Ex Vivo Culture of CD34+/Lin−/DR− Cells in Stroma-Derived Soluble Factors, Interleukin-3, and Macrophage Inflammatory Protein-1α Maintains Not Only Myeloid But Also Lymphoid Progenitors in a Novel Switch Culture Assay

Data analysis

1996 • 2,754 citations

Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis.

1981 • 1,281 citations

Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro

1989 • 699 citations

Human T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subset

1995 • 687 citations

Long-term culture of B lymphocytes and their precursors from murine bone marrow.

1982 • 612 citations

Role of interleukin-15 in the development of human CD56+ natural killer cells from CD34+ hematopoietic progenitor cells

1996 • 495 citations

STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells.

1994 • 459 citations

Molecular cloning of NKB1. A natural killer cell receptor for HLA-B allotypes.

1995 • 309 citations

Purified primitive human hematopoietic progenitor cells with long-term in vitro repopulating capacity adhere selectively to irradiated bone marrow stroma.

1990 • 275 citations

Direct contact between human primitive hematopoietic progenitors and bone marrow stroma is not required for long-term in vitro hematopoiesis

1992 • 245 citations

Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. I. Stimulatory role of a variety of mesenchymal cell activators and inhibitory role of TGF-beta

1990 • 227 citations

Direct adhesion to bone marrow stroma via fibronectin receptors inhibits hematopoietic progenitor proliferation.

1995 • 216 citations

Characterization of a human hematopoietic progenitor cell capable of forming blast cell containing colonies in vitro.

1988 • 213 citations

CD34+CD38dim cells in the human thymus can differentiate into T, natural killer, and dendritic cells but are distinct from pluripotent stem cells

1996 • 200 citations

Differentiation of natural killer (NK) cells from human primitive marrow progenitors in a stroma-based long-term culture system: identification of a CD34+7+ NK progenitor

1994 • 198 citations

Soluble factor(s) produced by human bone marrow stroma increase cytokine-induced proliferation and maturation of primitive hematopoietic progenitors while preventing their terminal differentiation

1993 • 173 citations

The generation of human natural killer cells from CD34+/DR- primitive progenitors in long-term bone marrow culture

1992 • 167 citations

Differentiation of natural killer (NK) cells from human primitive marrow progenitors in a stroma-based long-term culture system: identification of a CD34+7+ NK progenitor

1994 • 164 citations

Adhesion-dependent survival of normal and leukemic human B lymphoblasts on bone marrow stromal cells

1994 • 160 citations

Effect of flt3 ligand on the ex vivo expansion of human CD34+ hematopoietic progenitor cells

1995 • 159 citations

Human hematopoietic precursors in long-term culture: single CD34+ cells that lack detectable T cell, B cell, and myeloid cell antigens produce multiple colony-forming cells when cultured with marrow stromal cells.

1990 • 149 citations

The Efficient Design of Transplantable Tumour Assays

1963 • 147 citations

Expression of cytoplasmic CD3 epsilon proteins in activated human adult natural killer (NK) cells and CD3 gamma, delta, epsilon complexes in fetal NK cells. Implications for the relationship of NK and T lymphocytes.

1992 • 147 citations

Expression of a functional c-kit receptor on a subset of natural killer cells.

1993 • 143 citations

Stromal fibroblast heparan sulfate is required for cytokine-mediated ex vivo maintenance of human long-term culture-initiating cells

1996 • 137 citations

Macrophage inflammatory protein 1 alpha, interleukin 3 and diffusible marrow stromal factors maintain human hematopoietic stem cells for at least eight weeks in vitro.

1994 • 132 citations

Characterization and purification of a primitive hematopoietic cell type in adult mouse marrow capable of lymphomyeloid differentiation in long-term marrow "switch" cultures

1995 • 131 citations

Role of monocytes in the expansion of human activated natural killer cells

1992 • 118 citations

Role of monocytes in the expansion of human activated natural killer cells

1992 • 111 citations

Human natural killer cell committed thymocytes and their relation to the T cell lineage.

1993 • 107 citations

Lymphokine requirement for the generation of natural killer cells from CD34+ hematopoietic progenitor cells

1995 • 100 citations

Development of a bone marrow culture for maintenance and growth of normal human B cell precursors.

1991 • 97 citations

Autologous activated natural killer cells suppress primitive chronic myelogenous leukemia progenitors in long-term culture

1996 • 88 citations

Genesis of human oncolytic natural killer cells from primitive CD34+CD33- bone marrow progenitors.

1993 • 87 citations

Culture of phenotypically defined hematopoietic stem cells and other progenitors at limiting dilution on Dexter monolayers [see comments]

1991 • 72 citations

Stem cell factor production by human marrow stromal fibroblasts.

1995 • 68 citations

A novel single-cell proliferation assay shows that long-term culture- initiating cell (LTC-IC) maintenance over time results from the extensive proliferation of a small fraction of LTC-IC

1995 • 61 citations

Human natural killer cell expansion is regulated by thrombospondin- mediated activation of transforming growth factor-beta 1 and independent accessory cell-derived contact and soluble factors

1996 • 58 citations

Human natural killer cell expansion is regulated by thrombospondin- mediated activation of transforming growth factor-beta 1 and independent accessory cell-derived contact and soluble factors

1996 • 46 citations

CD34+/CD33- cells reselected from macrophage inflammatory protein 1 alpha+interleukin-3--supplemented "stroma-noncontact" cultures are highly enriched for long-term bone marrow culture initiating cells

1994 • 41 citations

Natural Killer Cell Proliferation Is Dependent on Human Serum and Markedly Increased Utilizing an Enriched Supplemented Basal Medium

1995 • 38 citations

Regulation of B cell differentiation by bone marrow stromal cells

1992 • 32 citations

In vitro biosynthesis of leukemia inhibitory factor/human interleukin for DA cells by human endothelial cells: differential regulation by interleukin-1 alpha and glucocorticoids

1995 • 31 citations

Contact-mediated maturational effects of thymic stromal cells on murine thymocytes in culture.

1989 • 20 citations

Synthesis and deposition of glycosaminoglycans in the murine hemopoietic stromal line S17: modulators of the hemopoietic microenvironment.

1992 • 16 citations

CD3 gamma, CD3 delta, and CD3 zeta mRNA in adult human marrow hematopoietic progenitors correlates with surface CD2 and CD7 expression.

1996 • 12 citations