The Role of Apoptosis in the Normal Aging Brain, Skeletal Muscle, and Heart

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Mitochondria and Apoptosis

1998 • 8,909 citations

The biochemistry of apoptosis

2000 • 7,314 citations

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

BCL-2 family members and the mitochondria in apoptosis

1999 • 3,657 citations

Post-embryonic cell lineages of the nematode, Caenorhabditis elegans

1977 • 3,432 citations

Mitochondrial free radical generation, oxidative stress, and aging11This article is dedicated to the memory of our dear friend, colleague, and mentor Lars Ernster (1920–1998), in gratitude for all he gave to us.

2000 • 2,864 citations

A model for p53-induced apoptosis

1997 • 2,502 citations

The mitochondrial permeability transition

1995 • 2,412 citations

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

1999 • 2,157 citations

Shrinkage necrosis: A distinct mode of cellular death

1971 • 1,448 citations

Life and Death of Neurons in the Aging Brain

1997 • 1,323 citations

Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats.

1996 • 1,045 citations

The Free Radical Theory of Aging

2003 • 902 citations

Free radical theory of aging

1992 • 876 citations

Mitochondria as regulators of apoptosis: doubt no more

1998 • 838 citations

Mitochondrio‐nuclear translocation of AIF in apoptosis and necrosis

2000 • 778 citations

The central executioners of apoptosis: caspases or mitochondria?

1998 • 772 citations

Apoptosis and disease

1993 • 684 citations

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

2000 • 625 citations

Production of Nitric Oxide by Mitochondria

1998 • 573 citations

Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals

2000 • 536 citations

Modulation of the Mitochondrial Permeability Transition Pore by Pyridine Nucleotides and Dithiol Oxidation at Two Separate Sites

1996 • 522 citations

Glycoxidation and lipoxidation in atherogenesis

2000 • 512 citations

Inhibitory Effects of Antioxidants on Neonatal Rat Cardiac Myocyte Hypertrophy Induced by Tumor Necrosis Factor-α and Angiotensin II

1998 • 509 citations

The permeability transition pore as a mitochondrial calcium release channel: A critical appraisal

1996 • 466 citations

Oxidative Stress and Antioxidants in Exercise

2001 • 425 citations

Intracellular unesterified arachidonic acid signals apoptosis

2000 • 423 citations

Myocyte cell loss and myocyte cellular hyperplasia in the hypertrophied aging rat heart.

1990 • 389 citations

Mitochondrial Oxidative Stress Plays a Key Role in Aging and Apoptosis

2000 • 382 citations

Apoptosis in skeletal muscle with aging

2002 • 382 citations

Peroxynitrite-induced Apoptosis in HL-60 Cells

1995 • 300 citations

Aging and exercise training in skeletal muscle: responses of glutathione and antioxidant enzyme systems

1994 • 294 citations

Necrotic and apoptotic myocyte cell death in the aging heart of Fischer 344 rats

1996 • 275 citations

Myocyte cell loss and myocyte hypertrophy in the aging rat heart

1986 • 241 citations

Cell Suicide in Health and Disease

1996 • 226 citations

Mitochondrial Aging: Open Questions^a

1998 • 210 citations

Apoptosis in the aging process

2000 • 204 citations

Endogenous oxidative damage of mtDNA

1999 • 199 citations

Apoptosis and exercise

2001 • 192 citations

Protein oxidation and age-dependent alterations in calcium homeostasis

2000 • 179 citations

Mass spectrometric identification of proteins released from mitochondria undergoing permeability transition

2000 • 177 citations

Cytochromecrelease from mitochondria in the aging heart: a possible mechanism for apoptosis with age

2002 • 175 citations

Oxidative stress and aging in the Mongolian gerbil (Meriones unguiculatus)

1995 • 170 citations

Inducible NO synthase: role in cellular signalling

1999 • 166 citations

Bax- and Bak-induced cell death in the fission yeast Schizosaccharomyces pombe.

1997 • 160 citations

Apoptosis in dopaminergic neurons of the human substantia nigra during normal aging.

1997 • 149 citations

Neurotoxicity of methylglyoxal and 3-deoxyglucosone on cultured cortical neurons: Synergism between glycation and oxidative stress, possibly involved in neurodegenerative diseases

1999 • 146 citations

Understanding IAP function and regulation: a view from Drosophila

2000 • 146 citations

AGE DEPENDENT APOPTOSIS AND LOSS OF RHABDOSPHINCTER CELLS

2000 • 146 citations

Mitochondrial Production of Hydrogen Peroxide Regulation by Nitric Oxide and the Role of Ubisemiquinone

2000 • 145 citations

Regulation of Mitochondrial Respiration by Oxygen and Nitric Oxide

2000 • 145 citations

Aging Enhances the Activation of the Permeability Transition Pore in Mitochondria

2000 • 127 citations

Regional Expression and Role of Cyclooxygenase-2 Following Experimental Traumatic Brain Injury

2000 • 125 citations

Relationship between Antioxidants, Prooxidants, and the Aging Processa

1992 • 124 citations

What Does Cell Death Have To Do with Aging?

1997 • 122 citations

Free radical theory of aging: History

1992 • 102 citations

Intracellular Calcium, DNase Activity and Myocyte Apoptosis in Aging Fischer 344 Rats

1998 • 96 citations

Aging mechanisms

2000 • 84 citations

Aging and Regulation of Apoptosis

1997 • 82 citations

The flux of free radical attack through mitochondrial DNA is related to aging rate

2000 • 75 citations

Analysis of the pathways of nitric oxide utilization in mitochondria

2000 • 75 citations

Induction of Apoptosis by Glyoxal in Human Embryonic Lung Epithelial Cell Line L132

2000 • 74 citations

Oxidative‐stress‐dependent up‐regulation of Bcl‐2 expression in the central nervous system of aged Fisher‐344 rats

2001 • 73 citations

Apoptosis in skeletal muscle

2001 • 69 citations

Apoptosis: A Two‐edged Sword in Aging

1999 • 65 citations

B Cell Receptor-Stimulated Mitochondrial Phospholipase A2 Activation and Resultant Disruption of Mitochondrial Membrane Potential Correlate with the Induction of Apoptosis in WEHI-231 B Cells

2001 • 59 citations

Nitric oxide mediates hepatocyte injury

1998 • 57 citations

Molecular mechanisms of oxidative stress in aging: free radicals, aging, antioxidants and disease

2000 • 55 citations

Accelerated Formation of Nϵ-(carboxymethyl) Lysine, an Advanced Glycation End Product, by Glyoxal and 3-Deoxyglucosone in Cultured Rat Sensory Neurons

1998 • 55 citations

Developmental expression of Bcl-2 protein in human cortex

2000 • 37 citations

Identification of Age-Dependent Changes in Expression of Senescence-Accelerated Mouse (SAMP8) Hippocampal Proteins by Expression Array Analysis

2000 • 35 citations

Nitrite generation and antioxidant effects during neutrophil apoptosis

2000 • 30 citations

Global Climatic Change on Mars

1996 • 30 citations

[Neuronal death caused by apoptosis in Parkinson disease].

1997 • 22 citations

Neuroprotection by caspase inhibitors

1999 • 14 citations

Does nitric oxide prevent oxidative mediated lung injury?

2000 • 12 citations

Inhibition of IAP's protection by Diablo/Smac: new therapeutic opportunities?

2000 • 8 citations