B Cell Receptor-Stimulated Mitochondrial Phospholipase A2 Activation and Resultant Disruption of Mitochondrial Membrane Potential Correlate with the Induction of Apoptosis in WEHI-231 B Cells

Mitochondria and Apoptosis

1998 • 8,909 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

The mitochondrial permeability transition

1995 • 2,412 citations

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1996 • 1,902 citations

Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9

1998 • 1,642 citations

Mechanisms by which mitochondria transport calcium

1990 • 1,630 citations

Bax directly induces release of cytochrome c from isolated mitochondria

1998 • 1,514 citations

Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria

1997 • 1,389 citations

Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo

1998 • 1,292 citations

Intracellular ATP levels determine cell death fate by apoptosis or necrosis.

1997 • 1,218 citations

Bax and Adenine Nucleotide Translocator Cooperate in the Mitochondrial Control of Apoptosis

1998 • 1,183 citations

Redox Regulation of Cellular Signalling

1999 • 1,146 citations

MATURE T LYMPHOCYTE APOPTOSIS—Immune Regulation in a Dynamic and Unpredictable Antigenic Environment

1999 • 973 citations

Mitochondria as regulators of apoptosis: doubt no more

1998 • 838 citations

Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage

1997 • 835 citations

The central executioners of apoptosis: caspases or mitochondria?

1998 • 772 citations

The Permeability Transition Pore Complex: A Target for Apoptosis Regulation by Caspases and Bcl-2–related Proteins

1998 • 700 citations

Caspases and caspase inhibitors

1997 • 573 citations

The apoptosis-necrosis paradox. Apoptogenic proteases activated after mitochondrial permeability transition determine the mode of cell death

1997 • 470 citations

Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha.

1996 • 467 citations

Caspases Are Activated in a Branched Protease Cascade and Control Distinct Downstream Processes in Fas-induced Apoptosis

1998 • 450 citations

Apoptosis (the 1992 Frank Rose Memorial Lecture)

1993 • 447 citations

Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux

1998 • 414 citations

Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells

1997 • 367 citations

Fluorometric and Colorimetric Detection of Caspase Activity Associated with Apoptosis

1997 • 347 citations

Transient Poly(ADP-ribosyl)ation of Nuclear Proteins and Role of Poly(ADP-ribose) Polymerase in the Early Stages of Apoptosis

1998 • 274 citations

The Mitochondrial F0F1-ATPase Proton Pump Is Required for Function of the Proapoptotic Protein Bax in Yeast and Mammalian Cells

1998 • 273 citations

Oxidant, Mitochondria and Calcium

1999 • 269 citations

4-Hydroxyhexenal Is a Potent Inducer of the Mitochondrial Permeability Transition

1996 • 251 citations

Apoptosis without caspases: an inefficient molecular guillotine?

1999 • 247 citations

Apoptosis signaling in lymphocytes

1999 • 212 citations

The role of the Caspase family of cysteine proteases in apoptosis

1997 • 210 citations

Negative Selection of Immature B Cells by Receptor Editing or Deletion Is Determined by Site of Antigen Encounter

1999 • 209 citations

Cytofluorometric detection of mitochondrial alterations in early CD95/Fas/APO-1-triggered apoptosis of Jurkat T lymphoma cells. Comparison of seven mitochondrion-specific fluorochromes

1998 • 196 citations

Apoptosis and the maintenance of homoeostasis in the immune system

1996 • 178 citations

Implication of calpain in caspase activation during B cell clonal deletion

1999 • 178 citations

Bcl-2 and the Outer Mitochondrial Membrane in the Inactivation of Cytochrome c during Fas-mediated Apoptosis

1997 • 174 citations

ATP-dependent steps in apoptotic signal transduction.

1999 • 169 citations

Acceleration of apoptotic cell death after the cleavage of Bcl-XL protein by caspase-3-like proteases

1998 • 161 citations

The role of bcl‐x_L in CD40‐mediated rescue from anti‐μ‐induced apoptosis in WEHI‐231 B lymphoma cells

1995 • 154 citations

CED-4—The Third Horseman of Apoptosis

1997 • 116 citations

Bcl-xL rescues WEHI 231 B lymphocytes from oxidant-mediated death following diverse apoptotic stimuli.

1995 • 115 citations

Effects of N alpha-tosyl-L-lysyl-chloromethylketone on the activity of cytotoxic T lymphocytes.

1980 • 105 citations

Modulation of inner mitochondrial membrane channel activity

1992 • 97 citations

Characterization of cathepsin B specificity by site-directed mutagenesis. Importance of Glu245 in the S2-P2 specificity for arginine and its role in transition state stabilization.

1993 • 94 citations

CD4+ CD8+ thymocytes are preferentially induced to die following CD45 cross-linking, through a novel apoptotic pathway.

1997 • 86 citations

Accumulation of human promyelocytic leukemic (HL-60) cells at two energetic cell cycle checkpoints.

1995 • 85 citations

Decreased production of reactive oxygen intermediates is an early event during in vitro apoptosis of rat thymocytes

1996 • 75 citations

Lymphoma models for B cell activation and tolerance

1990 • 72 citations

Germinal Center B Cell Apoptosis Requires Both Caspase and Cathepsin Activity

1999 • 72 citations

Lack of Release of Cytochrome c from Mitochondria into Cytosol Early in the Course of Fas-mediated Apoptosis of Jurkat Cells

1998 • 66 citations

Mitochondrial contributions to cancer cell physiology: redox balance, cell cycle, and drug resistance.

1997 • 65 citations

CD40 inhibits B cell apoptosis by upregulating bcl-xL expression and blocking oxidant accumulation

1997 • 62 citations

Cell death in the regulation of immune responses

1997 • 56 citations

Cytochrome c Induces Caspase-Dependent Apoptosis in Intact Hematopoietic Cells and Overrides Apoptosis Suppression Mediated by bcl-2, Growth Factor Signaling, MAP-Kinase-Kinase, and Malignant Change

1998 • 55 citations

Antigen receptors on immature, but not mature, B and T cells are coupled to cytosolic phospholipase A2 activation: expression and activation of cytosolic phospholipase A2 correlate with lymphocyte maturation.

1996 • 49 citations

Death signals from the B cell antigen receptor target mitochondria, activating necrotic and apoptotic death cascades in a murine B cell line, WEHI-231

1999 • 47 citations

Baculovirus p35 and Z-VAD-fmk inhibit thapsigargin-induced apoptosis of breast cancer cells

1997 • 43 citations

Calpain and cell death.

1996 • 42 citations

Morphological, Biochemical, and Flow Cytometric Assays of Apoptosis

2000 • 42 citations

Inhibition of caspase activity prevents anti-IgM induced apoptosis but not ceramide generation in WEHI 231 B cells

1998 • 36 citations

Properties of DNA fragmentation activity generated by ATP depletion

2000 • 30 citations

Antagonistic Roles for Phospholipase D Activities in B Cell Signaling: While the Antigen Receptors Transduce Mitogenic Signals Via a Novel Phospholipase D Activity, Phosphatidylcholine-Phospholipase D Mediates Antiproliferative Signals

1998 • 24 citations

Lymphoma models for B-cell activation and tolerance

1988 • 24 citations

Cytochrome c Induces Caspase-Dependent Apoptosis in Intact Hematopoietic Cells and Overrides Apoptosis Suppression Mediated by bcl-2, Growth Factor Signaling, MAP-Kinase-Kinase, and Malignant Change

1998 • 3 citations

Pictures in cell biology

1997 • 3 citations