Chromatin changes during the cell cycle

The E2F transcription factor is a cellular target for the RB protein

1991 • 1,461 citations

Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity

1991 • 1,071 citations

Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport.

1991 • 858 citations

The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle

1991 • 708 citations

The A.T-DNA-binding domain of mammalian high mobility group I chromosomal proteins. A novel peptide motif for recognizing DNA structure.

1990 • 674 citations

The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SW15

1991 • 501 citations

Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes

1991 • 493 citations

Differential phosphorylation of vertebrate p34cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: identification of major phosphorylation sites.

1991 • 439 citations

Chromosome assembly in vitro: Topoisomerase II is required for condensation

1991 • 382 citations

Role of Nucleosomal Cores and Histone H1 in Regulation of Transcription by RNA Polymerase II

1991 • 379 citations

Sequence-Specific Antirepression of Histone H1-Mediated Inhibition of Basal RNA Polymerase II Transcription

1991 • 378 citations

Transcription factor access is mediated by accurately positioned nucleosomes on the mouse mammary tumor virus promoter.

1991 • 372 citations

The rate of nuclear cytoplasmic protein transport is determined by the casein kinase II site flanking the nuclear localization sequence of the SV40 T-antigen.

1991 • 351 citations

cdc2 phosphorylation is required for its interaction with cyclin.

1991 • 338 citations

Amino-terminal domains of c-myc and N-myc proteins mediate binding to the retinoblastoma gene product

1991 • 326 citations

Cell Cycle Regulation in the Yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe

1991 • 326 citations

G1/S phosphorylation of the retinoblastoma protein is associated with an altered affinity for the nuclear compartment

1991 • 319 citations

A 240 kd multisubunit protein complex, CBF3, is a major component of the budding yeast centromere

1991 • 313 citations

Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase.

1991 • 304 citations

Discrete nuclear domains of poly(A) RNA and their relationship to the functional organization of the nucleus.

1991 • 300 citations

Cyclin A and the retinoblastoma gene product complex with a common transcription factor

1991 • 296 citations

Sperm decondensation in Xenopus egg cytoplasm is mediated by nucleoplasmin

1991 • 281 citations

Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide.

1991 • 281 citations

Facilitated binding of GAL4 and heat shock factor to nucleosomal templates: differential function of DNA-binding domains.

1991 • 269 citations

Nucleosome Positioning: Occurrence, Mechanisms, and Functional Consequences

1991 • 248 citations

Parallel activation of the NIMA and p34cdc2 cell cycle-regulated protein kinases is required to initiate mitosis in A. nidulans

1991 • 243 citations

Activation domains of stably bound GAL4 derivatives alleviate repression of promoters by nucleosomes

1991 • 242 citations

The nuclear matrix: A heuristic model for investigating genomic organization and function in the cell nucleus

1991 • 241 citations

Mitotic Phosphorylation of the Oct-1 Homeodomain and Regulation of Oct-1 DNA Binding Activity

1991 • 237 citations

Nuclear import-export: In search of signals and mechanisms

1991 • 233 citations

Premature initiation of mitosis in yeast lacking RCC1 or an interacting GTPase

1991 • 231 citations

Cloning by differential screening of a Xenopus cDNA coding for a protein highly homologous to cdc2.

1991 • 225 citations

Role for cyclin A in the dependence of mitosis on completion of DMA replication

1991 • 212 citations

p34cdc2-mediated phosphorylation at T124 inhibits nuclear import of SV-40 T antigen proteins.

1991 • 203 citations

Protein motifs that recognize structural features of DNA

1991 • 200 citations

Loss of RCC1, a nuclear DNA-binding protein, uncouples the completion of DNA replication from the activation of cdc2 protein kinase and mitosis.

1991 • 195 citations

Nonfunctional mutants of the retinoblastoma protein are characterized by defects in phosphorylation, viral oncoprotein association, and nuclear tethering.

1991 • 186 citations

Coupling M phase and S phase: Controls maintaining the dependence of mitosis on chromosome replication

1991 • 183 citations

Irresistible force meets immovable object: Transcription and the nucleosome

1991 • 175 citations

RAP1 protein activates and silences transcription of mating-type genes in yeast.

