8) in the prevention of graft-versus-host disease after allogeneic bone-marrow transplantation

1988 • 20 citations

Deletion mapping of H-Y antigen to the long arm of the human Y chromosome

1992 • 19 citations

SV40 T-antigen is a histocompatibility antigen of SV40-transgenic mice

1988 • 19 citations

Tissue graft rejection in mice

1976 • 18 citations

The use of cytotoxic T cell lines to detect the segregation of a human minor alloantigen within families

1983 • 17 citations

Analysis of the functional epitopes on different HLA-A2 molecules

1984 • 17 citations

Differential binding of a minor histocompatibility antigen peptide to H-2 class I molecules correlates with immune responsiveness.

1993 • 16 citations

Evaluation of in vitro cytotoxic T lymphocyte assays as a predictive test for the occureence of graft vs host disease

1991 • 14 citations

Tissue graft rejection in mice

1977 • 14 citations

Conservation of minor histocompatibility antigens between human and non‐human primates

1996 • 13 citations

Loss of the ‘azoospermia factor’ (AZF) on Yq in man is not associated with loss of HYA

1993 • 13 citations

Multiple minor histocompatibility antigen disparities between a recipient and four HLA-identical potential sibling donors for bone marrow transplantation

1993 • 13 citations

A Genetic Linkage Map of Mouse Chromosome 2 Extending from Thrombospondin to Paired Box Gene 1, Including theH3Minor Histocompatibility Complex

1996 • 12 citations

Antigenic competition between minor (Non-H-2) histocompatibility antigens

1981 • 12 citations

Modification of the graft-versus-host syndrome by anti-lymphocyte serum treatment of the donor.

1968 • 11 citations

In vitro cell-mediated cytotoxicity to the male specific (H-Y) antigen in man

1981 • 11 citations

The recognition of abnormal sex chromosome constitution by HLA-restricted anti-H-Y cytotoxic T cells and antibody

1983 • 11 citations

Expression of human minor histocompatibility antigen on cultured kidney cells

1993 • 9 citations

Acquired tolerance for minor histocompatibility antigens after HLA identical bone marrow transplantation

1992 • 9 citations

Selective depletion of marrow-T cytotoxic lymphocytes (CD8) in the prevention of graft-versus-host disease after allogeneic bone-marrow transplantation

1988 • 8 citations

Tolerance to host minor histocompatibility antigens after allogenic bone marrow transplantation. Specific donor-host unresponsiveness is maintained by peripheral tolerizing cells.

1992 • 7 citations

A HUMAN MINOR HISTOCOMPATIBILITY ANTIGEN WHICH APPEARS TO SEGREGATE WITH THE MAJOR HISTOCOMPATIBILITY COMPLEX

1994 • 7 citations

Study of a human minor alloantigen in relation to clinical graft-versus-host disease.

1987 • 5 citations

Irritation of the Spinal Cord

1831 • 5 citations

Preliminary characterization of the cells causing an H-2-restricted GVH reaction

1984 • 2 citations

Isolation of human minor histocompatibility peptides from cultured kidney cells.

1993 • 2 citations

T4+ cells can initiate human graft-versus-host disease.

1987 • 1 citations

Graft-host tolerance in bone marrow transplant chimeras. Absence of graft-versus-host disease is associated with unresponsiveness to minor histocompatibility antigens expressed by all tissues

1994 • 1 citations