Transcriptional and post-transcriptional gene regulation of HTLV-1

Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma

1980 • 5,022 citations

ANTIBODIES TO HUMAN T-LYMPHOTROPIC VIRUS TYPE-I IN PATIENTS WITH TROPICAL SPASTIC PARAPARESIS

1985 • 2,840 citations

Major nucleolar proteins shuttle between nucleus and cytoplasm

1989 • 1,113 citations

Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease.

1984 • 886 citations

The location of cis-acting regulatory sequences in the human T cell lymphotropic virus type III (HTLV-III/LAV) long terminal repeat

1985 • 825 citations

Biological Role of the CCAAT/Enhancer-binding Protein Family of Transcription Factors

1998 • 799 citations

The pX Protein of HTLV-I Is a Transcriptional Activator of Its Long Terminal Repeats

1985 • 514 citations

HTLV-I Tax Induces Cellular Proteins that Activate the κB Element in the IL-2 Receptor α Gene

1988 • 480 citations

The Complementary Strand of the Human T-Cell Leukemia Virus Type 1 RNA Genome Encodes a bZIP Transcription Factor That Down-Regulates Viral Transcription

2002 • 471 citations

Multiple Viral Strategies of HTLV-1 for Dysregulation of Cell Growth Control

2001 • 457 citations

HIV-1 structural gene expression requires binding of the rev trans-activator to its RNA target sequence

1990 • 457 citations

Molecular mechanisms of human T-cell leukemia/lymphotropic virus type I infection

1995 • 373 citations

Control of cAMP-regulated enhancers by the viral transactivator Tax through CREB and the co-activator CBP

1996 • 344 citations

Human T-cell lymphotropic virus type I (HTLV-I) transcriptional activator, Tax, enhances CREB binding to HTLV-I 21-base-pair repeats by protein-protein interaction.

1992 • 318 citations

Sequence requirements for nucleolar localization of human T cell leukemia virus type I pX protein, which regulates viral RNA processing

1988 • 308 citations

Post-transcriptional regulator (rex) of HTLV-1 initiates expression of viral structural proteins but suppresses expression of regulatory proteins.

1988 • 273 citations

The trans-activator tax of human T-cell leukemia virus type 1 (HTLV-1) interacts with cAMP-responsive element (CRE) binding and CRE modulator proteins that bind to the 21-base-pair enhancer of HTLV-1.

1993 • 258 citations

Identification of p40x-responsive regulatory sequences within the human T-cell leukemia virus type I long terminal repeat

1987 • 251 citations

CBP-independent activation of CREM and CREB by the LIM-only protein ACT

1999 • 227 citations

Characterization of cellular factors that interact with the human T-cell leukemia virus type I p40x-responsive 21-base-pair sequence

1988 • 218 citations

The product of the c-ets-1 proto-oncogene and the related Ets2 protein act as transcriptional activators of the long terminal repeat of human T cell leukemia virus HTLV-1.

1990 • 189 citations

A Family of LIM-Only Transcriptional Coactivators: Tissue-Specific Expression and Selective Activation of CREB and CREM

2000 • 188 citations

The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins

1998 • 184 citations

The Human Interleukin-2 Receptor: Normal and Abnormal Expression in T Cells and in Leukemias Induced by the Human T-Lymphotropic Retroviruses

1986 • 182 citations

Persistent activation of NF-κB by the Tax transforming protein of HTLV-1: hijacking cellular IκB kinases

1999 • 181 citations

Anchoring of CREB Binding Protein to the Human T-Cell Leukemia Virus Type 1 Promoter: a Molecular Mechanism of Tax Transactivation

1997 • 179 citations

HTLV-1-encoded p30II is a post-transcriptional negative regulator of viral replication

2004 • 174 citations

An Exposed KID-Like Domain in Human T-Cell Lymphotropic Virus Type 1 Tax Is Responsible for the Recruitment of Coactivators CBP/p300

1998 • 174 citations

HTLV-I tax induces cellular proteins that activate the kappa B element in the IL-2 receptor alpha gene

1988 • 171 citations

Inhibition of Human Immunodeficiency Virus Rev and Human T-Cell Leukemia Virus Rex Function, but Not Mason-Pfizer Monkey Virus Constitutive Transport Element Activity, by a Mutant Human Nucleoporin Targeted to Crm1

1998 • 170 citations

Life, Death, and Tax: Role of HTLV-I Oncoprotein in Genetic Instability and Cellular Transformation

2004 • 169 citations

Transactivation by the human T-cell leukemia virus Tax protein is mediated through enhanced binding of activating transcription factor-2 (ATF-2) ATF-2 response and cAMP element-binding protein (CREB).

