HMGI/Y proteins: flexible regulators of transcription and chromatin structure

Crystal structure of the nucleosome core particle at 2.8 Å resolution

1997 • 8,906 citations

Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm

1999 • 2,867 citations

Intrinsically disordered protein

2001 • 2,134 citations

Chromosomal translocations in human cancer

1994 • 1,551 citations

Chromatin Structure and Function

1979 • 1,050 citations

Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome

1995 • 994 citations

Regulation of DNA-Dependent Activities by the Functional Motifs of the High-Mobility-Group Chromosomal Proteins

1999 • 837 citations

HMG domain proteins: architectural elements in the assembly of nucleoprotein structures

1994 • 813 citations

High-Mobility-Group Chromosomal Proteins: Architectural Components That Facilitate Chromatin Function

1996 • 752 citations

Ordered Recruitment of Chromatin Modifying and General Transcription Factors to the IFN-β Promoter

2000 • 716 citations

The A.T-DNA-binding domain of mammalian high mobility group I chromosomal proteins. A novel peptide motif for recognizing DNA structure.

1990 • 674 citations

The High Mobility Group protein HMG I(Y) is required for NF-κB-dependent virus induction of the human IFN-β gene

1992 • 632 citations

Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C

1995 • 608 citations

AT-hook motifs identified in a wide variety of DNA-binding proteins

1998 • 465 citations

Recruitment of CBP/p300 by the IFNβ Enhanceosome Is Required for Synergistic Activation of Transcription

1998 • 433 citations

Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains

1995 • 422 citations

The solution structure of an HMG-I(Y)–DNA complex defines a new architectural minor groove binding motif

1997 • 372 citations

HIV-1 cDNA Integration: Requirement of HMG I(Y) Protein for Function of Preintegration Complexes In Vitro

1997 • 358 citations

The Mechanism of Transcriptional Synergy of an In Vitro Assembled Interferon-β Enhanceosome

1997 • 333 citations

Acetylation of HMG I(Y) by CBP Turns off IFNβ Expression by Disrupting the Enhanceosome

1998 • 321 citations

SAR-dependent mobilization of histone H1 by HMG-I/Y in vitro: HMG-I/Y is enriched in H1-depleted chromatin.

1993 • 288 citations

Growth Factor-Induced Delayed Early Response Genes

1992 • 287 citations

Reversal of intrinsic DNA bends in the IFNβ gene enhancer by transcription factors and the architectural protein HMG I(Y)

1995 • 280 citations

DNA Bending by Asymmetric Phosphate Neutralization

1994 • 248 citations

Regulation of Cell-Type-Specific Interleukin-2 Receptor α-Chain Gene Expression: Potential Role of Physical Interactions between Elf-1, HMG-I(Y), and NF-κ B Family Proteins

1995 • 244 citations

Alternative processing of mRNAs encoding mammalian chromosomal high-mobility-group proteins HMG-I and HMG-Y.

1989 • 241 citations

Architectural Transcription Factor HMGI(Y) Promotes Tumor Progression and Mesenchymal Transition of Human Epithelial Cells

2001 • 236 citations

In vivo modulation of Hmgic reduces obesity

2000 • 221 citations

Two Functionally Distinct Forms of the RSC Nucleosome-Remodeling Complex, Containing Essential AT Hook, BAH, and Bromodomains

1999 • 216 citations

Organization, inducible-expression and chromosome localization of the human HMG-I(Y) nonhistone protein gene

1993 • 205 citations

The expression of a truncated HMGI-C gene induces gigantism associated with lipomatosis.

1999 • 205 citations

Retroviral DNA Integration

1999 • 201 citations

What does ‘chromatin remodeling’ mean?

2000 • 197 citations

LPP,the Preferred Fusion Partner Gene ofHMGICin Lipomas, Is a Novel Member of the LIM Protein Gene Family

1996 • 196 citations

Inhibition of HMGI-C Protein Synthesis Suppresses Retrovirally Induced Neoplastic Transformation of Rat Thyroid Cells

1995 • 195 citations

Complete murine cDNA sequence, genomic structure, and tissue expression of the high mobility group protein HMG-I(Y).

