Mathematical Modeling of Herpes Simplex Virus Distribution in Solid Tumors: Implications for Cancer Gene Therapy

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Delivery of molecular and cellular medicine to solid tumors

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Diffusion and Convection in Collagen Gels: Implications for Transport in the Tumor Interstitium

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Herpesviruses and heparan sulfate: an intimate relationship in aid of viral entry

2001 • 501 citations

Phase II Trial of Intratumoral Administration of ONYX-015, a Replication-Selective Adenovirus, in Patients With Refractory Head and Neck Cancer

2001 • 467 citations

Clinical trial results with oncolytic virotherapy: a century of promise, a decade of progress

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Herpesviruses and heparan sulfate: an intimate relationship in aid of viral entry

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The next frontier of molecular medicine: Delivery of therapeutics

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Direct measurement of interstitial convection and diffusion of albumin in normal and neoplastic tissues by fluorescence photobleaching.

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Degradation of Fibrillar Collagen in a Human Melanoma Xenograft Improves the Efficacy of an Oncolytic Herpes Simplex Virus Vector

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Transport of fluid and macromolecules in tumors

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Taxane-induced apoptosis decompresses blood vessels and lowers interstitial fluid pressure in solid tumors: clinical implications.

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Glycoprotein C-independent binding of herpes simplex virus to cells requires cell surface heparan sulphate and glycoprotein B

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Herpes simplex virus glycoproteins E and I facilitate cell-to-cell spread in vivo and across junctions of cultured cells

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Heparan Sulfate Proteoglycan Binding by Herpes Simplex Virus Type 1 Glycoproteins B and C, Which Differ in Their Contributions to Virus Attachment, Penetration, and Cell-to-Cell Spread

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Direct comparison of binding equilibrium, thermodynamic, and rate constants determined by surface‐ and solution‐based biophysical methods

2002 • 261 citations

Validation and analysis of a mathematical model of a replication-competent oncolytic virus for cancer treatment: implications for virus design and delivery.

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Viruses as antitumor weapons: defining conditions for tumor remission.

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Linker-insertion nonsense and restriction-site deletion mutations of the gB glycoprotein gene of herpes simplex virus type 1

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Hindered transport of spherical macromolecules in fibrous membranes and gels

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Matrix Metalloproteinases-1 and -8 Improve the Distribution and Efficacy of an Oncolytic Virus

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Intratumoral Spread of Wild-Type Adenovirus Is Limited After Local Injection of Human Xenograft Tumors: Virus Persists and Spreads Systemically at Late Time Points

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Examination of the Kinetics of Herpes Simplex Virus Glycoprotein D Binding to the Herpesvirus Entry Mediator, Using Surface Plasmon Resonance

1998 • 108 citations

Thermodynamic analysis of protein interactions with biosensor technology

1998 • 108 citations

Intratumoral infusion of fluid: estimation of hydraulic conductivity and implications for the delivery of therapeutic agents

1998 • 106 citations

Cancer Cell Death Enhances the Penetration and Efficacy of Oncolytic Herpes Simplex Virus in Tumors

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Quantitative Spatiotemporal Analysis of Antibody Fragment Diffusion and Endocytic Consumption in Tumor Spheroids

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Accessibility of circulating immunoglobulin G to the extravascular compartment of solid rat tumors.

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Available volume fraction of macromolecules in the extravascular space of a fibrosarcoma: implications for drug delivery.

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Kinetic Analysis of Glycoprotein C of Herpes Simplex Virus Types 1 and 2 Binding to Heparin, Heparan Sulfate, and Complement Component C3b

2002 • 80 citations

Systemic dissemination of viral vectors during intratumoral injection.

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Replicative Oncolytic Herpes Simplex Viruses in Combination Cancer Therapies

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The competitive dynamics between tumor cells, a replication-competent virus and an immune response

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Widespread intratumoral virus distribution with fractionated injection enables local control of large human rhabdomyosarcoma xenografts by oncolytic herpes simplex viruses

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Rotation of a sphere in Brinkman fluids

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THE EXTRACELLULAR SPACE IN BRAIN TUMOURS

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Identification and Minimization of Nonideal Binding Effects in BIAcore Analysis: Ferritin/Anti-ferritin Fab′ Interaction as a Model System

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A Thermodynamic Characterization of the Binding of Thrombin Inhibitors to Human Thrombin, Combining Biosensor Technology, Stopped-Flow Spectrophotometry, and Microcalorimetry

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THE EXTRACELLULAR SPACE IN BRAIN TUMOURS

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Prerequisites for effective adenovirus mediated gene therapy of colorectal liver metastases in the rat using an intracellular neutralizing antibody fragment to p21-Ras

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