Delivering nanomedicine to solid tumors

Angiogenesis in cancer and other diseases

2000 • 8,734 citations

Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review

2000 • 6,190 citations

Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy

2005 • 5,086 citations

Determining the Size and Shape Dependence of Gold Nanoparticle Uptake into Mammalian Cells

2006 • 4,620 citations

Tumors: Wounds That Do Not Heal

1986 • 4,202 citations

Renal clearance of quantum dots

2007 • 4,071 citations

Nanoparticle therapeutics: an emerging treatment modality for cancer

2008 • 3,976 citations

Vascular-specific growth factors and blood vessel formation

2000 • 3,667 citations

Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.

1995 • 3,139 citations

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

2009 • 2,945 citations

The effect of particle design on cellular internalization pathways

2008 • 2,739 citations

Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis

2004 • 2,655 citations

Nanoparticles in Medicine: Therapeutic Applications and Developments

2007 • 2,417 citations

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

2010 • 2,406 citations

Shape effects of filaments versus spherical particles in flow and drug delivery

2007 • 2,396 citations

Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment

1998 • 2,375 citations

Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy

2001 • 2,069 citations

Phase III Trial of Nanoparticle Albumin-Bound Paclitaxel Compared With Polyethylated Castor Oil–Based Paclitaxel in Women With Breast Cancer

2005 • 1,997 citations

Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes

1990 • 1,962 citations

Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer

2004 • 1,935 citations

Clearance Properties of Nano-Sized Particles and Molecules as Imaging Agents: Considerations and Caveats

2008 • 1,924 citations

Role of target geometry in phagocytosis

2006 • 1,919 citations

Polymer conjugates as anticancer nanomedicines

2006 • 1,894 citations

AZD2171, a Pan-VEGF Receptor Tyrosine Kinase Inhibitor, Normalizes Tumor Vasculature and Alleviates Edema in Glioblastoma Patients

2007 • 1,742 citations

Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.

1995 • 1,682 citations

Openings between Defective Endothelial Cells Explain Tumor Vessel Leakiness

2000 • 1,627 citations

Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation

1997 • 1,590 citations

Reduced cardiotoxicity and comparable efficacy in a phase IIItrial of pegylated liposomal doxorubicin HCl(CAELYX™/Doxil®) versus conventional doxorubicin forfirst-line treatment of metastatic breast cancer

2004 • 1,574 citations

The emerging nanomedicine landscape

2006 • 1,568 citations

Cremophor EL

2001 • 1,531 citations

Determinants of tumor blood flow: a review.

1988 • 1,362 citations

Transport of molecules in the tumor interstitium: a review.

1987 • 1,360 citations

Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation

2004 • 1,176 citations

Recurrent Epithelial Ovarian Carcinoma: A Randomized Phase III Study of Pegylated Liposomal Doxorubicin Versus Topotecan

2001 • 1,175 citations

Vascular Normalization by Vascular Endothelial Growth Factor Receptor 2 Blockade Induces a Pressure Gradient Across the Vasculature and Improves Drug Penetration in Tumors

2004 • 1,160 citations

Mechanics of receptor-mediated endocytosis

2005 • 1,158 citations

Hypersensitivity reactions from taxol.

1990 • 1,153 citations

Role of extracellular matrix assembly in interstitial transport in solid tumors.

2000 • 1,126 citations

Barriers to Drug Delivery in Solid Tumors

1994 • 1,064 citations

Tissue-Penetrating Delivery of Compounds and Nanoparticles into Tumors

2009 • 1,029 citations

Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers

2006 • 1,025 citations

Coadministration of a Tumor-Penetrating Peptide Enhances the Efficacy of Cancer Drugs

2010 • 995 citations

Lymphatic Metastasis in the Absence of Functional Intratumor Lymphatics

2002 • 939 citations

Magnetofection: enhancing and targeting gene delivery by magnetic force in vitro and in vivo

2002 • 915 citations

Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft.