1988 • 192 citations

Growth factor-induced delayed early response genes.

1992 • 192 citations

Multiple closely-linked NFAT/octamer and HMG I(Y) binding sites are part of the interleukin-4 promoter

1993 • 191 citations

A Striking Similarity in the Organization of the E-Selectin and Bate Interferon gene Promoters

1994 • 187 citations

HMG-I/Y, a New c-Myc Target Gene and Potential Oncogene

2000 • 179 citations

The role of HMG I(Y) in the assembly and function of the IFN-beta enhanceosome

1999 • 165 citations

Cooperativity between two NF-kappa B complexes, mediated by high-mobility-group protein I(Y), is essential for cytokine-induced expression of the E-selectin promoter.

1994 • 159 citations

SARs are cis DNA elements of chromosome dynamics: Synthesis of a SAR repressor protein

1995 • 156 citations

Adenovirus-mediated suppression of HMGI(Y) protein synthesis as potential therapy of human malignant neoplasias

2000 • 154 citations

Multivalent DNA-binding properties of the HMG-1 proteins.

1996 • 152 citations

Upwardly mobile proteins

2000 • 152 citations

An IL-2 response element in the human IL-2 receptor alpha chain promoter is a composite element that binds Stat5, Elf-1, HMG-I(Y) and a GATA family protein.

1996 • 152 citations

Transgenic Mice Expressing a Truncated Form of the High Mobility Group I-C Protein Develop Adiposity and an Abnormally High Prevalence of Lipomas

2000 • 147 citations

Increased expression of high mobility group protein I(Y) in high grade prostatic cancer determined by in situ hybridization.

1993 • 134 citations

Genetics of uterine leiomyomata

2000 • 131 citations

Posttranscriptional gene regulation and specific binding of the nonhistone protein HMG-I by the 3' untranslated region of bovine interleukin 2 cDNA.

1987 • 128 citations

Phosphorylation by cdc2 kinase modulates DNA binding activity of high mobility group I nonhistone chromatin protein.

1991 • 128 citations

Analysis of the HMGI nuclear proteins in mouse neoplastic cells induced by different procedures

1989 • 128 citations

Truncated and chimeric HMGI-C genes induce neoplastic transformation of NIH3T3 murine fibroblasts

1998 • 127 citations

Phosphorylation of the DNA-binding domain of nonhistone high-mobility group I protein by cdc2 kinase: reduction of binding affinity.

1991 • 124 citations

HMGI(Y) and HMGI-C Dysregulation

1999 • 121 citations

HMG I-like proteins from leaf and nodule nuclei interact with different AT motifs in soybean nodulin promoters.

1990 • 121 citations

Intra- and Intermolecular Cooperative Binding of High-Mobility-Group Protein I(Y) to the Beta-Interferon Promoter

1997 • 120 citations

HMG Protein Family Members Stimulate Human Immunodeficiency Virus Type 1 and Avian Sarcoma Virus Concerted DNA Integration In Vitro

1999 • 118 citations

The importance of being unfolded

1997 • 118 citations

A striking similarity in the organization of the E-selectin and beta interferon gene promoters.

1994 • 117 citations

Translocation breakpoints upstream of theHMGIC gene in uterine leiomyomata suggest dysregulation of this gene by a mechanism different from that in lipomas

1996 • 117 citations

A Poly(dA-dT) Upstream Activating Sequence Binds High-Mobility Group I Protein and Contributes to Lymphotoxin (Tumor Necrosis Factor-β) Gene Regulation

1992 • 115 citations

Expression of HMGI(Y) proteins in squamous intraepithelial and invasive lesions of the uterine cervix.

1998 • 114 citations

Identification of high mobility group protein I(Y) as potential progression marker for prostate cancer by differential hybridization analysis.

1991 • 113 citations

Mechanism by which the IFN-β enhanceosome activates transcription

1999 • 112 citations

High Mobility Group Protein I(Y) Is Required for Function and for c-Rel Binding to CD28 Response Elements within the GM-CSF and IL-2 Promoters

1996 • 109 citations

Expression ofHMGI-C, a member of the high mobility group protein family, in a subset of breast cancers: Relationship to histologic grade

1997 • 109 citations

Changes in nuclear proteins on transformation of rat epithelial thyroid cells by a murine sarcoma retrovirus.

