Vascular Normalization by Vascular Endothelial Growth Factor Receptor 2 Blockade Induces a Pressure Gradient Across the Vasculature and Improves Drug Penetration in Tumors

Molecular regulation of vessel maturation

2003 • 2,446 citations

Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment

1998 • 2,375 citations

Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy

2001 • 2,069 citations

Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer

2004 • 1,935 citations

Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer.

2000 • 1,536 citations

Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal

1999 • 1,248 citations

Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity

2000 • 1,159 citations

Abnormalities in Pericytes on Blood Vessels and Endothelial Sprouts in Tumors

2002 • 955 citations

Lymphatic Metastasis in the Absence of Functional Intratumor Lymphatics

2002 • 939 citations

Interstitial-lymphatic mechanisms in the control of extracellular fluid volume

1993 • 902 citations

Transport of molecules across tumor vasculature

1987 • 856 citations

Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody

1996 • 718 citations

Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions.

2000 • 676 citations

In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy

2001 • 603 citations

Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse.

1992 • 501 citations

Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors

2003 • 481 citations

Absence of functional lymphatics within a murine sarcoma: a molecular and functional evaluation.

2000 • 466 citations

Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors

2003 • 436 citations

Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice.

1992 • 368 citations

Effect of antivascular endothelial growth factor treatment on the intratumoral uptake of CPT-11

2003 • 325 citations

Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts.

2001 • 300 citations

Oncotic pressure in solid tumors is elevated.

2000 • 293 citations

Interstitial hypertension in superficial metastatic melanomas in humans.

1991 • 217 citations

Enhancement of fluid filtration across tumor vessels: Implication for delivery of macromolecules

1999 • 195 citations

Blockade of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling for therapy of metastatic human pancreatic cancer.

2002 • 189 citations

Effect of Transvascular Fluid Exchange on Pressure–Flow Relationship in Tumors: A Proposed Mechanism for Tumor Blood Flow Heterogeneity

1996 • 179 citations

Transmural Coupling of Fluid Flow in Microcirculatory Network and Interstitium in Tumors

1997 • 144 citations

A systems approach to cancer therapy

1996 • 123 citations

Antiangiogenesis drug promising for metastatic colorectal cancer

2003 • 95 citations

Radioimmunotherapy of Cancer

2000 • 63 citations

INTERSTITIAL HYPERTENSION IN HUMAN PRIMARY AND METASTATIC TUMORS

1991 • 20 citations