Modeling tissue-specific signaling and organ function in three dimensions

Disruption of epithelial cell-matrix interactions induces apoptosis

1994 • 3,167 citations

Taking Cell-Matrix Adhesions to the Third Dimension

2001 • 2,940 citations

The microenvironment of the tumour–host interface

2001 • 2,307 citations

Putting tumours in context

2001 • 2,145 citations

COLLAGEN SUBSTRATA FOR STUDIES ON CELL BEHAVIOR

1972 • 1,530 citations

Basement membrane complexes with biological activity

1986 • 1,489 citations

Carcinoma-associated fibroblasts stimulate tumor progression of initiated human epithelium

2000 • 1,445 citations

Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies

1997 • 1,444 citations

Role of laminin and basement membrane in the morphological differentiation of human endothelial cells into capillary-like structures.

1988 • 1,209 citations

Suppression of ICE and Apoptosis in Mammary Epithelial Cells by Extracellular Matrix

1995 • 1,184 citations

Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells.

1992 • 1,047 citations

Living Tissue Formed in Vitro and Accepted as Skin-Equivalent Tissue of Full Thickness

1981 • 1,042 citations

Maspin, a Serpin with Tumor-Suppressing Activity in Human Mammary Epithelial Cells

1994 • 913 citations

Cell interactions with three-dimensional matrices

2002 • 874 citations

Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells

2001 • 854 citations

Primary culture of parenchymal liver cells on collagen membranes

1975 • 808 citations

Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction

1996 • 772 citations

β4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium

2002 • 772 citations

The Role of Apoptosis in Creating and Maintaining Luminal Space within Normal and Oncogene-Expressing Mammary Acini

2002 • 763 citations

Two different laminin domains mediate the differentiation of human endothelial cells into capillary-like structures in vitro

1989 • 746 citations

Getting under the skin of epidermal morphogenesis

2002 • 723 citations

Biology of HER2 and Its Importance in Breast Cancer

2001 • 710 citations

Functional differentiation and alveolar morphogenesis of primary mammary cultures on reconstituted basement membrane

1989 • 700 citations

Maintenance and induction of morphological differentiation in dissociated mammary epithelium on floating collagen membranes

1977 • 641 citations

Reciprocal interactions between β1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: A different perspective in epithelial biology

1998 • 625 citations

Multi‐faceted regulation of cell differentiation by extracellular matrix

1993 • 610 citations

The organizing principle: microenvironmental influences in the normal and malignant breast

2002 • 603 citations

Signals for death and survival: A two-step mechanism for cavitation in the vertebrate embryo

1995 • 601 citations

Influence of a reconstituted basement membrane and its components on casein gene expression and secretion in mouse mammary epithelial cells.

1987 • 591 citations

Building epithelial architecture: insights from three-dimensional culture models

2002 • 584 citations

ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini

2001 • 559 citations

Support of cultured hepatocytes by a laminin-rich gel. Evidence for a functionally significant subendothelial matrix in normal rat liver.

1987 • 547 citations

Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells.

2000 • 537 citations

Cell-cell and cell-matrix interactions differentially regulate the expression of hepatic and cytoskeletal genes in primary cultures of rat hepatocytes.

1988 • 534 citations

Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition

2002 • 486 citations

Extracellular matrix-dependent tissue-specific gene expression in mammary epithelial cells requires both physical and biochemical signal transduction.

1994 • 466 citations

How does extracellular matrix control capillary morphogenesis?

1989 • 466 citations

Rac1 orientates epithelial apical polarity through effects on basolateral laminin assembly

2001 • 444 citations

Know thy neighbor: stromal cells can contribute oncogenic signals

2001 • 422 citations

c-Jun and JunB Antagonistically Control Cytokine-Regulated Mesenchymal–Epidermal Interaction in Skin

2000 • 412 citations

Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesis.

2000 • 400 citations

Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties

2002 • 381 citations

A hierarchy of ECM-mediated signalling regulates tissue-specific gene expression

1995 • 378 citations

Human papillomavirus type 16 alters human epithelial cell differentiation in vitro.

1988 • 377 citations

Extracellular matrix signaling: integration of form and function in normal and malignant cells

1998 • 360 citations

Retinoids as important regulators of terminal differentiation: examining keratin expression in individual epidermal cells at various stages of keratinization.

1987 • 343 citations

Engineering cellular microenvironments to improve cell-based drug testing

2002 • 337 citations

Role of mesenchymal-epithelial interactions in normal and abnormal development of the mammary gland and prostate

1994 • 323 citations

Lineage-specific morphogenesis in the developing pancreas: role of mesenchymal factors

1996 • 320 citations

Experimental observations of a nuclear matrix

2001 • 311 citations

Taking the Study of Cancer Cell Survival to a New Dimension

2002 • 302 citations

Transfection of human nm23-H1 into the human MDA-MB-435 breast carcinoma cell line: effects on tumor metastatic potential, colonization and enzymatic activity.

