Ubiquitination of Human T-Cell Leukemia Virus Type 1 Tax Modulates Its Activity

Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma

1980 • 5,022 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera.

1981 • 2,281 citations

Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease.

1982 • 2,170 citations

Protein regulation by monoubiquitin

2001 • 1,195 citations

A Proteolytic Pathway That Recognizes Ubiquitin as a Degradation Signal

1995 • 804 citations

How the ubiquitin–proteasome system controls transcription

2003 • 790 citations

Ubiquitination and deubiquitination: Targeting of proteins for degradation by the proteasome

2000 • 560 citations

Human T Cell Leukemia Virus Type 1 Oncoprotein Tax Targets the Human Mitotic Checkpoint Protein MAD1

1998 • 528 citations

The tat Gene of Human T-Lymphotropic Virus Type 1 Induces Mesenchymal Tumors in Transgenic Mice

1987 • 522 citations

Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro.

1990 • 439 citations

HIV-1 Tat transcriptional activity is regulated by acetylation

1999 • 411 citations

Multifaceted Activities of the HIV-1 Transactivator of Transcription, Tat

1999 • 411 citations

Regulation of Transcriptional Activation Domain Function by Ubiquitin

2001 • 363 citations

Transformation to continuous growth of primary human T lymphocytes by human T-cell leukemia virus type I X-region genes transduced by a Herpesvirus saimiri vector.

1989 • 359 citations

Deadly encounter: ubiquitin meets apoptosis

2002 • 356 citations

Recruitment of a 19 S Proteasome Subcomplex to an Activated Promoter

2002 • 340 citations

HTLV-I Trans-Activator Protein, Tax, is a Trans-Repressor of the Human β-Polymerase Ggene

1990 • 329 citations

G-protein-coupled receptors function as oligomers in vivo

2000 • 313 citations

Role of human T-cell leukemia virus type 1 X region proteins in immortalization of primary human lymphocytes in culture

1992 • 311 citations

A Transgenic Mouse Model for Human Neurofibromatosis

1987 • 278 citations

HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p16INK4A and counteracts its inhibitory activity towards CDK4.

1996 • 273 citations

The 19S Regulatory Particle of the Proteasome Is Required for Efficient Transcription Elongation by RNA Polymerase II

2001 • 266 citations

Regulating the Regulators

2003 • 261 citations

Two types of defective human T-lymphotropic virus type I provirus in adult T-cell leukemia

1996 • 248 citations

The human T-lymphotropic virus type I tax gene can cooperate with the ras oncogene to induce neoplastic transformation of cells.

1990 • 222 citations

Human T-cell leukemia virus type I and adult T-cell leukemia

2003 • 192 citations

Proteasome-mediated degradation of transcriptional activators correlates with activation domain potency in vivo

1999 • 190 citations

Deubiquitinating enzymes—the importance of driving in reverse along the ubiquitin–proteasome pathway

2003 • 189 citations

Human T-Cell Leukemia Virus Type 1 Tax and Cell Cycle Progression: Role of Cyclin D-cdk and p110Rb

1998 • 188 citations

Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro

1990 • 181 citations

Deubiquitinating Enzymes: Their Diversity and Emerging Roles

1999 • 179 citations

HTLV-1 Tax induces expression of various immediate early serum responsive genes.

1991 • 177 citations

A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter

2003 • 174 citations

Genetic analysis of the ubiquitin system

1991 • 158 citations

DNA Single-Strand Break Repair and Spinocerebellar Ataxia

2003 • 147 citations

p53 functional impairment and high p21waf1/cip1 expression in human T- cell lymphotropic/leukemia virus type I-transformed T cells

1996 • 145 citations

Physical Interaction of Human T-Cell Leukemia Virus Type 1 Tax with Cyclin-Dependent Kinase 4 Stimulates the Phosphorylation of Retinoblastoma Protein

2002 • 140 citations

Human T-cell leukemia virus type 1 Tax protein transforms rat fibroblasts via two distinct pathways

1997 • 139 citations

Inactivation of p53 by Human T-Cell Lymphotropic Virus Type 1 Tax Requires Activation of the NF-κB Pathway and Is Dependent on p53 Phosphorylation

2000 • 136 citations

Stimulation of Cyclin-Dependent Kinase Activity and G₁- to S-Phase Transition in Human Lymphocytes by the Human T-Cell Leukemia/Lymphotropic Virus Type 1 Tax Protein

