Inhibition of IAP's protection by Diablo/Smac: new therapeutic opportunities?

Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

2000 • 3,415 citations

IAP family proteins---suppressors of apoptosis

1999 • 2,570 citations

Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

2000 • 2,344 citations

An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif

1993 • 1,049 citations

Apoptotic Pathways

2000 • 993 citations

Ubiquitin Protein Ligase Activity of IAPs and Their Degradation in Proteasomes in Response to Apoptotic Stimuli

2000 • 989 citations

The inhibitors of apoptosis (IAPs) and their emerging role in cancer

1998 • 985 citations

The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy

1995 • 976 citations

Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases

1999 • 750 citations

The Drosophila Caspase Inhibitor DIAP1 Is Essential for Cell Survival and Is Negatively Regulated by HID

1999 • 499 citations

Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function

2000 • 448 citations

Cell-specific Induction of Apoptosis by Microinjection of Cytochrome c

1997 • 348 citations

An exegesis of IAPs: salvation and surprises from BIR motifs

1999 • 345 citations

Evidence of a Novel Event during Neuronal Death

1998 • 276 citations

The hippocampal neurons of neuronal apoptosis inhibitory protein 1 (NAIP1)-deleted mice display increased vulnerability to kainic acid-induced injury

2000 • 98 citations

The little devil of death

2000 • 43 citations