1994 • 904 citations

Surface modification of nanoparticles to oppose uptake by the mononuclear phagocyte system

1995 • 869 citations

Transport of molecules across tumor vasculature

1987 • 856 citations

Tumor Regression by Targeted Gene Delivery to the Neovasculature

2002 • 848 citations

Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection

1989 • 836 citations

Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation

2003 • 820 citations

Particle size and surface charge affect particle uptake by human dendritic cells in an in vitro model

2005 • 806 citations

Targeting of drugs and nanoparticles to tumors

2010 • 802 citations

Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

2009 • 783 citations

Cancer cells compress intratumour vessels

2004 • 781 citations

Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction

1996 • 772 citations

Delivery of molecular and cellular medicine to solid tumors

2012 • 766 citations

Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy.

1990 • 742 citations

Targeted pharmaceutical nanocarriers for cancer therapy and imaging

2007 • 739 citations

Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody

1996 • 718 citations

Design considerations for tumour-targeted nanoparticles

2009 • 712 citations

Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure.

1988 • 703 citations

Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging

2009 • 702 citations

Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions.

2000 • 676 citations

Pegylated-liposomal doxorubicin versus doxorubicin, bleomycin, and vincristine in the treatment of AIDS-related Kaposi's sarcoma: results of a randomized phase III clinical trial.

1998 • 625 citations

Herceptin acts as an anti-angiogenic cocktail

2002 • 608 citations

Microvascular permeability of normal and neoplastic tissues

1986 • 601 citations

Effect of Vascular Normalization by Antiangiogenic Therapy on Interstitial Hypertension, Peritumor Edema, and Lymphatic Metastasis: Insights from a Mathematical Model

2007 • 582 citations

Intravascular Delivery of Particulate Systems: Does Geometry Really Matter?

2008 • 576 citations

Role of tumor–host interactions in interstitial diffusion of macromolecules: Cranial vs. subcutaneous tumors

2001 • 576 citations

Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases

2010 • 552 citations

Fractals and cancer.

2000 • 549 citations

Diffusion of Macromolecules in Agarose Gels: Comparison of Linear and Globular Configurations

1999 • 549 citations

Diffusion and Convection in Collagen Gels: Implications for Transport in the Tumor Interstitium

2002 • 519 citations

Delivery of molecular and cellular medicine to solid tumors1PII of original article: S0169-409X(97)00027-6. The article was originally published in Advanced Drug Delivery Reviews 26 (1997) 71–90.1

2001 • 509 citations

Microvascular architecture in a mammary carcinoma: branching patterns and vessel dimensions.

1991 • 505 citations

Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse.

1992 • 501 citations

Multicenter phase II trial of Genexol-PM, a Cremophor-free, polymeric micelle formulation of paclitaxel, in patients with metastatic breast cancer

2007 • 500 citations

Absence of functional lymphatics within a murine sarcoma: a molecular and functional evaluation.

2000 • 466 citations

Surgery with molecular fluorescence imaging using activatable cell-penetrating peptides decreases residual cancer and improves survival

2010 • 465 citations

Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows.

1994 • 463 citations

Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis

2008 • 442 citations

Neovasculature induced by vascular endothelial growth factor is fenestrated.

1997 • 441 citations

Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo

2005 • 433 citations

Randomized phase III trial of liposomal daunorubicin versus doxorubicin, bleomycin, and vincristine in AIDS-related Kaposi's sarcoma.

1996 • 431 citations

Cationic liposomes target angiogenic endothelial cells in tumors and chronic inflammation in mice.

1998 • 425 citations

Lipid‐based nanotherapeutics for siRNA delivery

2009 • 414 citations

Stealth® PEGylated polycyanoacrylate nanoparticles for intravenous administration and splenic targeting

1999 • 388 citations

Diffusion of Particles in the Extracellular Matrix: The Effect of Repulsive Electrostatic Interactions

2010 • 382 citations

Degradation of Fibrillar Collagen in a Human Melanoma Xenograft Improves the Efficacy of an Oncolytic Herpes Simplex Virus Vector

2006 • 377 citations

Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors.

2002 • 369 citations

Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice.

