Localization of human T-cell leukemia virus type 1 tax to subnuclear compartments that overlap with interchromatin speckles

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

hnRNP PROTEINS AND THE BIOGENESIS OF mRNA

1993 • 1,486 citations

The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1

1988 • 1,256 citations

Transcriptional activation: A complex puzzle with few easy pieces

1994 • 1,112 citations

Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus

1990 • 723 citations

Normal and mutant human β-globin pre-mRNAs are faithfully and efficiently spliced in vitro

1984 • 679 citations

Transformation of rat cells by DNA of human adenovirus 5

1973 • 664 citations

Visualization of focal sites of transcription within human nuclei.

1993 • 656 citations

Macromolecular Domains within the Cell Nucleus

1993 • 611 citations

Circulating CD8+ cytotoxic T lymphocytes specific for HTLV-I pX in patients with HTLV-I associated neurological disease

1990 • 603 citations

Activators and targets

1990 • 582 citations

Fluorescent labeling of nascent RNA reveals transcription by RNA polymerase II in domains scattered throughout the nucleus

1993 • 541 citations

Associations between distinct pre-mRNA splicing components and the cell nucleus.

1991 • 523 citations

The pX Protein of HTLV-I Is a Transcriptional Activator of Its Long Terminal Repeats

1985 • 514 citations

Visualization of replication factories attached to a nucleoskeleton

1993 • 472 citations

Transcription-dependent colocalization of the U1, U2, U4/U6, and U5 snRNPs in coiled bodies

1992 • 402 citations

HTLV-I Trans-Activator Protein, Tax, is a Trans-Repressor of the Human β-Polymerase Ggene

1990 • 329 citations

Ultrastructural distribution of nuclear ribonucleoproteins as visualized by immunocytochemistry on thin sections.

1984 • 306 citations

Antinuclear antibodies (ANAs): Diagnostically specific immune markers and clues toward the understanding of systemic autoimmunity

1988 • 274 citations

In vivo evidence that transcription and splicing are coordinated by a recruiting mechanism

1993 • 272 citations

Nascent pre-mRNA transcripts are associated with nuclear regions enriched in splicing factors.

1991 • 239 citations

Activation of endogenous c-fos proto-oncogene expression by human T-cell leukemia virus type I-encoded p40tax protein in the human T-cell line, Jurkat

1989 • 239 citations

Direct evidence that p40x of human T-cell leukemia virus type I is a trans-acting transcriptional activator.

1986 • 229 citations

Higher order nuclear organization: three-dimensional distribution of small nuclear ribonucleoprotein particles.

1990 • 225 citations

Characterization of cellular factors that interact with the human T-cell leukemia virus type I p40x-responsive 21-base-pair sequence

1988 • 218 citations

Identification of the gene responsible for human T-cell leukaemia virus transcriptional regulation

1985 • 215 citations

Immunoelectron microscopic localization of snRNPs

1984 • 208 citations

Interaction of the human T-cell lymphotrophic virus type I (HTLV-I) transcriptional activator Tax with cellular factors that bind specifically to the 21-base-pair repeats in the HTLV-I enhancer.

1991 • 188 citations

HTLV-1 Tax induces expression of various immediate early serum responsive genes.

1991 • 177 citations

Molecular biology of the type I human T-cell leukemia virus (HTLV-I) and adult T-cell leukemia.

1991 • 153 citations

Mutational analysis of human T-cell leukemia virus type I Tax: regions necessary for function determined with 47 mutant proteins

1992 • 135 citations

Multiple tandemly repeated binding sites for cellular nuclear factor 1 that surround the major immediate-early promoters of simian and human cytomegalovirus

1987 • 127 citations

Purification and visualization of native spliceosomes

1988 • 121 citations

Distinct regions in human T-cell lymphotropic virus type I tax mediate interactions with activator protein CREB and basal transcription factors

1995 • 119 citations

The organization of spliceosomal components in the nuclei of higher plants

1995 • 115 citations

Protein domains involved in both in vivo and in vitro interactions between human T-cell leukemia virus type I tax and CREB

