Programmed drug delivery: nanosystems for tumor targeting

Drug Delivery Systems: Entering the Mainstream

2004 • 4,336 citations

The dawning era of polymer therapeutics

2003 • 3,190 citations

The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting

2001 • 2,374 citations

Colloidosomes: Selectively Permeable Capsules Composed of Colloidal Particles

2002 • 1,986 citations

Drug delivery strategy utilizing conjugation via reversible disulfide linkages: role and site of cellular reducing activities

2003 • 1,341 citations

Gene transfer into muscle by electroporation in vivo

1998 • 943 citations

Magnetofection: enhancing and targeting gene delivery by magnetic force in vitro and in vivo

2002 • 915 citations

The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems.

1994 • 668 citations

Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene-transfer vehicle.

1992 • 657 citations

Electrochemotherapy: results of cancer treatment using enhanced delivery of bleomycin by electroporation

2003 • 534 citations

Polymer hollow particles with controllable holes in their surfaces

2005 • 531 citations

Efficacy of liposomes and hyperthermia in a human tumor xenograft model: importance of triggered drug release.

2000 • 497 citations

Optical tracking of organically modified silica nanoparticles as DNA carriers: A nonviral, nanomedicine approach for gene delivery

2005 • 453 citations

Chemical Approaches to Triggerable Lipid Vesicles for Drug and Gene Delivery

2003 • 449 citations

Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid

2006 • 388 citations

Electropermeabilization of skeletal muscle enhances gene transfer in vivo

1999 • 383 citations

Toward Synthetic Viruses: Endosomal pH-Triggered Deshielding of Targeted Polyplexes Greatly Enhances Gene Transfer in vitro and in vivo

2004 • 319 citations

Polyethylenimine with acid-labile linkages as a biodegradable gene carrier

2004 • 317 citations

Novel Shielded Transferrin−Polyethylene Glycol−Polyethylenimine/DNA Complexes for Systemic Tumor-Targeted Gene Transfer

2002 • 308 citations

Acetals as pH-Sensitive Linkages for Drug Delivery

2004 • 300 citations

Therapeutic applications of microbubbles

2002 • 286 citations

A versatile reducible polycation-based system for efficient delivery of a broad range of nucleic acids

2005 • 280 citations

Insights into the mechanism of magnetofection using PEI‐based magnetofectins for gene transfer

2004 • 279 citations

Magnetic Colloidosomes Derived from Nanoparticle Interfacial Self-Assembly

2005 • 271 citations

Thermosensitive liposomes: Extravasation and release of contents in tumor microvascular networks

1996 • 268 citations

Pros and Cons of the Liposome Platform in Cancer Drug Targeting

2006 • 259 citations

Novel Temperature-Sensitive Liposomes with Prolonged Circulation Time

2004 • 251 citations

IL-12 Plasmid Delivery by in Vivo Electroporation for the Successful Treatment of Established Subcutaneous B16.F10 Melanoma

2002 • 243 citations

Strategies to Improve DNA Polyplexes for in Vivo Gene Transfer: Will “Artificial Viruses” Be the Answer?

2004 • 241 citations

Bioinspired pH-Responsive Polymers for the Intracellular Delivery of Biomolecular Drugs

2003 • 228 citations

Design and synthesis of pH-responsive polymeric carriers that target uptake and enhance the intracellular delivery of oligonucleotides

2003 • 222 citations

In VivoElectroporation for Gene Therapy

2006 • 221 citations

Photochemical internalisation in drug and gene delivery

2003 • 217 citations

Gene Transfer with Echo-enhanced Contrast Agents: Comparison between Albunex, Optison, and Levovist in Mice—Initial Results

2003 • 213 citations

Acid-triggered release via dePEGylation of DOPE liposomes containing acid-labile vinyl ether PEG–lipids

2003 • 203 citations

Gene silencing through RNA interference (RNAi) in vivo: Strategies based on the direct application of siRNAs

2006 • 201 citations

Stabilized plasmid–lipid particles containing PEG-diacylglycerols exhibit extended circulation lifetimes and tumor selective gene expression

2005 • 192 citations

Multifunctional cargo systems for biotechnology

2007 • 189 citations

In vitro and in vivo transfection of plasmid DNA in the Dunning prostate tumor R3327-AT1 is enhanced by focused ultrasound

2000 • 182 citations

Targeting of stealth liposomes to erbB-2 (Her/2) receptor: in vitro and in vivo studies

1996 • 179 citations

Evaluation in vitro of adriamycin immunoconjugates synthesized using an acid-sensitive hydrazone linker.