1992 • 368 citations

Transport of fluid and macromolecules in tumors

1991 • 362 citations

A Near‐Infrared‐Fluorescence‐Quenched Gold‐Nanoparticle Imaging Probe for In Vivo Drug Screening and Protease Activity Determination

2008 • 346 citations

Transport of fluid and macromolecules in tumors. II. Role of heterogeneous perfusion and lymphatics

1990 • 345 citations

Imaging Steps of Lymphatic Metastasis Reveals That Vascular Endothelial Growth Factor-C Increases Metastasis by Increasing Delivery of Cancer Cells to Lymph Nodes: Therapeutic Implications

2006 • 345 citations

Does a targeting ligand influence nanoparticle tumor localization or uptake?

2008 • 341 citations

Taxane-induced apoptosis decompresses blood vessels and lowers interstitial fluid pressure in solid tumors: clinical implications.

1999 • 339 citations

Effect of antivascular endothelial growth factor treatment on the intratumoral uptake of CPT-11

2003 • 325 citations

Sustained Small Interfering RNA Delivery by Mesoporous Silicon Particles

2010 • 314 citations

Effect of the surface charge of liposomes on their uptake by angiogenic tumor vessels

2003 • 301 citations

Extravascular diffusion in normal and neoplastic tissues.

1984 • 294 citations

Selective Filtering of Particles by the Extracellular Matrix: An Electrostatic Bandpass

2009 • 285 citations

Solid stress generated by spheroid growth estimated using a linear poroelasticity model☆

2003 • 281 citations

Role of Tumor Vascular Architecture in Nutrient and Drug Delivery: An Invasion Percolation-Based Network Model

1996 • 271 citations

Interstitial hypertension in human breast and colorectal tumors.

1992 • 251 citations

Targeting of albumin-embedded paclitaxel nanoparticles to tumors

2008 • 230 citations

True

2000 • 222 citations

Scale-Invariant Behavior and Vascular Network Formation in Normal and Tumor Tissue

1995 • 222 citations

In VivoElectroporation for Gene Therapy

2006 • 221 citations

Interstitial hypertension in superficial metastatic melanomas in humans.

1991 • 217 citations

Effect of host microenvironment on the microcirculation of human colon adenocarcinoma.

1997 • 214 citations

Therapeutic Nanoparticles to Combat Cancer Drug Resistance

2009 • 212 citations

Simultaneous measurement of RBC velocity, flux, hematocrit and shear rate in vascular networks

2010 • 205 citations

N-isopropylacrylamide copolymers for the preparation of pH-sensitive liposomes and polymeric micelles

2001 • 197 citations

Neovascular targeting therapy: paclitaxel encapsulated in cationic liposomes improves antitumoral efficacy.

2003 • 193 citations

Mesoporous Silica Nanoparticles for Cancer Therapy: Energy-Dependent Cellular Uptake and Delivery of Paclitaxel to Cancer Cells

2007 • 187 citations

InAs(ZnCdS) Quantum Dots Optimized for Biological Imaging in the Near-Infrared

2009 • 182 citations

Effect of Transvascular Fluid Exchange on Pressure–Flow Relationship in Tumors: A Proposed Mechanism for Tumor Blood Flow Heterogeneity

1996 • 179 citations

Geometric resistance to blood flow in solid tumors perfused ex vivo: effects of tumor size and perfusion pressure.

1989 • 173 citations

Heparan Sulfate Mediates bFGF Transport through Basement Membrane by Diffusion with Rapid Reversible Binding

1999 • 173 citations

Two-photon fluorescence correlation microscopy reveals the two-phase nature of transport in tumors

2004 • 172 citations

Diffusion Anisotropy in Collagen Gels and Tumors: The Effect of Fiber Network Orientation

2010 • 160 citations

Role of host microenvironment in angiogenesis and microvascular functions in human breast cancer xenografts: mammary fat pad versus cranial tumors.

