Multiscale Measurements Distinguish Cellular and Interstitial Hindrances to Diffusion In Vivo

Drug penetration in solid tumours

2006 • 2,562 citations

Role of extracellular matrix assembly in interstitial transport in solid tumors.

2000 • 1,126 citations

Barriers to Drug Delivery in Solid Tumors

1994 • 1,064 citations

Cancer cells compress intratumour vessels

2004 • 781 citations

Biological and Chemical Applications of Fluorescence Correlation Spectroscopy: A Review

2001 • 636 citations

Diffusion and Convection in Collagen Gels: Implications for Transport in the Tumor Interstitium

2002 • 519 citations

Two-photon fluorescence correlation spectroscopy: method and application to the intracellular environment

1995 • 482 citations

Degradation of Fibrillar Collagen in a Human Melanoma Xenograft Improves the Efficacy of an Oncolytic Herpes Simplex Virus Vector

2006 • 377 citations

Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice.

1992 • 368 citations

Extravascular diffusion in normal and neoplastic tissues.

1984 • 294 citations

Physiological contribution of the astrocytic environment of neurons to intersynaptic crosstalk

2004 • 250 citations

Diffusion in a pore of varying cross section

1958 • 237 citations

The transport barrier in intraperitoneal therapy

2005 • 228 citations

Measurements of dog blood-brain transfer constants by ventriculocisternal perfusion

1975 • 207 citations

Measurement of Molecular Diffusion in Solution by Multiphoton Fluorescence Photobleaching Recovery

1999 • 207 citations

Fluorescence photobleaching with spatial Fourier analysis: measurement of diffusion in light-scattering media

1993 • 190 citations

Geometric and viscous components of the tortuosity of the extracellular space in the brain

1998 • 178 citations

Hindrance of solute diffusion within membranes as measured with microporous membranes of known pore geometry

1972 • 175 citations

Two-photon fluorescence correlation microscopy reveals the two-phase nature of transport in tumors

2004 • 172 citations

Increased collagen content in insulin-resistant skeletal muscle

2005 • 143 citations

A New FRAP/FRAPa Method for Three-Dimensional Diffusion Measurements Based on Multiphoton Excitation Microscopy

2008 • 67 citations

Diffusivities of macromolecules in composite hydrogels

2004 • 66 citations

Permeability of Interstitial Space of Muscle (Rat Diaphragm) to Solutes of Different Molecular Weights

1978 • 39 citations

Extracellular Space Diffusion in Central Nervous System: Anisotropic Diffusion Measured by Elliptical Surface Photobleaching

2005 • 38 citations

Three-Dimensional Modeling of the Brain's ECS by Minimum Configurational Energy Packing of Fluid Vesicles

2007 • 16 citations