Aging and Regulation of Apoptosis

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

1995 • 6,950 citations

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

The Fas Death Factor

1995 • 4,070 citations

AGEING AND PARKINSON'S DISEASE: SUBSTANTIA NIGRA REGIONAL SELECTIVITY

1991 • 3,275 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

Cell Death During Development of the Nervous System

1991 • 3,033 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

Mechanisms and Genes of Cellular Suicide

1995 • 2,514 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

1995 • 1,968 citations

The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death

1994 • 1,920 citations

Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

1995 • 1,625 citations

Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

1994 • 1,549 citations

The retardation of aging and disease by dietary restriction

1989 • 1,494 citations

Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

1995 • 1,477 citations

Programmed Cell Death and the Control of Cell Survival: Lessons from the Nervous System

1993 • 1,470 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

Mutations in Fas Associated with Human Lymphoproliferative Syndrome and Autoimmunity

1995 • 1,306 citations

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2

1994 • 1,145 citations

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.

1994 • 1,085 citations

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.

1993 • 1,035 citations

Genetic Control of Programmed Cell Death in Drosophila

1994 • 1,028 citations

Programmed cell death: Apoptosis and oncogenesis

1991 • 856 citations

Isolation, Characterization, and use of Stem Cells from the CNS

1995 • 819 citations

Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain.

1990 • 787 citations

Continuous c-fos expression precedes programmed cell death in vivo

1993 • 784 citations

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

1994 • 708 citations

A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues.

1992 • 633 citations

bcl-2 inhibits death of central neural cells induced by multiple agents.

1993 • 631 citations

The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration

1991 • 548 citations

The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death

1990 • 533 citations

Evidence for Apoptotic Cell Death in Alzheimer's Disease

1995 • 482 citations

Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved.

1995 • 478 citations

Repression of c- fos Transcription and an Altered Genetic Program in Senescent Human Fibroblasts

1990 • 478 citations

2,3,7,8-Tetrachlorodibenzo- p -Dioxin Kills Immature Thymocytes by Ca ²⁺ -Mediated Endonuclease Activation

1988 • 460 citations

Apoptosis and the cell cycle

1995 • 431 citations

β-Amyloid Peptide Free Radical Fragments Initiate Synaptosomal Lipoperoxidation in a Sequence-Specific Fashion: Implications to Alzheimer′s Disease

1994 • 406 citations

Cell cycle and apoptosis: Common pathways to life and death

1995 • 404 citations

BCL2 translocation frequency rises with age in humans.

1994 • 372 citations

The bcl-2 candidate proto-oncogene product is a 24-kilodalton integral-membrane protein highly expressed in lymphoid cell lines and lymphomas carrying the t(14;18) translocation.

1989 • 349 citations

Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells.

1995 • 334 citations

Naturally occurring and induced neuronal death in the chick embryo in vivo requires protein and RNA synthesis: Evidence for the role of cell death genes

1990 • 332 citations

Contenders in FasL/TNF death signaling

1995 • 319 citations

Cleavage of actin by interleukin 1 beta-converting enzyme to reverse DNase I inhibition.

1996 • 298 citations

bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death.

1995 • 289 citations

Age- and peroxidative stress-related modifications of the cerebral enzymatic activities linked to mitochondria and the glutathione system

1995 • 284 citations

Food restriction eliminates preneoplastic cells through apoptosis and antagonizes carcinogenesis in rat liver.

1994 • 274 citations

bcl-2 transgene expression can protect neurons against developmental and induced cell death.

1995 • 261 citations

Superoxide dismutase, aging, and degenerative disease

1994 • 234 citations

Ceramide: A stress signal and mediator of growth suppression and apoptosis

1995 • 233 citations

Apoptosis and Its Role in Human Disease

1994 • 232 citations

Expression of bcl‐2 inhibits necrotic neural cell death

1995 • 216 citations

Cell death: Current difficulties in discriminating apoptosis from necrosis in the context of pathological processes in vivo

1995 • 205 citations

A transmembrane domain of the putative channel subunit MEC-4 influences mechanotransduction and neurodegeneration in C. elegans

1994 • 204 citations

Protection against oxidative damage to CNS by α-phenyl-tert-butyl nitrone (PBN) and other spin-trapping agents: A novel series of nonlipid free radical scavengers

1991 • 183 citations

Prevention of age-related T cell apoptosis defect in CD2-fas-transgenic mice.

1995 • 151 citations

Dietary restriction : implications for the design and interpretation of toxicity and carcinogenicity studies

1995 • 148 citations

Biological Effects of Dietary Restriction

1991 • 144 citations

Cells en route to apoptosis are characterized by the upregulation of c‐fos, c‐myc, c‐jun, cdc2, and RB phosphorylation, resembling events of early cell‐cycle traverse

1995 • 144 citations

Rates of apoptosis and proliferation vary with caloric intake and may influence incidence of spontaneous hepatoma in C57BL/6 x C3H F1 mice.

1994 • 131 citations

Neurotrophic Factors Enter the Clinic

1994 • 125 citations

Molecular aspects of aging

1985 • 116 citations

Grafting in the mammalian central nervous system

1993 • 114 citations

Molecular aspects of aging

1996 • 90 citations

Programmed Cell Death: New Thoughts and Relevance to Aging

1990 • 90 citations

Age-related changes in the intrinsic rate of apoptosis in livers of diet-restricted and ad libitum-fed B6C3F1 mice.

1995 • 86 citations

Control of fibroblast senescence and activation of programmed cell death

1994 • 78 citations

Genomic Instability and Aging

1992 • 73 citations

Ischemia/reperfusion-induced changes in membrane proteins and lipids of gerbil cortical synaptosomes

1995 • 72 citations

Accelerated programmed cell death of MRL-lpr/lpr T lymphocytes.

1992 • 71 citations

Aging and immune function: Cellular and biochemical analyses

1994 • 67 citations

A Unifying Hypothesis To Explain the Retardation of Aging and Tumorigenesis by Caloric Restriction

1995 • 64 citations

An endonuclease fromCaenorhabditis elegans: Partial purification and characterization

1988 • 55 citations

Apoptosis and Autoimmunity

1995 • 49 citations

Biological effects of dietary restriction

1991 • 43 citations

Commitment to Cell Death Is Signaled by the Appearance of a Terminin Protein of 30 kDa

1994 • 37 citations

Effect of fructose-1,6-bisphosphate on glutamate uptake and glutamine synthetase activity in hypotix astrocyte cultures

1994 • 18 citations

Down‐regulation of statin, a nonproliferation‐specific nuclear protein, and up‐regulation of c‐myc after initiation of programmed cell death in mouse fibroblasts

1995 • 12 citations