2002 • 158 citations

Tissue Perfusion Inhomogeneity During Early Tumor Growth in Rats<xref ref-type="fn" rid="fn2">2</xref>

1979 • 152 citations

Transmural Coupling of Fluid Flow in Microcirculatory Network and Interstitium in Tumors

1997 • 144 citations

Proteolytic Actuation of Nanoparticle Self‐Assembly

2006 • 142 citations

Matrix Metalloproteinases-1 and -8 Improve the Distribution and Efficacy of an Oncolytic Virus

2007 • 140 citations

Transport of fluid and macromolecules in tumors. IV. A microscopic model of the perivascular distribution

1991 • 139 citations

Viscous resistance to blood flow in solid tumors: effect of hematocrit on intratumor blood viscosity.

1989 • 137 citations

Enhanced macromolecule diffusion deep in tumors after enzymatic digestion of extracellular matrix collagen and its associated proteoglycan decorin

2007 • 137 citations

Programmed drug delivery: nanosystems for tumor targeting

2007 • 133 citations

Onset of Abnormal Blood and Lymphatic Vessel Function and Interstitial Hypertension in Early Stages of Carcinogenesis

2006 • 132 citations

In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts

2009 • 130 citations

Highly efficient electro-gene therapy of solid tumor by using an expression plasmid for the herpes simplex virus thymidine kinase gene

2000 • 130 citations

In vivo diffusion of lactoferrin in brain extracellular space is regulated by interactions with heparan sulfate

2008 • 127 citations

Taming Vessels to Treat Cancer

2008 • 120 citations

Local Release of Highly Loaded Antibodies from Functionalized Nanoporous Support for Cancer Immunotherapy

2010 • 112 citations

Geometric Resistance and Microvascular Network Architecture of Human Colorectal Carcinoma

1997 • 108 citations

Copolymers of N‐isopropylacrylamide can trigger pH sensitivity to stable liposomes

1998 • 105 citations

Self-Assembled Gold Nanoparticle Molecular Probes for Detecting Proteolytic Activity In Vivo

2010 • 103 citations

Intraperitoneal Immunotherapy for Metastatic Ovarian Carcinoma: Resistance of Intratumoral Collagen to Antibody Penetration

2006 • 100 citations

Temperature Dependent Gene Expression Induced by PNIPAM-Based Copolymers: Potential of Hyperthermia in Gene Transfer

2006 • 97 citations

Available volume fraction of macromolecules in the extravascular space of a fibrosarcoma: implications for drug delivery.

1999 • 97 citations

Ultrasound Facilitates Transduction of Naked Plasmid DNA into Colon Carcinoma Cells in Vitro and in Vivo

2000 • 88 citations

Mathematical Modeling of Herpes Simplex Virus Distribution in Solid Tumors: Implications for Cancer Gene Therapy

2009 • 80 citations

Measurement of capillary filtration coefficient in a solid tumor.

1991 • 80 citations

Multiscale Measurements Distinguish Cellular and Interstitial Hindrances to Diffusion In Vivo

2009 • 73 citations

A New Target for Tumor Therapy

2009 • 69 citations

Blood flow and venous pH of tissue-isolated Walker 256 carcinoma during hyperglycemia.

1988 • 67 citations

Perfusion of Single Tumor Microvessels: Application to Vascular Permeability Measurement

1996 • 66 citations

pH-responsive shielding of non-viral gene vectors

2006 • 65 citations

Targeting Cancer with ‘Smart Bombs‘: Equipping Plant Virus Nanoparticles for A ‘Seek and Destroy’ Mission

2009 • 59 citations

Photochemically Enhanced Gene Delivery of EGF Receptor-targeted DNA Polyplexes

2004 • 59 citations

Environment-Responsive Multifunctional Liposomes

2009 • 52 citations

Non-Uniform Plasma Leakage Affects Local Hematocrit and Blood Flow: Implications for Inflammation and Tumor Perfusion

2007 • 45 citations

Cost-Effectiveness of Genexol-PM for Treating Metastatic Breast Cancer

2010 • 14 citations

Simultaneous measurement of RBC velocity, flux, hematocrit and shear rate in vascular networks in vivo

2010 • 6 citations