1995 • 101 citations

Human T-cell leukemia virus type-1 (HTLV-1) Tax is expressed at the same level in infected cells of HTLV-1-associated myelopathy or tropical spastic paraparesis patients as in asymptomatic carriers but at a lower level in adult T-cell leukemia cells

1995 • 93 citations

The Mammalian Heat Shock (or Stress) Response: A Cellular Defense Mechanism

1987 • 91 citations

Induction of Micronuclei by HTLV-I Tax: A Cellular Assay for Function

1993 • 89 citations

Spliceosomes and Snurposomes

1991 • 85 citations

Purification and characterization of multiple nuclear factors that bind to the TAX-inducible enhancer within the human T-cell leukemia virus type 1 long terminal repeat.

1989 • 81 citations

Identification of a functional mammalian spliceosome containing unspliced pre-mRNA.

1988 • 75 citations

The amino terminus of Tax is required for interaction with the cyclic AMP response element binding protein

1995 • 74 citations

Mechanisms of tax regulation of human T cell leukemia virus type I gene expression

1995 • 70 citations

Interaction of cellular proteins with the human T-cell leukemia virus type I transcriptional control region. Purification of cellular proteins that bind the 21-base pair repeat elements.

1990 • 67 citations

Abundant synthesis of functional human T-cell leukemia virus type I p40x protein in eucaryotic cells by using a baculovirus expression vector

1987 • 66 citations

Binding of the HTLV-I Tax1 transactivator to the inducible 21 bp enhancer is mediated by the cellular factor HEB1.

1991 • 66 citations

Definition of a minimal activation domain in human T-cell leukemia virus type I Tax

1995 • 58 citations

Probing Functional Organization within the Nucleus: Is Genome Structure Integrated with RNA Metabolism?

1993 • 55 citations

Rapid effect of heat shock on two heterogeneous nuclear ribonucleoprotein-associated antigens in HeLa cells.

1989 • 55 citations

A splicing factor that is inactivated during in vivo heat shock is functionally equivalent to the [U4/U6.U5] triple snRNP-specific proteins.

1992 • 55 citations

Interaction of host cell proteins with the human T-cell leukemia virus type I transcriptional control region. II. A comprehensive map of protein-binding sites facilitates construction of a simple chimeric promoter responsive to the viral tax2 gene product.

1990 • 49 citations

The human T-cell leukemia virus (HTLV) transactivator (tax) protein

1992 • 49 citations

Regulatory Elements Involved in Tax-Mediated Transactivation of the HTLV-I LTR

1993 • 47 citations

Mechanisms of human T-cell leukemia virus-induced leukemogenesis

1992 • 45 citations

In vitro activation of transcription by the human T-cell leukemia virus type I Tax protein.

1992 • 45 citations

Purification and Characterization of Multiple Nuclear Factors That Bind to the TAX-Inducible Enhancer within the Human T-Cell Leukemia Virus Type 1 Long Terminal Repeat

1989 • 38 citations

Cellular factors involved in transcription and Tax-mediated trans-activation directed by the TGACGT motifs in human T-cell leukemia virus type I promoter

1990 • 37 citations

Inactivation of splicing factors in HeLa cells subjected to heat shock

1990 • 35 citations

DNA and RNA within the nucleus: How much sequence‐specific spatial organization?

1991 • 26 citations

In Vitro Activation of Transcription by the Human T-Cell Leukemia Virus Type I Tax Protein

1992 • 20 citations

Detection and characterization of a factor which rescues spliceosome assembly from a heat-inactivated HeLa cell nuclear extract.

1991 • 19 citations

Organization of (pre-)mRNA metabolism in the cell nucleus

1994 • 16 citations

Alteration by heat shock and immunological characterization of Drosophila small nuclear ribonucleoproteins.

1989 • 10 citations

Detection and Characterization of a Factor Which Rescues Spliceosome Assembly from a Heat-Inactivated HeLa Cell Nuclear Extract

1991 • 8 citations