1998 • 133 citations

Human T-cell leukemia virus type 1 Tax releases cell cycle arrest induced by p16INK4a

1997 • 131 citations

Functional activities of the human T-cell leukemia virus type I Tax oncoprotein: cellular signaling through NF-κB

2001 • 126 citations

Disruption of Nucleotide Excision Repair by the Human T-Cell Leukemia Virus Type 1 Tax Protein

1999 • 120 citations

Defective DNA Repair in Cells With Human T-Cell Leukemia/Bovine Leukemia Viruses: Role of tax Gene

1999 • 117 citations

Prevalent Loss of Mitotic Spindle Checkpoint in Adult T-cell Leukemia Confers Resistance to Microtubule Inhibitors

2002 • 110 citations

Genome-wide expression changes induced by HTLV-1 Tax: evidence for MLK-3 mixed lineage kinase involvement in Tax-mediated NF-κB activation

2001 • 101 citations

Transcriptional regulation: Kamikaze activators

2000 • 95 citations

Inactivation of hTERT transcription by Tax

2003 • 89 citations

Induction of Micronuclei by HTLV-I Tax: A Cellular Assay for Function

1993 • 89 citations

Critical Role of Human T-Lymphotropic Virus Type 1 Accessory Proteins in Viral Replication and Pathogenesis

2002 • 85 citations

Stable Ubiquitination of Human T-Cell Leukemia Virus Type 1 Tax Is Required for Proteasome Binding

2004 • 79 citations

Regulation of human T cell leukemia virus expression ¹

1990 • 78 citations

Clastogenic Effect of the Human T-cell Leukemia Virus Type I Tax Oncoprotein Correlates with Unstabilized DNA Breaks

2000 • 73 citations

Human T-Lymphotropic Virus Type 1 Oncoprotein Tax Promotes Unscheduled Degradation of Pds1p/Securin and Clb2p/Cyclin B1 and Causes Chromosomal Instability

2003 • 72 citations

Human T-Cell Leukemia Virus Type 2 (HTLV-2) Tax Protein Transforms a Rat Fibroblast Cell Line but Less Efficiently than HTLV-1 Tax

2002 • 71 citations

Mechanisms of tax regulation of human T cell leukemia virus type I gene expression

1995 • 70 citations

Segregation of NF-κB activation through NEMO/IKKγ by Tax and TNFα: implications for stimulus-specific interruption of oncogenic signaling

2003 • 66 citations

CREB/ATF-Dependent Repression of Cyclin A by Human T-Cell Leukemia Virus Type 1 Tax Protein

2001 • 63 citations

Damaged DNA and miscounted chromosomes: Human T cell leukemia virus type I tax oncoprotein and genetic lesions in transformed cells

2002 • 54 citations

The HTLV-1 Tax Oncoprotein Attenuates DNA Damage Induced G1 Arrest and Enhances Apoptosis in p53 Null Cells

2003 • 49 citations

Mechanisms of human T-cell leukemia virus-induced leukemogenesis

1992 • 45 citations

Tax and Overlapping Rex Sequences Do Not Confer the Distinct Transformation Tropisms of Human T-Cell Leukemia Virus Types 1 and 2

2003 • 37 citations

Activation of HTLV-I Long Terminal Repeat by Stress-Inducing Agents and Protection of HTLV-I-Infected T-cells from Apoptosis by the Viral Tax Protein

2001 • 34 citations

Phosphorylation of bovine leukemia virus Tax protein is required for in vitro transformation but not for transactivation

1998 • 33 citations

The Human T-Lymphotropic Virus Type I tax Gene Can Cooperate with the ras Oncogene To Induce Neoplastic Transformation of Cells

1990 • 33 citations

Ubiquitin activated tumor necrosis factor receptor associated factor‐6 (TRAF6) is recycled via deubiquitination

2003 • 32 citations

Human T-Cell Leukemia Virus Type 1 Tax Oncoprotein Suppression of Multilineage Hematopoiesis of CD34 ⁺ Cells In Vitro

2003 • 32 citations

Pleiotropic Effects of HTLV Type 1 Tax Protein on Cellular Metabolism: Mitotic Checkpoint Abrogation and NF-κB Activation

2000 • 24 citations

Transcriptional Activity of HTLV‐I Tax Influences the Expression of Marker Genes Associated with Cellular Transformation

2001 • 11 citations