1993 • 298 citations

Hormonal effects on intracellular and secreted casein in cultures of mouse mammary epithelial cells on floating collagen membranes.

1977 • 292 citations

Role of stroma in carcinogenesis of the prostate

2002 • 288 citations

Multiple stages and genetic alterations in immortalization, malignant transformation, and tumor progression of human skin keratinocytes

1998 • 286 citations

Lumen formation by epithelial cell lines in response to collagen overlay: a morphogenetic model in culture.

1982 • 282 citations

Phenotypic Reversion or Death of Cancer Cells by Altering Signaling Pathways in Three-Dimensional Contexts

2002 • 268 citations

Dynamics of Basement Membrane Formation by Keratinocyte–Fibroblast Interactions in Organotypic Skin Culture

1998 • 256 citations

Desmosomal adhesion regulates epithelial morphogenesis and cell positioning

2001 • 249 citations

The human myoepithelial cell is a natural tumor suppressor.

1997 • 247 citations

Phenotypic and functional characterization in vitro of a multipotent epithelial cell present in the normal adult human breast

1998 • 239 citations

A new diploid nontumorigenic human breast epithelial cell line isolated and propagated in chemically defined medium

1987 • 237 citations

Experimental mammary epithelial morphogenesis in anin vivo model: Evidence for distinct cellular progenitors of the ductal and lobular phenotype

1996 • 234 citations

Tissue phenotype depends on reciprocal interactions between the extracellular matrix and the structural organization of the nucleus

1998 • 234 citations

Keratinocyte Growth Regulation in Defined Organotypic Cultures Through IL-1-Induced Keratinocyte Growth Factor Expression in Resting Fibroblasts

2000 • 229 citations

The Keratinocyte handbook

1994 • 229 citations

The mammary gland

1991 • 216 citations

Epidermal morphogenesis and induction of the 67 kD keratin polypeptide by culture of human keratinocytes at the liquid-air interface

1985 • 215 citations

Beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium

2002 • 211 citations

The Differentiated State of Normal and Malignant Cells or How to Define a “Normal” Cell in Culture

1981 • 208 citations

Integrin expression during human epidermal development in vivo and in vitro

1991 • 203 citations

Cellular growth and survival are mediated by β1 integrins in normal human breast epithelium but not in breast carcinoma

1995 • 203 citations

Principles and practices for treatment of cutaneous wounds with cultured skin substitutes

2002 • 201 citations

Epidermis generated in vitro: practical considerations and applications

1991 • 199 citations

Differentiation of canalicular cell processes in bone cells by basement membrane matrix components: Regulation by discrete domains of laminin

1990 • 198 citations

Influence of Human Dermal Fibroblasts on Epidermalization

1989 • 192 citations

The role of c-erbB-2/HER2/neu in breast cancer progression and metastasis.

2001 • 182 citations

SECRETION OF COLLAGEN BY CORNEAL EPITHELIUM

1973 • 179 citations

Tumor-stroma interactions directing phenotype and progression of epithelial skin tumor cells

2002 • 175 citations

CEACAM1-4S, a cell–cell adhesion molecule, mediates apoptosis and reverts mammary carcinoma cells to a normal morphogenic phenotype in a 3D culture

2003 • 168 citations

An in vitro tubulogenesis system using cell lines derived from the embryonic kidney shows dependence on multiple soluble growth factors

1997 • 161 citations

Cancer as a disease of epithelial–mesenchymal interactions and extracellular matrix regulation

2002 • 160 citations

A Novel Function for the nm23-H1 Gene: Overexpression in Human Breast Carcinoma Cells Leads to the Formation of Basement Membrane and Growth Arrest

1994 • 157 citations

A role for dystroglycan in epithelial polarization: loss of function in breast tumor cells.

2002 • 156 citations

A new look into an old problem: keratins as tools to investigate determination, morphogenesis, and differentiation in skin.

1989 • 155 citations

Differentiation of Embryonal Stem Cells into Keratinocytes: Comparison of Wild-Type and β1Integrin-Deficient Cells

1996 • 154 citations

Role of laminin-1 and TGF-β3 in acinar differentiation of a human submandibular gland cell line (HSG)

1996 • 144 citations

Human fetal enterocytes in vitro: modulation of the phenotype by extracellular matrix.

1996 • 130 citations

TGF-beta and retinoic acid: regulators of growth and modifiers of differentiation in human epidermal cells.

1990 • 129 citations

Designer microenvironments for the analysis of cell and tissue function

1990 • 124 citations

Reconstruction of 'simplified' skin: control of fabrication

1984 • 123 citations

Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon

1999 • 122 citations

The plasticity of human breast carcinoma cells is more than epithelial to mesenchymal conversion.