1990 • 178 citations

Endosomolysis by Masking of a Membrane-Active Agent (EMMA) for Cytoplasmic Release of Macromolecules

2002 • 159 citations

Direct measurement of the extravasation of polyethyleneglycol-coated liposomes into solid tumor tissue by in vivo fluorescence microscopy

1996 • 157 citations

Dna-loaded albumin microbubbles enhance ultrasound-mediated transfection in vitro

2002 • 154 citations

Vectors based on reducible polycations facilitate intracellular release of nucleic acids

2003 • 148 citations

pH-sensitive PEG lipids containing orthoester linkers: new potential tools for nonviral gene delivery

2004 • 146 citations

Polyacetal−Doxorubicin Conjugates Designed for pH-Dependent Degradation

2003 • 144 citations

pH-Responsive Oligodeoxynucleotide (ODN)−Poly(Ethylene Glycol) Conjugate through Acid-Labile β-Thiopropionate Linkage: Preparation and Polyion Complex Micelle Formation

2003 • 142 citations

Low‐pH‐sensitive poly(ethylene glycol) (PEG)‐stabilized plasmid nanolipoparticles: effects of PEG chain length, lipid composition and assembly conditions on gene delivery

2004 • 140 citations

Ultrasound enhancement of cationic lipid-mediated gene transfer to primary tumors following systemic administration

2000 • 140 citations

Highly efficient electro-gene therapy of solid tumor by using an expression plasmid for the herpes simplex virus thymidine kinase gene

2000 • 130 citations

Site-Specific Drug Delivery by Photochemical Internalization Enhances the Antitumor Effect of Bleomycin

2005 • 129 citations

Chemodosimetry of in vivo tumor liposomal drug concentration using MRI

2006 • 128 citations

Enhanced delivery of naked DNA to the skin by non-invasive in vivo electroporation

2002 • 118 citations

Polymer-coated polyethylenimine/DNA complexes designed for triggered activation by intracellular reduction

2004 • 117 citations

Evaluation of Gas-filled Microparticles and Sonoporation as Gene Delivery System: Feasibility Study in Rodent Tumor Models

2005 • 109 citations

Smart Polyion Complex Micelles for Targeted Intracellular Delivery of PEGylated Antisense Oligonucleotides Containing Acid‐Labile Linkages

2005 • 108 citations

EGF Receptor-Targeted Synthetic Double-Stranded RNA Eliminates Glioblastoma, Breast Cancer, and Adenocarcinoma Tumors in Mice

2005 • 103 citations

Electrically mediated plasmid DNA delivery to hepatocellular carcinomas in vivo

2000 • 102 citations

Temperature Dependent Gene Expression Induced by PNIPAM-Based Copolymers: Potential of Hyperthermia in Gene Transfer

2006 • 97 citations

Using magnetic forces to enhance non-viral gene transfer to airway epithelium in vivo

2006 • 91 citations

Ultrasound Facilitates Transduction of Naked Plasmid DNA into Colon Carcinoma Cells in Vitro and in Vivo

2000 • 88 citations

Successful application of targeted electrochemotherapy using novel flexible electrodes and low dose bleomycin to solid tumours

2005 • 83 citations

Gene Transfer with Poly-Melittin Peptides

2006 • 81 citations

Photochemical Internalisation: A Novel Drug Delivery System

2002 • 81 citations

Low-dose tumor necrosis factor-α augments antitumor activity of stealth liposomal doxorubicin (DOXIL®) in soft tissue sarcoma-bearing rats

2000 • 81 citations

Enhanced cytosolic delivery of plasmid DNA by a sulfhydryl-activatable listeriolysin O/protamine conjugate utilizing cellular reducing potential

2003 • 77 citations

Role of endosomes in gene transfection mediated by photochemical internalisation (PCI)

2000 • 76 citations

A doxorubicin–CNGRC-peptide conjugate with prodrug properties

2002 • 76 citations

Optimizing targeted gene delivery: Chemical modification of viral vectors and synthesis of artificial virus vector systems

2006 • 75 citations

Recent Developments in the Application of Plasmid DNA-Based Vectors and Small Interfering RNA Therapeutics for Cancer

2006 • 68 citations

pH-responsive shielding of non-viral gene vectors

2006 • 65 citations

Eradication of p53-Mutated Head and Neck Squamous Cell Carcinoma Xenografts Using Nonviral p53 Gene Therapy and Photochemical Internalization

2006 • 63 citations

Novel Cationic Lipids Incorporating an Acid-Sensitive Acylhydrazone Linker: Synthesis and Transfection Properties

2004 • 60 citations

Photochemically Enhanced Gene Delivery of EGF Receptor-targeted DNA Polyplexes

2004 • 59 citations

Pharmaceutical evaluation of gas-filled microparticles as gene delivery system.

2002 • 56 citations

Targeting Vaccinia to Solid Tumors with Local Hyperthermia

2005 • 42 citations

Stimuli-responsive gene delivery vectors.

2003 • 26 citations

PCI-enhanced adenoviral transduction employs the known uptake mechanism of adenoviral particles

2005 • 24 citations

Light Directed Gene Transfer by Photochemical Internalisation

2003 • 24 citations

Prinzip, Technik und Indikation der Hyperthermie und Teilk�rperhyperthermie

2004 • 19 citations