Therapeutic targeting of the tumor microenvironment

Inflammation and cancer

2002 • 14,174 citations

Bevacizumab plus Irinotecan, Fluorouracil, and Leucovorin for Metastatic Colorectal Cancer

2004 • 10,779 citations

Tumor Angiogenesis: Therapeutic Implications

1971 • 9,898 citations

Angiogenesis in cancer and other diseases

2000 • 8,734 citations

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Involvement of chemokine receptors in breast cancer metastasis

2001 • 5,203 citations

Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy

2005 • 5,086 citations

The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited

2003 • 4,433 citations

Angiogenesis in health and disease

2003 • 4,127 citations

Dissemination and growth of cancer cells in metastatic sites

2002 • 3,796 citations

Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion

2005 • 3,543 citations

Tumour-educated macrophages promote tumour progression and metastasis

2004 • 3,259 citations

Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations

2002 • 2,711 citations

Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer

2004 • 2,481 citations

Cardiovascular Events Associated with Rofecoxib in a Colorectal Adenoma Chemoprevention Trial

2005 • 2,476 citations

Cancer and the chemokine network

2004 • 2,292 citations

Stromal fibroblasts in cancer initiation and progression

2004 • 2,230 citations

Putting tumours in context

2001 • 2,145 citations

Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy

2001 • 2,069 citations

Immunosuppressive networks in the tumour environment and their therapeutic relevance

2005 • 1,990 citations

High interstitial fluid pressure — an obstacle in cancer therapy

2004 • 1,979 citations

Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer

2004 • 1,935 citations

Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

2001 • 1,874 citations

Genes Expressed in Human Tumor Endothelium

2000 • 1,838 citations

Smoldering and polarized inflammation in the initiation and promotion of malignant disease

2005 • 1,730 citations

Role of integrins in cell invasion and migration

2002 • 1,719 citations

Aspirin Use and Reduced Risk of Fatal Colon Cancer

1991 • 1,695 citations

Basement membranes: structure, assembly and role in tumour angiogenesis

2003 • 1,652 citations

Radical causes of cancer

2003 • 1,611 citations

Colony-Stimulating Factor 1 Promotes Progression of Mammary Tumors to Malignancy

2001 • 1,556 citations

Clinical translation of angiogenesis inhibitors

2002 • 1,518 citations

Cytokines in cancer pathogenesis and cancer therapy

2004 • 1,465 citations

Carcinoma-associated fibroblasts stimulate tumor progression of initiated human epithelium

2000 • 1,445 citations

Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies

1997 • 1,444 citations

Integrin signalling during tumour progression

2004 • 1,430 citations

TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia

2004 • 1,346 citations

The IKK NF-κB system: a treasure trove for drug development

2004 • 1,340 citations

MMP-9 Supplied by Bone Marrow–Derived Cells Contributes to Skin Carcinogenesis

2000 • 1,306 citations

Molecular characterization of the tumor microenvironment in breast cancer

2004 • 1,278 citations

Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal

1999 • 1,248 citations

Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

2003 • 1,236 citations

VEGF-D promotes the metastatic spread of tumor cells via the lymphatics

2001 • 1,217 citations

Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation

2004 • 1,176 citations

Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

2003 • 1,172 citations

Vascular Normalization by Vascular Endothelial Growth Factor Receptor 2 Blockade Induces a Pressure Gradient Across the Vasculature and Improves Drug Penetration in Tumors

2004 • 1,160 citations

Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells.

1992 • 1,047 citations

Cell Adhesion Mediated Drug Resistance (CAM-DR): Role of Integrins and Resistance to Apoptosis in Human Myeloma Cell Lines

1999 • 850 citations

Mechanisms of normal and tumor-derived angiogenesis

2002 • 781 citations

Reconstruction of functionally normal and malignant human breast tissues in mice

2004 • 777 citations

Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: A mechanism for small cell lung cancer growth and drug resistance in vivo

1999 • 726 citations

Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy?

2002 • 685 citations

Cell surface glycoprotein of reactive stromal fibroblasts as a potential antibody target in human epithelial cancers.