1991 • 170 citations

Transcription of transposable element Activator (Ac) of Zea mays L

1987 • 156 citations

Differential Phosphorylation of the Transcription Factor Oct1 During the Cell Cycle

1991 • 145 citations

Cell cycle-dependent phosphorylation of human DNA polymerase alpha.

1991 • 144 citations

Structure–function relationships in eukaryotic nuclei

1991 • 138 citations

Phosphorylation by cdc2 kinase modulates DNA binding activity of high mobility group I nonhistone chromatin protein.

1991 • 128 citations

Assembly/disassembly of the nuclear envelope membrane: Cell cycle-dependent binding of nuclear membrane vesicles to chromatin in vitro

1991 • 126 citations

Phosphorylation of the DNA-binding domain of nonhistone high-mobility group I protein by cdc2 kinase: reduction of binding affinity.

1991 • 124 citations

Adaptation of Escherichia coli to respiratory conditions: Regulation of gene expression

1991 • 121 citations

Identification of phosphorylation sites in the repetitive carboxyl-terminal domain of the mouse RNA polymerase II largest subunit

1991 • 117 citations

A Poly(dA-dT) Upstream Activating Sequence Binds High-Mobility Group I Protein and Contributes to Lymphotoxin (Tumor Necrosis Factor-β) Gene Regulation

1992 • 115 citations

Histone-DNA interactions and their modulation by phosphorylation of -Ser-Pro-X-Lys/Arg- motifs.

1991 • 113 citations

Identification of high mobility group protein I(Y) as potential progression marker for prostate cancer by differential hybridization analysis.

1991 • 113 citations

A role for the p34cdc2 kinase and phosphatases in the regulation of phosphorylation and disassembly of lamin B2 during the cell cycle.

1991 • 108 citations

Cell cycle control of higher-order chromatin assembly around naked DNA in vitro.

1991 • 103 citations

Phosphorylation causes a conformational change in the carboxyl-terminal domain of the mouse RNA polymerase II largest subunit

1991 • 85 citations

The maternally expressed Drosophila gene encoding the chromatin-binding protein BJ1 is a homolog of the vertebrate gene Regulator of Chromatin Condensation, RCC1.

1991 • 76 citations

Histone H1-DNA Interactions and Their Relation to Chromatin Structure and Function

1991 • 68 citations

Changes in cell nuclei during S Phase: Progressive chromatin condensation and altered expression of the proliferation-associated nuclear proteins Ki-67, cyclin (PCNA), p105, and p34*1

1991 • 66 citations

Proteolytic removal of core histone amino termini and dephosphorylation of histone H1 correlate with the formation of condensed chromatin and transcriptional silencing during Tetrahymena macronuclear development.

1991 • 64 citations

Compartmentalization within the nucleus: discovery of a novel subnuclear region.

1991 • 64 citations

p34cdc2 acts as a lamin kinase in fission yeast.

1991 • 61 citations

A poly(dA-dT) upstream activating sequence binds high-mobility group I protein and contributes to lymphotoxin (tumor necrosis factor-beta) gene regulation.

1992 • 57 citations

Superhelical stress and nucleosome-mediated repression of 5S RNA gene transcription in vitro.

1991 • 54 citations

High‐mobility‐group proteins P1, I and Y as substrates of the M‐phase‐specific p^34cdc2/cyclin^cdc13 kinase

1991 • 51 citations

Synergistic effect of histone H1 and nucleolin on chromatin condensation in mitosis: role of a phosphorylated heteromer

1991 • 43 citations

Inhibition of proliferation of primary avian fibroblasts through expression of histone H5 depends on the degree of phosphorylation of the protein.

1991 • 36 citations

The chromatin structure of Saccharomyces cerevisiae autonomously replicating sequences changes during the cell division cycle.

1991 • 34 citations

Cyclic Adenosine 3′, 5′-Monophosphate-Dependent Phosphorylation of HMG 14 Inhibits Its Interactions with Nucleosomes

1991 • 20 citations

Metaphase‐specific* phosphorylations weaken the association between chromosomal proteins HMG 14 and 17, and DNA

1991 • 13 citations

A novel protein related to cell cycle-dependent alterations of chromatin structure

1991 • 13 citations

Phosphorylation and chromatin mechanics: the central importance of substrate conformation in determining the patterns of HL-60 nuclear phosphorylation

1991 • 5 citations