A Novel NF-κB Pathway Involving IKKβ and p65/RelA Ser-536 Phosphorylation Results in p53 Inhibition in the Absence of NF-κB Transcriptional Activity

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma

1980 • 5,022 citations

Van Damme A.

1986 • 3,477 citations

ANTIBODIES TO HUMAN T-LYMPHOTROPIC VIRUS TYPE-I IN PATIENTS WITH TROPICAL SPASTIC PARAPARESIS

1985 • 2,840 citations

NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

1999 • 2,147 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1

1997 • 1,294 citations

NF-κB: A lesson in family values

1995 • 1,266 citations

Phosphorylation of NF-κB p65 by PKA Stimulates Transcriptional Activity by Promoting a Novel Bivalent Interaction with the Coactivator CBP/p300

1998 • 1,200 citations

Complementation Cloning of NEMO, a Component of the IκB Kinase Complex Essential for NF-κB Activation

1998 • 1,070 citations

The Lymphotoxin-β Receptor Induces Different Patterns of Gene Expression via Two NF-κB Pathways

2002 • 891 citations

Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease.

1984 • 886 citations

Positive and Negative Regulation of IκB Kinase Activity Through IKKβ Subunit Phosphorylation

1999 • 855 citations

The I kappa B proteins: multifunctional regulators of Rel/NF-kappa B transcription factors.

1993 • 819 citations

IκB Kinases Phosphorylate NF-κB p65 Subunit on Serine 536 in the Transactivation Domain

1999 • 812 citations

Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB

2002 • 777 citations

Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)

2003 • 742 citations

The p65 (RelA) Subunit of NF-κB Interacts with the Histone Deacetylase (HDAC) Corepressors HDAC1 and HDAC2 To Negatively Regulate Gene Expression

2001 • 708 citations

Akt Suppresses Apoptosis by Stimulating the Transactivation Potential of the RelA/p65 Subunit of NF-κB

2000 • 637 citations

Histone H3 phosphorylation by IKK-α is critical for cytokine-induced gene expression

2003 • 568 citations

NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176

1998 • 533 citations

Differential regulation of IκB kinase α and β by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1

1998 • 531 citations

A nucleosomal function for IκB kinase-α in NF-κB-dependent gene expression

2003 • 512 citations

Post-activation Turn-off of NF-κB-dependent Transcription Is Regulated by Acetylation of p65

2003 • 502 citations

Infective dermatitis of Jamaican children: a marker for HTLV-I infection

1990 • 452 citations

Tumor Necrosis Factor α-induced Phosphorylation of RelA/p65 on Ser529 Is Controlled by Casein Kinase II

2000 • 445 citations

Distinct Roles of the IκB Kinase α and β Subunits in Liberating Nuclear Factor κB (NF-κB) from IκB and in Phosphorylating the p65 Subunit of NF-κB

2002 • 389 citations

IKKβ Plays an Essential Role in the Phosphorylation of RelA/p65 on Serine 536 Induced by Lipopolysaccharide

2003 • 383 citations

HER-2/neu Blocks Tumor Necrosis Factor-induced Apoptosis via the Akt/NF-κB Pathway

2000 • 375 citations

Activation of Nuclear Factor-κB-dependent Transcription by Tumor Necrosis Factor-α Is Mediated through Phosphorylation of RelA/p65 on Serine 529

1998 • 375 citations

Molecular mechanisms of human T-cell leukemia/lymphotropic virus type I infection

1995 • 373 citations

Tumor Necrosis Factor-α-induced IKK Phosphorylation of NF-κB p65 on Serine 536 Is Mediated through the TRAF2, TRAF5, and TAK1 Signaling Pathway

2003 • 348 citations

IκB Kinase (IKK)-Associated Protein 1, a Common Component of the Heterogeneous IKK Complex

1999 • 333 citations

Retroviral oncoprotein Tax induces processing of NF-kappaB2/p100 in T cells: evidence for the involvement of IKKalpha

2001 • 294 citations

Regulation of distinct biological activities of the NF-?B transcription factor complex by acetylation

2003 • 277 citations

A Selective IKK-2 Inhibitor Blocks NF-κB-dependent Gene Expression in Interleukin-1β-stimulated Synovial Fibroblasts

2003 • 276 citations

HTLV-I Tax Protein Binds to MEKK1 to Stimulate IκB Kinase Activity and NF-κB Activation

