Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm

The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases

1996 • 2,873 citations

The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen

1998 • 2,622 citations

Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution

1998 • 2,377 citations

Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.

1993 • 2,237 citations

A signature motif in transcriptional co-activators mediates binding to nuclear receptors

1997 • 2,100 citations

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ

1998 • 1,902 citations

UBIQUITIN-DEPENDENT PROTEIN DEGRADATION

1996 • 1,680 citations

PEST sequences and regulation by proteolysis

1996 • 1,606 citations

A Three-Dimensional Model of the Myoglobin Molecule Obtained by X-Ray Analysis

1958 • 1,537 citations

NACP, A Protein Implicated in Alzheimer's Disease and Learning, Is Natively Unfolded

1996 • 1,480 citations

Coupling of Local Folding to Site-Specific Binding of Proteins to DNA

1994 • 1,382 citations

The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function

1997 • 1,300 citations

NMR structure of the mouse prion protein domain PrP(121–231)

1996 • 1,251 citations

Structure and specificity of nuclear receptor–coactivator interactions

1998 • 922 citations

The PHD finger: Implications for chromatin-mediated transcriptional regulation

1995 • 857 citations

Chaperonin-mediated protein folding at the surface of groEL through a 'molten globule'-like intermediate

1991 • 853 citations

‘Molten‐globule state’: a compact form of globular proteins with mobile side‐chains

1983 • 723 citations

Solution Structure of the KIX Domain of CBP Bound to the Transactivation Domain of CREB: A Model for Activator:Coactivator Interactions

1997 • 714 citations

CYCLINS AND CELL CYCLE CHECKPOINTS

1999 • 706 citations

Mechanisms of cyclin-dependent kinase regulation: structures of cdks, their cyclin activators, and cip and INK4 inhibitors

1999 • 703 citations

Structure of the recombinant full-length hamster prion protein PrP(29–231): The N terminus is highly flexible

1997 • 666 citations

The Translation Initiation Factor eIF-4E Binds to a Common Motif Shared by the Translation Factor eIF-4γ and the Translational Repressors 4E-Binding Proteins

1995 • 662 citations

Backbone 1H and 15N resonance assignments of the N-terminal SH3 domain of drk in folded and unfolded states using enhanced-sensitivity pulsed field gradient NMR techniques

1994 • 648 citations

α‐lactalbumin: compact state with fluctuating tertiary structure?

1981 • 611 citations

α Helix-RNA Major Groove Recognition in an HIV-1 Rev Peptide-RRE RNA Complex

1996 • 587 citations

Structural basis for DNA bending by the architectural transcription factor LEF-1

1995 • 574 citations

Structural studies of p21Waf1/Cip1/Sdi1 in the free and Cdk2-bound state: conformational disorder mediates binding diversity.

1996 • 562 citations

Structural determinants of nuclear receptor assembly on DNA direct repeats

1995 • 561 citations

Copper binding to the prion protein: Structural implications of four identical cooperative binding sites

1999 • 541 citations

Non-globular domains in protein sequences: Automated segmentation using complexity measures

1994 • 537 citations

Protein Sorting to Mitochondria: Evolutionary Conservations of Folding and Assembly

1990 • 494 citations

Cap-Dependent Translation Initiation in Eukaryotes Is Regulated by a Molecular Mimic of eIF4G

1999 • 490 citations

The p300/CBP family: integrating signals with transcription factors and chromatin

1997 • 482 citations

Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform

1997 • 451 citations

A 'molten-globule' membrane-insertion intermediate of the pore-forming domain of colicin A

1991 • 416 citations

Determinants for selective RAR and TR recognition of direct repeat HREs.

1993 • 403 citations

Folding transition in the DMA-binding domain of GCN4 on specific binding to DNA

1990 • 378 citations

Protein disorder and the evolution of molecular recognition: theory, predictions and observations.

1998 • 378 citations

Structural and dynamic characterization of partially folded states of apomyoglobin and implications for protein folding

1998 • 372 citations

Solution Structure of a Bovine Immunodeficiency Virus Tat-TAR Peptide-RNA Complex

1995 • 343 citations

Design of DNA-Binding Peptides Based on the Leucine Zipper Motif

1990 • 296 citations

Induced α Helix in the VP16 Activation Domain upon Binding to a Human TAF

1997 • 286 citations

The ‘molten globule’ state is involved in the translocation of proteins across membranes?

1988 • 275 citations

Folding intermediates of SNARE complex assembly.

1999 • 272 citations

Thousands of proteins likely to have long disordered regions.

1998 • 234 citations

Transcriptional control: Versatile molecular glue

1996 • 231 citations

The active form of the steroidogenic acute regulatory protein, StAR, appears to be a molten globule

1999 • 229 citations

Unity in Function in the Absence of Consensus in Sequence: Role of Leader Peptides in Export

1989 • 222 citations

The patterns of binding of RAR, RXR and TR homo- and heterodimers to direct repeats are dictated by the binding specificites of the DNA binding domains.