1993 • 161 citations

Mechanism of DNA-binding enhancement by the human T-cell leukaemia virus transactivator Tax

1995 • 150 citations

Two cis-acting elements responsible for posttranscriptional trans-regulation of gene expression of human T-cell leukemia virus type I.

1988 • 150 citations

Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity.

2004 • 147 citations

Effector domains of human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex are functionally interchangeable and share an essential peptide motif

1991 • 147 citations

PCAF Interacts with Tax and Stimulates Tax Transactivation in a Histone Acetyltransferase-Independent Manner

1999 • 134 citations

The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases

1999 • 134 citations

Trans-Activator Gene of HTLV-II Induces IL-2 Receptor and IL-2 Cellular Gene Expression

1986 • 129 citations

Functional activities of the human T-cell leukemia virus type I Tax oncoprotein: cellular signaling through NF-κB

2001 • 126 citations

HTLV-I tax gene product activates transcription via pre-existing cellular factors and cAMP responsive element

1989 • 125 citations

Human T-Cell Leukemia Virus Type 1 Tax Requires Direct Access to DNA for Recruitment of CREB Binding Protein to the Viral Promoter

1998 • 120 citations

Regulation of Gene Expression by HTLV-I Tax Protein

1998 • 120 citations

Differential Transcriptional Activation by Human T-Cell Leukemia Virus Type 1 Tax Mutants Is Mediated by Distinct Interactions with CREB Binding Protein and p300

1998 • 119 citations

Distinct regions in human T-cell lymphotropic virus type I tax mediate interactions with activator protein CREB and basal transcription factors

1995 • 119 citations

Nucleolar targeting signal of Rex protein of human T-cell leukemia virus type I specifically binds to nucleolar shuttle protein B-23

1993 • 116 citations

Localization of human T-cell leukemia virus type 1 tax to subnuclear compartments that overlap with interchromatin speckles

1996 • 114 citations

p300 and p300/cAMP-responsive Element-binding Protein Associated Factor Interact with Human T-cell Lymphotropic Virus Type-1 Tax in a Multi-histone Acetyltransferase/Activator-Enhancer Complex

2000 • 109 citations

Human T-cell Lymphotropic Virus Type 1 Tax Induction of Biologically Active NF-κB Requires IκB Kinase-1-mediated Phosphorylation of RelA/p65

2004 • 107 citations

Tumor Necrosis Factor α Promotes Nuclear Localization of Cytokine-inducible CCAAT/Enhancer Binding Protein Isoforms in Hepatocytes

1996 • 104 citations

Domain-specific Interaction with the IκB Kinase (IKK) Regulatory Subunit IKKγ Is an Essential Step in Tax-mediated Activation of IKK

2000 • 101 citations

Protein domains involved in both in vivo and in vitro interactions between human T-cell leukemia virus type I tax and CREB

1995 • 101 citations

Expansion of CREB's DNA recognition specificity by Tax results from interaction with Ala-Ala-Arg at positions 282-284 near the conserved DNA-binding domain of CREB.

1994 • 97 citations

Interaction of the human T-lymphotropic virus type 1 Tax dimer with CREB and the viral 21-base-pair repeat

1996 • 96 citations

The contribution of NF-κB activity to spontaneous proliferation and resistance to apoptosis in human T-cell leukemia virus type 1 Tax-induced tumors

2001 • 94 citations

CREB-2, a Cellular CRE-Dependent Transcription Repressor, Functions in Association with Tax as an Activator of the Human T-Cell Leukemia Virus Type 1 Promoter

1998 • 94 citations

Nucleolar targeting signal of human T-cell leukemia virus type I rex-encoded protein is essential for cytoplasmic accumulation of unspliced viral mRNA.

1989 • 93 citations

PDZ domain-binding motif of human T-cell leukemia virus type 1 Tax oncoprotein augments the transforming activity in a rat fibroblast cell line

2003 • 92 citations

cAMP inducibility of transcriptional repressor ICER in developing and mature human T lymphocytes.