1985 • 108 citations

Chromatin remodeling: a marriage between two families?

1998 • 108 citations

Molecular Cloning of a Rat 49-kDa TBP-Interacting Protein (TIP49) That Is Highly Homologous to the Bacterial RuvB

1997 • 105 citations

Structure and Function of the HMGI(Y) Family of Architectural Transcription Factors

2000 • 105 citations

Complementation of integrase function in HIV-1 virions

1997 • 105 citations

High mobility group chromosomal proteins bind to AT-rich tracts flanking plant genes

1991 • 103 citations

Purification and postsynthetic modifications of friend erythroleukemic cell high mobility group protein HMG-I

1986 • 100 citations

Pancreatic duct cell carcinomas express high levels of high mobility group I(Y) proteins.

2000 • 99 citations

Chromosomal Translocations in Benign Tumors:The HMGI Proteins

1998 • 98 citations

Changes in Superhelicity Are Introduced into Closed Circular DNA by Binding of High Mobility Group Protein I/Y

1995 • 94 citations

Functional Interaction between the POU Domain Protein Tst-1/Oct-6 and the High-Mobility-Group Protein HMG-I/Y

1995 • 94 citations

Competition between HMG-I(Y), HMG-1 and histone H1 on four-way junction DNA

1997 • 94 citations

Specific Gain- and Loss-of-Function Phenotypes Induced by Satellite-Specific DNA-Binding Drugs Fed to Drosophila melanogaster

2000 • 90 citations

Description of a novel fusion transcript between HMGI-C, a gene encoding for a member of the high mobility group proteins, and the mitochondrial aldehyde dehydrogenase gene.

1995 • 89 citations

A Role for Poly(ADP-ribose) Polymerase in the Transcriptional Regulation of the Melanoma Growth Stimulatory Activity (CXCL1) Gene Expression

2001 • 88 citations

Short Peptide Fragments Derived from HMG-I/Y Proteins Bind Specifically to the Minor Groove of DNA

1994 • 88 citations

The Role of High-Mobility Group I(Y) Proteins in Expression of IL-2 and T Cell Proliferation

2000 • 88 citations

Hoechst 33258, distamycin A, and high mobility group protein I (HMG-I) compete for binding to mouse satellite DNA

1992 • 87 citations

Retroviral cDNA Integration: Stimulation by HMG I Family Proteins

2000 • 86 citations

HMGI(Y) and Sp1 in addition to NF-κB regulate transcription of the MGSA/GROα gene

1995 • 85 citations

Interaction of high mobility group-I (Y) nonhistone proteins with nucleosome core particles.

1993 • 85 citations

HMGIY is the target of 6p21.3 rearrangements in various benign mesenchymal tumors

1998 • 85 citations

Hypoxia Induces High-Mobility-Group Protein I(Y) and Transcription of the Cyclooxygenase-2 Gene in Human Vascular Endothelium

1998 • 84 citations

HMGI(Y) activation by chromosome 6p21 rearrangements in multilineage mesenchymal cells from pulmonary hamartoma.

1997 • 84 citations

Elevated high mobility group-I(Y) gene expression is associated with progressive transformation of mouse mammary epithelial cells.

1993 • 82 citations

Plant chromosomal high mobility group (HMG) proteins

1995 • 82 citations

Directional binding of HMG-I(Y) on four-way junction DNA and the molecular basis for competitive binding with HMG-1 and histone H1

1999 • 81 citations

Expression of mRNAs encoding mammalian chromosomal proteins HMG-I and HMG-Y during cellular proliferation

1990 • 79 citations

High mobility group proteins HMG‐1 and HMG‐I/Y bind to a positive regulatory region of the pea plastocyanin gene promoter

1997 • 77 citations

Endometrial polyp: Another benign tumor characterized by 12q13–q15 changes

1993 • 77 citations

Chromatin Opening of DNA Satellites by Targeted Sequence-Specific Drugs

2000 • 77 citations

The gene for the human architectural transcription factor HMGI-C consists ofn five exons each coding for a distinct functional element