1990 • 677 citations

Inflammation and necrosis promote tumour growth

2004 • 646 citations

Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis

2004 • 618 citations

An amino-bisphosphonate targets MMP-9–expressing macrophages and angiogenesis to impair cervical carcinogenesis

2004 • 597 citations

Modeling tissue-specific signaling and organ function in three dimensions

2003 • 573 citations

Integrins: roles in cancer development and as treatment targets

2004 • 568 citations

ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini

2001 • 559 citations

An amino-bisphosphonate targets MMP-9–expressing macrophages and angiogenesis to impair cervical carcinogenesis

2004 • 559 citations

Anti-TNF-α therapies: the next generation

2003 • 558 citations

Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells

2003 • 557 citations

Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiationRole of oxygenation, angiopoietin-1, and matrix metalloproteinases

2004 • 549 citations

A reevaluation of integrins as regulators of angiogenesis

2002 • 546 citations

Physiological levels of tumstatin, a fragment of collagen IV α3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via αVβ3 integrin

2003 • 543 citations

Fibroblast Activation Protein, a Dual Specificity Serine Protease Expressed in Reactive Human Tumor Stromal Fibroblasts

1999 • 521 citations

PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis

2004 • 516 citations

Suppression of Tumor Lymphangiogenesis and Lymph Node Metastasis by Blocking Vascular Endothelial Growth Factor Receptor 3 Signaling

2002 • 512 citations

Contribution of bone marrow–derived endothelial cells to human tumor vasculature

2005 • 490 citations

Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy

2004 • 482 citations

A Multitargeted, Metronomic, and Maximum-Tolerated Dose “Chemo-Switch” Regimen is Antiangiogenic, Producing Objective Responses and Survival Benefit in a Mouse Model of Cancer

2004 • 479 citations

PDGF receptors as cancer drug targets

2003 • 462 citations

Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy.

2002 • 431 citations

Nitric oxide and oxygen radicals in infection, inflammation, and cancer.

1998 • 425 citations

New insights into the role of extracellular matrix during tumor onset and progression

2002 • 415 citations

A Phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer.

2003 • 404 citations

Adult bone marrow-derived cells recruited during angiogenesis comprise precursors for periendothelial vascular mural cells

2004 • 395 citations

Malignant transformation in a nontumorigenic human prostatic epithelial cell line.

2001 • 343 citations

Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells

2005 • 333 citations

Focus on lymphangiogenesis in tumor metastasis

2005 • 332 citations

Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis

2005 • 331 citations

Small molecule inhibitors of IkappaB kinase are selectively toxic for subgroups of diffuse large B-cell lymphoma defined by gene expression profiling.

2005 • 314 citations

Chemokines in neoplastic progression

2004 • 269 citations

Stage-specific vascular markers revealed by phage display in a mouse model of pancreatic islet tumorigenesis

2003 • 248 citations

Mammalian heparanase: involvement in cancer metastasis, angiogenesis and normal development

2002 • 229 citations

Regression of established tumors and metastases by potent vascular endothelial growth factor blockade

2003 • 227 citations

The Id proteins and angiogenesis

2001 • 224 citations

Progressive vascular changes in a transgenic mouse model of squamous cell carcinoma

2003 • 222 citations

Small Molecule Inhibitors of IκB Kinase Are Selectively Toxic for Subgroups of Diffuse Large B-Cell Lymphoma Defined by Gene Expression Profiling

2005 • 219 citations

Promotion of tumor growth by murine fibroblast activation protein, a serine protease, in an animal model.

2002 • 211 citations

CD133 positive endothelial progenitor cells contribute to the tumour vasculature in non-small cell lung cancer

2004 • 205 citations

Endothelial progenitor cells in infantile hemangioma

2003 • 203 citations

Cancer: looking outside the genome

2000 • 187 citations

Drug resistance and the microenvironment: nature and nurture

2003 • 178 citations

Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesisImplications for cellular surrogate marker analysis of antiangiogenesis

2005 • 173 citations

A functional heparan sulfate mimetic implicates both heparanase and heparan sulfate in tumor angiogenesis and invasion in a mouse model of multistage cancer

2005 • 159 citations

Tumor Specific VEGF-A and VEGFR2/KDR Protein are Co-expressed in Breast Cancer

2003 • 118 citations

Cell adhesion is a key determinant in de novo multidrug resistance (MDR): new targets for the prevention of acquired MDR.

2001 • 116 citations

Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture

2004 • 107 citations

Mesenchyme-induced changes in the neoplastic characteristics of the Dunning prostatic adenocarcinoma.

1991 • 101 citations

Utilization of Bone Marrow-Derived Endothelial Cell Precursors in Spontaneous Prostate Tumors Varies with Tumor Grade

2004 • 72 citations

Helper strategy in tumor immunology: Expansion of helper lymphocytes and utilization of helper lymphokines for experimental and clinical immunotherapy

1988 • 69 citations

Urokinase plasminogen activator receptor (CD87) expression of tumor-associated macrophages in ductal carcinoma in situ, breast cancer, and resident macrophages of normal breast tissue

1999 • 69 citations

Angiogenesis inhibitors suffer new setback

2002 • 57 citations

Interference with TGF‐β1 and ‐β3 in tumor stroma lowers tumor interstitial fluid pressure independently of growth in experimental carcinoma

2002 • 53 citations