Nuclear factor of activated T cells contributes to the function of the CD28 response region of the granulocyte macrophage-colony stimulating factor promoter

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

Structure, Regulation and Function of NF-kappaB

1994 • 2,110 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

CREB-binding protein/p300 are transcriptional coactivators of p65

1997 • 819 citations

Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28

1991 • 660 citations

Transcriptional regulation of the IL-2 gene

1995 • 579 citations

New perspectives of C1328-137-mediated T cell costimulation

1995 • 526 citations

NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes

1994 • 523 citations

Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA

1998 • 510 citations

Selection of Optimal κB/Rel DNA-Binding Motifs: Interaction of Both Subunits of NF-κB with DNA Is Required for Transcriptional Activation

1992 • 501 citations

Isolation of the Cyclosporin-Sensitive T Cell Transcription Factor NFATp

1993 • 415 citations

Control of Granulocytes and Macrophages: Molecular, Cellular, and Clinical Aspects

1991 • 377 citations

Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells.

1995 • 347 citations

AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes.

1994 • 288 citations

Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation.

1992 • 286 citations

NF-kappa B: a family of inducible and differentially expressed enhancer-binding proteins in human T cells.

1990 • 260 citations

Novel NFAT Sites That Mediate Activation of the Interleukin-2 Promoter in Response to T-Cell Receptor Stimulation

1995 • 259 citations

The ups and downs of T cell costimulation

1994 • 240 citations

The architecture of the interleukin-2 promoter: a reflection of T lymphocyte activation

1995 • 229 citations

Upstream-Downstream: CD28 Cosignaling Pathways and T Cell Function

1996 • 229 citations

CD28 Mediates Transcriptional Upregulation of the Interleukin-2 (IL-2) Promoter through a Composite Element Containing the CD28RE and NF-IL-2B AP-1 Sites

1997 • 224 citations

The interleukin 2 CD28-responsive complex contains at least three members of the NF kappa B family: c-Rel, p50, and p65.

1993 • 201 citations

The granulocyte-macrophage colony-stimulating factor/interleukin 3 locus is regulated by an inducible cyclosporin A-sensitive enhancer.

1993 • 201 citations

Activation of interleukin-2 gene transcription via the T-cell surface molecule CD28 is mediated through an NF-kB-like response element

1991 • 194 citations

Angiogenesis: Models and Modulators

1995 • 193 citations

Nuclear Factor of Activated T Cells (NFAT)-dependent Transactivation Regulated by the Coactivators p300/CREB-binding Protein (CBP)

1998 • 193 citations

Recombinant NFAT1 (NFATp) Is Regulated by Calcineurin in T Cells and Mediates Transcription of Several Cytokine Genes

1996 • 192 citations

Requirement for nuclear factor (NF)-kappa B p65 and NF-interleukin-6 binding elements in the tumor necrosis factor response region of the granulocyte colony-stimulating factor promoter

1994 • 157 citations

Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor.

1996 • 147 citations

The role of NFATp in cyclosporin A-sensitive tumor necrosis factor-alpha gene transcription.

1994 • 134 citations

Human Granulocyte-Macrophage Colony-Stimulating Factor Enhancer Function Is Associated with Cooperative Interactions between AP-1 and NFATp/c

1995 • 133 citations

Nuclear proteins interacting with the promoter region of the human granulocyte/macrophage colony-stimulating factor gene.

1988 • 129 citations

Regulation of T-cell lymphokine gene transcription by the accessory molecule CD28.

1992 • 115 citations

High Mobility Group Protein I(Y) Is Required for Function and for c-Rel Binding to CD28 Response Elements within the GM-CSF and IL-2 Promoters

1996 • 109 citations

Involvement of Rel, Fos, and Jun proteins in binding activity to the IL-2 promoter CD28 response element/AP-1 sequence in human T cells.

1997 • 104 citations

Regulation of granulocyte-macrophage colony-stimulating factor and E- selectin expression in endothelial cells by cyclosporin A and the T- cell transcription factor NFAT

1995 • 99 citations

Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc

1997 • 96 citations

The subunit composition of NF-kappa B complexes changes during B-cell development.

1994 • 93 citations

A T cell nuclear factor resembling NF-AT binds to an NF-kappa B site and to the conserved lymphokine promoter sequence “cytokine-1”.

1992 • 90 citations

Regulation of the Interleukin-2 CD28-Responsive Element by NF-ATp and Various NF-κB/Rel Transcription Factors

1997 • 90 citations

Coordinate Transactivation of the Interleukin-2 CD28 Response Element by c-Rel and ATF-1/CREB2

1998 • 89 citations

Effect of CD28 signal transduction on c-Rel in human peripheral blood T cells.

1994 • 89 citations

The binding of a Fos/Jun heterodimer can completely disrupt the structure of a nucleosome

1997 • 79 citations

Signals for Activation of the GM-CSF Promoter and Enhancer in T Cells

1997 • 75 citations

Multiple signals are required for function of the human granulocyte-macrophage colony-stimulating factor gene promoter in T cells.

1995 • 74 citations

Mechanism Responsible for T-Cell Antigen Receptor- and CD28- or Interleukin 1 (IL-1) Receptor-Initiated Regulation of IL-2 Gene Expression by NF-κB

1998 • 67 citations

GM-CSF and IL-2 share common control mechanisms in response to costimulatory signals in T cells

1995 • 39 citations

Costimulation of cytokine gene expression in T cells by the human T leukemia/lymphotropic virus type 1 trans activator Tax

1996 • 23 citations

Overexpression of p65 and c-Jun Substitutes for B7-1 Costimulation by Targeting the CD28RE Within the IL-2 Promoter

1998 • 23 citations

A sequence-specific single-strand DNA binding protein that contacts repressor sequences in the human GM-CSF promoter

1994 • 15 citations

Regulation of IL-2 gene transcription via the T-cell surface molecule CD28

1991 • 3 citations