1995 • 76 citations

Multiple ISWI ATPase Complexes from Xenopus laevis

2000 • 73 citations

Constitutive Activation of Epstein-Barr Virus (EBV) Nuclear Antigen 1 Gene Transcription by IRF1 and IRF2 during Restricted EBV Latency

1997 • 73 citations

Substrate Structure Influences Binding of the Non-Histone Protein HMG-I(Y) to Free and Nucleosomal DNA

1996 • 72 citations

The Activity of Mammalian brm/SNF2α Is Dependent on a High-Mobility-Group Protein I/Y-Like DNA Binding Domain

1999 • 72 citations

Modeling the Late Steps in HIV-1 Retroviral Integrase-catalyzed DNA Integration

2000 • 69 citations

A novel AT-rich DNA binding protein that combines an HMG I-like DNA binding domain with a putative transcription domain.

1994 • 69 citations

Enhancement of Serum-response Factor-dependent Transcription and DNA Binding by the Architectural Transcription Factor HMG-I(Y)

1998 • 68 citations

HMG I(Y) interferes with the DNA binding of NF-AT factors and the induction of the interleukin 4 promoter in T cells

1996 • 67 citations

In vivo analysis of scaffold-associated regions in Drosophila: a synthetic high-affinity SAR binding protein suppresses position effect variegation

1998 • 66 citations

High Mobility Group-I(Y) Protein Facilitates Nuclear Factor-κB Binding and Transactivation of the Inducible Nitric-oxide Synthase Promoter/Enhancer

1999 • 66 citations

Chromosomal localization of the murine gene and two related sequences encoding high-mobility-group I and Y proteins

1992 • 66 citations

Differential in Vivo Modifications of the HMGI(Y) Nonhistone Chromatin Proteins Modulate Nucleosome and DNA Interactions

2000 • 66 citations

AT-rich promoter elements of soybean heat shock gene Gmhsp 17.5E bind two distinct sets of nuclear proteins in vitro

1992 • 65 citations

Expression of HMGI-C and HMGI(Y) in ordinary lipoma and atypical lipomatous tumors: immunohistochemical reactivity correlates with karyotypic alterations.

1997 • 63 citations

A retrospective study of high mobility group protein I(Y) as progression marker for prostate cancer determined by in situ hybridization

1996 • 63 citations

Functional roles of the transcription factor Oct-2A and the high mobility group protein I/Y in HLA-DRA gene expression.

1995 • 62 citations

Interleukin 4-inducible Phosphorylation of HMG-I(Y) Is Inhibited by Rapamycin

1995 • 60 citations

Comparison of multiple forms of the high mobility group I proteins in rodent and human cells

1991 • 60 citations

Purification and assays for high mobility group HMG-I(Y) protein function

1999 • 60 citations

HMG-I(Y) recognizes base-unpairing regions of matrix attachment sequences and its increased expression is directly linked to metastatic breast cancer phenotype.

1999 • 59 citations

Binding of HMG-I(Y) Imparts Architectural Specificity to a Positioned Nucleosome on the Promoter of the Human Interleukin-2 Receptor α Gene

2000 • 59 citations

A poly(dA-dT) upstream activating sequence binds high-mobility group I protein and contributes to lymphotoxin (tumor necrosis factor-beta) gene regulation.

1992 • 57 citations

Retinoid-dependent Recruitment of a Histone H1 Displacement Activity by Retinoic Acid Receptor

1999 • 56 citations

High mobility group I(Y)-like DNA-binding domains on a bacterial transcription factor.

1996 • 55 citations

Identification of sites on chromosomal protein HMG‐I phosphorylated by casein kinase II

1989 • 55 citations

Regulation of HMGIC expression: an architectural transcription factor involved in growth control and development

1999 • 54 citations

FR900482 class of anti-tumor drugs cross-links oncoprotein HMG I/Y to DNA in vivo

2000 • 54 citations

Insect proteins homologous to mammalian high mobility group proteins I/Y (HMG I/Y). Characterization and binding to linear and four-way junction DNA

1994 • 53 citations

Role of activating protein‐1 and high mobility group‐I(Y) protein in the induction of CD44 gene expression by interleukin‐1β in vascular smooth muscle cells

2000 • 53 citations

Selective Nucleosome Disruption by Drugs That Bind in the Minor Groove of DNA

1999 • 51 citations

Mass spectrometric analysis of the HMGY protein from Lewis lung carcinoma. Identification of phosphorylation sites.