1996 • 91 citations

PDZ domains: More than just a glue

2001 • 91 citations

Dominant negative mutants of human T-cell leukemia virus type I Rex and human immunodeficiency virus type 1 Rev fail to multimerize in vivo

1993 • 90 citations

HTLV-I Tax induces a novel interaction between p65/RelA and p53 that results in inhibition of p53 transcriptional activity

2004 • 90 citations

Protein Profile of Tax-associated Complexes

2003 • 88 citations

Crystal Structure of the CCAAT Box/Enhancer-binding Protein β Activating Transcription Factor-4 Basic Leucine Zipper Heterodimer in the Absence of DNA

2001 • 87 citations

Indirect binding of human T-cell leukemia virus type I tax1 to a responsive element in the viral long terminal repeat.

1989 • 85 citations

The type I human T-cell leukemia virus (HTLV-I) Rex trans-activator binds directly to the HTLV-I Rex and the type 1 human immunodeficiency virus Rev RNA response elements.

1991 • 83 citations

A 36-kilodalton cellular transcription factor mediates an indirect interaction of human T-cell leukemia/lymphoma virus type I TAX1 with a responsive element in the viral long terminal repeat.

1990 • 81 citations

Functional interaction of the HTLV-1 transactivator Tax with activating transcription factor-4 (ATF4)

1997 • 81 citations

Ubiquitination of Human T-Cell Leukemia Virus Type 1 Tax Modulates Its Activity

2004 • 81 citations

Seizing of T Cells by Human T-Cell Leukemia⧸Lymphoma Virus Type 1

2003 • 80 citations

Secondary structure of the human T-cell leukemia virus type 1 rex-responsive element is essential for rex regulation of RNA processing and transport of unspliced RNAs

1990 • 79 citations

Stable Ubiquitination of Human T-Cell Leukemia Virus Type 1 Tax Is Required for Proteasome Binding

2004 • 79 citations

A Novel NF-κB Pathway Involving IKKβ and p65/RelA Ser-536 Phosphorylation Results in p53 Inhibition in the Absence of NF-κB Transcriptional Activity

2004 • 78 citations

Functional analysis of human T-cell leukemia virus type I rex-response element: direct RNA binding of Rex protein correlates with in vivo activity

1991 • 76 citations

The interaction of HTLV-1 Tax with HDAC1 negatively regulates the viral gene expression

2002 • 75 citations

Definition of the human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex protein activation domain by functional exchange

1992 • 75 citations

The amino terminus of Tax is required for interaction with the cyclic AMP response element binding protein

1995 • 74 citations

HTLV-I Tax self-association in optimal trans-activation function

1997 • 73 citations

The PDZ Protein TIP-1 Interacts with the Rho Effector Rhotekin and Is Involved in Rho Signaling to the Serum Response Element

2000 • 72 citations

Induction of the HTLV-I LTR by Jun Occurs through the Tax-Responsive 21-bp elements

1991 • 71 citations

Mechanisms of tax regulation of human T cell leukemia virus type I gene expression

1995 • 70 citations

Multiple sequence elements are required for regulation of human T-cell leukemia virus gene expression.

1987 • 69 citations

Involvement of Human CRM1 (Exportin 1) in the Export and Multimerization of the Rex Protein of Human T-Cell Leukemia Virus Type 1

1998 • 69 citations

Activation of the IL-2 gene promoter by HTLV-I tax involves induction of NF-AT complexes bound to the CD28-responsive element.

1996 • 69 citations

Transcription Factor Binding and Histone Modifications on the Integrated Proviral Promoter in Human T-cell Leukemia Virus-I-infected T-cells

2002 • 67 citations

The Coactivator CBP Stimulates Human T-cell Lymphotrophic Virus Type I Tax Transactivation in Vitro

1998 • 67 citations

The human T-cell leukemia virus type 1 posttranscriptional trans-activator Rex contains a nuclear export signal

1996 • 67 citations

The Oncoprotein Tax Binds the SRC-1-Interacting Domain of CBP/p300 To Mediate Transcriptional Activation

2001 • 66 citations

In vitro binding of human T-cell leukemia virus rex proteins to the rex-response element of viral transcripts

1991 • 64 citations

Molecular Interactions Involved in the Transactivation of the Human T-Cell Leukemia Virus Type 1 Promoter Mediated by Tax and CREB-2 (ATF-4)

