The High Mobility Group protein HMG I(Y) is required for NF-κB-dependent virus induction of the human IFN-β gene

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes

1986 • 6,284 citations

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

The inducible transcription activator NF-κB: regulation by distinct protein subunits

1991 • 1,079 citations

Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements

1988 • 984 citations

Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes

1989 • 970 citations

IMF-κB and Rel: Participants in a Multiform Transcriptional Regulatory System

1993 • 967 citations

The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product

1990 • 900 citations

[12] Unidirectional digestion with exonuclease III in DNA sequence analysis

1987 • 898 citations

Calcium phosphate-mediated gene transfer: a highly efficient transfection system for stably transforming cells with plasmid DNA.

1988 • 897 citations

Transcriptional regulation

1991 • 893 citations

Immunoglobulin gene transcription is activated by downstream sequence elements

1983 • 830 citations

The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B.

1991 • 805 citations

The HMG domain of lymphoid enhancer factor 1 bends DNA and facilitates assembly of functional nucleoprotein structures

1992 • 684 citations

A protein binds to a satellite DNA repeat at three specific sites that would be brought into mutual proximity by DNA folding in the nucleosome

1984 • 674 citations

The A.T-DNA-binding domain of mammalian high mobility group I chromosomal proteins. A novel peptide motif for recognizing DNA structure.

1990 • 674 citations

In situ detection of sequence-specific DNA binding activity specified by a recombinant bacteriophage.

1988 • 535 citations

Integration host factor: A protein for all reasons

1988 • 501 citations

The involvement of NF-κB in β-interferon gene regulation reveals its role as widely inducible mediator of signal transduction

1989 • 494 citations

Structural features of the HMG chromosomal proteins and their genes

1990 • 474 citations

Construction of plasmids that expressE.coli β-galactosidase in mammalian cells

1989 • 458 citations

Isolation of a rel -related Human cDNAThat Potentially Encodes the 65-kD Subunit of NF-κB

1991 • 448 citations

Interferons and other regulatory cytokines

1988 • 429 citations

Cloning of an NF-κB subunit which stimulates HIV transcription in synergy with p65

1991 • 410 citations

Independent modes of transcriptional activation by the p50 and p65 subunits of NF-kappa B.

1992 • 373 citations

Identification and characterization of a novel repressor of beta-interferon gene expression.

1991 • 351 citations

DNA binding of purified transcription factor NF-kappa B. Affinity, specificity, Zn2+ dependence, and differential half-site recognition.

1991 • 349 citations

Cloning of a mitogen-inducible gene encoding a κB DNA-binding protein with homology to the rel oncogene and to cell-cycle motifs

1990 • 330 citations

Double-stranded RNA activates binding of NF-kappa B to an inducible element in the human beta-interferon promoter.

1989 • 317 citations

Generation of p50 subunit of NF-kB by processing of p105 through an ATP-dependent pathway

1991 • 316 citations

Human and Drosophila Homeodomain Proteins That Enhance the DNA-Binding Activity of Serum Response Factor

1992 • 314 citations

A mammalian high mobility group protein recognizes any stretch of six A.T base pairs in duplex DNA.

1986 • 313 citations

Interferons and other regulatory cytokines

1989 • 306 citations

NF-kappa B contacts DNA by a heterodimer of the p50 and p65 subunit.

1991 • 287 citations

Human β-interferon gene expression is regulated by an inducible enhancer element

1985 • 283 citations

A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site.

1992 • 281 citations

Critical role of a common transcription factor, IRF-1, in the regulation of IFN-beta and IFN-inducible genes.

1992 • 247 citations

Distinct combinations of NF-kappa B subunits determine the specificity of transcriptional activation.

1992 • 245 citations

Alternative processing of mRNAs encoding mammalian chromosomal high-mobility-group proteins HMG-I and HMG-Y.

1989 • 241 citations

Interferon-β gene regulation: Tandemly repeated sequences of a synthetic 6 bp oligomer function as a virus-inducible enhancer

1987 • 233 citations

Cloning of the DNA-binding subunit of human nuclear factor kappa B: the level of its mRNA is strongly regulated by phorbol ester or tumor necrosis factor alpha.

1991 • 230 citations

TFIID binds in the minor groove of the TATA box

1991 • 206 citations

Complete murine cDNA sequence, genomic structure, and tissue expression of the high mobility group protein HMG-I(Y).

1988 • 192 citations

Interaction of TFIID in the minor groove of the TATA element

1991 • 170 citations

Two different virus-inducible elements are required for human beta-interferon gene regulation.

1989 • 168 citations

HMG has DNA wrapped up

1992 • 161 citations

A protein structural motif that bends DNA

1989 • 155 citations

Induction of human interferon gene expression is associated with a nuclear factor that interacts with the NF-kappa B site of the human immunodeficiency virus enhancer

1989 • 135 citations

Bending and supercoiling of DNA at the attachment site of bacteriophage λ

1990 • 128 citations

Involvement of acis-element that binds an H2TF-l/NFxB like factor(s) in the virus-induced interferon-β gene expression

1989 • 118 citations

A Poly(dA-dT) Upstream Activating Sequence Binds High-Mobility Group I Protein and Contributes to Lymphotoxin (Tumor Necrosis Factor-β) Gene Regulation

1992 • 115 citations

The NF-ϰB transcription factor induces DNA bending which is modulated by its 65-kD subunit

1990 • 109 citations

Synergism between distinct enhanson domains in viral induction of the human beta interferon gene.

1990 • 82 citations

Cloning of cDNAs coding for human HMG I and HMG Y proteins: both are capable of binding to the octamer sequence motif

1989 • 66 citations

Purification and Characterization of a High-Mobility-Group-Like DNA-Binding Protein That Stimulates rRNA Synthesis In Vitro

1988 • 63 citations

Cis-acting sequences from mouse rDNA promote plasmid DNA amplification and persistence in mouse cells: implication of HMG-I in their function

1989 • 62 citations

A poly(dA-dT) upstream activating sequence binds high-mobility group I protein and contributes to lymphotoxin (tumor necrosis factor-beta) gene regulation.

1992 • 57 citations

Kappa B-specific DNA binding proteins are differentially inhibited by enhancer mutations and biological oxidation.

1991 • 35 citations

A conformational study of the sequence specific binding of HMG-I (Y) with the bovine interleukin-2 cDNA.

1988 • 34 citations

Purification and characterization of a high-mobility-group-like DNA-binding protein that stimulates rRNA synthesis in vitro.

1988 • 28 citations

Comparison of constitutive and inducible transcriptional enhancement mediated by kappa B-related sequences: modulation of activity in B cells by human T-cell leukemia virus type I tax gene.

1991 • 26 citations