1992 • 50 citations

Modulation of Activity of Moloney Murine Leukemia Virus Preintegration Complexes by Host Factors In Vitro

1998 • 49 citations

Chromatin changes during the cell cycle

1992 • 49 citations

Phosphorylation of HMG‐I by Protein Kinase C Attenuates Its Binding Affinity to the Promoter Regions of Protein Kinase C γ and Neurogranin/RC3 Genes

2000 • 49 citations

Specific Binding of High-Mobility-Group I (HMGI) Protein and Histone H1 to the Upstream AT-Rich Region of the Murine Beta Interferon Promoter: HMGI Protein Acts as a Potential Antirepressor of the Promoter

1999 • 47 citations

Induction of Early Transcription in One-Cell Mouse Embryos by Microinjection of the Nonhistone Chromosomal Protein HMG-I

2000 • 47 citations

A soybean embryo cDNA encodes a DNA binding protein with histone and HMG-protein-like domains

1991 • 47 citations

HMG I/Y regulates long-range enhancer-dependent transcription on DNA and chromatin by changes in DNA topology

2000 • 46 citations

The human chromosomal protein HMG I contains two identical palindrome amino acid sequences

1987 • 45 citations

Expression of the HMGI(Y) gene products in human neuroblastic tumours correlates with differentiation status

2000 • 44 citations

Induction of High Mobility Group-I(Y) Protein by Endotoxin and Interleukin-1β in Vascular Smooth Muscle Cells

1999 • 43 citations

Molecules in focus The high mobility group protein, HMGI-C

1998 • 43 citations

Mechanisms of Murine RANTES Chemokine Gene Induction by Newcastle Disease Virus

1996 • 42 citations

Architecture of High Mobility Group Protein I-C·DNA Complex and Its Perturbation upon Phosphorylation by Cdc2 Kinase

2000 • 41 citations

Differential Regulation of a Multipromoter Gene.

1995 • 41 citations

The Architectural Transcription Factor High Mobility Group I(Y) Participates in Photoreceptor-Specific Gene Expression

2000 • 41 citations

Hepatic Nuclear Factor 3 and High Mobility Group I/Y Proteins Bind the Insulin Response Element of the Insulin-Like Growth Factor-Binding Protein-1 Promoter*

1997 • 39 citations

Amplification and expression of theHMGIC gene in a benign endometrial polyp

1998 • 39 citations

An HMG I/Y-containing repressor complex and supercoiled DNA topology are critical for long-range enhancer-dependent transcription in vitro.

1997 • 39 citations

Effects of Epidermal Growth Factor and Estrogen on the Regulation of the HMG-I/Y Gene in Human Mammary Epithelial Cell Lines

1997 • 38 citations

Cdc2 and Mitogen-activated Protein Kinases Modulate DNA Binding Properties of the Putative Transcriptional RegulatorChironomus High Mobility Group Protein I

1997 • 38 citations

Cellular and SV40 Chromatin: Replication, Segregation, Ubiqiritination, Nuclease-hypersensitive Sites, HMG-containing Nueleosomes, and Heterochromatin-specific Protein

1983 • 38 citations

Involvement of a High-Mobility-Group Protein in the Transcriptional Activity of Herpes Simplex Virus Latency-Active Promoter 2

1996 • 37 citations

The HMGI-C gene is a likely candidate for the autosomal dwarf locus in the chicken

1998 • 36 citations

The t(3;12)(q27;q14-q15) with underlyingHMGIC-LPP fusion is not determining an adipocytic phenotype

1998 • 35 citations

High-Mobility-Group Protein I Can Modulate Binding of Transcription Factors to the U5 Region of the Human Immunodeficiency Virus Type 1 Proviral Promoter

2000 • 35 citations

Nuclear factor of activated T cells contributes to the function of the CD28 response region of the granulocyte macrophage-colony stimulating factor promoter

1999 • 33 citations

Genomic changes in endometrial polyps associated with tamoxifen show no evidence for its action as an external carcinogen.