1998 • 260 citations

IKKγ Serves as a Docking Subunit of the IκB Kinase (IKK) and Mediates Interaction of IKK with the Human T-cell Leukemia Virus Tax Protein

1999 • 227 citations

Transient and Selective NF-κB p65 Serine 536 Phosphorylation Induced by T Cell Costimulation Is Mediated by IκB Kinase β and Controls the Kinetics of p65 Nuclear Import

2004 • 224 citations

Role of Adapter Function in Oncoprotein-mediated Activation of NF-κB

1999 • 216 citations

Activation of Nuclear Transcription Factor NF-κB by Interleukin-1 Is Accompanied by Casein Kinase II-mediated Phosphorylation of the p65 Subunit

1997 • 208 citations

Immortalization of CD4⁺and CD8⁺T Lymphocytes by Human T-Cell Leukemia Virus Type 1 Tax Mutants Expressed in a Functional Molecular Clone

1999 • 204 citations

IKKβ and Phosphatidylinositol 3-Kinase/Akt Participate in Non-pathogenic Gram-negative Enteric Bacteria-induced RelA Phosphorylation and NF-κB Activation in Both Primary and Intestinal Epithelial Cell Lines

2002 • 167 citations

Inactivation of IκBβ by the Tax Protein of Human T-Cell Leukemia Virus Type 1: a Potential Mechanism for Constitutive Induction of NF-κB

1996 • 166 citations

Inactivation of p53 by Human T-Cell Lymphotropic Virus Type 1 Tax Requires Activation of the NF-κB Pathway and Is Dependent on p53 Phosphorylation

2000 • 136 citations

Mechanisms of T-Cell Activation by Human T-Cell Lymphotropic Virus Type I

1999 • 127 citations

Efficient Replication by Herpes Simplex Virus Type 1 Involves Activation of the IκB Kinase-IκB-p65 Pathway

2004 • 120 citations

Regulation of Gene Expression by HTLV-I Tax Protein

1998 • 120 citations

Human T-cell Lymphotropic Virus Type 1 Tax Induction of Biologically Active NF-κB Requires IκB Kinase-1-mediated Phosphorylation of RelA/p65

2004 • 107 citations

Human T-Cell Leukemia Virus Type 1 Tax Protein Abrogates Interleukin-2 Dependence in a Mouse T-Cell Line

1999 • 86 citations

Tax-Independent Constitutive IκB Kinase Activation in Adult T-Cell Leukemia Cells

2004 • 80 citations

Integration of the NfκB p65 subunit into the vitamin D receptor transcriptional complex: Identification of p65 domains that inhibit 1,25‐dihydroxyvitamin D3‐stimulated transcription

2004 • 80 citations

Tax-Independent Constitutive IκB Kinase Activation in Adult T-Cell Leukemia Cells

2004 • 70 citations

Latent Membrane Protein 1 of Epstein-Barr Virus Stimulates Processing of NF-κB2 p100 to p52

2003 • 70 citations

Arthritis in a human T lymphotropic virus type I (HTLV-I) carrier.

1990 • 64 citations

Characterization of the Recombinant IKK1/IKK2 Heterodimer

2000 • 62 citations

Constitutive phosphorylation and turnover of I kappa B alpha in human T-cell leukemia virus type I-infected and Tax-expressing T cells

1995 • 60 citations

NF-κB p65 transactivation domain is involved in the NF-κB-inducing kinase pathway

2003 • 59 citations

All-trans-Retinoic Acid Inhibits Jun N-terminal Kinase-dependent Signaling Pathways

1998 • 57 citations

Retinal vasculitis in human T-lymphotropic virus type I associated myelopathy.

1989 • 40 citations

The Human T-cell Leukemia Virus Type-1 Tax Protein Regulates the Activity of the IκB Kinase Complex

1999 • 35 citations

Analysis of p53 Inactivation in a Human T-Cell Leukemia Virus Type 1 Tax Transgenic Mouse Model

2001 • 34 citations

Activation of I-κB Kinase by the HTLV Type 1 Tax Protein: Mechanistic Insights into the Adaptor Function of IKKγ

2000 • 33 citations

Simultaneous Reconstitution of Multiple CMV-Specific CD8+ T-Cell Populations with Divergent Functionality in Hematopoietic Stem Cell Transplant Recipients.

2004 • 1 citations