Apoptosis: A Two‐edged Sword in Aging

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Mitochondria and Apoptosis

1998 • 8,909 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

1995 • 6,950 citations

Caspases: Enemies Within

1998 • 6,923 citations

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

The Bcl-2 Protein Family: Arbiters of Cell Survival

1998 • 5,359 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Fas Death Factor

1995 • 4,070 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

1998 • 3,169 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

Programmed Cell Death in Animal Development

1997 • 2,690 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis

1997 • 1,848 citations

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

1995 • 1,761 citations

Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

1994 • 1,549 citations

Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

1995 • 1,477 citations

Shrinkage necrosis: A distinct mode of cellular death

1971 • 1,448 citations

Mutations in Fas Associated with Human Lymphoproliferative Syndrome and Autoimmunity

1995 • 1,306 citations

Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats.

1996 • 1,045 citations

Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice.

1996 • 1,020 citations

Programmed cell death: Apoptosis and oncogenesis

1991 • 856 citations

Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons

1998 • 852 citations

Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage

1997 • 835 citations

Apoptosis in Human Acute Myocardial Infarction

1997 • 825 citations

Estrogen promotes apoptosis of murine osteoclasts mediated by TGF–β

1996 • 799 citations

Cell suicide for beginners

1998 • 686 citations

Oxidative damage during aging targets mitochondrial aconitase

1997 • 612 citations

Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia.

1994 • 571 citations

A mouse model for mitochondrial myopathy and cardiomyopathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator

1997 • 554 citations

Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis.

1996 • 529 citations

Retinopathy induced in mice by targeted disruption of the rhodopsin gene

1997 • 527 citations

Modulation of cell death by Bcl-x _L through caspase interaction

1998 • 505 citations

Bcl-2: Prolonging Life in a Transgenic Mouse Model of Familial Amyotrophic Lateral Sclerosis

1997 • 482 citations

Evidence for Apoptotic Cell Death in Alzheimer's Disease

1995 • 482 citations

Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved.

1995 • 478 citations

Increased Oxidative Damage Is Correlated to Altered Mitochondrial Function in Heterozygous Manganese Superoxide Dismutase Knockout Mice

1998 • 454 citations

Mitochondrial adenine nucleotide translocase is modified oxidatively during aging

1998 • 408 citations

Contribution of the mitochondrial permeability transition to lethal injury after exposure of hepatocytes to t-butylhydroperoxide

1995 • 384 citations

A potential role for apoptosis in neurodegeneration and Alzheimer's disease

1995 • 382 citations

In situ evidence for DNA fragmentation in Huntingtonʼs disease striatum and Alzheimerʼs disease temporal lobes

1995 • 350 citations

Expression of a Dominant Negative Mutant of Interleukin-1β Converting Enzyme in Transgenic Mice Prevents Neuronal Cell Death Induced by Trophic Factor Withdrawal and Ischemic Brain Injury

1997 • 345 citations

Peptide inhibitors of the ice protease family arrest programmed cell death of motoneurons in vivo and in vitro

1995 • 324 citations

Cleavage of actin by interleukin 1 beta-converting enzyme to reverse DNase I inhibition.

1996 • 298 citations

In Vivo Evidence That the Stromelysin-3 Metalloproteinase Contributes in a Paracrine Manner to Epithelial Cell Malignancy

1998 • 290 citations

Food restriction eliminates preneoplastic cells through apoptosis and antagonizes carcinogenesis in rat liver.

1994 • 274 citations

Aging and Cancer: The Double‐Edged Sword of Replicative Senescence

1997 • 246 citations

Differential expression of metalloproteinase and tissue inhibitor of metalloproteinase genes in aged human fibroblasts

1992 • 235 citations

DNA End Labeling (TUNEL) in Huntington's Disease and Other Neuropathological Conditions

1995 • 221 citations

Cell death: Current difficulties in discriminating apoptosis from necrosis in the context of pathological processes in vivo

1995 • 205 citations

Bisphosphonates induce apoptosis in mouse macrophage-like cells in vitro by a nitric oxide-independent mechanism

1996 • 196 citations

Blocking apoptosis prevents blindness in Drosophila retinal degeneration mutants

1998 • 157 citations

Prevention of age-related T cell apoptosis defect in CD2-fas-transgenic mice.

1995 • 151 citations

Mechanisms of Cell Death in the Inherited Retinal Degenerations

1998 • 140 citations

Stroke-Damaged Neurons May Commit Cellular Suicide

1998 • 135 citations

Rates of apoptosis and proliferation vary with caloric intake and may influence incidence of spontaneous hepatoma in C57BL/6 x C3H F1 mice.

1994 • 131 citations

What Does Cell Death Have To Do with Aging?

1997 • 122 citations

Multiple Mitochondrial DNA Deletions Associated With Age in Skeletal Muscle of Rhesus Monkeys

1993 • 114 citations

High levels of bcl‐2 protein in circulating t lymphocytes, but not b lymphocytes, of patients with systemic lupus erythematosus

1994 • 103 citations

Is Apoptosis Key in Alzheimer's Disease?

1998 • 100 citations

Control of fibroblast senescence and activation of programmed cell death

1994 • 78 citations

Dietary Restriction, Tumors, and Aging in Rodents

1989 • 71 citations

A Unifying Hypothesis To Explain the Retardation of Aging and Tumorigenesis by Caloric Restriction

1995 • 64 citations

Diet Restriction Increases Apoptosis in the Gut of Aging Rats

1998 • 58 citations

Caspases (Interleukin-1β-Converting Enzyme Family Proteases) Are Involved in the Regulation of the Survival of Osteoclasts

1998 • 57 citations

Characterization of interior cleavage of retinoblastoma protein in apoptosis

1997 • 51 citations

Apoptosis and Autoimmunity

1995 • 49 citations

Calorie restriction modulates lymphocyte subset phenotype and increases apoptosis in MRLlpr mice

1995 • 38 citations

The medical nucleus of the solitary tract mediates the trigeminally evoked pressor response.

1998 • 34 citations