1998 • 31 citations

Tumor promoter induces high mobility group HMG-Y protein expression in transformation-sensitive but not -resistant cells

1998 • 31 citations

Structural Changes Induced by Binding of the High-Mobility Group I Protein to a Mouse Satellite DNA Sequence

2000 • 30 citations

HMG protein binding to an A/T-rich positive regulatory region of the pea plastocyanin gene promoter

1994 • 29 citations

Expression of theHMGI(Y) gene in human colorectal cancer

1999 • 27 citations

The HMG-I(Y) A·T-hook Peptide Motif Confers DNA-binding Specificity to a Structured Chimeric Protein

1999 • 27 citations

Isolation and characterization of the gene coding for murine high-mobility-group protein HMGI-C

1995 • 26 citations

HMG-I(Y) Phosphorylation Status as a Nuclear Target Regulated through Insulin Receptor Substrate-1 and the I4R Motif of the Interleukin-4 Receptor

1997 • 26 citations

Binding of HMG-I(Y) elicits structural changes in a silencer of the human ?-globin gene

1999 • 25 citations

Two genes for the high mobility group protein HMG-Y are present in the genome of Canavalia gladiata D.C.

1997 • 25 citations

Protein Footprinting Reveals Specific Binding Modes of a High Mobility Group Protein I to DNAs of Different Conformation

1998 • 25 citations

The single-copy gene encoding high-mobility-group protein HMG-I/Y from pea contains a single intron and is expressed in all organs.

1997 • 25 citations

¹H and ¹³C NMR assignments and molecular modelling of a minor groove DNA‐binding peptide from the HMG‐I protein

1995 • 24 citations

Plant chromosomal HMGI/Y proteins and histone H1 exhibit a protein domain of common origin

1999 • 24 citations

Positive Factor 1 (PF1) from oat is an HMGY- and H1 histone-like protein that binds a functionally defined AT-rich DNA element in the oat phytochrome A gene (PHYA3) promoter

1994 • 24 citations

Characterisation and promoter analysis of the Arabidopsis gene encoding high-mobility-group protein HMG-I/Y.

1998 • 21 citations

PU.1-mediated Transcription Is Enhanced by HMG-I(Y)-dependent Structural Mechanisms

2001 • 20 citations

Calcium-dependent ADP-ribosylation of high-mobility-group I (HMGI) proteins

1996 • 20 citations

Bugs on Drugs Go GAGAA

2000 • 19 citations

A new journal—in more than one way

2000 • 17 citations

Genomic structure and expression of the murine Hmgi(y) gene

2000 • 16 citations

The Host-Cell Architectural Protein HMG I(Y) Modulates Binding of Herpes Simplex Virus Type 1 ICP4 to Its Cognate Promoter

1999 • 16 citations

Replacement of Conserved Threonines by Alanine Residues in High Mobility Group Protein HMG-I(Y): Effect on DNA Binding Affinity

1995 • 16 citations

Potentiation of the malignant phenotype of the undifferentiated ARO thyroid cell line by insertion of thebcl-2 gene

1999 • 15 citations

Morphine treatment affects the regulation of high mobility group I-type chromosomal phosphoproteevs in C6 glioma cells

2000 • 12 citations

Structural and functional properties of linker histones and high mobility group proteins in polytene chromosomes.

1996 • 11 citations

Human papillomavirus type 16 E6 protein up-regulates the expression of the high mobility group protein HMG-I(Y) gene in mouse 10T1/2 cells

1996 • 8 citations

Point Mutations within AT-Hook Domains of the HMGI Homologue HMGIYL1 Affect Binding to Gene Promoter but Not to Four-Way Junction DNA

2000 • 8 citations

Hepatic Nuclear Factor 3 and High Mobility Group I/Y Proteins Bind the Insulin Response Element of the Insulin-Like Growth Factor-Binding Protein-1 Promoter

1997 • 7 citations

Introduction and foreword to the special issue on protein flexibility and folding

2001 • 4 citations

Identification of Nuclear Factors That Bind to the Mouse Tyrosinase Gene Regulatory Region

1994 • 3 citations