Mitochondrial Aging: Open Questions^a

Oxidants, antioxidants, and the degenerative diseases of aging.

1993 • 6,011 citations

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

The Free Radical Theory of Aging Matures

1998 • 3,846 citations

Oxidative Stress, Caloric Restriction, and Aging

1996 • 3,136 citations

Protein Oxidation and Aging

1992 • 2,687 citations

Oxidative damage and mitochondrial decay in aging.

1994 • 2,024 citations

Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

1997 • 1,762 citations

Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

1988 • 1,709 citations

Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse

1994 • 785 citations

DNA oxidation matters: The HPLC–electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine

1998 • 694 citations

Genetic analysis of ageing: role of oxidative damage and environmental stresses

1996 • 647 citations

Oxidative damage during aging targets mitochondrial aconitase

1997 • 612 citations

The Absence of a Pyrimidine Dimer Repair Mechanism in Mammalian Mitochondria

1974 • 517 citations

Repair of Oxidative Damage to Nuclear and Mitochondrial DNA in Mammalian Cells

1997 • 508 citations

Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species

1993 • 484 citations

Untitled

1997 • 432 citations

Mitochondrial decay in hepatocytes from old rats: Membrane potential declines, heterogeneity and oxidants increase

1997 • 427 citations

Biochemical basis of lipofuscin, ceroid, and age pigment-like fluorophores

1996 • 377 citations

Oxidative damage to mitochondrial DNA and its relationship to ageing

1995 • 350 citations

Genetic and functional changes in mitochondria associated with aging

1997 • 311 citations

Hydrogen peroxide release by mitochondria increases during aging

1991 • 292 citations

Mammalian Mitochondria Possess Homologous DNA Recombination Activity

1996 • 275 citations

Low Mitochondrial Free Radical Production Per Unit O₂Consumption Can Explain the Simultaneous Presence of High Longevity and High Aerobic Metabolic Rate in Birds

1994 • 260 citations

Reactive oxygen and DNA damage in mitochondria

1992 • 234 citations

Mitochondrial superoxide and hydrogen peroxide generation, protein oxidative damage, and longevity in different species of flies

1995 • 234 citations

Mitochondrial DNA in Aging and Disease

1997 • 227 citations

Mitochondrial DNA mutations in human degenerative diseases and aging

1995 • 224 citations

A network theory of ageing: the interactions of defective mitochondria, aberrant proteins, free radicals and scavengers in the ageing process

1996 • 220 citations

Caloric Restriction and Aging

1996 • 219 citations

Deleterious mitochondrial DNA mutations accumulate in aging human tissues

1992 • 212 citations

A Ginkgo Biloba Extract (EGb 761) Prevents Mitochondrial Aging by Protecting Against Oxidative Stress

1998 • 212 citations

Involvement of free radicals in ageing: a consequence or cause of senescence

1993 • 173 citations

The free radical hypothesis of aging: An appraisal of the current status

1993 • 166 citations

Critical Evaluation of the Free Radical Theory of Aging

1996 • 165 citations

Preferential mitochondrial DNA injury caused by glucose oxidase as a steady generator of hydrogen peroxide in human fibroblasts

1997 • 154 citations

An Oxidative Damage-specific Endonuclease from Rat Liver Mitochondria

1997 • 152 citations

Artifacts associated with the measurement of oxidized DNA bases.

1997 • 138 citations

Modelling the effects of age-related mtDNA mutation accumulation; Complex I deficiency, superoxide and cell death

1995 • 124 citations

Biochemical Correlates of Longevity in Two Closely Related Rodent Species

1993 • 115 citations

Conditions allowing redox-cycling ubisemiquinone in mitochondria to establish a direct redox couple with molecular oxygen

1996 • 103 citations

Artifacts Associated with the Measurement of Oxidized DNA Bases

1997 • 100 citations

Purification of All Forms of HeLa Cell Mitochondrial DNA and Assessment of Damage to It Caused by Hydrogen Peroxide Treatment of Mitochondria or Cells

1995 • 94 citations

Mitochondrial Decay in Aging: Reversal through Supplementation of Acetyl-l-Carnitine and N-tert-Butyl-alpha-phenyl-nitronea

1998 • 88 citations

The beneficial effects of dietary restriction: reduced oxidative damage and enhanced apoptosis

1996 • 86 citations

The rate of mitochondrial mutagenesis is faster in mice than humans

1997 • 85 citations

mtDNA Mutations Confer Cellular Sensitivity to Oxidant Stress That Is Partially Rescued by Calcium Depletion and Cyclosporin A

1997 • 84 citations

Age-Associated Alterations of the Mitochondrial Genome

1997 • 77 citations

[38] Detection and quantification of oxidative adducts of mitochondrial DNA

1996 • 75 citations

Age-Related Mitochondrial DNA Deletions

1998 • 56 citations

Longevity and antioxidant enzymes, non-enzymatic antioxidants and oxidative stress in the vertebrate lung: a comparative study

1994 • 53 citations

The process and theories of aging.

1995 • 52 citations

Mitochondrial mutations, cellular instability and ageing: modelling the population dynamics of mitochondria

1993 • 44 citations

Evidence for and against the causal involvement of mitochondrial DNA mutation in mammalian ageing

1992 • 22 citations

Oxidative stress and human ageing

1995 • 12 citations