1993 • 218 citations

Triple post‐transcriptional control

1990 • 217 citations

Temperature dependence of intramolecular dynamics of the basic leucine zipper of GCN4: implications for the entropy of association with DNA

1999 • 215 citations

Molten Globule-Like State of Cytochrome c under Conditions Simulating Those Near the Membrane Surface

1996 • 206 citations

Solution Structure of a TBP–TAFII230 Complex

1998 • 203 citations

ZZ and TAZ: new putative zinc fingers in dystrophin and other proteins

1996 • 196 citations

The C-terminal half of the anti-sigma factor, FlgM, becomes structured when bound to its target, σ28

1997 • 193 citations

Molecular recognition in the bovine immunodeficiency virus Tat peptide-TAR RNA complex

1995 • 177 citations

Structural Characterization of the FK506 Binding Protein Unfolded in Urea and Guanidine Hydrochloride

1994 • 177 citations

KEKE motifs

1994 • 173 citations

A novel inhibitor of cap-dependent translation initiation in yeast: p20 competes with eIF4G for binding to eIF4E

1997 • 167 citations

Structural characterization of a minimal functional transactivation domain from the human glucocorticoid receptor.

1995 • 160 citations

Structural and functional analysis of the NF-kappa B p65 C terminus. An acidic and modular transactivation domain with the potential to adopt an alpha-helical conformation.

1994 • 158 citations

Conformational preferences in the Ser¹³³‐phosphorylated and non‐phosphorylated forms of the kinase inducible transactivation domain of CREB

1998 • 144 citations

How representative are the known structures of the proteins in a complete genome? A comprehensive structural census

1998 • 136 citations

Predicting Disordered Regions from Amino Acid Sequence: Common Themes Despite Differing Structural Characterization.

1998 • 135 citations

Retinol-binding protein is in the molten globule state at low pH

1992 • 130 citations

Role of Secondary Structure in Discrimination between Constitutive and Inducible Activators

1999 • 127 citations

NMR analysis of main-chain conformational preferences in an unfolded fibronectin-binding protein

1997 • 124 citations

4E Binding Proteins Inhibit the Translation Factor eIF4E without Folded Structure

1998 • 121 citations

Rapid degradation of apoplastocyanin in Cu(II)-deficient cells of Chlamydomonas reinhardtii.

1986 • 120 citations

Conformational states of ribulose bisphosphate carboxylase and their interaction with chaperonin 60

1992 • 108 citations

Costabilization of Peptide and RNA Structure in an HIV Rev Peptide-RRE Complex

1994 • 108 citations

Solution Structure of the Core NFATC1/DNA Complex

1998 • 107 citations

1H Nuclear-Magnetic-Resonance Studies of the Molecular Conformation of Monomeric Glucagon in Aqueous Solution

1978 • 103 citations

The C-Terminal Half of the Anti-Sigma Factor FlgM Contains a Dynamic Equilibrium Solution Structure Favoring Helical Conformations

1998 • 98 citations

Purification and characterization of the carboxyl-terminal transactivation domain of Vmw65 from herpes simplex virus type 1.

1992 • 93 citations

The Cap-binding Protein eIF4E Promotes Folding of a Functional Domain of Yeast Translation Initiation Factor eIF4G1

1999 • 90 citations

High resolution solution structure of ribosomal protein L11-C76, a helical protein with a flexible loop that becomes structured upon binding to RNA

1997 • 88 citations

Characterization of a folding intermediate of apoplastocyanin trapped by proline isomerization

1993 • 88 citations

Independent Ligand-Induced Folding of the RNA-Binding Domain and Two Functionally Distinct Antitermination Regions in the Phage λ N Protein

1998 • 86 citations

Structural studies of the acidic transactivation domain of the Vmw65 protein of herpes simplex virus using proton NMR

1992 • 72 citations

Complexes of N Antitermination Protein of Phage λ with Specific and Nonspecific RNA Target Sites on the Nascent Transcript

1997 • 68 citations

DNA-induced conformational changes are the basis for cooperative dimerization by the DNA binding domain of the retinoid X receptor

1998 • 67 citations

Metal-ion-center assembly of ferredoxin and plastocyanin in isolated chloroplasts.

1990 • 66 citations

Probing Protein/Protein Interactions with Mass Spectrometry and Isotopic Labeling: Analysis of the p21/Cdk2 Complex

1996 • 63 citations

High-resolution solution structure of the retinoid X receptor DNA-binding domain

1998 • 62 citations

Yeast heat shock transcription factor N‐terminal activation domains are unstructured as probed by heteronuclear NMR spectroscopy

1996 • 58 citations

Oct-1 POU and octamer DNA co-operate to recognise the Bob-1 transcription co-activator via induced folding

1999 • 45 citations

Ligand Binding Is the Principal Determinant of Stability for the p21^H-ras Protein

1998 • 44 citations

The Exchangeable Yeast Ribosomal Acidic Protein YP2β Shows Characteristics of a Partly Folded State under Physiological Conditions

1997 • 41 citations

ZZ and TAZ: new putative zinc fingers in dystrophin and other proteins

1996 • 38 citations

Millisecond to Microsecond Time Scale Dynamics of the Retinoid X and Retinoic Acid Receptor DNA-Binding Domains and Dimeric Complex Formation

1999 • 27 citations

New RNA recognition features revealed in ancient ribosomal proteins

1997 • 19 citations

Deleted Work

1955 • 0 citations