2000 • 63 citations

CREB/ATF-Dependent Repression of Cyclin A by Human T-Cell Leukemia Virus Type 1 Tax Protein

2001 • 63 citations

HTLV-1 Oncoprotein Tax and Cellular transcription Factors

1995 • 61 citations

Transcription Regulatory Complexes Bind the Human T-Cell Leukemia Virus 5′ and 3′ Long Terminal Repeats To Control Gene Expression

2004 • 60 citations

HTLV-1 Rex is required for viral spread and persistence in vivo but is dispensable for cellular immortalization in vitro

2003 • 60 citations

Expression of the target antigen for cytotoxic T lymphocytes on adult T‐cell‐leukemia cells

1993 • 59 citations

CAAT/enhancer binding protein is able to bind to ATF/CRE elements

1991 • 59 citations

Activation of IKKα and IKKβ through their fusion with HTLV-I Tax protein

2000 • 58 citations

Cytoplasmic Forms of Human T-Cell Leukemia Virus Type 1 Tax Induce NF-κB Activation

1998 • 57 citations

Apoptosis Induced by the Histone Deacetylase Inhibitor FR901228 in Human T-Cell Leukemia Virus Type 1-Infected T-Cell Lines and Primary Adult T-Cell Leukemia Cells

2004 • 57 citations

Acetylation of Nucleosomal Histones by p300 Facilitates Transcription from Tax-Responsive Human T-Cell Leukemia Virus Type 1 Chromatin Template

2002 • 54 citations

p300-Mediated Tax Transactivation from Recombinant Chromatin: Histone Tail Deletion Mimics Coactivator Function

2002 • 54 citations

Tax Relieves Transcriptional Repression by Promoting Histone Deacetylase 1 Release from the Human T-Cell Leukemia Virus Type 1 Long Terminal Repeat

2004 • 53 citations

Molecular interactions between the coactivator CBP and the human T-cell leukemia virus tax protein

1998 • 52 citations

The HTLV-1 Rex Protein Induces Nuclear Accumulation of Unspliced Viral RNA by Avoiding Intron Excision and Degradation

1996 • 50 citations

Among all human T-cell leukemia virus type 1 proteins, tax, polymerase, and envelope proteins are predicted as preferential targets for the HLA-A2-restricted cytotoxic T-cell response

1996 • 50 citations

Human T-cell Leukemia Virus Type I Tax Repression of p73β Is Mediated through Competition for the C/H1 Domain of CBP

2001 • 49 citations

HTLV-1 oncoprotein Tax deregulates transcription of cellular genes through multiple mechanisms

1995 • 48 citations

Function of the human T-cell leukemia virus type 1 21-base-pair repeats in basal transcription

1997 • 46 citations

Myb protein binds to multiple sites in the human T cell lymphotropic virus type 1 long terminal repeat and transactivates LTR-mediated expression

1992 • 45 citations

Differential Requirements for Activation of Integrated and Transiently Transfected Human T-Cell Leukemia Virus Type 1 Long Terminal Repeat

2002 • 45 citations

Differential Activation of Viral and Cellular Promoters by Human T-cell Lymphotropic Virus-1 Tax and cAMP-responsive Element Modulator Isoforms

1997 • 44 citations

Tartrate-resistant acid phosphatase: gene structure and function

1997 • 44 citations

Tax Recruitment of CBP/p300, via the KIX Domain, Reveals a Potent Requirement for Acetyltransferase Activity That Is Chromatin Dependent and Histone Tail Independent

2003 • 44 citations

Roles of viral and cellular proteins in the expression of alternatively spliced HTLV-1 pX mRNAs11The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government.

2003 • 43 citations

Transdominant repressors for human T-cell leukemia virus type I rex and human immunodeficiency virus type 1 rev function

1991 • 43 citations

Phosphorylation of the Rex protein of human T-cell leukemia virus type I.

1992 • 41 citations

Activation of the human T-cell leukemia virus type I enhancer is mediated by binding sites for Elf-1 and the pets factor

1993 • 41 citations

Cell cycle dysregulation by HTLV-I: role of the TAX oncoprotein

2002 • 40 citations

Transcription factor AP-2 activates gene expression of HTLV-I.