2001 • 118 citations

Basement membrane as a spatial organizer of polarized epithelia. Exogenous basement membrane reorients pancreatic epithelial tumor cells in vitro.

1986 • 118 citations

Organotypic Cocultures with Genetically Modified Mouse Fibroblasts as a Tool to Dissect Molecular Mechanisms Regulating Keratinocyte Growth and Differentiation

2001 • 117 citations

3-D Coculture of Hepatic Sinusoidal Cells with Primary Hepatocytes—Design of an Organotypical Model

1996 • 115 citations

Trisomy 7p and malignant transformation of human breast epithelial cells following epidermal growth factor withdrawal.

1996 • 115 citations

The mammary fat pad.

1998 • 109 citations

Order and Disorder: The Role of Extracellular Matrix in Epithelial Cancer

2002 • 106 citations

Essential role of biliary glycoprotein (CD66a) in morphogenesis of the human mammary epithelial cell line MCF10F

1999 • 102 citations

Studying actin-dependent processes in tissue culture

2002 • 97 citations

The living skin equivalent as a model in vitro for ranking the toxic potential of dermal irritants

1992 • 94 citations

Improved Barrier Structure Formation in Air-Exposed Human Keratinocyte Culture Systems

1994 • 88 citations

AZU-1: A Candidate Breast Tumor Suppressor and Biomarker for Tumor Progression

2000 • 88 citations

Structural cues from the tissue microenvironment are essential determinants of the human mammary epithelial cell phenotype.

1998 • 86 citations

Function of AP-1 target genes in mesenchymal–epithelial cross-talk in skin

2002 • 81 citations

Laminin-1 and ?6?1 integrin regulate acinar morphogenesis of normal and malignant human prostate epithelial cells

2001 • 79 citations

Tumour-stromal interactions. Role of the stroma in mammary development.

2001 • 77 citations

Growth of exocrine acinar cells on a reconstituted basement membrane gel

1987 • 76 citations

Preferential growth of mammary tumors in intact mammary fatpads.

1981 • 75 citations

A Novel Method for Growing Human Breast Epithelium in Vivo Using Mouse and Human Mammary Fibroblasts

2002 • 75 citations

Influence of microenvironment on mammary epithelial cell survival in primary culture

1999 • 68 citations

Mammary Epithelial Cell and Adipocyte Co-Culture in a 3-D Matrix: The First Step towards Tissue-Engineered Human Breast Tissue

2001 • 63 citations

Differentiation of Separated Mouse Mammary Luminal Epithelial and Myoepithelial Cells Cultured on EHS Matrix Analyzed by Indirect Immunofluorescence of Cytoskeletal Antigens

1999 • 57 citations

Organotypic arrangement of mouse embryonic lung cells on a basement membrane extract: involvement of laminin

1990 • 55 citations

Polarity determination in breast tissue: desmosomal adhesion, myoepithelial cells, and laminin 1

2003 • 54 citations

Dermal Fibroblast-Derived Growth Factors Restore the Ability of β1 Integrin-Deficient Embryonal Stem Cells to Differentiate into Keratinocytes

2001 • 53 citations

Organization and Growth of Mammary Epithelia in the Mammary Gland Fat Pad

1988 • 52 citations

Survival in three dimensions

2002 • 47 citations

Follicle‐like structure and polarized monolayer: Role of the extracellular matrix on thyroid cell organization in primary culture

1998 • 46 citations

Transforming growth factor alpha induces collagen degradation and cell migration in differentiating human epidermal raft cultures.

1991 • 46 citations

Form and Function in the Mammary Gland

1987 • 43 citations

Integrin expression and differentiation in transformed human epidermal cells is regulated by fibroblasts

1992 • 37 citations

Tri‐dimensional prostate cell cultures in simulated microgravity and induced changes in lipid second messengers and signal transduction

2001 • 36 citations

E7-transduced human breast epithelial cells show partial differentiation in three-dimensional culture.

1999 • 34 citations

Effects of electroporation on the tubulin cytoskeleton and directed migration of corneal fibroblasts cultured within collagen matrices

1996 • 32 citations

In vitro karyotype evolution and cytogenetic instability in the non-tumorigenic human breast epithelial cell line HMT-3522

1994 • 29 citations

Proliferation and terminal differentiation of human epidermal keratinocytes in culture

1988 • 23 citations

Mutant cadherin affects epithelial morphogenesis and invasion, but not transformation

2001 • 22 citations

MAINTENANCE OF THE DIFFERENTIATED TYPE II CELL CHARACTERISTICS BY CULTURE ON AN ACELLULAR HUMAN AMNION MEMBRANE

2001 • 19 citations

Cell Nucleus in Context

2000 • 18 citations

Using Cost-Effectiveness Analysis to Define a Breast Cancer Benefits Package for the Uninsured

2002 • 18 citations

Three down and counting: the transformation of human mammary cells from normal to malignant in three steps

2001 • 3 citations