1992 • 39 citations

Coiled-Coil Motif as a Structural Basis for the Interaction of HTLV Type 1 Tax with Cellular Cofactors

2000 • 35 citations

The Human T-cell Leukemia Virus Type-1 Tax Protein Regulates the Activity of the IκB Kinase Complex

1999 • 35 citations

Direct Binding of the N-Terminus of HTLV-1 Tax Oncoprotein to Cyclin-Dependent Kinase 4 Is a Dominant Path To Stimulate the Kinase Activity

2003 • 35 citations

Critical role of hnRNP A1 in HTLV-1 replication in human transformed T lymphocytes.

2005 • 34 citations

Activation of I-κB Kinase by the HTLV Type 1 Tax Protein: Mechanistic Insights into the Adaptor Function of IKKγ

2000 • 33 citations

The U5 sequence is a cis-acting repressive element for genomic RNA expression of human T cell leukemia virus type I

1990 • 33 citations

Molecular mechanisms of regulation of HTLV-1 gene expression and its association with leukemogenesis

1989 • 30 citations

Setting the stage for transformation: HTLV-1 Tax inhibition of p53 function

2005 • 29 citations

Requirements for Interleukin 2 Promoter Transactivation by the Tax Protein of Human T-Cell Leukemia Virus Type 1

1996 • 29 citations

Insight Into the Tumor Suppressor Function of CBP Through the Viral Oncoprotein Tax

2001 • 28 citations

Specific TATAA and bZIP requirements suggest that HTLV-I Tax has transcriptional activity subsequent to the assembly of an initiation complex.

2004 • 28 citations

Inhibitory Effect of Tannic Acid on Human Immunodeficiency Virus Promoter Activity Induced by 12-O-Tetra Decanoylphorbol-13-acetate in Jurkat T-Cells

1996 • 28 citations

Protein kinase inhibitor H-7 blocks accumulation of unspliced mRNA of human T-cell leukemia virus type I (HTLV-I)

1990 • 28 citations

Dominant-negative mutants are clustered in a domain of the human T-cell leukemia virus type I Rex protein: implications for trans dominance

1992 • 27 citations

Multimer Formation Is Not Essential for Nuclear Export of Human T-Cell Leukemia Virus Type 1 Rextrans-Activator Protein

1998 • 24 citations

Distinct nuclear body components, PML and SMRT, regulate the trans-acting function of HTLV-1 Tax oncoprotein

2003 • 23 citations

Heterogeneous Nuclear Ribonucleoprotein A1 Interferes with the Binding of the Human T Cell Leukemia Virus Type 1 Rex Regulatory Protein to Its Response Element

2002 • 22 citations

Mechanisms of HTLV-1 transformation

2004 • 21 citations

cAMP-response Element-binding Protein Induces Directed DNA Bending of the HTLV-I 21-Base Pair Repeat

1996 • 20 citations

Interaction between C/EBPβ and Tax down-regulates human T-cell leukemia virus type I transcription

2003 • 18 citations

Nucleocytoplasmic transport of HTLV-1 RNA is regulated by two independent LTR encoded nuclear retention elements

1998 • 17 citations

Repression of tax-mediated human t-lymphotropic virus type 1 transcription by inducible cAMP early repressor (ICER) protein in peripheral blood mononuclear Cells

2000 • 16 citations

Host-HTLV Type I Interaction at the Molecular Level

1994 • 16 citations

The Activation Domain of a Hormone Inducible HTLV-1 Rex Protein Determines Colocalization with the Nuclear Pore

1997 • 13 citations

The detection of human T cell leukemia virus proviral DNA and its application for classification and diagnosis of T cell malignancy

1984 • 12 citations

Cell cycle dysregulation by HTLV-I role of the TAX oncoprotein

2002 • 10 citations

Kinase-Inducible Domain-Like Region of HTLV Type 1 Tax Is Important for NF-κB Activation

2000 • 7 citations

Mechanisms of Tax Regulation of Human T Cell Leukemia Virus Type I Gene Expression

1995 • 6 citations

The presence of HTLV-I proviral DNA in the central nervous system of patients with HTLV-I-associated myelopathy/tropical spastic paraparesis

1994 • 6 citations

The expanding role of Tax in transcription.

2004 • 5 citations

Paradoxical effects of DNA binding polyamides on HTLV-1 transcription

2004 • 5 citations

KTP同型取代晶体的结构与性能关系

1996 • 1 citations